Babu p ajay (13 resultados)

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Taschenbuch. Condición: Neu. A STRUCTURE BASED DRUG DESIGN STUDY ON VEGFR-2 INHIBITORS | Exploiting Molecular Docking and In-Silico Validation | Ajay Babu P (u. a.) | Taschenbuch | 72 S. | Englisch | 2011 | LAP LAMBERT Academic Publishing | EAN 9783844319897 | Verantwortliche Person für die EU: OmniScriptum GmbH & Co. KG, Bahnhofstr. 28, 66111 Saarbrücken, info[at]akademikerverlag[dot]de | Anbieter: preigu. …

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Taschenbuch. Condición: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -VEGF (Vascular Endothelial Growth Factor) is a potent angiogenic signal implicated with a key role in several pathological processes, including tumour vascularization, angiogenesis, and endothelial cell growth. The members of VEGF family bind to tyrosine kinase receptors on the cell surface to initiate a signalling cascade. VEGFR-2 is one such Receptor Tyrosine Kinase(RTK) that is found to mediate a majority of the cellular responses to VEGF. A structure based drug design study was performed on VEGFR-2 inhibitors based on the article Hetaryl imidazoles: A novel dual inhibitors of VEGF receptors 1 and 2 . The target protein was retrieved from the Protein Data Bank (I.D. 2OH4), based on the Ramachandran plot. The structures of reported inhibitors were obtained in 3-D format using standard software packages. These 3-D analogues were docked to the protein of choice using Molegro Virtual Docker. Based on a correlation between experimentally obtained log IC50 values and the results of the docking study, direct drug design was carried out. Novel inhibitors with significantly higher moldock scores were obtained with simple modifications to the original structure. 72 pp. Englisch.…

Condición: New. Print on Demand pp. 72 2:B&W 6 x 9 in or 229 x 152 mm Perfect Bound on Creme w/Gloss Lam.

Condición: New. Dieser Artikel ist ein Print on Demand Artikel und wird nach Ihrer Bestellung fuer Sie gedruckt. Autor/Autorin: Babu P AjayDr. Ajay Babu has over 12 years of professional experience, working primarily as a bioinformatician and guiding over 500 academic projects of students from life science courses.Viswa Teja Colluru and Naishitha Anaparthy.…

Condición: New. PRINT ON DEMAND pp. 72.

Taschenbuch. Condición: Neu. This item is printed on demand - Print on Demand Titel. Neuware -VEGF (Vascular Endothelial Growth Factor) is a potent angiogenic signal implicated with a key role in several pathological processes, including tumour vascularization, angiogenesis, and endothelial cell growth. The members of VEGF family bind to tyrosine kinase receptors on the cell surface to initiate a signalling cascade. VEGFR-2 is one such Receptor Tyrosine Kinase(RTK) that is found to mediate a majority of the cellular responses to VEGF. A structure based drug design study was performed on VEGFR-2 inhibitors based on the article ¿Hetaryl imidazoles: A novel dual inhibitors of VEGF receptors 1 and 2¿. The target protein was retrieved from the Protein Data Bank (I.D. 2OH4), based on the Ramachandran plot. The structures of reported inhibitors were obtained in 3-D format using standard software packages. These 3-D analogues were docked to the protein of choice using Molegro Virtual Docker. Based on a correlation between experimentally obtained log IC50 values and the results of the docking study, direct drug design was carried out. Novel inhibitors with significantly higher moldock scores were obtained with simple modifications to the original structure.VDM Verlag, Dudweiler Landstraße 99, 66123 Saarbrücken 72 pp. Englisch.…