Uri galili (33 resultados)

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Taschenbuch. Condición: Neu. The Natural Anti-Gal Antibody as Foe Turned Friend in Medicine | Uri Galili | Taschenbuch | Englisch | 2017 | Elsevier Science | EAN 9780128133620 | Verantwortliche Person für die EU: Elsevier B.V., Radarweg 29, 1043 NX AMSTERDAM, NIEDERLANDE, productsafety[at]elsevier[dot]com | Anbieter: preigu. …

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Taschenbuch. Condición: Neu. ¿-Gal and Anti-Gal | ¿1,3-Galactosyltransferase, ¿-Gal Epitopes, and the Natural Anti-Gal Antibody Subcellular Biochemistry | Uri Galili (u. a.) | Taschenbuch | xx | Englisch | 2012 | Springer | EAN 9781461371601 | Verantwortliche Person für die EU: Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg, juergen[dot]hartmann[at]springer[dot]com | Anbieter: preigu. …

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Taschenbuch. Condición: Neu. Druck auf Anfrage Neuware - Printed after ordering - It has been 15 years since the first report on the isolation of anti-Gal from human serum and the demonstration that this antibody is the most prevalent antibody in humans (Galili et al. , ]. Exp. Med. 160: 1519, 1984). Subsequent interdisciplinary studies in immunology, carbohydrate biochemistry, molecular biology, and evo lution demonstrated the highly restricted specificity of anti-Gal for the carbohy drate epitope Gal al-3Galpl-4GIcNAc-R, (termed here the a-gal epitope), the unprecedented evolutionary pattern of distribution of a-gal and anti-Gal in mam mals, and explained the evolution of this antigen and antibody by analysis of the a 1 ,3galactosyltransferase gene, the gene that encodes the enzyme that synthesizes the a-gal epitope. These studies have suggested that a major selection process that occurred in the course of evolution of ancestral Old World primates resulted in the inactivation of the a1 ,3galactosyltransferase gene and the subsequent appearance of anti-Gal in these primates. Other studies in immunoparasitology have demon strated the possible physiologic significance of anti-Gal in protection against cer tain parasitic infections. Major scientific attention was focused on a-gal and anti-Gal with the real ization in the early nineties that the interaction between this antigen and antibody is the major obstacle to xenotransplantation. The success of immunosuppressive drugs, in the last two decades of the 20th century, in preventing allograft rejection, has raised hopes for cure in many patients in need of organ transplant. Because of limited supply of allografts, only 20% of patients receive the needed organ. …

Buch. Condición: Neu. Druck auf Anfrage Neuware - Printed after ordering - It has been 15 years since the first report on the isolation of anti-Gal from human serum and the demonstration that this antibody is the most prevalent antibody in humans (Galili et al. , ]. Exp. Med. 160: 1519, 1984). Subsequent interdisciplinary studies in immunology, carbohydrate biochemistry, molecular biology, and evo lution demonstrated the highly restricted specificity of anti-Gal for the carbohy drate epitope Gal al-3Galpl-4GIcNAc-R, (termed here the a-gal epitope), the unprecedented evolutionary pattern of distribution of a-gal and anti-Gal in mam mals, and explained the evolution of this antigen and antibody by analysis of the a 1 ,3galactosyltransferase gene, the gene that encodes the enzyme that synthesizes the a-gal epitope. These studies have suggested that a major selection process that occurred in the course of evolution of ancestral Old World primates resulted in the inactivation of the a1 ,3galactosyltransferase gene and the subsequent appearance of anti-Gal in these primates. Other studies in immunoparasitology have demon strated the possible physiologic significance of anti-Gal in protection against cer tain parasitic infections. Major scientific attention was focused on a-gal and anti-Gal with the real ization in the early nineties that the interaction between this antigen and antibody is the major obstacle to xenotransplantation. The success of immunosuppressive drugs, in the last two decades of the 20th century, in preventing allograft rejection, has raised hopes for cure in many patients in need of organ transplant. Because of limited supply of allografts, only 20% of patients receive the needed organ. …

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Taschenbuch. Condición: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -The Natural Anti-Gal Antibody as Foe Turned Friend in Medicine provides a comprehensive review of the natural anti-Gal antibody, which is the most abundant antibody in humans constituting ~1% of immunoglobulins and the carbohydrate antigen it recognizes, the -gal epitope. It discusses the discovery of this antigen/antibody system, its evolution in mammals, the pathological effects of this antibody, and its possible use in various therapies in humans. Most significantly, the book discusses microbial and regenerative therapies in which an antibody present in all humans may be harnessed as an in vivo pharmaceutical agent that enables a wide variety of therapies. Some of these therapies are described as experimental studies that are compiled in this book, other already studied therapies in the area of cancer immunotherapy are also included in this book. 304 pp. Englisch.…

Taschenbuch. Condición: Neu. nach der Bestellung gedruckt Neuware - Printed after ordering - The Natural Anti-Gal Antibody as Foe Turned Friend in Medicine provides a comprehensive review of the natural anti-Gal antibody, which is the most abundant antibody in humans constituting ~1% of immunoglobulins and the carbohydrate antigen it recognizes, the -gal epitope. It discusses the discovery of this antigen/antibody system, its evolution in mammals, the pathological effects of this antibody, and its possible use in various therapies in humans. Most significantly, the book discusses microbial and regenerative therapies in which an antibody present in all humans may be harnessed as an in vivo pharmaceutical agent that enables a wide variety of therapies. Some of these therapies are described as experimental studies that are compiled in this book, other already studied therapies in the area of cancer immunotherapy are also included in this book.…

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Condición: New. Dieser Artikel ist ein Print on Demand Artikel und wird nach Ihrer Bestellung fuer Sie gedruckt. 1. Evolution of alpha 1,3-Galactosyltransferase and of the alpha-Gal Epitope U. Galili. 2. The a 1,3-Galactosyltransferase Gene D.H. Joziasse, et al. 3. Structure Function Studies of a New World Monkey alpha 1,3Galactosyltransferase: Analysis of Alter.…

Gebunden. Condición: New. Dieser Artikel ist ein Print on Demand Artikel und wird nach Ihrer Bestellung fuer Sie gedruckt. 1. Evolution of alpha 1,3-Galactosyltransferase and of the alpha-Gal Epitope U. Galili. 2. The a 1,3-Galactosyltransferase Gene D.H. Joziasse, et al. 3. Structure Function Studies of a New World Monkey alpha 1,3Galactosyltransferase: Analysis of Alter.…

Buch. Condición: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -It has been 15 years since the first report on the isolation of anti-Gal from human serum and the demonstration that this antibody is the most prevalent antibody in humans (Galili et al. , ]. Exp. Med. 160: 1519, 1984). Subsequent interdisciplinary studies in immunology, carbohydrate biochemistry, molecular biology, and evo lution demonstrated the highly restricted specificity of anti-Gal for the carbohy drate epitope Gal al-3Galpl-4GIcNAc-R, (termed here the a-gal epitope), the unprecedented evolutionary pattern of distribution of a-gal and anti-Gal in mam mals, and explained the evolution of this antigen and antibody by analysis of the a 1 ,3galactosyltransferase gene, the gene that encodes the enzyme that synthesizes the a-gal epitope. These studies have suggested that a major selection process that occurred in the course of evolution of ancestral Old World primates resulted in the inactivation of the a1 ,3galactosyltransferase gene and the subsequent appearance of anti-Gal in these primates. Other studies in immunoparasitology have demon strated the possible physiologic significance of anti-Gal in protection against cer tain parasitic infections. Major scientific attention was focused on a-gal and anti-Gal with the real ization in the early nineties that the interaction between this antigen and antibody is the major obstacle to xenotransplantation. The success of immunosuppressive drugs, in the last two decades of the 20th century, in preventing allograft rejection, has raised hopes for cure in many patients in need of organ transplant. Because of limited supply of allografts, only 20% of patients receive the needed organ. 416 pp. Englisch. …

Taschenbuch. Condición: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -It has been 15 years since the first report on the isolation of anti-Gal from human serum and the demonstration that this antibody is the most prevalent antibody in humans (Galili et al. , ]. Exp. Med. 160: 1519, 1984). Subsequent interdisciplinary studies in immunology, carbohydrate biochemistry, molecular biology, and evo lution demonstrated the highly restricted specificity of anti-Gal for the carbohy drate epitope Gal al-3Galpl-4GIcNAc-R, (termed here the a-gal epitope), the unprecedented evolutionary pattern of distribution of a-gal and anti-Gal in mam mals, and explained the evolution of this antigen and antibody by analysis of the a 1 ,3galactosyltransferase gene, the gene that encodes the enzyme that synthesizes the a-gal epitope. These studies have suggested that a major selection process that occurred in the course of evolution of ancestral Old World primates resulted in the inactivation of the a1 ,3galactosyltransferase gene and the subsequent appearance of anti-Gal in these primates. Other studies in immunoparasitology have demon strated the possible physiologic significance of anti-Gal in protection against cer tain parasitic infections. Major scientific attention was focused on a-gal and anti-Gal with the real ization in the early nineties that the interaction between this antigen and antibody is the major obstacle to xenotransplantation. The success of immunosuppressive drugs, in the last two decades of the 20th century, in preventing allograft rejection, has raised hopes for cure in many patients in need of organ transplant. Because of limited supply of allografts, only 20% of patients receive the needed organ. 416 pp. Englisch. …

Buch. Condición: Neu. This item is printed on demand - Print on Demand Titel. Neuware -1 Evolution of l,3Galactosyltransferase and of the -Gal Epitope.- 2 The 1,3-Galactosyltransferase Gene.- 3 Structure Function Studies of a New World Monkey 1,3Galactosyltransferase: Analysis of Alternative Splicing and Expression in Baculovirus System.- 4 The Natural Anti-Gal Antibody.- 5 -Gal Epitopes in Animal Tissue Glycoproteins and Glycolipids.- 6 The Griffonia simplicifolia I - B4 Isolectin: A Probe for -D- Galactosyl End Groups.- 7 -Gal Epitopes on Viral Glycoproteins.- 8 -Galactosyl-Bearing Epitopes as Potent Immunogens in Chagas' Disease and Leishmaniasis.- 9 Enterotoxin A of Clostridium difficile and -Gal Epitopes.- 10 Anti-Gal, -Gal Epitopes, and Xenotransplantation.- 11 Generation of 1,3Galactosyltransferase Deficient Mice.- 12 Anti-Xenograft Immune Responses in 1,3-Galactosyltransferase Knock-Out Mice.- 13 Modulation of Gal Epitope Expression on Porcine Cells.- 14 Graves' Disease as a Model for Anti-Gal Involvement in Autoimmune Diseases.- 15 Enhancement of Autologous Tumor Vaccine Immunogenicity by Anti-Gal.Springer-Verlag KG, Sachsenplatz 4-6, 1201 Wien 416 pp. Englisch.…