Alternative splicing cancer (33 resultados)

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Paperback. Condición: New. This book Alternative Splicing and Cancer explores the crucial role alternative splicing, a post-transcriptional process, plays in human health and diseases, particularly cancer. Diving deep into the complexities of gene expression and protein diversity, the book illuminates how abnormal splicing contributes to aggressive tumor formation, affecting cellular functions such as proliferation, survival, and immune evasion. With a focus on understanding molecular mechanisms, this book unravels potential diagnostic and prognostic targets, opening doors for enhanced anti-cancer treatment efficacy. An indispensable resource for anyone intrigued by the interplay between gene splicing and cancer biology, it paves the way towards innovative therapeutic strategies.…

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Taschenbuch. Condición: Neu. Regulation of the Krüppel-like Factor 6 Tumor Suppressor | Ras Promotes Cancer Cell Growth via Alternative Splicing-Mediated Inactivation of KLF6 | Steven Yea | Taschenbuch | Kartoniert / Broschiert | Englisch | 2008 | VDM Verlag Dr. Müller | EAN 9783639103359 | Verantwortliche Person für die EU: OmniScriptum GmbH & Co. KG, Bahnhofstr. 28, 66111 Saarbrücken, info[at]akademikerverlag[dot]de | Anbieter: preigu.…

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Paperback. Condición: New. This book Alternative Splicing and Cancer explores the crucial role alternative splicing, a post-transcriptional process, plays in human health and diseases, particularly cancer. Diving deep into the complexities of gene expression and protein diversity, the book illuminates how abnormal splicing contributes to aggressive tumor formation, affecting cellular functions such as proliferation, survival, and immune evasion. With a focus on understanding molecular mechanisms, this book unravels potential diagnostic and prognostic targets, opening doors for enhanced anti-cancer treatment efficacy. An indispensable resource for anyone intrigued by the interplay between gene splicing and cancer biology, it paves the way towards innovative therapeutic strategies.…

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Taschenbuch. Condición: Neu. nach der Bestellung gedruckt Neuware - Printed after ordering - KLF6 is a ubiquitously expressed Krüppel-liketranscription factor whose role in vitro and in vivorole has not been fully identified. Like othermembers of the Krüppel-like family, KLF6 contains aconserved C-terminal three zinc finger DNA-bindingdomain (C2H2 motifs) and a unique N-terminaltransactivation domain. KLF6 directly binds DNA at GCbox promoter elements. Transcriptional targets ofKLF6 include collagen 1, transforming growth factorbeta 1 (TGF 1), types I and II TGF receptors,urokinase type plasminogen activator (uPA), and thehuman immunodeficiency virus long terminal repeat(HIV-1 LTR). Here, we identify a novel mechanism ofcarcinogenesis, whereby oncogenic Ras signalingenhances alternative splicing-mediated inactivationof the KLF6 tumor suppressor in hepatocellularcarcinomas. These Ras-dependent splice forms areshown to abrogate KLF6-mediated growth suppression,and ectopic KLF6 splice variant expression canrestore a Ras-transformed phenotype.…

Paperback. Condición: new. Paperback. This book Alternative Splicing and Cancer explores the crucial role alternative splicing, a post-transcriptional process, plays in human health and diseases, particularly cancer. Diving deep into the complexities of gene expression and protein diversity, the book illuminates how abnormal splicing contributes to aggressive tumor formation, affecting cellular functions such as proliferation, survival, and immune evasion. With a focus on understanding molecular mechanisms, this book unravels potential diagnostic and prognostic targets, opening doors for enhanced anti-cancer treatment efficacy. An indispensable resource for anyone intrigued by the interplay between gene splicing and cancer biology, it paves the way towards innovative therapeutic strategies. This book "Alternative Splicing and Cancer" explores the crucial role alternative splicing, a post-transcriptional process, plays in human health and diseases, particularly cancer. This item is printed on demand. Shipping may be from our UK warehouse or from our Australian or US warehouses, depending on stock availability.…

Condición: New. Dieser Artikel ist ein Print on Demand Artikel und wird nach Ihrer Bestellung fuer Sie gedruckt. Muzafar A. Macha, currently an Assistant Professor and Ramalingaswami Fellow at Watson-Crick Centre for Molecular Medicine, IUST, Kashmir, India, possesses a strong background in Biochemistry, Head and Neck Cancers (HNCs), and therapeutic modaliti.…