9783659635533 - structure and functional correlations of human glucokinase de yellapu, nanda kumar; p.v.g.k., sarma; matcha, bhaskar (6 resultados)
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Librería: Revaluation Books, Exeter, Reino UnidoRevaluation Books
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Paperback. Condición: Brand New. 172 pages. 8.66x5.91x0.39 inches. In Stock.
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Taschenbuch. Condición: Neu. Structure and Functional Correlations of Human Glucokinase | Nanda Kumar Yellapu (u. a.) | Taschenbuch | 172 S. | Englisch | 2016 | LAP LAMBERT Academic Publishing | EAN 9783659635533 | Verantwortliche Person für die EU: preigu GmbH & Co. KG, Lengericher Landstr. 19, 49078 Osnabrück, mail[at]preigu[d…ot]de | Anbieter: preigu.
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Taschenbuch. Condición: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Glucokinase plays a critical role in glucose homeostasis and the mutations in Glucokinase gene results in altered catalysis of the enzyme leading to type 2 diabetic condition. The catalysis takes place by super open and closed confo…rmations of enzyme which will be disturbed by the mutations. The in silico mutagenic studies reveal several mysterious points about the impact of mutations on the structural and functional behaviour of glucokinase that are in best correlation with its enzyme activities. This study provides an insight into the understanding of the clear possible reasons for the altered activities of glucokinase under mutated condition and the probable consequences with respect to the pathogenesis of diabetes. This problem can be solved by the usage of glucokinase activators that have the ability to bind with the allosteric site of glucokinase and increase its activity by specific folds. Structure based drug design helps to develop more efficient lead molecules based on the structural information of the glucokinase. These molecules can be used to for the treatment and management of type 2 diabetes. 172 pp. Englisch.
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Condición: New. Dieser Artikel ist ein Print on Demand Artikel und wird nach Ihrer Bestellung fuer Sie gedruckt. Autor/Autorin: Yellapu Nanda KumarDr. Nanda Kumar Yellapu is a Bioinformatics Scientist at Biomedical Informatics Centre of Vector Control Research Centre (ICMR), Pondicherry, India. He obtained his Masters degree fro…m SVIMS University and PhD from.
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Taschenbuch. Condición: Neu. This item is printed on demand - Print on Demand Titel. Neuware -Glucokinase plays a critical role in glucose homeostasis and the mutations in Glucokinase gene results in altered catalysis of the enzyme leading to type 2 diabetic condition. The catalysis takes place by super open and closed conformat…ions of enzyme which will be disturbed by the mutations. The in silico mutagenic studies reveal several mysterious points about the impact of mutations on the structural and functional behaviour of glucokinase that are in best correlation with its enzyme activities. This study provides an insight into the understanding of the clear possible reasons for the altered activities of glucokinase under mutated condition and the probable consequences with respect to the pathogenesis of diabetes. This problem can be solved by the usage of glucokinase activators that have the ability to bind with the allosteric site of glucokinase and increase its activity by specific folds. Structure based drug design helps to develop more efficient lead molecules based on the structural information of the glucokinase. These molecules can be used to for the treatment and management of type 2 diabetes.VDM Verlag, Dudweiler Landstraße 99, 66123 Saarbrücken 172 pp. Englisch.
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Librería: AHA-BUCH GmbH, Einbeck, AlemaniaAHA-BUCH GmbH
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Taschenbuch. Condición: Neu. nach der Bestellung gedruckt Neuware - Printed after ordering - Glucokinase plays a critical role in glucose homeostasis and the mutations in Glucokinase gene results in altered catalysis of the enzyme leading to type 2 diabetic condition. The catalysis takes place by super open and closed conformati…ons of enzyme which will be disturbed by the mutations. The in silico mutagenic studies reveal several mysterious points about the impact of mutations on the structural and functional behaviour of glucokinase that are in best correlation with its enzyme activities. This study provides an insight into the understanding of the clear possible reasons for the altered activities of glucokinase under mutated condition and the probable consequences with respect to the pathogenesis of diabetes. This problem can be solved by the usage of glucokinase activators that have the ability to bind with the allosteric site of glucokinase and increase its activity by specific folds. Structure based drug design helps to develop more efficient lead molecules based on the structural information of the glucokinase. These molecules can be used to for the treatment and management of type 2 diabetes.
