Nucleic acid metal ion interactions (17 resultados)

Hardcover. Condición: Very Good. No Jacket. First Edition. In "Nucleic Acid-Metal Ion Interactions" (Metal Ions in Biology Series: Volume 1) by Thomas G. Spiro, we present a First Edition/First Printing in Near Fine/VG+ condition, complete with a Good dust jacket. The hardcover edition features bright silver covers adorned with blue printed lettering, creating an elegant and visually appealing design.The covers are in excellent shape, and the binding is square and tight, ensuring the book's enduring quality. Inside, the interior pages are clean and unmarked, providing a pristine reading experience for those delving into the intriguing subject matter.The jacket condition reveals some chips, light shelf wear, and a 2" tear, yet it remains in Good condition, protecting the book while showcasing its informative content.This volume serves as the first in the series, offering valuable insights and new directions arising from research into the structural chemistry found at biological sites with metal ions. The book delves into the exciting field of interactions between metal ions and nucleic acids, shedding light on their significance and potential applications.Within its pages, selected papers explore essential ongoing investigations in five key areas: the discovery and therapeutic application of anticancer properties of cis-dichlorodiammine platinum (II) and related metal complexes; possible modes of action of platinum anticancer agents, as well as the uses of heavy metal complexes in probing the structure of nucleic acids; metals as mutagens and carcinogens; metal ion interactions with transfer RNA, the nucleic acid with high-resolution three-dimensional crystal structures; and the various modes through which metal ions may interact with constituents of nucleic acids.For your peace of mind, the book will be carefully packaged for shipment, ensuring it arrives in excellent condition and protected from any potential damage during transit. As part of our commitment to excellent service, a USPS electronic tracking number will be issued free of charge, enabling you to monitor the progress of your shipment.For those seeking more information or pictures regarding this captivating edition, please feel free to contact me. "Nucleic Acid-Metal Ion Interactions" stands as a significant contribution to the exploration of metal ions' roles in biological systems, making it a valuable addition to any scientific library.…

Hardcover. Condición: Good. No Jacket. Missing dust jacket; Pages can have notes/highlighting. Spine may show signs of wear. ~ ThriftBooks: Read More, Spend Less.

Condición: Brand New. New. US edition. Expediting shipping for all USA and Europe orders excluding PO Box. Excellent Customer Service.

Condición: as new. Appears unread. May have a retail sticker on back cover or remainder mark on the text block.

Condición: Brand New. New. US edition. Expediting shipping for all USA and Europe orders excluding PO Box. Excellent Customer Service.

Condición: New. This is a Brand-new US Edition. This Item may be shipped from US or any other country as we have multiple locations worldwide.

Condición: Brand New. New. US edition. Expediting shipping for all USA and Europe orders excluding PO Box. Excellent Customer Service.

Condición: Brand New. New. US edition. Expediting shipping for all USA and Europe orders excluding PO Box. Excellent Customer Service.

Condición: New. This is a Brand-new US Edition. This Item may be shipped from US or any other country as we have multiple locations worldwide.

Condición: New. pp. xiv + 433 1st Edition.

Condición: New. pp. xiv + 433 Illus.

Condición: New. Brand New! Fast Delivery This is an International Edition and ship within 24-48 hours. Deliver by FedEx and Dhl, & Aramex, UPS, & USPS and we do accept APO and PO BOX Addresses. Order can be delivered worldwide within 6-10 days and we do have flat rate for up to 2LB. Extra shipping charges will be requested if the Book weight is more than 5 LB. This Item May be shipped from India, United states & United Kingdom. Depending on your location and availability.…

Condición: New. pp. xiv + 433.

Hardcover. Condición: new. Hardcover. Natural biochemical processes are routinely being discovered in living cells that involve RNA. Some of these processes, such as RNA interference, are now being exploited for biotechnology and medicinal applications. DNA has also proven in recent years to be more than a passive storehouse of information. For example, non-B-form DNA structures formed by G-rich DNA have been shown to participate in the regulation of gene expression, a discovery that presents new possibilities for drug targets in the genome. The current quest to understand how nucleic acid functions at the most fundamental level requires that we have a detailed understanding of nucleic acid-metal ion interactions. Because RNA and DNA are polyanions the structure and biological function of these biopolymers depends strongly on their association with metal ions. While this intimate connection between metal ions and nucleic function has been appreciated for decades, the noncovalent and dynamic nature of these interactions has continually presented challenges to the development of accurate and quantitative descriptions. Over the past few years the development of solution state spectroscopic techniques and the achievement of high resolution X-ray crystal structures have provided tremendous insights into the nature of nucleic acid-metal ion interactions, including direct evidence for their importance in determining nucleic acid structure, from the dictation of folding pathways followed by large RNA molecules to the subtle modulation of DNA groove widths. This new book provides a comprehensive review of the experimental studies that define our current understanding of nucleic acid-metal ion interactions with a particular emphasis being placed on experimental biophysical studies. However, the book is not merely a current review of the literature, as original material and fresh perspectives on published results are also presented. Particularly noteworthy topics include: -The chapter by Williams and fellow workers which reviews information provided by x-ray crystal structures and discusses what this information has revealed about the unique nature of Mg2+ interactions with RNA phosphate groups. The authors provide fresh insights, based upon structural comparisons, for how these interactions govern the local folding pathways of RNA. By dedicating separate chapters to the participation of metal ions in the kinetics and thermodynamics of RNA folding, this volume provides a more in depth treatise of both areas than is typically possible for reviews in which these two related, but distinct, topics are combined -Polyelectrolyte models of nucleic acids have proven to be extremely valuable for understanding the sequestering counterions in a so-called diffuse cloud around polymeric DNA. J. Michael Schurr provides a comprehensive review of polyanion models. Despite the success of polyelectrolyte models in describing some physical properties of nucleic acids, this topic is not always sufficiently understood by many researchers to make use of these models and this chapter serves as a valuable and up to date introduction to this topic. -The chapter by Pizarro and Sadler on metal ion-nucleic acid interactions in disease and medicine is complemented by a chapter by Lippert on coordinative bond formation between metal ions and nucleic acid bases. Together, these two chapters provide an overview of transition metal ion interactions with nucleic acids that illustrates the promise and peril that is associated with direct metal ion coordination to nucleic acid bases in living cells. The book is sufficiently detailed to serve as a reference source for researchers active in the field of nucleic acids biophysics and molecular biology. In addition, chapter authors have added introductory material and enough background material in each chapter so that the book can also can serve as an ent Shipping may be from multiple locations in the US or from the UK, depending on stock availability.…

Gebunden. Condición: New. Provides a perspective on nucleic acid-metal ion interactions with an emphasis on experimental biophysical studies which will prove indispensable to biophysicists and molecular biologists.&Uumlber den AutorrnrnNicholas V Hud is at the Georg.

Hardcover. Condición: Brand New. 1st edition. 433 pages. 9.25x6.25x1.25 inches. In Stock.

Buch. Condición: Neu. Neuware - This book provides a perspective of nucleic acid-metal ion interactions with an emphasis on experimental biophysical studies. Topics covered range from x-ray crystallographic studies of transition metal ion coordination by the nucleotide bases to the application of polyelectrolyte theory for understanding the nature of delocalized counterions that surround nucleic acids in solution. Separate chapters cover how nucleic acid-metal ions play a role in the kinetics and thermodynamics of RNA folding, as well as the role of metal ions in RNA catalysis, in disease and in medicine. The book will serve as a reference source for researchers in nucleic acids biophysics and molecular biology, but it also includes enough background material for students and researchers who have not previously worked in the field.…