Isbn: 9786200457592 - new piperazine derivatives: biologic and spectroscopic study: a new piperazine derivatives were synthesized. all compounds were characterized by nmr, ft-ir, mass spectral data (8 resultados)

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Taschenbuch. Condición: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -A new piperazine derivatives: 2,2¿-(piperazine-1,4-diyl)bis(N¿-((Z)-2,4-dihydroxybenzylidene)acetohydrazide), 2.2¿-(piperazine-1,4-diyl)bis (N¿-((Z)-2-hydroxy-4-methoxybenzylidene)acetohydrazide) and 2.2¿-(piperazine-1,4-diyl) bis N¿-((Z)-1-(2-hydroxynaphthalen-1-yl) ethylidene) aceto hydrazide) were synthesized. The characterization of all compounds was characterized by NMR, FT-IR, Mass spectral data and elemental analysis. 1H and 13C shielding tensors of all compounds were calculated with GIAO/DFT/B3LYP/6-31 G(d) methods in DMSO. Molecular electrostatic potential surface and frontier orbital analysis were also carried out. HOMO-LUMO energy gap was calculated which allowed the calculation of relative reactivity descriptors like chemical hardness, chemical inertness, chemical potential, nucleophilicity and electrophilicity index of all compounds. Molecular docking studies of compounds were performed for Lanosterol-14a-demethylase (CYP51) enzyme (PDB ID: 3JUS). The microbiological effect of all compounds were tested against five human pathogenic bacteria and three fungal by using microdilution and disc diffusion methods. 96 pp. Englisch.…

Taschenbuch. Condición: Neu. nach der Bestellung gedruckt Neuware - Printed after ordering - A new piperazine derivatives: 2,2'-(piperazine-1,4-diyl)bis(N'-((Z)-2,4-dihydroxybenzylidene)acetohydrazide), 2.2'-(piperazine-1,4-diyl)bis (N'-((Z)-2-hydroxy-4-methoxybenzylidene)acetohydrazide) and 2.2'-(piperazine-1,4-diyl) bis N'-((Z)-1-(2-hydroxynaphthalen-1-yl) ethylidene) aceto hydrazide) were synthesized. The characterization of all compounds was characterized by NMR, FT-IR, Mass spectral data and elemental analysis. 1H and 13C shielding tensors of all compounds were calculated with GIAO/DFT/B3LYP/6-31 G(d) methods in DMSO. Molecular electrostatic potential surface and frontier orbital analysis were also carried out. HOMO-LUMO energy gap was calculated which allowed the calculation of relative reactivity descriptors like chemical hardness, chemical inertness, chemical potential, nucleophilicity and electrophilicity index of all compounds. Molecular docking studies of compounds were performed for Lanosterol-14a-demethylase (CYP51) enzyme (PDB ID: 3JUS). The microbiological effect of all compounds were tested against five human pathogenic bacteria and three fungal by using microdilution and disc diffusion methods.…

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Taschenbuch. Condición: Neu. This item is printed on demand - Print on Demand Titel. Neuware -A new piperazine derivatives: 2,2'-(piperazine-1,4-diyl)bis(N'-((Z)-2,4-dihydroxybenzylidene)acetohydrazide), 2.2'-(piperazine-1,4-diyl)bis (N'-((Z)-2-hydroxy-4-methoxybenzylidene)acetohydrazide) and 2.2'-(piperazine-1,4-diyl) bis N'-((Z)-1-(2-hydroxynaphthalen-1-yl) ethylidene) aceto hydrazide) were synthesized. The characterization of all compounds was characterized by NMR, FT-IR, Mass spectral data and elemental analysis. 1H and 13C shielding tensors of all compounds were calculated with GIAO/DFT/B3LYP/6-31 G(d) methods in DMSO. Molecular electrostatic potential surface and frontier orbital analysis were also carried out. HOMO-LUMO energy gap was calculated which allowed the calculation of relative reactivity descriptors like chemical hardness, chemical inertness, chemical potential, nucleophilicity and electrophilicity index of all compounds. Molecular docking studies of compounds were performed for Lanosterol-14a-demethylase (CYP51) enzyme (PDB ID: 3JUS). The microbiological effect of all compounds were tested against five human pathogenic bacteria and three fungal by using microdilution and disc diffusion methods.VDM Verlag, Dudweiler Landstraße 99, 66123 Saarbrücken 96 pp. Englisch.…

Taschenbuch. Condición: Neu. New Piperazine Derivatives: Biologic and Spectroscopic Study | A new piperazine derivatives were synthesized. All compounds were characterized by NMR, FT-IR, Mass spectral data | Neslihan Özbek (u. a.) | Taschenbuch | 96 S. | Englisch | 2019 | LAP LAMBERT Academic Publishing | EAN 9786200457592 | Verantwortliche Person für die EU: BoD - Books on Demand, In de Tarpen 42, 22848 Norderstedt, info[at]bod[dot]de | Anbieter: preigu Print on Demand.…