Formulating poorly water soluble (43 resultados)

Taschenbuch. Condición: Neu. Solubility Enhancement of Poorly Water Soluble Drug By Nanosizing | Brief Introduction To Different Nanosuspension Formulating Technologies | Divyesh Thakar | Taschenbuch | Englisch | LAP Lambert Academic Publishing | EAN 9783659166211 | Verantwortliche Person für die EU: preigu GmbH & Co. KG, Lengericher Landstr. 19, 49078 Osnabrück, mail[at]preigu[dot]de | Anbieter: preigu.…

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Condición: gut. 2011. Formulating Poorly Water Soluble Drugs (AAPS Advances in the Pharmaceutical Sciences Series, 3, Band 3) In englischer Sprache. pages.

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Taschenbuch. Condición: Neu. Formulating Poorly Water Soluble Drugs | Robert O. Williams Iii (u. a.) | Taschenbuch | xii | Englisch | 2014 | Springer | EAN 9781489985927 | Verantwortliche Person für die EU: Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg, juergen[dot]hartmann[at]springer[dot]com | Anbieter: preigu. …

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Taschenbuch. Condición: Neu. Druck auf Anfrage Neuware - Printed after ordering - This volume is intended to provide the reader with a breadth of understanding regarding the many challenges faced with the formulation of poorly water-soluble drugs as well as in-depth knowledge in the critical areas of development with these compounds. Further, this book is designed to provide practical guidance for overcoming formulation challenges toward the end goal of improving drug therapies with poorly water-soluble drugs. Enhancing solubility via formulation intervention is a unique opportunity in which formulation scientists can enable drug therapies by creating viable medicines from seemingly undeliverable molecules. With the ever increasing number of poorly water-soluble compounds entering development, the role of the formulation scientist is growing in importance. Also, knowledge of the advanced analytical, formulation, and process technologies as well as specific regulatory considerations related to the formulation of these compounds is increasing in value. Ideally, this book will serve as a useful tool in the education of current and future generations of scientists, and in this context contribute toward providing patients with new and better medicines.…

Buch. Condición: Neu. Druck auf Anfrage Neuware - Printed after ordering - A pharmaceutical scientist s approach toward solubility enhancement of a poorly water-soluble molecule typically includes detailed characterization of the compound s physiochemical properties, solid-state modifications, advanced formulation design, non-conventional process technologies, advanced analytical characterization, and specialized product performance analysis techniques. The scientist must also be aware of the unique regulatory considerations pertaining to the non-conventional approaches often utilized for poorly water-soluble drugs. One faced with the challenge of developing a drug product from a poorly soluble compound must possess at minimum a working knowledge of each of the abovementioned facets and detailed knowledge of most. In light of the magnitude of the growing solubility problem to drug development, this is a significant burden especially when considering that knowledge in most of these areas is relatively new and continues to develop. There are numerous literature resources available to pharmaceutical scientists to educate and provide guidance toward formulations development with poorly water-soluble drugs; however, a single, comprehensive reference is lacking. Furthermore, without access to a vast journal library, the detailed methods used to implement these approaches are not available. The objective of this volume is therefore to consolidate within a single text the most current knowledge, practical methods, and regulatory considerations pertaining to formulations development with poorly water-soluble molecules. …

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Buch. Condición: Neu. Druck auf Anfrage Neuware - Printed after ordering - The objective of thisthird editionis to consolidate within a single text the most current knowledge, practical methods, and regulatory considerations pertaining to formulations development with poorly water-soluble molecules. A pharmaceutical scientist's approach toward solubility enhancement of a poorly water-soluble molecule typically includes detailed characterization of the compound's physiochemical properties, solid-state modifications, advanced formulation design, non-conventional process technologies, advanced analytical characterization, and specialized product performance analysis techniques. The scientist must also be aware of the unique regulatory considerations pertaining to the non-conventional approaches often utilized for poorly water-soluble drugs. One faced with the challenge of developing a drug product from a poorly soluble compound must possess ataminimum a working knowledge of each of theabove mentionedfacetsand detailed knowledge of most. In light of the magnitude of the growing solubility problem to drug development, this is a significant burden especially when considering that knowledge in most of these areas is relatively new and continues to develop. …

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Taschenbuch. Condición: Neu. nach der Bestellung gedruckt Neuware - Printed after ordering - Telmisartan is BCS class II anti hypertensive drug. t1/2 of Telmisartan is approximately 24 hours. So, it was proposed to design a nanosuspension for enhancement of solubility to get quick and rapid onset of drug action. It has been formulated in the form of redispersible powder because of patient compliance and convenience in oral administration. Hence the aim of present work was to develop a new Telmisartan nanosuspension formualation for quick onset of action which is required in hypertension condition. Nanosuspension was prepared by Media milling method by using different stabilizers. Study of effect of different concentration of different stabilizers and their combinations, different concentrations of media and at different time interval was done. Factorial design was applied and different batches were formulated and evaluated. Optimization was done from the factorial batches. Optimized formulation was found to be good stabilized with good in vitro drug release profile.…

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