ISBN: 9781849733649 - computational approaches to nuclear receptors: volume 30 (drug discovery series) (15 resultados)

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Hardcover. Condición: new. Hardcover. Nuclear receptors (NR) are ligand-induced activated transcription factors that are involved in numerous biological processes. Since the 1990's when the first structures were determined by means of X ray diffraction, the number of NR structures has increased considerably. Moreover several "omics" projects (genomics, pharmcogenomics and proteomics) have opened up great opportunities for the discovery of new targets, the characterization of abnormal protein patterns, the selection of "tailored" drugs and the evaluation of drug efficacy even with a lack of structural data. Furthermore, structure-based drug design, computational methods for in silico screening and nanobiotechnology- based tools are simplifying this time-consuming and money-intensive research of lead compounds and, possibly, new drugs. Biological interactions such as those that occur between a protein and ligand are concerted events where flexible molecules interact. Thus understanding flexibility of large molecules or biological complexes is of primary importance to help define the right model to approximate the reality for drug discovery, virtual screening, food safety analysis, etc. NRs are known as flexible targets, with many structural similarities, in particular for their Ligand Binding Domain: these similarities could be assumed to share behavioural qualities that belong to this class of compounds. Thus to supply a possible, complete and exhaustive answer to questions about the behaviour of NRs, their interactions with new potential drugs, endocrine disruptors such as animal and human food toxins, food additives or industry residuals, it is mandatory to approach the problem from a different point of view: a molecular modelling approach, steered synthesis, and in vitro and in vivo tests, etc. The aim of this book is to provide a state of the art review on investigations into Nuclear Receptors. The aim of this book is to provide a state of the art review on investigations into Nuclear Receptors Shipping may be from multiple locations in the US or from the UK, depending on stock availability.…

Gebunden. Condición: New. The aim of this book is to provide a state of the art review on investigations into Nuclear Receptors&Uumlber den AutorrnrnProfessor Cozzini s main research interests have been the development of chemistry software and Database Design and t.

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Buch. Condición: Neu. Neuware - Nuclear receptors (NR) are ligand induced activated transcription factors involved in numerous biological processes. This book provides a state of the art review on investigations into modeling nuclear receptors looking at the strengths, weaknesses and limitations of the approaches described. The contents include an introduction to their structure and function, a critical overview of experimental structural data as a base for modeling, the latest in the development of theoretical approaches to nuclear receptors modeling, computational studies of nuclear receptors to predict interactions with small ligands, in vitro and in vivo experiments to validate computational simulations, experimental applications and case studies, and nuclear receptors as targets for endocrine disruptor screening.…