Pal prasenjit (33 resultados)

Soft cover. Condición: New. ISBN:9789354616808.

Condición: New.

Soft cover. Condición: New. To generate an excellent research output, we need to train up our scholars with advanced and appropriate research methodology. Even with a big research project, the outputs are poor because of a fragile methodology or design. The book, Research Methodology: Techniques and Methods, has been a well thought out book creation to serve the scholars and faculties with a multi disciplinary background. Starting from research design to multivariate analytical techniques, it has travelled through various research acumens and requirement. It has also dealt with in a unique way on participatory research, report writing, statistical software, reference writing and grounded theory. The book has also accommodated non-linear programming in the most fascinating way. From complex algorithm to useful statistical tools, it will cover the inquiries and interests of scholars and faculties across the terrains of experience and perception.…

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Hardback. Condición: New.

Paperback. Condición: New.

Hardcover. Condición: New. ISBN:9789358878738.

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Hardcover. Condición: New. When the global research is mostly hovering around the semiconductor chips, the new trend is solution research. It is elegantly true for methodological solution for new age social science researches, which is apparently complex, multidimensional, yet enthralling. We are now blending physics and mathematics to social science researches to make it more concrete, predictable, amenable to social ecology and adaptable to change kinetics. The book has covered almost all classical and modern mathematical and statistical solutions to research and prediction. Perhaps this is the solitary book that illustriously compounded an array of linear and non-linear analytical tools and techniques by incorporating ANN, FCM, CCA, AHP and very essentially grounded theory, Meta analysis, game theory and participatory data analyses. I hope and believe, the book is going to add ripples and resurrection in the young minds and creativities for making research the more of an excitement and, less of monotony and rigmarole for the global audience.…

Paperback. Condición: Brand New. 1st edition. 76 pages. 9.25x7.50x0.25 inches. In Stock.

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Hardback. Condición: New.

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hardcover. Condición: New. NEW. SHIPS FROM MULTIPLE LOCATIONS. book.

Condición: New. 2025. 1st Edition. hardcover. . . . . .

Hardcover. Condición: Brand New. 306 pages. In Stock.

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Condición: New.

Condición: As New. Unread book in perfect condition.

Condición: As New. Unread book in perfect condition.

Condición: New. 2025. 1st Edition. hardcover. . . . . . Books ship from the US and Ireland.

HRD. Condición: New. New Book. Delivered from our UK warehouse in 4 to 14 business days. THIS BOOK IS PRINTED ON DEMAND. Established seller since 2000.

Condición: New. Print on Demand.

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Taschenbuch. Condición: Neu. nach der Bestellung gedruckt Neuware - Printed after ordering - The Ca+2-dependent mammalian Proprotein Convertase Subtilisin Kexins (PCSKs) or Proprotein/ Prohormone Convertases (PCs) are a family of endoproteases that play critical roles not only in normal development and metabolism but also in various physiological and pathological conditions. These were initiated by the proteolytic processing of large inactive proproteins into their shorter bioactive mature forms by the PCSK enzymes. These events take place in a highly selective, orchestrated, and stepwise manner. Among the various proprotein substrates of PCSK enzymes, particularly important are the precursor growth factors that include proPDGF-A, B, proIGF-1, 2 and proVEGF-C because of their strong implications in neoplasia initiation, progression, and metastasis. As a result of these findings, PCSK enzymes, particularly furin or PCSK3, became a major target for possible interventions of cancer via the use of their selective inhibitors. Significant progress has been accomplished in the development of peptide and protein-based PCSK inhibitors. However, non-peptide PCSK9 inhibitors are more preferable because of their drug-like and other characteristics. So far, a few non-peptide inhibitors of PCSK enzymes of various types of chemical structures have been described in the literature. These include (i) Carbocyclic compounds of diterpene and streptamine class. (ii) Nitrogen (N)-based heterocyclic compounds of various types and chemical structures such as (a) pyrrolidine bis piperazines, (b) Cu/Zn chelating terpyridine derivatives; (iii) Oxygen (O)-based Heterocyclic compounds of varying types of chemical structures such as (a) Flavonoids, (b) Coumarins of simple and dimeric types, (c) Quinonoids, (d) Iridoids; (iv) Aromatic compounds such as (a) Aryl guanidino and amidino derivatives, (b) Naphthyl fluorescein derivative, and (c) Phenyl Arsonic acids; and (v) C2-symmetrical aromatic azo-compounds. When measured against a small peptidyl-MCA fluorogenic substrate, these inhibitors displayed IC50 values ranging from nM to M. A number of these inhibitors exhibited significant anti-PCSK activity when tested in ex vivo or cell culture conditions. This article provides an overall review of all non-peptide PCSK inhibitors so far reported in the literature along with those we identified recently for the first time and not yet published. The potential implications of these molecules as biochemical, therapeutical, or clinical agents will also be discussed.Table of Contents: Introduction / Historical Perspectives / Class of PCSK Inhibitors / Comparative Analyses of Peptide and Non-peptide Inhibitors / Class of Non-peptide Inhibitors of PCSKs / Comparison of Activities of Non-peptide Inhibitors of PCSK Enzymes / Blockade of Proprotein Processing by Non-peptide PCSK Inhibitors in Cellular Models / Animal Study with Non-peptide PCSK Inhibitors / Future Perspectives of Non-peptide PCSK Inhibitors and Concluding Remarks / Acknowledgments / References.…