timothy springer (43 resultados)

Hardcover. Condición: Fair. No Jacket. 287 numbered pages; a few minor marks to edges of closed pages; light to med wear to corners, edges, and spine of green hardcover; no dustjacket; med bumps and peel to corners and bottom of spine; heavy rub to cover; numerous minor scratches/ dings to cover; weighs 1 pound and 8 ounces; measures 9.3 by 6.2 by .75 inches; 022318;

gebundene Ausgabe. Condición: Gut. 287 Seiten; Der Erhaltungszustand des hier angebotenen Werks ist trotz seiner Bibliotheksnutzung sehr sauber. Es befindet sich neben dem Rückenschild lediglich ein Bibliotheksstempel im Buch; ordnungsgemäß entwidmet. Sprache: Englisch Gewicht in Gramm: 650.

Condición: Good. 602 pp., Hardcover, ex library, else text and binding clean and tight. - If you are reading this, this item is actually (physically) in our stock and ready for shipment once ordered. We are not bookjackers. Buyer is responsible for any additional duties, taxes, or fees required by recipient's country.

Hardcover. Condición: Very Good - (ex-library). No Jacket. b/w Illustration Ilustrador. First Edition. ex-library with usual marks, 8vo, 287pp. Size: 8vo - over 7¾" - 9¾" tall. Book.

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Gebundene Ausgabe. Condición: Gut. 602 Seiten ex Library Book aus einer wissentschaftlichen Bibliothek Sprache: Englisch Gewicht in Gramm: 550.

XV, 287 S. mit zahlreichen Abbildungen, 0387969837 Sprache: Englisch Gewicht in Gramm: 700 Groß 8°, Original-Pappband (Hardcover), Bibliotheks-Exemplar mit Rückenschild, Stempel auf Titel, insgesamt sehr gutes und innen sauberes Exemplar,

Condición: New. In.

Condición: New. pp. 308.

Condición: Used. pp. 287 1st Edition.

Condición: Used. pp. 287.

Paperback. Condición: Brand New. 302 pages. 9.25x6.10x0.63 inches. In Stock.

Condición: Used. pp. 287.

Condición: New.

Taschenbuch. Condición: Neu. Leukocyte Adhesion Molecules | Proceedings of the First International Conference on: "Structure, Function and Regulation of Molecules Involved in Leukocyte Adhesion", Held in Titisee, West Germany, September 28 - October 2, 1988 | Timothy A. Springer (u. a.) | Taschenbuch | xv | Englisch | 2011 | Springer | EAN 9781461279273 | Verantwortliche Person für die EU: Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg, juergen[dot]hartmann[at]springer[dot]com | Anbieter: preigu.

Taschenbuch. Condición: Neu. Druck auf Anfrage Neuware - Printed after ordering - Leukocyte adhesion molecules promise to be highly effective as antigens in the antibody-directed leucocyte elimination treatment prior to grafting or in cases of acute and chronic inflammatory disease. This comprehensive review of contemporary research provides thorough discussions of the structure of these molecules, their in vitro function, and the role that they play in vivo as evidenced by results shown in inflammatory models where antibodies against these molecules are given to inhibit their function. The blend of basic science and clinical applications provides clear evidence of the biological relevance of cell-cell interactions and the many potential clinical dividends afforded by understanding the molecular basis of cell adhesion.

Condición: As New. Unread book in perfect condition.

Condición: New. In.

Condición: New.

Condición: As New. Unread book in perfect condition.

Hardback. Condición: New. A guide to the issues relevant to the design, analysis, and interpretation of toxicity studies that examine chemicals for use in the environment Statistical Analysis of Ecotoxicity Studies offers a guide to the design, analysis, and interpretation of a range of experiments that are used to assess the toxicity of chemicals. While the book highlights ecotoxicity studies, the methods presented are applicable to the broad range of toxicity studies. The text contains myriad datasets (from laboratory and field research) that clearly illustrate the book's topics. The datasets reveal the techniques, pitfalls, and precautions derived from these studies. The text includes information on recently developed methods for the analysis of severity scores and other ordered responses, as well as extensive power studies of competing tests and computer simulation studies of regression models that offer an understanding of the sensitivity (or lack thereof) of various methods and the quality of parameter estimates from regression models. The authors also discuss the regulatory process indicating how test guidelines are developed and review the statistical methodology in current or pending OECD and USEPA ecotoxicity guidelines. This important guide: Offers the information needed for the design and analysis to a wide array of ecotoxicity experiments and to the development of international test guidelines used to assess the toxicity of chemicalsContains a thorough examination of the statistical issues that arise in toxicity studies, especially ecotoxicityIncludes an introduction to toxicity experiments and statistical analysis basicsIncludes programs in R and excelCovers the analysis of continuous and Quantal data, analysis of data as well as Regulatory IssuesPresents additional topics (Mesocosm and Microplate experiments, mixtures of chemicals, benchmark dose models, and limit tests) as well as software Written for directors, scientists, regulators, and technicians, Statistical Analysis of Ecotoxicity Studies provides a sound understanding of the technical and practical issues in designing, analyzing, and interpreting toxicity studies to support or challenge chemicals for use in the environment.

Condición: New. pp. 632.

Hardcover. Condición: New.

Condición: New. Brand new! Please provide a physical shipping address.

Taschenbuch. Condición: Neu. Hybridoma Technology in the Biosciences and Medicine | Timothy Springer | Taschenbuch | xxv | Englisch | 2012 | Springer | EAN 9781468449662 | Verantwortliche Person für die EU: Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg, juergen[dot]hartmann[at]springer[dot]com | Anbieter: preigu.

Paperback. Condición: Brand New. reprint edition. 627 pages. 9.45x6.61x1.43 inches. In Stock.

Hardcover. Condición: Brand New. har/psc edition. 393 pages. 11.00x8.75x1.00 inches. In Stock.

Hardcover. Condición: New. NEW. SHIPS FROM MULTIPLE LOCATIONS. book.

Taschenbuch. Condición: Neu. Druck auf Anfrage Neuware - Printed after ordering - InhaltsangabeI. The Production and Improvement through Genetic Engineering of Monoclonal Antibodies.- 1. Monoclonal Antibody Strategy and Techniques.- 1. Introduction.- 2. Factors That Control Immunogenicity.- 3. Strategy and Tactics for the Preparation of Monoclonal Antibodies.- 4. Procedures for the Production of Monoclonal Antibodies.- 5. Screening Assays for Monoclonal Antibody.- References.- 2. Strategies for Production of Human Monoclonal Antibodies.- 1. Introduction.- 2. Human versus Mouse Monoclonal Antibodies.- 3. Epstein-Barr Virus.- 4. Human Hybridomas. Fusion Partners.- 5. Epstein-Barr Virus Hybridoma Technique.- 6. Large-Scale Production of Human Monoclonal Antibodies.- 7. Possible Limitations and Future Developments.- References.- 3. The Antibody Combining Site.- 1. Introduction.- 2. Structure of the Antibody Combining Site.- 3. Digoxin-Specific Monoclonal Antibodies.- 4. A Look into the Future.- References.- 4. The Generation of Better Monoclonal Antibodies through Somatic Mutation.- 1. Introduction.- 2. Class and Subclass Switch Variants.- 3. Deletion Mutants.- 4. Antigen Binding Mutants.- 5. Conclusion.- References.- 5. Switching the Isotype of Monoclonal Antibodies.- 1. Introduction.- 2. Mouse Immunoglobulin isotypes.- 3. The Genetics of Immunoglobulin Isotype Expression.- 4. Spontaneous Isotype Switching in Myelomas and Hybridomas.- 5. Techniques of Switch Variant Selection.- 6. Kinetics of Isotype Switching.- 7. Effects of Mutagens on the Rate of Isotype Switching.- References.- 6. The Analysis of Structural Diversity in the Antibody Response.- 1. Introduction.- 2. RNA Sequencing.- 3. Analyzing Immunoglobulin Diversity by mRNA Sequencing.- 4. Protocol.- 5. Analyzing the Structural Diversity of the Antibody Response.- References.- 7. Expressions of Cloned Immunoglobulin Genes.- 1. Introduction.- 2. Mechanism of Immunoglobulin Gene Assembly.- 3. Assembly of Transfected Genes.- 4. Control of Immunoglobulin Gene Expression.- 5. Expression of Introduced Genes.- 6. Transgenic Mice.- 7. Summary.- References.- II. Monoclonal Antibodies in Biomedical Research: Principles and Applications.- 8. The Immunochemistry of Monoclonal Antibodies: Studies on One Immunologic Supergene (HLA) with the Products of Another.- 1. Introduction.- 2. Fragmentation of IgG to Give F(ab')2 and Fab.- 3. Fab/c: A Univalent Fragment with Effector Function.- 4. Isotype Switch Variants.- 5. Binding of Monoclonal Antibodies to Cell Surface Antigens.- 6. Hybrid Antibodies.- 7. Enhancing Effects of Monoclonal Antibodies in Solution.- 8. Quantitative Serologic Analysis of HLA-A, B Molecules.- 9. Epitope Mapping.- References.- 9. Purification of Membrane Glycoproteins with Monoclonal Antibody Affinity Columns.- 1. Introduction.- 2. Key Aspects in Monoclonal Antibody Affinity Chromatography.- 3. Purifications Based on Antigenic Determinants Stable to Denaturation.- References.- 10. Transferrin Receptor.- 1. Introduction.- 2. Structure of the Transferrin Receptor.- 3. Functional Aspects of the Transferrin Receptor.- 4. Gene Transfer and Molecular Cloning of the Human Transferrin Receptor.- 5. Concluding Remarks.- References.- 11. Functional and Structural Interrelationships among the Mac-1, LFA-1 Family of Leukocyte Adhesion Glycoproteins, and their Deficiency in a Novel Heritable Disease.- 1. Introduction.- 2. Probing Cell Surface Functions with Monoclonal Antibodies.- 3. Functional Properties of LFA-1.- 4. Functional Properties of Mac-1, a Molecule Related to LFA-1.- 5. Glycoprotein Family Interrelationships.- 6. Mac-1, LFA-1 Deficiency Disease.- References.- 12. Demonstration of Receptor Function of Membrane Proteins by Selection and Immobilization with Monoclonal Antibodies.- 1. Background.- 2. Demonstration of Specificity of Monoclonal Antibody-Immobilized Antigen for Particulate Ligand.- 3. Demonstration of Specificity of Monoclonal Antibody-Immobilized Antigen for Soluble Ligand.- 4. Summary.

Hardback. Condición: New. A guide to the issues relevant to the design, analysis, and interpretation of toxicity studies that examine chemicals for use in the environment Statistical Analysis of Ecotoxicity Studies offers a guide to the design, analysis, and interpretation of a range of experiments that are used to assess the toxicity of chemicals. While the book highlights ecotoxicity studies, the methods presented are applicable to the broad range of toxicity studies. The text contains myriad datasets (from laboratory and field research) that clearly illustrate the book's topics. The datasets reveal the techniques, pitfalls, and precautions derived from these studies. The text includes information on recently developed methods for the analysis of severity scores and other ordered responses, as well as extensive power studies of competing tests and computer simulation studies of regression models that offer an understanding of the sensitivity (or lack thereof) of various methods and the quality of parameter estimates from regression models. The authors also discuss the regulatory process indicating how test guidelines are developed and review the statistical methodology in current or pending OECD and USEPA ecotoxicity guidelines. This important guide: Offers the information needed for the design and analysis to a wide array of ecotoxicity experiments and to the development of international test guidelines used to assess the toxicity of chemicalsContains a thorough examination of the statistical issues that arise in toxicity studies, especially ecotoxicityIncludes an introduction to toxicity experiments and statistical analysis basicsIncludes programs in R and excelCovers the analysis of continuous and Quantal data, analysis of data as well as Regulatory IssuesPresents additional topics (Mesocosm and Microplate experiments, mixtures of chemicals, benchmark dose models, and limit tests) as well as software Written for directors, scientists, regulators, and technicians, Statistical Analysis of Ecotoxicity Studies provides a sound understanding of the technical and practical issues in designing, analyzing, and interpreting toxicity studies to support or challenge chemicals for use in the environment.