gene expression profiling cancer (37 resultados)

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Taschenbuch. Condición: Neu. Mechanisms of Leptin in Breast Cancer Development and Progression | Profiling of Leptin Regulated Gene and Protein Expression in Human Breast Cancer Cells | Candida Perera (u. a.) | Taschenbuch | 128 S. | Englisch | 2010 | LAP LAMBERT Academic Publishing | EAN 9783838373331 | Verantwortliche Person für die EU: preigu GmbH & Co. KG, Lengericher Landstr. 19, 49078 Osnabrück, mail[at]preigu[dot]de | Anbieter: preigu.

Taschenbuch. Condición: Neu. Data Analytics in Gene Expression Profiling | Exploring gene expression for cancer | Farzana Kabir Ahmad | Taschenbuch | Englisch | 2021 | Scholars' Press | EAN 9786138965282 | Verantwortliche Person für die EU: preigu GmbH & Co. KG, Lengericher Landstr. 19, 49078 Osnabrück, mail[at]preigu[dot]de | Anbieter: preigu.

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Taschenbuch. Condición: Neu. The application of gene expression profiling to clinical breast cancer research | Sherene Loi | Taschenbuch | 280 S. | Englisch | 2014 | LAP LAMBERT Academic Publishing | EAN 9783838329734 | Verantwortliche Person für die EU: BoD - Books on Demand, In de Tarpen 42, 22848 Norderstedt, info[at]bod[dot]de | Anbieter: preigu.

Taschenbuch. Condición: Neu. Understanding Breast Cancer dynamics using Gene Expression Profiling | Potential of Gene expression profiling for Breast Cancer prognosis and classification | Jai Prakash Mehta | Taschenbuch | 396 S. | Englisch | 2011 | LAP LAMBERT Academic Publishing | EAN 9783838359311 | Verantwortliche Person für die EU: BoD - Books on Demand, In de Tarpen 42, 22848 Norderstedt, info[at]bod[dot]de | Anbieter: preigu.

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Paperback. Condición: new. Paperback. Colon cancer is a common malignancy affecting both women and men. In 2012, it is expected to be the fourth most commonly diagnosed cancer (after prostate, breast, and lung cancer) with an estimated 103,170 new cases and, combined with rectal cancer, is the second most common cause of cancer deaths (after lung cancer) with 51,690 deaths. The most important prognostic factor for colon cancer is stage at diagnosis. About 40 percent of patients with colon cancer are initially diagnosed with stage I disease (these localized tumors do not invade through the muscularis propria). Stage I disease has a 5-year survival rate of over 95 percent. Five-year survival rates for patients diagnosed with stage II disease are between 58 and 83 percent. Stage II colon cancer is characterized by full-thickness tumor invasion of the bowel wall and the absence of lymph node and distant metastases. Stage II disease is now subdivided into IIA (T3 tumors that invade through the muscularis propria into the pericolorectal tissues), IIB (T4a tumors that directly penetrate to the surface of the visceral peritoneum), and IIC (T4b tumors where tumor directly invades or is adherent to other organs or structures). The relative 5-year survival rate for stage II T4a tumors is higher than for T4b lesions. Stages III and IV have a worse prognosis. A number of negative prognostic factors, that is, factors associated with increased risk of recurrence, have been identified in stage II disease including T4 tumors (which tend to be large); obstruction or bowel perforation at initial diagnosis; an inadequately low number of assessed lymph nodes from surgery (12 or fewer); poorly differentiated histology, vascular, lymphatic, and perineural invasion; a high preoperative level of carcinoembryonic antigen; and the presence of indeterminate or positive resection margins. Gene expression profiles (GEPs), also known as gene expression patterns or signatures, measure the activity of "expression" of multiple genes using a single sample. Gene expression results from DNA transcription into messenger RNA (mRNA); mRNA then serves as the template for protein synthesis. Gene expression is determined by analyzing RNA in the sample, generally using either reverse transcription quantitative polymerase chain reaction or DNA microarrays. GEP tests use defined protocols to evaluate the specimens to be analyzed: preparing the RNA samples, copying into DNA, normalizing the raw expression measurements, and computing summary results (summary indices). Data from a GEP test can provide information about a cell's type, its current state of activity, and its local environment. This Brief will focus on the use of GEP tests for both prognostic and predictive outcomes. For the purposes of this Technical Brief, prognostic outcomes relate to disease prognosis such as recurrence of tumor or survival. The prognostic outcome often assesses disease recurrence over time (usually over 3 to 5 years) and is generally measured by disease-free survival. In contrast, use of GEP assays for predictive outcomes is different. This use correlates the GEP result with benefit (reduced recurrence rate and improved survival) from adjuvant chemotherapy. Predictive assays are especially important in that their use could result in improved survival. This item is printed on demand. Shipping may be from our UK warehouse or from our Australian or US warehouses, depending on stock availability.

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Taschenbuch. Condición: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -The book has three main results parts. Chapter 3 illustrates the first independent validation study of a 70-gene signature developed from gene expression profiling for use in breast cancer prognosis and demonstration of its ability to add independent prognostic information to the clinical prognostic factors currently used. The successful validation of this study preceded the design and implementation of a world-wide randomized clinical trial evaluating the gene signature s clinical utility. This trial has commenced and is currently recruiting in Europe. Chapter 4 describes the finding that proliferation-related genes can predict clinical outcome consistently in breast cancer and many gene signatures developed for predicting breast cancer prognosis derive a significant proportion of their prognostic power from these genes. Finally, chapter 5 describes the use of proliferation-related genes to define two distinct prognostic molecular subgroups within estrogen receptor positive breast cancers. 280 pp. Englisch.

Taschenbuch. Condición: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Breast cancer is the most common type of cancer among females, both in incidence and death. As meaningful biological understanding of the disease is confounded by the existence of various molecular groups and sub-groups, the challenge for targeted drug development may lie in understanding the molecular mechanisms of various sub-groups in breast cancer. This book describes the gene expression profiling approach for deeper understanding of the dynamics of breast cancer progression and prognosis. 396 pp. Englisch.

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Condición: New. Dieser Artikel ist ein Print on Demand Artikel und wird nach Ihrer Bestellung fuer Sie gedruckt. The book has three main results parts. Chapter 3 illustrates the first independent validation study of a 70-gene signature developed from gene expression profiling for use in breast cancer prognosis and demonstration of its ability to add independent progno.

Condición: New. Dieser Artikel ist ein Print on Demand Artikel und wird nach Ihrer Bestellung fuer Sie gedruckt. Autor/Autorin: Mehta Jai PrakashCurrently, I am working as Bioinformatician at University College Dublin, Ireland. My area of work in analysing Next generation Sequencing data generated from Illumina Genome Analyser. Educational Qualification: .

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HRD. Condición: New. New Book. Delivered from our UK warehouse in 4 to 14 business days. THIS BOOK IS PRINTED ON DEMAND. Established seller since 2000.

Taschenbuch. Condición: Neu. nach der Bestellung gedruckt Neuware - Printed after ordering - Obesity is a recently established risk factor for breast cancer. A characteristic of obesity is elevated circulating levels of adipocyte-derived hormone leptin. Evidence indicates leptin plays an important role in breast cancer development and progression; however the mechanisms involved are poorly understood. Towards better defining the role of leptin in breast cancer, herein we describe the identification of leptin-regulated genes and proteins in hormone responsive MCF-7 human breast cancer cells. Leptin significantly increased the proliferation and protein secretion in MCF-7 cells. The effect of leptin in modulating the extracellular environment and inhibiting apoptosis was also determined. These data suggest leptin regulates mammary tumor cell behavior through multiple mechanisms. In addition to regulating mitogenic cell signaling pathways, leptin influences mammary tumor cell growth by regulating apoptosis, cell cycle, secretion of autocrine/ paracrine factors and modulating the extracellular environment. Identification of leptin-regulated factors provides valuable mechanistic links into the relationship between obesity and breast cancer.

Taschenbuch. Condición: Neu. nach der Bestellung gedruckt Neuware - Printed after ordering - Microarray technology has shifted to a new era in molecular classification, however, interpreting gene expression data to remain a challenging issue due to their innate nature of 'high dimensional low sample size'. Furthermore, this data is often overwhelmed, overfitting and confused by the complexity of data analysis. Small sample size and a large number of variables to be analysed posed significant challenges during data analysis, mainly in learning network structure. Moreover, the ability to study the gene interactions that form tumour growth is a great difficulty to computational biology researchers as gene does not work alone but involves complex interactions. This book aims to propose a dynamic Bayesian network-based model in order to identify gene signatures from large-scale gene expression profiles. The dynamic Bayesian network-based model attempts to discover the gene regulation that yields to breast cancer progression.

Buch. Condición: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -The contribution of modern-day genetics in designing efficient gene expression profiles for cancer is immense. The progress of technology and science in recent years provides the opportunity for discovery and application of new techniques for treating various diseases that affect humanity. Methods for finding and analyzing the profile of gene expression of infected cells give scientists the ability to develop more targeted and effective treatments, especially for diseases such as cancer. The development of gene expression profiling is one of the most important achievements in cancer genetics in our time. It is essentially the driving force behind personalized and precision medicine. This book highlights recent developments, applications, and breakthroughs in the field of gene expression profiling in cancer. 78 pp. Englisch.

Gebunden. Condición: New. Dieser Artikel ist ein Print on Demand Artikel und wird nach Ihrer Bestellung fuer Sie gedruckt. KlappentextrnrnThe contribution of modern-day genetics in designing efficient gene expression profiles for cancer is immense. The progress of technology and science in recent years provides the opportunity for discovery and application of new te.

Taschenbuch. Condición: Neu. This item is printed on demand - Print on Demand Titel. Neuware -Breast cancer is the most common type of cancer among females, both in incidence and death. As meaningful biological understanding of the disease is confounded by the existence of various molecular groups and sub-groups, the challenge for targeted drug development may lie in understanding the molecular mechanisms of various sub-groups in breast cancer. This book describes the gene expression profiling approach for deeper understanding of the dynamics of breast cancer progression and prognosis.VDM Verlag, Dudweiler Landstraße 99, 66123 Saarbrücken 396 pp. Englisch.