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Buch. Condición: Neu. Neuware - Epidemiology and Carcinogenesis.- Evidence from Animal Studies for the Carcinogenicity of Inhaled Diesel Exhaust.- Interpretation of Carcinogenicity and Effective Dose in Chronic Exposures of Rats to High Diesel Exhaust Concentrations.- Carcinogenicity of Dinitroarenes in Rat Lung.- In Vivo Metabolism and Genotoxic Effects of the Air Pollutant and Marker for Nitro-PAH's, 2-Nitrofluorene.- Chemistry, Detection, and Occurrence.- Nitroarenes: Their Detection, Mutagenicity and Occurrence in the Environment.- The Atmospheric Formation of Nitroarenes and Their Occurrence in Ambient Air.- Metabolism of 1-Nitropyrene Oxides and Effect of Nitrogen Dioxide on Arene Activation.- Molecular Mechanisms.- Mutagenic and Biochemical Consequences of the Reaction of Arylamines with DNA.- Mutagenesis Induced by a Single Acetylaminofluorene Adduct within the Narl Site is Position Dependent.- Unusual Hydrogen Bonding Patterns in 2-Aminofluorene (AF) and 2-Acetylaminofluorene (AAF) Modified DNA.- DNA Adduct Formation during Chronic Administration of an Aromatic Amine.- Aerial Oxidation of Acetylaminofluorene-Derived DNA Adducts.- Mutations and Homologous Recombination Induced by N-Substituted Aryl Compounds in Mammalian Cells.- Comparison of the Mutagenic Potency of DNA Adducts Formed by Reactive Derivatives of Aflatoxin, Benzidine and 1-Nitropyrene in a Plasmid System.- Mutations Induced in the lacI Gene of E. coli by 1-Nitroso-8-Nitropyrene and Furylfuramide: The Influence of Plasmid pKM101 and Excision Repair on the Mutational Spectrum.- DNA Adduct Formation by 1-Nitropyrene 4,5- and 9,10-Oxide.- Nitropolycyclic Aromatic Hydrocarbons and Diesel Exhaust: Potential Role of DNA Binding in Carcinogenicity.- Validation/Application of 32 -Postlabeling Analysis for the Detection of DNA Adducts Resulting from Complex Air Pollution Sources Containing PAHs and Nitrated PAHs.- Analysis of NO2-PAH DNA Adducts by Mass Spectrometry.- Metabolism.- Generation of Reactive Intermediates from 2-Nitrofluorene that Bind Covalently to DNA, RNA and Protein In Vitro and In Vivo in the Rat.- Activation of Carcinogenic N-Arylhydroxamic Acids by Peroxidase/H2O2/Halide Systems: Route to C-Nitroso Aromatics.- Biochemical Studies on the Putative Nitroso Metabolite of Chloramphenicol: A New Model for the Cause of Aplastic Anemia.- Mechanisms of FANFT/ANFT Induced Bladder Cancer.- Mutagenic Arylazides, Arylnitrenes, Arylnitrenium Ions.- Products Obtained by In Vitro Reaction of 4,5-Epoxy4,5-Dihydro-1-Nitropyrene with DNA.- Oxidative Metabolism of Nitrated Polycyclic Aromatic Hydrocarbons in Mammalian Cell Fractions.- Metabolic Activation of 6-Nitrochrysene and 6-Aminochrysene In Vitro and In Vivo.- Summary.- The Possible Role of Nitroarenes in Human Cancer.- Abstracts Presented at the Meeting.- Contributor Index.…

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Taschenbuch. Condición: Neu. Neuware - I have been privileged to witness and participate in the great growth of knowledge on chemical carcinogenesis and mutagenesis since 1939 when I entered graduate school in biochemistry at the University of Wisconsin Madison. I immediately started to work with the carcinogenic aminoazo dyes un der the direction of Professor CARL BAUMANN. In 1942 I joined a fellow graduate student, ELIZABE1H CAVERT, in marriage and we soon commenced a joyous part nership in research on chemical carcinogenesis at the McArdle Laboratory for Cancer Research in the University of Wisconsin Medical School in Madison. This collaboration lasted 45 years. I am very grateful that this volume is dedi cated to the memory of Elizabeth. The important and varied topics that are reviewed here attest to the continued growth of the fields of chemical car cinogenesis and mutagenesis, including their recent and fruitful union with viral oncology. I feel very optimistic about the application of knowledge in these fields to the eventual solution of numerous problems, including the detection and estimation of the risks to humans of environmental chemical carcinogens and re lated factors.…