ISBN: 9783659536762 - calcium channel blockers against mptp induced parkinson’s in rats (8 resultados)

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Taschenbuch. Condición: Neu. Calcium Channel Blockers Against MPTP Induced Parkinson's In Rats | Puneet Kumar (u. a.) | Taschenbuch | 84 S. | Englisch | 2014 | LAP LAMBERT Academic Publishing | EAN 9783659536762 | Verantwortliche Person für die EU: preigu GmbH & Co. KG, Lengericher Landstr. 19, 49078 Osnabrück, mail[at]preigu[dot]de | Anbieter: preigu. …

Taschenbuch. Condición: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -The present study has been designed to investigate the protective effect of calcium channel blockers against MPTP - induced Parkinson's disease-like symptoms in rats. The novel protocol showed that repeated bilateral infusion of MPTP into the SNpc by stereotactic surgery caused degeneration of nigrostriatal dopaminergic neurons. Body weight and behavioral parameters (locomotor, rotarod and activity on narrow beam walk) were assessed on 14th, 21st and 28th day post-MPTP administration. Malondialdehyde, nitrite concentration, superoxide dismutase, catalase levels and Cytokines level (TNF- and IL-1beta) were measured on the 28th day. Administration of MPTP significantly impaired behavioral and biochemical parameters, suggesting significant mitochondrial dysfunction as compared to sham control rats. Further, increased level of TNF- and IL-1beta conferred neuroinflammation after MPTP administration in brain. Post treatment with cilnidipine dual L- and N- type and verapamil L-type for 14 days significantly improved behavioral parameters and oxidative damage as compared to MPTP-treated group. Calcium channel blockers treatment also reduced the cytokine levels in brain. 84 pp. Englisch.…

Taschenbuch. Condición: Neu. nach der Bestellung gedruckt Neuware - Printed after ordering - The present study has been designed to investigate the protective effect of calcium channel blockers against MPTP - induced Parkinson's disease-like symptoms in rats. The novel protocol showed that repeated bilateral infusion of MPTP into the SNpc by stereotactic surgery caused degeneration of nigrostriatal dopaminergic neurons. Body weight and behavioral parameters (locomotor, rotarod and activity on narrow beam walk) were assessed on 14th, 21st and 28th day post-MPTP administration. Malondialdehyde, nitrite concentration, superoxide dismutase, catalase levels and Cytokines level (TNF- and IL-1beta) were measured on the 28th day. Administration of MPTP significantly impaired behavioral and biochemical parameters, suggesting significant mitochondrial dysfunction as compared to sham control rats. Further, increased level of TNF- and IL-1beta conferred neuroinflammation after MPTP administration in brain. Post treatment with cilnidipine dual L- and N- type and verapamil L-type for 14 days significantly improved behavioral parameters and oxidative damage as compared to MPTP-treated group. Calcium channel blockers treatment also reduced the cytokine levels in brain.…

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Condición: New. Dieser Artikel ist ein Print on Demand Artikel und wird nach Ihrer Bestellung fuer Sie gedruckt. Autor/Autorin: Kumar PuneetDr. Puneet Kumar M. Pharm., PDCR., Ph.D., working as Associate Professor at ISF College of Pharmacy Moga, Punjab, India. Presently, Dr. Kumar involves in research and teaching both at graduate and post graduate level. H.…

Taschenbuch. Condición: Neu. This item is printed on demand - Print on Demand Titel. Neuware -The present study has been designed to investigate the protective effect of calcium channel blockers against MPTP - induced Parkinson's disease-like symptoms in rats. The novel protocol showed that repeated bilateral infusion of MPTP into the SNpc by stereotactic surgery caused degeneration of nigrostriatal dopaminergic neurons. Body weight and behavioral parameters (locomotor, rotarod and activity on narrow beam walk) were assessed on 14th, 21st and 28th day post-MPTP administration. Malondialdehyde, nitrite concentration, superoxide dismutase, catalase levels and Cytokines level (TNF-¿ and IL-1ß) were measured on the 28th day. Administration of MPTP significantly impaired behavioral and biochemical parameters, suggesting significant mitochondrial dysfunction as compared to sham control rats. Further, increased level of TNF-¿ and IL-1ß conferred neuroinflammation after MPTP administration in brain. Post treatment with cilnidipine dual L- and N- type and verapamil L-type for 14 days significantly improved behavioral parameters and oxidative damage as compared to MPTP-treated group. Calcium channel blockers treatment also reduced the cytokine levels in brain.VDM Verlag, Dudweiler Landstraße 99, 66123 Saarbrücken 84 pp. Englisch.…