Isbn: 9780849303302 - intelligent machines: myths and realities (10 resultados)

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Hardcover. Condición: New. 1st Edition. SHRINKWRAPPED: US SELLER SHIPS FROM USA. SHRINK-WRAPPED NEW: Renin Angiotensin System and the Heart 1st Edition 2004 Renin Angiotensin System and the Heart 1st Edition by Walmor C. De Mello (Editor) OUR REFERENCE: 133E12-0470862920-HC-1P3-lb-Red DESCRIPTION Recent studies have shown that the heart possesses an intrinsic renin angiotensin system that is controlled by tissue-specific parameters that are activated by biomechanical stress. This book reviews the latest information on the way in which both the plasma and cardiac renin angiotensin systems affect heart function. It covers the cell and molecular biology of these systems, with contributions on renin synthesis, uptake and the intracellular signalling pathways. Particular insight comes from transgenic mouse models in which either mouse or human genes for various components of the renin angiotensin system are expressed. Other topics covered include wound healing as well as the trophic effects of aldosterone. Contains the findings on the renin angiotensin system and the heart Written by an international team of distinguished scientists Covers both the cellular and molecular basis of the renin angiotensin system and the clinical relevance of this research Editorial Reviews Review "Recommended for the intended audience of cardiologists, nephrologists, cell and molecular biologists, physiologists, pathologists and pharmacologists as well as medical libraries." (E-STREAMS, May 2005) From the Back Cover The renin angiotensin system exerts a major influence on heart function under both normal and pathologic conditions. The latter include heart failure, hypertension, cardiac hypertrophy, interstitial fibrosis, post-myocardial infarction remodeling, contractile dysfunction and vascular injury. Recent studies have shown that the heart possesses an intrinsic renin angiotensin system that is controlled by tissue-specific parameters activated by biomechanical stress. This book reviews the latest information on the way both the plasma and cardiac renin angiotensin systems affect heart function. It covers the cell and molecular biology of these systems, with contributions on renin synthesis, uptake and the intracellular signaling pathways. Particular insight comes from transgenic mouse models in which either mouse or human genes for various components of the renin angiotensin system are expressed; for example, overexpression of the angiotensin I receptor results in cardiac hypertrophy in the absence of hypertension. Other topics covered are wound healing as well as the trophic effects of aldosterone. ACE inhibitors and antogonists of angiotensin II receptors are successful drugs; the studies decribed in this book contribute to our knowledge of how such therapies work and how they might be improved in the future. In particular, there are chapters on ACE2 and its role in heart failure, angiotensin II in myocardial fibrosis and the renin angiotensin system in hypertensive heart disease. This book should be of interest to cardiologists, nephrologists, cell and molecular biologists, physiologists, pathologists and pharmacologists. Product details ASIN ‏ : ‎ 0470862920 Publisher ‏ : ‎ Wiley; 1st edition (April 30, 2004) Language ‏ : ‎ English Hardcover ‏ : ‎ 256 pages ISBN-10 ‏ : ‎ 0470862920 ISBN-13 ‏ : ‎ 978-0470862926.…

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Condición: New. pp. 344.

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