Idioma: Inglés
Publicado por Kluwer Academic Publishers, 1998
ISBN 10: 0792387295 ISBN 13: 9780792387299
Librería: 20th Century Lost & Found, La Grande, OR, Estados Unidos de America
EUR 15,31
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Añadir al carritoHardcover. Condición: As New. This volume is the proceedings of the William Harvey Research Conference held in Cannes, France, on the 20th and 21st March, 1997. It describes the present knowledge of the structures of the cyclooxygenase isoforms and the experimental and clinical effects of selective inhibitors of cyclooxygenase-2.
Idioma: Inglés
Publicado por Kluwer Academic Publishers, Dordrecht, 1998
ISBN 10: 0792387295 ISBN 13: 9780792387299
Librería: PsychoBabel & Skoob Books, Didcot, Reino Unido
EUR 6,90
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Añadir al carritohardcover. Condición: Very Good. VG+ hardcover. 150 pp.
Librería: Ammareal, Morangis, Francia
EUR 5,55
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Añadir al carritoHardcover. Condición: Très bon. Ancien livre de bibliothèque avec équipements. Edition 1996. Ammareal reverse jusqu'à 15% du prix net de cet article à des organisations caritatives. ENGLISH DESCRIPTION Book Condition: Used, Very good. Former library book. Edition 1996. Ammareal gives back up to 15% of this item's net price to charity organizations.
Idioma: Inglés
Publicado por Portland Press, London, 1992
ISBN 10: 1855780380 ISBN 13: 9781855780385
Librería: Cotswold Internet Books, Cheltenham, Reino Unido
Original o primera edición
EUR 14,73
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Añadir al carritoCondición: Used - Very Good. VG paperback. 1st ed. Portland Press Proceedings, ISSN: 0966-4068. A tidy copy in tight binding Used - Very Good. VG paperback.
Idioma: Inglés
Publicado por Kluwer Academic Publishers, 1998
ISBN 10: 0792387295 ISBN 13: 9780792387299
Librería: Fireside Bookshop, Stroud, GLOS, Reino Unido
Miembro de asociación: PBFA
Original o primera edición
EUR 10,23
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Añadir al carritoCloth/Laminated Boards. Condición: Very Good. First Edition. Type: Book This volume is the proceedings of the William Harvey Research Conference held in Cannes, France, on the 20th and 21st March, 1997. It describes the present knowledge of the structures of the cyclooxygenase isoforms and the experimental and clinical effects of selective inhibitors of cyclooxygenase-2. The pathophysiological significance of the cyclooxygenase enzymes in tumorigenesis, programmed cell death, vascular disease and asthma is also covered.150pp.
Idioma: Inglés
Publicado por Kluwer Academic Publishers, 1999
ISBN 10: 0792387295 ISBN 13: 9780792387299
Librería: Fireside Bookshop, Stroud, GLOS, Reino Unido
Miembro de asociación: PBFA
EUR 10,23
Cantidad disponible: 1 disponibles
Añadir al carritoCloth/Laminated Boards. Condición: Very Good. Reprint. Type: Book This volume is the proceedings of the William Harvey Research Conference held in Cannes, France, on the 20th and 21st March, 1997. It describes the present knowledge of the structures of the cyclooxygenase isoforms and the experimental and clinical effects of selective inhibitors of cyclooxygenase-2. The pathophysiological significance of the cyclooxygenase enzymes in tumorigenesis, programmed cell death, vascular disease and asthma is also covered.150pp.
Idioma: Inglés
Publicado por Kluwer Academic Publishers, 1996
ISBN 10: 0792387147 ISBN 13: 9780792387145
Librería: Fireside Bookshop, Stroud, GLOS, Reino Unido
Miembro de asociación: PBFA
EUR 12,02
Cantidad disponible: 1 disponibles
Añadir al carritoCloth/Laminated Boards. Condición: Very Good. Type: Book This volume of conference proceedings reviews the general pathophysiological significance of the isoforms of cyclooxygenase, and the likely value of selective COX-2 inhibitors in the treatment of rheumatoid conditions. Also covered is the possible use of antibodies against cytokines and cell adhesion receptors in the treatment of inflammatory conditions. N.B.Top edge front board slightly bumped.147pp.
Idioma: Inglés
Publicado por Kluwer Academic Publishers, 1996
ISBN 10: 0792387147 ISBN 13: 9780792387145
Librería: Fireside Bookshop, Stroud, GLOS, Reino Unido
Miembro de asociación: PBFA
EUR 12,02
Cantidad disponible: 1 disponibles
Añadir al carritoCloth/Laminated Boards. Condición: Very Good. Type: Book This volume of conference proceedings reviews the general pathophysiological significance of the isoforms of cyclooxygenase, and the likely value of selective COX-2 inhibitors in the treatment of rheumatoid conditions. Also covered is the possible use of antibodies against cytokines and cell adhesion receptors in the treatment of inflammatory conditions. N.B.Top edge front board slightly bumped.147pp.
Idioma: Inglés
Publicado por Kluwer Academic Publishers, 1998
ISBN 10: 0792387384 ISBN 13: 9780792387381
Librería: Fireside Bookshop, Stroud, GLOS, Reino Unido
Miembro de asociación: PBFA
EUR 48,10
Cantidad disponible: 1 disponibles
Añadir al carritoCloth/Laminated Boards. Condición: Very Good. Type: Book This volume contains the proceedings of the William Harvey Research Conference held in London on the 12th and 13th June 1997. It covers the biosynthesis of leukotrienes, their release in pathological conditions, progress in the characterization of leukotriene receptors, and the elucidation of signal transduction mechanisms following receptor activation. Particular attention has been directed at the use of the increasing number of available leukotriene receptor antagonists and biosynthesis inhibitors in diseases such as asthma and rhinitis. 143pp.
Librería: Ria Christie Collections, Uxbridge, Reino Unido
EUR 116,49
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Añadir al carritoCondición: New. In.
Librería: Ria Christie Collections, Uxbridge, Reino Unido
EUR 116,49
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Añadir al carritoCondición: New. In.
Librería: Ria Christie Collections, Uxbridge, Reino Unido
EUR 116,49
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Añadir al carritoCondición: New. In.
EUR 113,67
Cantidad disponible: 10 disponibles
Añadir al carritoPaperback. Condición: New.
Librería: GreatBookPrices, Columbia, MD, Estados Unidos de America
EUR 132,14
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Añadir al carritoCondición: As New. Unread book in perfect condition.
Librería: Ria Christie Collections, Uxbridge, Reino Unido
EUR 128,79
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Añadir al carritoCondición: New. In.
Librería: Ria Christie Collections, Uxbridge, Reino Unido
EUR 128,79
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Añadir al carritoCondición: New. In.
Librería: GreatBookPricesUK, Woodford Green, Reino Unido
EUR 128,78
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Añadir al carritoCondición: New.
Librería: GreatBookPrices, Columbia, MD, Estados Unidos de America
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Añadir al carritoCondición: New.
EUR 145,26
Cantidad disponible: 4 disponibles
Añadir al carritoCondición: New. pp. ix + 150.
Librería: Books Puddle, New York, NY, Estados Unidos de America
EUR 147,78
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Añadir al carritoCondición: New. pp. 200.
Librería: GreatBookPricesUK, Woodford Green, Reino Unido
EUR 140,53
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Añadir al carritoCondición: As New. Unread book in perfect condition.
Librería: Revaluation Books, Exeter, Reino Unido
EUR 152,36
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Añadir al carritoPaperback. Condición: Brand New. 150 pages. 9.45x6.30x0.37 inches. In Stock.
Librería: Revaluation Books, Exeter, Reino Unido
EUR 152,36
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Añadir al carritoPaperback. Condición: Brand New. 1996 edition. 160 pages. 9.25x6.10x0.47 inches. In Stock.
Librería: Revaluation Books, Exeter, Reino Unido
EUR 153,88
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Añadir al carritoPaperback. Condición: Brand New. reprint edition. 248 pages. 8.75x6.00x0.75 inches. In Stock.
Librería: preigu, Osnabrück, Alemania
EUR 95,25
Cantidad disponible: 5 disponibles
Añadir al carritoTaschenbuch. Condición: Neu. Selective COX-2 Inhibitors | Pharmacology, Clinical Effects and Therapeutic Potential | John R. Vane (u. a.) | Taschenbuch | ix | Englisch | 2012 | Springer | EAN 9789401060417 | Verantwortliche Person für die EU: Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg, juergen[dot]hartmann[at]springer[dot]com | Anbieter: preigu.
Librería: preigu, Osnabrück, Alemania
EUR 95,70
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Añadir al carritoTaschenbuch. Condición: Neu. New Targets in Inflammation | Inhibitors of COX-2 or Adhesion Molecules Proceedings of a conference held on April 15-16, 1996, in New Orleans, USA, supported by an educational grant from Boehringer Ingelheim | N. Bazan (u. a.) | Taschenbuch | ix | Englisch | 2012 | Springer Netherland | EAN 9789401062657 | Verantwortliche Person für die EU: Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg, juergen[dot]hartmann[at]springer[dot]com | Anbieter: preigu.
Librería: Ria Christie Collections, Uxbridge, Reino Unido
EUR 163,98
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Librería: Ria Christie Collections, Uxbridge, Reino Unido
EUR 165,74
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Añadir al carritoCondición: New. In.
Librería: AHA-BUCH GmbH, Einbeck, Alemania
EUR 112,77
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Añadir al carritoTaschenbuch. Condición: Neu. Druck auf Anfrage Neuware - Printed after ordering - For the past 100 years the mainstay of therapy for rheumatoid arthritis (RA) has been aspirin or other drugs of the non-steroid anti-inflammatory group. In 1971 Vane pro posed that both the beneficial and toxic actions of these drugs was through inhibition of prostaglandin synthesis. The recent discovery that prostaglandins responsible for pain and other symptoms at inflammatory foci are synthesized by an inducible cyclooxygenase (COX-2) that is encoded by a gene distinct from that of the consti tutive enzyme (COX-I) provided a new target for therapy of RA. A drug that would selectively inhibit COX-2 would hopefully produce the symptomatic benefit provided by existing NSAIDs without the gastrointestinal and renal toxicity due to the inhibition of COX-I. Drugs selective for COX-2 are now available. Experimental studies have shown them to be effective with minimal toxicity, and in clinical trials gastric and renal toxicities are less. Highly selective COX-2 inhibitors, perhaps designed with knowledge of the crystal structures of COX-I and COX-2, are also available. Other experimental studies, including those in animals lacking effective genes for COX-lor COX-2 and in experimental carcinomas, suggest there is still much to be learned of the pathophysiological functions of these enzymes. The inflammatory response is a complex reaction involving many mediators that derive from white blood cells, endothelial cells and other tissues. Preliminary data have revealed that inhibitors of the cytokines and adhesion molecules that play a crucial role in the migration of white cells to inflammatory sites may be useful in RA.
Librería: AHA-BUCH GmbH, Einbeck, Alemania
EUR 112,77
Cantidad disponible: 1 disponibles
Añadir al carritoTaschenbuch. Condición: Neu. Druck auf Anfrage Neuware - Printed after ordering - The mainstay of therapy for rheumatoid disease is the non-steroid antiinflammatory drugs (NSAIDs), despite their inherent gastrointestinal toxicity and ability to cause renal damage in susceptible patients. The theory that the beneficial and toxic effects of NSAIDs stem from a reduction in prostanoid production through inhibition of cyclooxygenase implied that particular toxicities were inevitable with NSAIDs and would always be correlated with efficacy. However, over the years, it became apparent that at therapeutic doses, some NSAIDs had greater toxic side-effects than others, a fact not explained by the general theory. A significant clarification arose from the discovery that there are two distinct isoforms of COX, a constitutive enzyme (COX-I) responsible for the production of prostanoids necessary for platelet aggregation and protection of the gastric mucosa and kidney; and an inducible enzyme (COX-2) that is newly synthesized at sites of tissue damage and produces prostaglandins that manifest pathological effects. It became clear that different NSAIDs had greater or lesser effects on COX-I when used in therapeutic doses, explaining the variation in side-effects. ' The elucidation of the crystal structure of these different enzymes and the skills of medicinal chemists have led to the synthesis of new chemicals with a selectivity for the inducible enzyme, and thus with therapeutic efficacy without those toxic effects result ing from inhibition of the constitutive enzyme.