Meinhard kieser (68 resultados)

Paperback. Condición: new. Paperback. Meinhard Kieser vermittelt anhand realer Beispiele die grundlegenden Prinzipien der Fallzahlberechnung und demonstriert deren Anwendung. Fuer die haeufigsten Anwendungssituationen werden die entsprechenden Fallzahlberechnungsformeln hergeleitet. Einsteiger haben somit die Moeglichkeit, die Grundlagen der Fallzahlplanung zu erlernen und einzuueben. Es werden ausserdem die statistischen Hintergruende der Formeln und allgemeinere Zusammenhaenge erlaeutert und Hinweise gegeben, was bei jeder Fallzahlberechnung beachtet werden sollte. Damit geht das essential deutlich ueber eine reine Formelsammlung hinaus und ist eine wertvolle Ergaenzung fuer Personen, die bereits in der medizinischen Forschung taetig sind und Erfahrung bei der Fallzahlberechnung gesammelt haben. Meinhard Kieser vermittelt anhand realer Beispiele die grundlegenden Prinzipien der Fallzahlberechnung und demonstriert deren Anwendung. Shipping may be from multiple locations in the US or from the UK, depending on stock availability.…

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Paperback. Condición: Brand New. 66 pages. German language. 8.26x5.82x0.32 inches. In Stock.

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PAP. Condición: New. New Book. Shipped from UK. Established seller since 2000.

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Paperback. Condición: New. 2020 ed. This book provides an extensive overview of the principles and methods of sample size calculation and recalculation in clinical trials. Appropriate calculation of the required sample size is crucial for the success of clinical trials. At the same time, a sample size that is too small or too large is problematic due to ethical, scientific, and economic reasons. Therefore, state-of-the art methods are required when planning clinical trials. Part I describes a general framework for deriving sample size calculation procedures. This enables an understanding of the common principles underlying the numerous methods presented in the following chapters. Part II addresses the fixed sample size design, where the required sample size is determined in the planning stage and is not changed afterwards. It covers sample size calculation methods for superiority, non-inferiority, and equivalence trials, as well as comparisons between two and more than two groups. A wide range of further topics is discussed, including sample size calculation for multiple comparisons, safety assessment, and multi-regional trials. There is often some uncertainty about the assumptions to be made when calculating the sample size upfront. Part III presents methods that allow to modify the initially specified sample size based on new information that becomes available during the ongoing trial. Blinded sample size recalculation procedures for internal pilot study designs are considered, as well as methods for sample size reassessment in adaptive designs that use unblinded data from interim analyses. The application is illustrated using numerous clinical trial examples, and software code implementing the methods is provided.The book offers theoretical background and practical advice for biostatisticians and clinicians from the pharmaceutical industry and academia who are involved in clinical trials. Covering basic as well as more advanced and recently developed methods, it is suitable forbeginners, experienced applied statisticians, and practitioners. To gain maximum benefit, readers should be familiar with introductory statistics. The content of this book has been successfully used for courses on the topic.…

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Taschenbuch. Condición: Neu. Druck auf Anfrage Neuware - Printed after ordering - Meinhard Kieser vermittelt anhand realer Beispiele die grundlegenden Prinzipien der Fallzahlberechnung und demonstriert deren Anwendung. Für die häufigsten Anwendungssituationen werden die entsprechenden Fallzahlberechnungsformeln hergeleitet. Einsteiger haben somit die Möglichkeit, die Grundlagen der Fallzahlplanung zu erlernen und einzuüben. Es werden außerdem die statistischen Hintergründe der Formeln und allgemeinere Zusammenhänge erläutert und Hinweise gegeben, was bei jeder Fallzahlberechnung beachtet werden sollte. Damit geht das essential deutlich über eine reine Formelsammlung hinaus und ist eine wertvolle Ergänzung für Personen, die bereits in der medizinischen Forschung tätig sind und Erfahrung bei der Fallzahlberechnung gesammelt haben.…

hardcover. Condición: Sehr gut. 271 Seiten; 9783319737690.2 Gewicht in Gramm: 1.

Kartoniert / Broschiert. Condición: New. This book provides an extensive overview of the principles and methods of sample size calculation and recalculation in clinical trials. Blinded sample size recalculation procedures for internal pilot study designs are considered, as well as methods for samp.

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Taschenbuch. Condición: Neu. Druck auf Anfrage Neuware - Printed after ordering - This book provides an extensive overview of the principles and methods of sample size calculation and recalculation in clinical trials. Appropriate calculation of the required sample size is crucial for the success of clinical trials. At the same time, a sample size that is too small or too large is problematic due to ethical, scientific, and economic reasons. Therefore, state-of-the art methods are required when planning clinical trials. Part I describes a general framework for deriving sample size calculation procedures. This enables an understanding of the common principles underlying the numerous methods presented in the following chapters. Part II addresses the fixed sample size design, where the required sample size is determined in the planning stage and is not changed afterwards. It covers sample size calculation methods for superiority, non-inferiority, and equivalence trials, as well as comparisons between two and more than two groups. A wide range of further topics is discussed, including sample size calculation for multiple comparisons, safety assessment, and multi-regional trials. There is often some uncertainty about the assumptions to be made when calculating the sample size upfront. Part III presents methods that allow to modify the initially specified sample size based on new information that becomes available during the ongoing trial. Blinded sample size recalculation procedures for internal pilot study designs are considered, as well as methods for sample size reassessment in adaptive designs that use unblinded data from interim analyses. The application is illustrated using numerous clinical trial examples, and software code implementing the methods is provided.The book offers theoretical background and practical advice for biostatisticians and clinicians from the pharmaceutical industry and academia who are involved in clinical trials. Covering basic as well as more advanced and recently developed methods, it is suitable forbeginners, experienced applied statisticians, and practitioners. To gain maximum benefit, readers should be familiar with introductory statistics. The content of this book has been successfully used for courses on the topic.…

Condición: New.

Condición: As New. Unread book in perfect condition.

Condición: New.

Paperback. Condición: New. 2020 ed. This book provides an extensive overview of the principles and methods of sample size calculation and recalculation in clinical trials. Appropriate calculation of the required sample size is crucial for the success of clinical trials. At the same time, a sample size that is too small or too large is problematic due to ethical, scientific, and economic reasons. Therefore, state-of-the art methods are required when planning clinical trials. Part I describes a general framework for deriving sample size calculation procedures. This enables an understanding of the common principles underlying the numerous methods presented in the following chapters. Part II addresses the fixed sample size design, where the required sample size is determined in the planning stage and is not changed afterwards. It covers sample size calculation methods for superiority, non-inferiority, and equivalence trials, as well as comparisons between two and more than two groups. A wide range of further topics is discussed, including sample size calculation for multiple comparisons, safety assessment, and multi-regional trials. There is often some uncertainty about the assumptions to be made when calculating the sample size upfront. Part III presents methods that allow to modify the initially specified sample size based on new information that becomes available during the ongoing trial. Blinded sample size recalculation procedures for internal pilot study designs are considered, as well as methods for sample size reassessment in adaptive designs that use unblinded data from interim analyses. The application is illustrated using numerous clinical trial examples, and software code implementing the methods is provided.The book offers theoretical background and practical advice for biostatisticians and clinicians from the pharmaceutical industry and academia who are involved in clinical trials. Covering basic as well as more advanced and recently developed methods, it is suitable forbeginners, experienced applied statisticians, and practitioners. To gain maximum benefit, readers should be familiar with introductory statistics. The content of this book has been successfully used for courses on the topic.…

Condición: New. 1st ed. 2020 edition NO-PA16APR2015-KAP.

Taschenbuch. Condición: Neu. Methods and Applications of Sample Size Calculation and Recalculation in Clinical Trials | Meinhard Kieser | Taschenbuch | Springer Series in Pharmaceutical Statistics | xiv | Englisch | 2021 | Springer | EAN 9783030495305 | Verantwortliche Person für die EU: Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg, juergen[dot]hartmann[at]springer[dot]com | Anbieter: preigu.…