Transient receptor potential channels (133 resultados)

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Paperback or Softback. Condición: New. Transient Receptor Potential (TRP) Channels in Drug Discovery: Old Concepts & New Thoughts. Book.

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Taschenbuch. Condición: Neu. Druck auf Anfrage Neuware - Printed after ordering - Professorial Dissertation from the year 2014 in the subject Medicine - Pharmacology, Pharmacy, grade: Passed, LMU Munich (Pharmacy/Pharmacology), language: English, abstract: Lysosomes are cell organelles involved in the breakdown of proteins, lipids, and other molecules and have been implicated not only in endolysosomal storage disorders (LSDs) such as mucolipidoses or mucopolysaccharidoses but also in metabolic diseases, neurodegenerative disorders such as Alzheimer's and Parkinson's disease, pigmentation disorders, or infectious diseases. Highly critical for the proper function of lysosomes, endosomes, and lysosome-related organelles is the tight regulation of various fusion and fission processes and the regulation of proton and other ionic concentrations within the endolysosomal system. Calcium permeable, non-selective cation channels of the TRP (transient receptor potential) superfamily, namely TRPML channels (mucolipins) and TPCs (two-pore channels) have been found to play important roles in these processes. This thesis provides insights into the function and physiology of TRPML and TPC channels, explains the molecular basis of pathologies associated with diseases caused by loss or mutation of these channels, and discusses potential therapeutic approaches.…

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Condición: New. pp. 246.

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Paperback. Condición: New. This book provides an original account of behavioral aspects with important ramifications for the study of transient receptor potential (TRP) channels functioning. It explains, in terms of specified somato-sensory mechanisms and systems, how TRP channels work. Through exploration of animal models by testing paw withdrawal reflexes to thermal and mechanical stimuli, it is shown that TRP channels are promising targets for the development of a new group of analgesic drugs at the periphery and central levels and opportunities for therapeutic intervention.…

Condición: New. 2019. Paperback. . . . . .

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Hardcover. Condición: Good. Oversized hardcover, xxiii + 1095 pages, colour illustrations in text, NOT ex-library. Yellow highlighting on 40 pages. A short pen line in side margin of one page, two lines on p.857. Other pages are clean. 6 straightened page corner folds. Binding is loosened but secure and stable. Boards show storage wear: scratches, two small areas of surface damage (rear panel), a couple of scuff-marks on lower edges, shelfwear. Published without a dust jacket. -- Contents: Structural Biology of TRP Channels; Functional and Structural Studies of TRP Channels Heterologously Expressed in Budding Yeast; Natural Product Ligands of TRP Channels; Synthetic Modulators of TRP Channel Activity; Study of TRP Channels by Automated Patch Clamp Systems; TRPC2: Of Mice But Not Men; TRPM1: New Trends for an Old TRP; Non-selective Monovalent Cationic Channels TRPm4 and TRPM5; TRPM7, the Mg2+ Inhibited Channel and Kinase; TRPM8 in Health and Disease: Cold Sensing and Beyond; TRPML1; TRPML2 and the Evolution of Mucolipins; TRPML3 Channel: From Gene to Function; TRPV5 and TRPV6 in Transcellular Ca2+ Transport: Regulation, Gene Duplication, and Polymorphisms in African Populations; TRPV5 Promoter as a Tool for Generation of Transgenic Mouse Models; TRPP Channels and Polycystins; TRP Channels in Yeast; C. elegans TRP Channels; Investigations of the In Vivo Requirements of Transient Receptor Potential Ion Channels Using Frog and Zebrafish Model Systems; TRP Channels in Parasites; Receptor Signaling Integration by TRP Channelsomes; Gating Mechanisms of Canonical Transient Receptor Potential Channel Proteins: Role of Phosphoinositols and Diacylglycerol; TRPC Ion Channels: Association with Orail and STIMI1 Proteins and Participation in Capacitative and Non-capacitative Calcium Entry; Contribution of TRPc1 and Orail to Ca2+ Entry Activated by Store Depletion; Primary Thermosensory Events in Cells; Thermo-TRP Channels: Biophysics of Polymodal Receptors; Complex Regulation of TRPv1 and Related Thermo-TRPs: Implications for Therapeutic Intervention; Voltage Sensing in Thermo-TRP Channels; TRP Channels as Mediators of Oxidative Stress; Regulation of TRP Signalling by Ion Channel Translocation Between Cell Compartments; Emerging Roles of Canonical TRP Channels in Neuronal Function; TRP Channels and Neural Persistent Activity; Role of TRP Channels in Pain Sensation; TRPV1: A Therapy Target That Attracts the Pharmaceutical Interests; Expression and Function of TRP Channels in Liver Cells; Expression and Physiological Roles of TRP Channels in Smooth Muscle Cells; TRPM Channels in the Vasculature; Molecular Expression and Functional Role of Canonical Transient Receptor Potential Channels in Airway Smooth Muscle Cells; TRP Channels in Skeletal Muscle: Gene Expression, function and Implications for Disease; TRP Channels in Vascular Endothelial Cells; TRP Channels in the Cardiopulmonary Vasculature; TRP Channels of Islets; Multiple Roles for TRPs in the Taste System: Not Your Typical TRPs; Roles of Transient Receptor Potential Proteins (TRPs) in Epidermal Keratinocytes; TRP Channels in Urinary Bladder Mechanosensation; Role of TRP Ion Channels in Testicular Function; TRP Channels in Female Reproductive Organs and Placenta; Oncogenic TRP Channels; TRPV Channels in Tumor Growth and Progression; Role of Transient Receptor Potential Channels in Respiratory Symptoms and Pathophysiology; TRP Channels and Psychiatric Disorders; Transient Receptor Potential Genes and Human Inherited Disease; Index.…

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Condición: New. KlappentextrnrnThe year 2017 marks the 20th anniversary of the molecular cloning of the long sought-after capsaicin receptor, now known as TRPV1 (Transient Receptor Potential Vanilloid 1). This seminal discovery has opened up a hot new field o.

Taschenbuch. Condición: Neu. Neuware - The year 2017 marks the 20th anniversary of the molecular cloning of the long sought-after capsaicin receptor, now known as TRPV1 (Transient Receptor Potential Vanilloid 1). This seminal discovery has opened up a 'hot' new field of basic research and launched drug discovery efforts into the large family (by the latest count, 28 mammalian members and 27 in humans) of TRP ion channels. Indeed, it took less than a decade for the first potent, small molecule TRPV1 antagonists to enter phase 1 clinical trials, closely followed by TRPA1 and TRPM8 antagonists. The literature on TRP channels is immense. TRPV1 alone is a keyword in over 5000 publications searchable in PubMed. Clearly, it is not possible to capture the entire literature in a single thematic issue. Consequently, the selection of articles presented in this book represents a sampling of the literature, and is admittedly subjective. We tried to survey the wide range of human diseases in which TRP channels have been implicated, ranging from chronic pain through asthma and diabetes to cancer, and highlight the channels that appear to hold the greatest promise for therapeutic targeting. With this book, we hope to convince readers that TRP channels constitute a formidable family of potential therapeutic targets that will likely continue to demand attention.…

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Taschenbuch. Condición: Neu. Neuware.

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Paperback. Condición: New. This book provides an original account of behavioral aspects with important ramifications for the study of transient receptor potential (TRP) channels functioning. It explains, in terms of specified somato-sensory mechanisms and systems, how TRP channels work. Through exploration of animal models by testing paw withdrawal reflexes to thermal and mechanical stimuli, it is shown that TRP channels are promising targets for the development of a new group of analgesic drugs at the periphery and central levels and opportunities for therapeutic intervention.…

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Paperback. Condición: Sehr gut. Gebraucht - Sehr gut - ungelesen,als Mängelexemplar gekennzeichnet, mit leichten Mängeln an Schnitt oder Einband durch Lager- oder Transportschaden -Transient Receptor Potential Channels offers a unique blend of thoughtfully selected topics ranging from the structural biology of this fascinating group of ion channels to their emerging roles in human diseases. This single book covers TRP channels of yeasts, flies, fishes frogs and humans. And from the biophysics of primary thermo-sensory events in cells to the thermosensation at whole organism level, from physiology of pain to the development of pain-killers, from psychiatric illnesses to cancers, from skin cells to sperms, from taste buds to testes, from established facts to heated debates, this book contains something for every TRP enthusiasts, beginner and expert alike. It includes crucial background information, critical analysis of cutting edge research, and ideas and thoughts for numerous testable hypotheses. It also shows directions for future research in this highly dynamic field. It is a book readers will be just as eager to give to others as keep for themselves.Springer-Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 1118 pp. Englisch.…