Idioma: Inglés
Publicado por Royal Society of Chemistry, 2011
ISBN 10: 1849731837 ISBN 13: 9781849731836
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Idioma: Inglés
Publicado por Royal Society of Chemistry, 2011
ISBN 10: 1849731837 ISBN 13: 9781849731836
Librería: Basi6 International, Irving, TX, Estados Unidos de America
EUR 88,27
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Idioma: Inglés
Publicado por Royal Society of Chemistry, 2011
ISBN 10: 1849731837 ISBN 13: 9781849731836
Librería: SMASS Sellers, IRVING, TX, Estados Unidos de America
EUR 91,61
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Idioma: Inglés
Publicado por Royal Society of Chemistry, 2011
ISBN 10: 1849731837 ISBN 13: 9781849731836
Librería: Romtrade Corp., STERLING HEIGHTS, MI, Estados Unidos de America
EUR 106,51
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Añadir al carritoCondición: New. This is a Brand-new US Edition. This Item may be shipped from US or any other country as we have multiple locations worldwide.
Idioma: Inglés
Publicado por Royal Society of Chemistry, 2011
ISBN 10: 1849731837 ISBN 13: 9781849731836
Librería: Basi6 International, Irving, TX, Estados Unidos de America
EUR 106,51
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Idioma: Inglés
Publicado por Royal Society of Chemistry, 2011
ISBN 10: 1849731837 ISBN 13: 9781849731836
Librería: SMASS Sellers, IRVING, TX, Estados Unidos de America
EUR 110,53
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Idioma: Inglés
Publicado por Royal Society of Chemistry RSC, 2011
ISBN 10: 1849731837 ISBN 13: 9781849731836
Librería: Books Puddle, New York, NY, Estados Unidos de America
EUR 122,86
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Añadir al carritoCondición: New. pp. 548 1st Edition.
Idioma: Inglés
Publicado por Royal Society of Chemistry, 2011
ISBN 10: 1849731837 ISBN 13: 9781849731836
Librería: Majestic Books, Hounslow, Reino Unido
EUR 125,75
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Añadir al carritoCondición: New. pp. 548.
Idioma: Inglés
Publicado por Royal Society of Chemistry, 2011
ISBN 10: 1849731837 ISBN 13: 9781849731836
Librería: Biblios, Frankfurt am main, HESSE, Alemania
EUR 126,81
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Añadir al carritoCondición: New. pp. 548.
Idioma: Inglés
Publicado por Royal Society of Chemistry, 2011
ISBN 10: 1849731837 ISBN 13: 9781849731836
Librería: Romtrade Corp., STERLING HEIGHTS, MI, Estados Unidos de America
EUR 166,45
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Añadir al carritoCondición: New. This is a Brand-new US Edition. This Item may be shipped from US or any other country as we have multiple locations worldwide.
Idioma: Inglés
Publicado por Royal Society of Chemistry, 2011
ISBN 10: 1849731837 ISBN 13: 9781849731836
Librería: Basi6 International, Irving, TX, Estados Unidos de America
EUR 166,45
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Idioma: Inglés
Publicado por Royal Society of Chemistry, 2011
ISBN 10: 1849731837 ISBN 13: 9781849731836
Librería: SMASS Sellers, IRVING, TX, Estados Unidos de America
EUR 175,06
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Idioma: Inglés
Publicado por Royal Society of Chemistry, Cambridge, 2011
ISBN 10: 1849731837 ISBN 13: 9781849731836
Librería: Grand Eagle Retail, Bensenville, IL, Estados Unidos de America
EUR 254,06
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Añadir al carritoHardcover. Condición: new. Hardcover. G protein-coupled receptors (GPCRs) are the largest family of cell-surface receptors, with more than 800 members identified thus far in the human genome. They regulate the function of most cells in the body, and represent approximately 3% of the genes in the human genome. These receptors respond to a wide variety of structurally diverse ligands, ranging from small molecules, such as biogenic amines, nucleotides and ions, to lipids, peptides, proteins, and even light. Ligands (agonists and antagonists) acting on GPCRs are important in the treatment of numerous diseases, including cardiovascular and mental disorders, retinal degeneration, cancer, and AIDS. It is estimated that these receptors represent about one third of the actual identified targets of clinically used drugs. The determination of rhodopsin crystal structure and, more recently, of opsin, 1 and 2 adrenergic and A2A adenosine receptors provides both academia and industry with extremely valuable data for a better understanding of the molecular determinants of receptor function and a more reliable rationale for drug design. GPCR structure and function constitutes a hot topic. The book, which lies between the fields of chemical biology, molecular pharmacology and medicinal chemistry, is divided into three parts. The first part considers what receptor structures tell us about the mechanism of receptor activation. Part II focuses on receptor function. It discusses what the data from biophysical and mutational studies, and the analysis of the interactions of the receptor with ligands and regulator proteins, tell us about the process of signal transduction. The final part, on modelling and simulation, details new insights on the link between structure and mechanism and their implications in drug design. This book considers the relationship between structure and function in G protein-coupled receptors (GPCRs) and the implications for drug design. Shipping may be from multiple locations in the US or from the UK, depending on stock availability.
Idioma: Inglés
Publicado por Royal Society of Chemistry, 2011
ISBN 10: 1849731837 ISBN 13: 9781849731836
Librería: Mispah books, Redhill, SURRE, Reino Unido
EUR 232,01
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Añadir al carritoHardcover. Condición: Like New. LIKE NEW. SHIPS FROM MULTIPLE LOCATIONS. book.
Idioma: Inglés
Publicado por ROYAL SOCIETY OF CHEMISTRY, 2011
ISBN 10: 1849731837 ISBN 13: 9781849731836
Librería: moluna, Greven, Alemania
EUR 235,54
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Librería: UK BOOKS STORE, London, LONDO, Reino Unido
EUR 305,95
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Añadir al carritoCondición: New. Brand New! Fast Delivery This is an International Edition and ship within 24-48 hours. Deliver by FedEx and Dhl, & Aramex, UPS, & USPS and we do accept APO and PO BOX Addresses. Order can be delivered worldwide within 6-10 days and we do have flat rate for up to 2LB. Extra shipping charges will be requested if the Book weight is more than 5 LB. This Item May be shipped from India, United states & United Kingdom. Depending on your location and availability.
Idioma: Inglés
Publicado por Royal Society of Chemistry, 2011
ISBN 10: 1849731837 ISBN 13: 9781849731836
Librería: Revaluation Books, Exeter, Reino Unido
EUR 318,59
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Añadir al carritoHardcover. Condición: Brand New. 1st edition. 548 pages. 9.30x6.30x1.30 inches. In Stock.
Idioma: Inglés
Publicado por RSC Publishing Aug 2011, 2011
ISBN 10: 1849731837 ISBN 13: 9781849731836
Librería: AHA-BUCH GmbH, Einbeck, Alemania
EUR 329,91
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Añadir al carritoBuch. Condición: Neu. Neuware - G protein-coupled receptors (GPCRs) constitute the largest family of cell-surface receptors, with more than 800 members identified thus far in the human genome. They regulate the function of most cells in the body, and represent approximately 3% of the genes in the human genome. These receptors respond to a wide variety of structurally diverse ligands, ranging from small molecules, such as biogenic amines, nucleotides and ions, to lipids, peptides, proteins and even light. Ligands (agonists and antagonists) acting on GPCRs are important commonly used in drug therapy of numerous diseases, including cardiovascular and mental disorders, retinal degeneration, cancer, and AIDS. It is estimated that these receptors represent about one third of the actual identified targets of clinically used drugs. This book, which lies between the fields of chemical biology, molecular pharmacology and medicinal chemistry, is divided into three parts. The first part considers what receptor structures tell us about the mechanism of receptor activation. Part II focuses on receptor function. It discusses what the data from biophysical and mutational studies, and the analysis of the interactions of the receptor with ligands and regulator proteins, tell us about the process of signal transduction. The final part, on modelling and simulation, details what new insights on the link between structure and mechanism can be provided by theoretical studies and their implications in drug design. The various chapters present an update on the latest developments in GPCR structures and detailed structural changes linked to activation. They cover the latest news of the extraordinary complex function of these receptors, concentrating on the many aspects that are currently revolutionizing our current views of these proteins: receptor constitutive activity, receptor oligomerization, functional selectivity, biased agonism, multiple signalling pathways, multiple accessory proteins, functional cross talk and the mechanism of signal integration. This complex picture is tackled from complementary experimental and theoretical approaches, which represent a clear statement of our current knowledge of the GPCR complexity.