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ISBN 10: 1460993691 ISBN 13: 9781460993699
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Añadir al carritoCondición: New. Bruce, Travis Ilustrador.
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Añadir al carritoCondición: As New. Bruce, Travis Ilustrador. Unread book in perfect condition.
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Publicado por CreateSpace Independent Publishing Platform, 2011
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Añadir al carritoCondición: New. Bruce, Travis Ilustrador.
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Publicado por Royal Society of Chemistry, 2012
ISBN 10: 1849733643 ISBN 13: 9781849733649
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Publicado por Royal Society of Chemistry, 2012
ISBN 10: 1849733643 ISBN 13: 9781849733649
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Publicado por Royal Society of Chemistry, 2012
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Publicado por Royal Society of Chemistry, 2012
ISBN 10: 1849733643 ISBN 13: 9781849733649
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Añadir al carritoCondición: New. pp. 192.
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Publicado por Royal Society of Chemistry, 2012
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Publicado por Royal Society of Chemistry, 2012
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Publicado por Royal Society of Chemistry, 2012
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Publicado por Royal Society of Chemistry, 2012
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Publicado por Royal Society of Chemistry, 2012
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Publicado por Royal Society of Chemistry, 2012
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Publicado por Royal Society of Chemistry, 2012
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Publicado por Royal Society of Chemistry, Cambridge, 2012
ISBN 10: 1849733643 ISBN 13: 9781849733649
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Añadir al carritoHardcover. Condición: new. Hardcover. Nuclear receptors (NR) are ligand-induced activated transcription factors that are involved in numerous biological processes. Since the 1990's when the first structures were determined by means of X ray diffraction, the number of NR structures has increased considerably. Moreover several "omics" projects (genomics, pharmcogenomics and proteomics) have opened up great opportunities for the discovery of new targets, the characterization of abnormal protein patterns, the selection of "tailored" drugs and the evaluation of drug efficacy even with a lack of structural data. Furthermore, structure-based drug design, computational methods for in silico screening and nanobiotechnology- based tools are simplifying this time-consuming and money-intensive research of lead compounds and, possibly, new drugs. Biological interactions such as those that occur between a protein and ligand are concerted events where flexible molecules interact. Thus understanding flexibility of large molecules or biological complexes is of primary importance to help define the right model to approximate the reality for drug discovery, virtual screening, food safety analysis, etc. NRs are known as flexible targets, with many structural similarities, in particular for their Ligand Binding Domain: these similarities could be assumed to share behavioural qualities that belong to this class of compounds. Thus to supply a possible, complete and exhaustive answer to questions about the behaviour of NRs, their interactions with new potential drugs, endocrine disruptors such as animal and human food toxins, food additives or industry residuals, it is mandatory to approach the problem from a different point of view: a molecular modelling approach, steered synthesis, and in vitro and in vivo tests, etc. The aim of this book is to provide a state of the art review on investigations into Nuclear Receptors. The aim of this book is to provide a state of the art review on investigations into Nuclear Receptors Shipping may be from multiple locations in the US or from the UK, depending on stock availability.
Idioma: Inglés
Publicado por Rsc, 2012
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Añadir al carritoHardcover. Condición: New. ISBN:9781849733649.
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Publicado por ROYAL SOCIETY OF CHEMISTRY, 2012
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Añadir al carritoGebunden. Condición: New. The aim of this book is to provide a state of the art review on investigations into Nuclear ReceptorsÜber den AutorrnrnProfessor Cozzini s main research interests have been the development of chemistry software and Database Design and t.
Idioma: Inglés
Publicado por Royal Society of Chemistry, 2012
ISBN 10: 1849733643 ISBN 13: 9781849733649
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Añadir al carritoCondición: New. Brand New! Fast Delivery This is an International Edition and ship within 24-48 hours. Deliver by FedEx and Dhl, & Aramex, UPS, & USPS and we do accept APO and PO BOX Addresses. Order can be delivered worldwide within 6-10 days and we do have flat rate for up to 2LB. Extra shipping charges will be requested if the Book weight is more than 5 LB. This Item May be shipped from India, United states & United Kingdom. Depending on your location and availability.
Idioma: Inglés
Publicado por Royal Society of Chemistry, 2012
ISBN 10: 1849733643 ISBN 13: 9781849733649
Librería: GreatBookPrices, Columbia, MD, Estados Unidos de America
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Publicado por Royal Society of Chemistry, 2012
ISBN 10: 1849733643 ISBN 13: 9781849733649
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Añadir al carritoHardcover. Condición: Brand New. 300 pages. 9.50x6.25x0.50 inches. In Stock.
Idioma: Inglés
Publicado por RSC Publishing Nov 2012, 2012
ISBN 10: 1849733643 ISBN 13: 9781849733649
Librería: AHA-BUCH GmbH, Einbeck, Alemania
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Añadir al carritoBuch. Condición: Neu. Neuware - Nuclear Receptors (NRs) are ligand-induced activated transcription factors that are involved in numerous biological processes. Since the 90's when the first structures were determined by means of X-ray diffraction, the number has increased considerably. Moreover several 'omics' projects have opened up great opportunities for the discovery of new targets, the characterization of abnormal protein patterns, the selection of 'tailored' drugs and the evaluation of drug efficacy even with a lack of structural data. Furthermore, structure-based drug design, computational methods for in silico screening and nanobiotechnology-based tools are simplifying this time-consuming and expensive research of identifying lead compounds and, possibly new drugs. Biological interactions such as those that occur between a protein and ligand are concerted events where flexible molecules interact. Understanding the flexibility of large molecules or biological complexes is of primary importance to help define the right model to approximate the reality for drug discovery, virtual screening and food safety analysis. NRs are known as flexible targets, with many structural similarities, in particular for their Ligand Binding Domain. To understand the behaviour of NRs, it is mandatory to approach the subject from a different perspective. The aim of this book is to provide a state-of- the-art review on investigations into Nuclear Receptors. The contents provide an introduction to their structure and function, a critical overview of experimental structural data as a base for modeling, development of theoretical approaches to modeling and computational studies to predict interactions with small ligands, in vitro and in vivo experiments to validate computational simulations, experimental applications, and as targets for endocrine disruptor screening.