enders john c (3 resultados)

Single Issue Magazine. Condición: Fair. Clymer, John F. (cover); Hoffman, Frank; Adams, Hank; Sart, Tony; Nussdorf, Joseph; Gotlieb, Jules Ilustrador. First Edition. 54 pages. Features: Great colour cover art of Chinese battle scene by Clymer; The Good Old Days vs. The Good New Days; Ontario Premier Hepburn declares ".There will be no American dictatorship of our labour"; Hon. David A. Croll , former Ontario Labour Minister, argues in favour of industrial unionization; "I Hear You Calling Me" - short story; Night Raiders in China (part 1) - Gordon B. Enders' story of death in the yellow inferno; Mind over Mashie (short story); The Lady Who Blighted His Life (short story); Mr. Dunkle's Diary; Ed Sullivan's photos of 'Comers' - Anne Charpentier, Sam Snead, June Hart, Jack Holland and Thomas Thomas; Ulysses of Avenue A (short story); Family Scandal (part 4); To the Ladies; Mysterious Crime #5 - The Case of the Wisecracking "Uncle" of Broadway - who killed gambler Arnold Rothstein?; Review of movie "I Met Him in Paris"; Alias Emerald Annie (part 8 - table of contents says part 7); Forgotten Millions - unclaimed bank balances. Moderate wear. Unmarked. Address label. Back cover missing. Page 17-18 missing (contained Deanna Durbin article).

Offprint, single leaf folded once; a fine copy. The rare offprint of the paper announcing the first cultivation of polio virus in cell cultures, the breakthrough that made modern vaccines possible. After studying pathogenic bacteria for a decade, Harvard Medical School microbiologist John Enders (1897-1985) turned his attention to viruses, refining his culture techniques with the mumps before applying them to polio. 'Before this discovery, scientists had been able to grow polio virus only in the nervous tissue of susceptible laboratory animals, commonly monkeys, in a painstaking process that yielded minute quantities of the virus. The work of Enders, Weller, and Robbins had the tremendous practical effect of enabling scientists to prepare large amounts of polio virus, making possible the mass production of the Salk killed-virus vaccine and later, the Sabin live-virus vaccine. The impact of their work, however, was not limited to the study of polio. Their culture technique gave researchers an invaluable tool for the study of other viruses; made viral research much less laborious, time-consuming, and costly; and sparked revolutionary progress in the field; (America Association of Immunologists biography). Enders was responsible for 'one of the most gracious acts in the history of the Nobel Prize', refusing to accept the award when it was offered to him alone and insisting that his co-authors, 'those who did the work', be recognised equally (Rosen, 'Isolation of Poliovirus - John Enders and the Nobel Prize', New England Journal of Medicine, vol. 351, no. 1, October 2004). Garrison-Morton Medical Bibliography 4671.1.

Soft cover. Condición: Near Fine. 1st Edition. 2 pp. Near Fine. First Edition. The offprint is a single large folded sheet, with the article reprinted on pp. 1-2; what would be pp. 3-4 are blank. "John F. Enders, a bacteriologist, had become convinced as early as 1937 that viruses could be propagated by using tissue culture techniques, a procedure that would eliminate the difficult, time-consuming and costly process of cultivating viruses in live hosts. Thomas H. Weller, a specialist in tropical medicine, joined him in 1939, and after World War II Frederick C. Robbins, a specialist in the contagious diseases of children, became a member of the team. By the late 1940s and early 1950s, the team had succeeded in growing the polio virus in a variety of human tissues, including fetal intestine, embryonic skin, foreskin, kidney, and uterus. It was this development, which made possible the laboratory cultivation of large amounts of polio virus for experimental use, that led to great advances in research and enabled the preparation of a vaccine free of neural tissue. In 1954, Enders, Weller, and Robbins were awarded the Nobel Prize for their discovery" (Grolier, One Hundred Books Famous in Medicine no. 98, pp. 353-56, including fig. 176 showing the first page of the offprint). Enders, Weller, and Robbins shared the Nobel Prize in Physiology or Medicine in 1954 "for their discovery of the ability of poliomyelitis viruses to grow in cultures of various types of tissue." Garrison-Morton 4671.1: "J. F. Enders, T. H. Weller, and F. C. Robbins grew the poliomyelitis virus in cultures of different tissues. Their method proved of great value in virus research, and removed the final obstacles to vaccine production. They received the Nobel Prize in 1954." The story of the research by Enders, Weller, and Robbins is recounted in John R. Paul, A History of Poliomyelitis, pp. 373-81.