Brent gregory (46 resultados)

Idioma: Inglés
Editorial: Dynamite Entertainment, 2016
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Librería: HPB Inc., Dallas, TX, Estados Unidos de AmericaHPB Inc.
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EUR 4,32
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paperback. Condición: Very Good. Connecting readers with great books since 1972! Used books may not include companion materials, and may have some shelf wear or limited writing. We ship orders daily and Customer Service is our top priority. Peeples, Brent; Davilla, Sergio Fernandez (ilustrador).

Idioma: Inglés
Editorial: Dynamite Entertainment, 2016
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Librería: World of Books (was SecondSale), Montgomery, IL, Estados Unidos de AmericaWorld of Books (was SecondSale)
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EUR 7,83
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Condición: Good. Item in good condition. Textbooks may not include supplemental items i.e. CDs, access codes etc. Peeples, Brent; Davilla, Sergio Fernandez (ilustrador).

Idioma: Inglés
Editorial: Dynamic Forces Inc, 2016
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Librería: World of Books Inc, Montgomery, IL, Estados Unidos de AmericaWorld of Books Inc
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EUR 9,52
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Paperback. Condición: Good. When Little Lord Homicide makes his claim as heir to the Big City's underworld, the pint-sized child psychopath incites a gang war against the reigning Veiled Lady. and draws our disguised heroes into a web of intrigue and revenge. Peeples, Brent; Davilla, Sergio Fernandez (ilustrador).…

People of the Web
Little, Gregory L.; Schwarz, Berthold E. (intro.); Raynes, Brent (fwd./aftwd.); Robinson, Kenneth D. (ed.)
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- Primera edición
Librería: Atlantic Bookshop, Brooklyn, NY, Estados Unidos de AmericaAtlantic Bookshop
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EUR 10,80
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Soft cover. Condición: Very Good. 1st Edition. 8vo, card covers, 229pp., ills. First edition, second printing. VG+: clean, bright, sound, presentable.

Theology Today:
Editorial by Patrick Miller; Articles by L. Gregory Jones, Brent Waters, Rob Stuart, J. Wentzel van Husteen, Milton Coalter, Belden Lane, David Johnson, Vincent Wimbush, and E.P. Sanders; Critic's Corner with W. Jim Neidhardt; Poetry by Elizabeth Creamer.
Idioma: Inglés
Editorial: Princeton Theological Seminary, Princeton, New Jersey, 1993
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Librería: Andover Books and Antiquities, Andover, MA, Estados Unidos de AmericaAndover Books and Antiquities
Contactar con el vendedorVendedor de 3 estrellasCondición: Usado
EUR 4,50
Envío por EUR 11,36Se envía dentro de Estados Unidos de AmericaCantidad disponible: 1 disponibles
Softcover. 341 - 506 pp. Volume L, Number 3 (October 1993). Softcover. Good condition; some pen underlining; on covers: touches of wear and light color rubbing.

Idioma: Inglés
Editorial: Dynamic Forces Inc, Runnemede, 2016
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Librería: Grand Eagle Retail, Bensenville, IL, Estados Unidos de AmericaGrand Eagle Retail
Contactar con el vendedorVendedor de 5 estrellasCondición: Nuevo
EUR 21,17
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Paperback. Condición: new. Paperback. "Everything from the designs of the vehicles, the newlook of Green Hornet and villain Tik Tok are wonderfully designed and thenbrought to life through the clean, bright art. " - ComicBastardsFrom the pages of Bill Willingham'sLegenderry: A Steampunk Adventure. it's Green Hornet and Kato, goggles-deep inan all-out gang war. Against a Neo-Victorian backdrop of clockworks and bowlerhats, the classic pulp crusaders take their war against crime -- infiltratingthe enemy in their colorful masked guises -- to whole new levels of whimsy andwonder!When Little Lord Homicide makes hisclaim as heir to the Big City's underworld, the pint-sized child psychopathincites a gang war against the reigning Veiled Lady. and draws our disguisedheroes into a web of intrigue and revenge. As urban warriors from every dankalleyway pour into the violent cobblestone streets, a mysterious new playerknown as the Brass Hornet makes the chaos decidedly personal by offering aking's ransom for the Green Hornet'shead!"Fans of Green Hornet will see manyfamiliar elements of their favorite hero, but with a twist that keeps himfresh." - Major Spoilers"You're going to geta lot more entertainment than you're expecting." - Geeks ofDoom When Little Lord Homicide makes his claim as heir to the Big City's underworld, the pint-sized child psychopath incites a gang war against the reigning Veiled Lady. and draws our disguised heroes into a web of intrigue and revenge. Shipping may be from multiple locations in the US or from the UK, depending on stock availability. Peeples, Brent; Davilla, Sergio Fernandez (ilustrador). …
Editorial: Warner Home Video 1996-01-01 00:00:00, 1996
Librería: R Bookmark, Youngtown, AZ, Estados Unidos de AmericaR Bookmark
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EUR 3,37
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Añadir al carritodvd. Condición: Used - Good.

ISAAC ASIMOV'S SCIENCE FICTION - Mid-December 1991
Dozois, Gardner (editor) (Connie Willis; Isaac Asimov; Richard Paul Russo; Robert Frazier; Howard Waldrop; Gregory Frost; Peni R. Griffin; Michaelene Pendleton)
Editorial: Davis Publications, New York, 1991
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- Primera edición
Librería: WF Sandercombe, Burlington, ON, CanadaWF Sandercombe
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EUR 7,15
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Añadir al carritoSoft cover. Condición: Very Good+. First Edition. 176 pp. Digest format. Volume 15, number 15 . Very light wear. Cover art by Nicholas Jainschigg; interiors by: Nicholas Jainschigg; Laura Lakey; Richard Paul Russo; Gary Freeman; Robert Frazier; and Brent Cardillo. This issue contains: Short Stories: In the Late Cretaceous by Connie Willis; It's a Job by Isaac Asimov; The Hole in Edgar's Hillside by Gregory Frost; One Night in Mulberry Court by Peni R. Griffin; Professionals by Michaelene Pendleton; and Novelettes: Celebrate the Bullet by Richard Paul Russo; Cruising through Blueland by Robert Frazier; and Fin de Cycle by Howard Waldrop; along with Asimov's Editorial: Aliens; and all the usual features. Size: 12mo. Nicholas Jainschigg; Laura Lakey; Richard Paul Russo; Gary Freeman; Robert Frazier; Brent Cardillo; Nicholas Jainschigg; (ilustrador). Book. …

Editorial: Brenoggia Productions, 1989
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- Revista/Periódico
Librería: Chamblin Bookmine, Jacksonville, FL, Estados Unidos de AmericaChamblin Bookmine
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EUR 17,99
Envío por EUR 6,11Se envía dentro de Estados Unidos de AmericaCantidad disponible: 1 disponibles
Añadir al carrito8Vo Softcover. Condición: Good. 51pp. Staplebound softcover magazine. Text and photography is clean on unmarked, uncreased pages. Hinge is secure, textblock is square with pointed corners. Minimal overall shelf/timewear, coverwear.

Editorial: Brenoggia Productions, 1988
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- Revista/Periódico
Librería: Chamblin Bookmine, Jacksonville, FL, Estados Unidos de AmericaChamblin Bookmine
Contactar con el vendedorVendedor de 5 estrellasCondición: Usado - Aceptable
EUR 17,99
Envío por EUR 6,11Se envía dentro de Estados Unidos de AmericaCantidad disponible: 1 disponibles
Añadir al carrito8Vo Softcover. Condición: Good. 51pp. Staplebound softcover magazine. Text and photography is clean on unmarked, uncreased pages. Hinge is secure, textblock is square with pointed corners. Minimal overall shelf/timewear, coverwear.

Editorial: Brenoggia Productions, 1988
- Tapa blanda
- Revista/Periódico
Librería: Chamblin Bookmine, Jacksonville, FL, Estados Unidos de AmericaChamblin Bookmine
Contactar con el vendedorVendedor de 5 estrellasCondición: Usado - Aceptable
EUR 17,99
Envío por EUR 6,11Se envía dentro de Estados Unidos de AmericaCantidad disponible: 1 disponibles
Añadir al carrito8Vo Softcover. Condición: Good. 47pp. Staplebound softcover magazine. Text and photography is clean on unmarked, uncreased pages. Hinge is secure, textblock is square with pointed corners. Minimal overall shelf/timewear, coverwear, faintest edge patina.

Criminal Poisoning: Clinical and Forensic Perspectives: .
Christopher P. Holstege; Thomas Neer; Gregory B. Saathoff; R. Brent Furbee
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Librería: ThriftBooks-Atlanta, AUSTELL, GA, Estados Unidos de AmericaThriftBooks-Atlanta
Contactar con el vendedorVendedor de 5 estrellasCondición: Usado - Bueno
EUR 54,50
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Hardcover. Condición: Very Good. No Jacket. May have limited writing in cover pages. Pages are unmarked. ~ ThriftBooks: Read More, Spend Less.

Idioma: Inglés
Editorial: Dynamic Forces Inc, Runnemede, 2016
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Librería: AussieBookSeller, Truganina, VIC, AustraliaAussieBookSeller
Contactar con el vendedorVendedor de 5 estrellasCondición: Nuevo
EUR 26,20
Envío por EUR 32,32Se envía de Australia a Estados Unidos de AmericaCantidad disponible: 1 disponibles
Paperback. Condición: new. Paperback. "Everything from the designs of the vehicles, the newlook of Green Hornet and villain Tik Tok are wonderfully designed and thenbrought to life through the clean, bright art. " - ComicBastardsFrom the pages of Bill Willingham'sLegenderry: A Steampunk Adventure. it's Green Hornet and Kato, goggles-deep inan all-out gang war. Against a Neo-Victorian backdrop of clockworks and bowlerhats, the classic pulp crusaders take their war against crime -- infiltratingthe enemy in their colorful masked guises -- to whole new levels of whimsy andwonder!When Little Lord Homicide makes hisclaim as heir to the Big City's underworld, the pint-sized child psychopathincites a gang war against the reigning Veiled Lady. and draws our disguisedheroes into a web of intrigue and revenge. As urban warriors from every dankalleyway pour into the violent cobblestone streets, a mysterious new playerknown as the Brass Hornet makes the chaos decidedly personal by offering aking's ransom for the Green Hornet'shead!"Fans of Green Hornet will see manyfamiliar elements of their favorite hero, but with a twist that keeps himfresh." - Major Spoilers"You're going to geta lot more entertainment than you're expecting." - Geeks ofDoom When Little Lord Homicide makes his claim as heir to the Big City's underworld, the pint-sized child psychopath incites a gang war against the reigning Veiled Lady. and draws our disguised heroes into a web of intrigue and revenge. Shipping may be from our Sydney, NSW warehouse or from our UK or US warehouse, depending on stock availability. Peeples, Brent; Davilla, Sergio Fernandez (ilustrador). …

Taylor's master guide to gardening [Creating a garden -- Thinking about your garden -- A gardener's look at plants -- Thinking about design -- Elements in the landscape -- Special gardens -- Gallery of plants -- Encyclopedia of plants -- Growing healthy plants -- Soil -- Planting -- Increasing your own plants -- Ongoing care -- Lawns.]
Tenenbaum, Frances. ; Buchanan, Rita. ; Holmes, Roger; Nancy J. Stabile, Nancy Baubaire, Steve Bender, Kevin Connelly, John Dunmire, Galen Gates, Tim Hohn, John Mastalerz, Glenn Morris, Rob Nicholson, h Brent Pemberton, Judith Phillips, Gregory Piotrowski, Rob Proctor, Warren Schultz, Lauren Springer, Guy Sternberg, Martha Kennedy, Ken Druse, Galen GAtes, Derek Fell, Michael A Dirr, Charles Mann, Rita Buchanan, David Benner, Allan Armitage, Karen Bussolini, Rosalind Creasy, John Elsley, Thomas Eltzroth, Pamela Harper, Saxon Holt, Dency Kane, Tom Mannion, Monty Monses, Rick Mastelli, Scott Millard, Jerry Pavia, John Neubauer, Steven Still, Doug Wechsler, Tom Woodham, Alice Yarborough
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- Primera edición
Librería: Joseph Valles - Books, Stockbridge, GA, Estados Unidos de AmericaJoseph Valles - Books
Contactar con el vendedorVendedor de 5 estrellasCondición: Usado - Excelente
EUR 112,47
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Hardcover. Condición: Fine. Estado de la sobrecubierta: Fine. 1st Edition. 1st edition, 1st printing ; xi, 612 p. : col. ill. ; 31 cm.; ISBN: 061815907X; 9780618159079 ; Dewey: 635.9 ; OCLC: 61225501 ; green cloth in color photographic dustjacket ; "Provides information on growing trees, perennials, annuals, grasses, herbs, and bulbs, features the basics of garden design, and talks about environmentally sound controls of pests and diseases" ; Contents: Creating a garden -- Thinking about your garden -- A gardener's look at plants -- Thinking about design -- Elements in the landscape -- Special gardens -- Gallery of plants -- Encyclopedia of plants -- Growing healthy plants -- Soil -- Planting -- Increasing your own plants -- Ongoing care -- Lawns.; more than 3,000 species detailed, photo gallery of 1,000 of the best trees, shrubs, perennials, annuals, bulbs, herbs, succulents, and ferns best suited to the American garden, cross-referenced ; major section on creating a garden, illustrated with 200 photographs of garden scenes; complete guide to making and maintaining a garden, with analyzing soils, somposting, buying plans, propagating, pruning, watering, fertilizing ; a chapter on pests and diseases recommends only safe, organic controls ; heavy, thick volume ; slight wear to top of dustjacket ; else FINE/FINE. Book. …

Use of Novel Techniques to Quantify Phenotypes in Biological Treatment Processes
Robinson, Kevin G.; Sayler, Gary S.; Brown, Janalyn R.; Carley, Jack M.; Derrigo, Matthew; Dionisi, Hebe M.; Flowers, Jason; Garrett, Victoria M.; Gregory, Igrid; Harms, Gerda; Hawkins, Shawn A.; Layton, Alice C.; Parker, Jack J.; Wood, Brent C.; Meyers, Arthur J.
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Librería: GreatBookPrices, Columbia, MD, Estados Unidos de AmericaGreatBookPrices
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EUR 150,03
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Condición: New.

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Librería: BuchWeltWeit Ludwig Meier e.K., Bergisch Gladbach, AlemaniaBuchWeltWeit Ludwig Meier e.K.
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EUR 128,39
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Buch. Condición: Neu. Neuware -This comprehensive book examines the complex interplay between endocrine and kidney disorders, and how this inter-relationship impacts patients with chronic kidney disease. Authored by experts in areas of endocrinology and nephrology, chapters cover a variety of topics, including diabetes, metabolic syndrome, thyroid dysfunction, gonadal disorders, dyslipidemia, mineral bone disorders, obesity, and pituitary disorders. These comorbidities are thoroughlyexamined and provide the clinician, researcher, andtrainee witha greater understanding of the impact of endocrine disorders on kidney disease patients, the ability to identify persistent gaps in knowledge for future investigation, andmove closertowards the goal of improving the health and survival of thechronic kidney disease population. 354 pp. Englisch.…

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Librería: Books Puddle, Woodside, NY, Estados Unidos de AmericaBooks Puddle
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EUR 160,06
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Condición: New. pp. 306.

Use of Novel Techniques to Quantify Phenotypes in Biological Treatment Processes
Robinson, Kevin G.; Sayler, Gary S.; Brown, Janalyn R.; Carley, Jack M.; Derrigo, Matthew; Dionisi, Hebe M.; Flowers, Jason; Garrett, Victoria M.; Gregory, Igrid; Harms, Gerda; Hawkins, Shawn A.; Layton, Alice C.; Parker, Jack J.; Wood, Brent C.; Meyers, Arthur J.
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Librería: GreatBookPricesUK, Woodford Green, Reino UnidoGreatBookPricesUK
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EUR 147,37
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Condición: New.

Use of Novel Techniques to Quantify Phenotypes in Biological Treatment Processes
Robinson, Kevin G.; Sayler, Gary S.; Brown, Janalyn R.; Carley, Jack M.; Derrigo, Matthew; Dionisi, Hebe M.; Flowers, Jason; Garrett, Victoria M.; Gregory, Igrid; Harms, Gerda; Hawkins, Shawn A.; Layton, Alice C.; Parker, Jack J.; Wood, Brent C.; Meyers, Arthur J.
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Librería: GreatBookPrices, Columbia, MD, Estados Unidos de AmericaGreatBookPrices
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EUR 165,82
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Condición: As New. Unread book in perfect condition.

Use of Novel Techniques to Quantify Phenotypes in Biological Treatment Processes
Robinson, Kevin G.; Sayler, Gary S.; Brown, Janalyn R.; Carley, Jack M.; Derrigo, Matthew; Dionisi, Hebe M.; Flowers, Jason; Garrett, Victoria M.; Gregory, Igrid; Harms, Gerda; Hawkins, Shawn A.; Layton, Alice C.; Parker, Jack J.; Wood, Brent C.; Meyers, Arthur J.
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Librería: Ria Christie Collections, Uxbridge, Reino UnidoRia Christie Collections
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EUR 165,78
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Condición: New. In English.
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Librería: preigu, Osnabrück, Alemaniapreigu
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EUR 104,25
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Taschenbuch. Condición: Neu. Thyroid Function Testing | Gregory A. Brent | Taschenbuch | Endocrine Updates | x | Englisch | 2012 | Springer | EAN 9781461425755 | Verantwortliche Person für die EU: Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg, juergen[dot]hartmann[at]springer[dot]com | Anbieter: preigu.…

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Librería: Revaluation Books, Exeter, Reino UnidoRevaluation Books
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EUR 168,29
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Paperback. Condición: Brand New. 402 pages. 9.25x6.10x0.69 inches. In Stock.

Use of Novel Techniques to Quantify Phenotypes in Biological Treatment Processes
Robinson, Kevin G.; Sayler, Gary S.; Brown, Janalyn R.; Carley, Jack M.; Derrigo, Matthew; Dionisi, Hebe M.; Flowers, Jason; Garrett, Victoria M.; Gregory, Igrid; Harms, Gerda; Hawkins, Shawn A.; Layton, Alice C.; Parker, Jack J.; Wood, Brent C.; Meyers, Arthur J.
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Librería: GreatBookPricesUK, Woodford Green, Reino UnidoGreatBookPricesUK
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EUR 166,97
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Condición: As New. Unread book in perfect condition.

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Librería: Revaluation Books, Exeter, Reino UnidoRevaluation Books
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EUR 178,09
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Paperback. Condición: Brand New. illustrated edition. 220 pages. 10.75x8.25x0.75 inches. In Stock.

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Librería: Books Puddle, Woodside, NY, Estados Unidos de AmericaBooks Puddle
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EUR 188,89
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Condición: New.

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Librería: AHA-BUCH GmbH, Einbeck, AlemaniaAHA-BUCH GmbH
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EUR 166,33
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Taschenbuch. Condición: Neu. Druck auf Anfrage Neuware - Printed after ordering - Thyroid function tests are utilized by essentially all medical practitioners, across every clinical setting, in patients from newborns to the elderly. They are the most frequently measured endocrine tests. The sensitive thyrotropin (TSH) assay reflects thyroid hormone feedback to the pituitary, and is diagnostic of both thyroid h- mone excess as well as deficiency. The log-linear relationship between serum TSH and thyroxine concentrations means that small changes in serum thyroxine are amplified by changes in serum TSH. The availability of the sensitive TSH assay in essentially all clinical laboratories has improved and simplified the assessment of thyroid function for the diagnosis of thyroid disease and to monitor treatment. Serum free thyroxine and thyrotropin concentrations, as well as other thyroid tests, can be measured utilizing an automated immunoassay platform that provides rapid and accurate results. This simplified approach to thyroid assessment, often requ- ing only a serum TSH measurement, and rapid availability of the thyroid function tests results, has expanded the scope of thyroid testing and clinicians ordering and interpretingth yroid tests. There remain, however, many challenges in selecting the appropriate thyroid function test to order, the correct interpretation of results, and applying these results to the diagnosis and management of thyroid diseases. It is especially important to be aware of limitations of thyroid function tests, as well as special clinical c- cumstances that can influence thyroid function measurements. The serum TSH concentration, for example, may not accurately reflect thyroid status in many si- ations including after prolonged hyperthyroidism when serum TSH remains s- pressed for months, in the presence of hypothalamic orpituitary disease, or due to a number of interfering medications. The serum free thyroxine, measured by the analog method, is not accurate with high or low serum binding proteins and d- ing pregnancy. Hospitalized patients often have thyroid function test abnormalities that are transient and return to normal after recovery from the acute illness. Iodine excessand deficiency candramatically influence thyroid function tests. Significant insights have been gained into the regulation of thyroid hormone synthesis and especially the role of thyroid hormone metabolism in supplying t- sues locally with an adequate supply of thyroid hormone. In a number of instances, these factors influence the selection and interpretation of thyroid function tests. Polymorphisms, common sequence variations, in genes of components that regulate thyroid function and thyroid hormone action may also contribute to variability in thyroid function tests in a population. v vi Preface This volume draws on an outstanding international panel of experts in thyroid function tests and thyroid function assessment. They represent clinicians, clinical researchers, and basic science researchers, all with a focus on some aspect of the assessment of thyroid function. The chapters all provide a clinical perspective, but are informed by themost recent scientific advancements. The first section of the book (Chaps. 1-3) presents the most recent advances in thyroid physiology, a review of genetic influences on thyroid function tests, and a discussion on the influence of iodine on thyroid function. In Chap. 1, Drs. Huang and de Castro Neves describe thyroid hormone metabolism, emphasizing the key role of thyroid hormone activation and inactivation in thyroid hormone action. Dr. Visser is a world leader in studies ofthyroid metabolism and genetic influences on thyroid function. In Chap. 2, Dr. Visser and his colleagues, Drs. van der Deure, Medici, and Peeters, provide a clear view of this important and r- idly expanding field. The population variation in the TSH 'set point' (relationship between serum TSH and thyroxine in an individual), for example, is thought to be genetically determined, and influences the evaluati.…

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Librería: AHA-BUCH GmbH, Einbeck, AlemaniaAHA-BUCH GmbH
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EUR 182,90
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Buch. Condición: Neu. Druck auf Anfrage Neuware - Printed after ordering - This comprehensive book examines the complex interplay between endocrine and kidney disorders, and how this inter-relationship impacts patients with chronic kidney disease. Authored by experts in areas of endocrinology and nephrology, chapters cover a variety of topics, including diabetes, metabolic syndrome, thyroid dysfunction, gonadal disorders, dyslipidemia, mineral bone disorders, obesity, and pituitary disorders. These comorbidities are thoroughlyexamined and provide the clinician, researcher, andtrainee witha greater understanding of the impact of endocrine disorders on kidney disease patients, the ability to identify persistent gaps in knowledge for future investigation, andmove closertowards the goal of improving the health and survival of thechronic kidney disease population.…

Idioma: Inglés
Editorial: Springer US, 2010
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Librería: Buchpark, Trebbin, AlemaniaBuchpark
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EUR 120,88
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Condición: Gut. Zustand: Gut | Seiten: 304 | Sprache: Englisch | Produktart: Bücher | Thyroid function tests are utilized by essentially all medical practitioners, across every clinical setting, in patients from newborns to the elderly. They are the most frequently measured endocrine tests. The sensitive thyrotropin (TSH) assay reflects thyroid hormone feedback to the pituitary, and is diagnostic of both thyroid h- mone excess as well as deficiency. The log¿linear relationship between serum TSH and thyroxine concentrations means that small changes in serum thyroxine are amplified by changes in serum TSH. The availability of the sensitive TSH assay in essentially all clinical laboratories has improved and simplified the assessment of thyroid function for the diagnosis of thyroid disease and to monitor treatment. Serum free thyroxine and thyrotropin concentrations, as well as other thyroid tests, can be measured utilizing an automated immunoassay platform that provides rapid and accurate results. This simplified approach to thyroid assessment, often requ- ing only a serum TSH measurement, and rapid availability of the thyroid function tests results, has expanded the scope of thyroid testing and clinicians ordering and interpretingth yroid tests. There remain, however, many challenges in selecting the appropriate thyroid function test to order, the correct interpretation of results, and applying these results to the diagnosis and management of thyroid diseases. It is especially important to be aware of limitations of thyroid function tests, as well as special clinical c- cumstances that can influence thyroid function measurements. The serum TSH concentration, for example, may not accurately reflect thyroid status in many si- ations including after prolonged hyperthyroidism when serum TSH remains s- pressed for months, in the presence of hypothalamic or pituitary disease, or due to a number of interfering medications. The serum free thyroxine, measured by the analog method, is not accurate with high or low serum binding proteins and d- ing pregnanc.…

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Librería: Ria Christie Collections, Uxbridge, Reino UnidoRia Christie Collections
Contactar con el vendedorVendedor de 5 estrellasCondición: Nuevo
EUR 250,00
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Condición: New. In English.

Idioma: Inglés
Editorial: Springer, 2010
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Librería: AHA-BUCH GmbH, Einbeck, AlemaniaAHA-BUCH GmbH
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Buch. Condición: Neu. Druck auf Anfrage Neuware - Printed after ordering - Thyroid function tests are utilized by essentially all medical practitioners, across every clinical setting, in patients from newborns to the elderly. They are the most frequently measured endocrine tests. The sensitive thyrotropin (TSH) assay reflects thyroid hormone feedback to the pituitary, and is diagnostic of both thyroid h- mone excess as well as deficiency. The log-linear relationship between serum TSH and thyroxine concentrations means that small changes in serum thyroxine are amplified by changes in serum TSH. The availability of the sensitive TSH assay in essentially all clinical laboratories has improved and simplified the assessment of thyroid function for the diagnosis of thyroid disease and to monitor treatment. Serum free thyroxine and thyrotropin concentrations, as well as other thyroid tests, can be measured utilizing an automated immunoassay platform that provides rapid and accurate results. This simplified approach to thyroid assessment, often requ- ing only a serum TSH measurement, and rapid availability of the thyroid function tests results, has expanded the scope of thyroid testing and clinicians ordering and interpretingth yroid tests. There remain, however, many challenges in selecting the appropriate thyroid function test to order, the correct interpretation of results, and applying these results to the diagnosis and management of thyroid diseases. It is especially important to be aware of limitations of thyroid function tests, as well as special clinical c- cumstances that can influence thyroid function measurements. The serum TSH concentration, for example, may not accurately reflect thyroid status in many si- ations including after prolonged hyperthyroidism when serum TSH remains s- pressed for months, in the presence of hypothalamic orpituitary disease, or due to a number of interfering medications. The serum free thyroxine, measured by the analog method, is not accurate with high or low serum binding proteins and d- ing pregnancy. Hospitalized patients often have thyroid function test abnormalities that are transient and return to normal after recovery from the acute illness. Iodine excessand deficiency candramatically influence thyroid function tests. Significant insights have been gained into the regulation of thyroid hormone synthesis and especially the role of thyroid hormone metabolism in supplying t- sues locally with an adequate supply of thyroid hormone. In a number of instances, these factors influence the selection and interpretation of thyroid function tests. Polymorphisms, common sequence variations, in genes of components that regulate thyroid function and thyroid hormone action may also contribute to variability in thyroid function tests in a population. v vi Preface This volume draws on an outstanding international panel of experts in thyroid function tests and thyroid function assessment. They represent clinicians, clinical researchers, and basic science researchers, all with a focus on some aspect of the assessment of thyroid function. The chapters all provide a clinical perspective, but are informed by themost recent scientific advancements. The first section of the book (Chaps. 1-3) presents the most recent advances in thyroid physiology, a review of genetic influences on thyroid function tests, and a discussion on the influence of iodine on thyroid function. In Chap. 1, Drs. Huang and de Castro Neves describe thyroid hormone metabolism, emphasizing the key role of thyroid hormone activation and inactivation in thyroid hormone action. Dr. Visser is a world leader in studies ofthyroid metabolism and genetic influences on thyroid function. In Chap. 2, Dr. Visser and his colleagues, Drs. van der Deure, Medici, and Peeters, provide a clear view of this important and r- idly expanding field. The population variation in the TSH 'set point' (relationship between serum TSH and thyroxine in an individual), for example, is thought to be genetically determined, and influences the evaluati.…