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Protein Toxin Structure (Molecular Biology Intelligence Unit) - Tapa blanda

 
9783662223543: Protein Toxin Structure (Molecular Biology Intelligence Unit)
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ISBN 10: 3662223546 ISBN 13: 9783662223543
Editorial: Springer, 2013

Sinopsis

Joseph E. Alouf "The empirical basis of objective science has thus nothing ’abso lute’ about it. Science does not rest upon solid bedrock. The bold structure of its theories rises, as it were, above swamp. It is like a building erected on piles. The piles are driven down from above into the swamp, but not down to any natural or ’given’ base; and if we stop driving the piles deeper, it is not because we have reached firm ground. We simply stop when we are satisfied that the piles are firm enough to carry the structure, at least for the time being. " -Karl Popper (The Logic of Scientific Discovery) hen I was invited to write this introductory chapter I was hon W ored and pleased to have the opportunity to briefly highlight some important issues relevant to structural aspects of bacterial protein tox ins. The present book attempts for the first time to provide into one volume a series of chapters prepared by invited experts on the struc ture of these fascinating macromolecules. A particular emphasis is placed on the molecular features of these highly active biomolecules in rela tion to their biological properties and mechanisms of action. The researchers in bacterial protein toxinology of my generation have had the privilege of witnessing over 40 years the tremen dous development of this field of biological sciences, particularly in the past decade.

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Reseña del editor

Joseph E. Alouf "The empirical basis of objective science has thus nothing 'abso­ lute' about it. Science does not rest upon solid bedrock. The bold structure of its theories rises, as it were, above swamp. It is like a building erected on piles. The piles are driven down from above into the swamp, but not down to any natural or 'given' base; and if we stop driving the piles deeper, it is not because we have reached firm ground. We simply stop when we are satisfied that the piles are firm enough to carry the structure, at least for the time being. " -Karl Popper (The Logic of Scientific Discovery) hen I was invited to write this introductory chapter I was hon­ W ored and pleased to have the opportunity to briefly highlight some important issues relevant to structural aspects of bacterial protein tox­ ins. The present book attempts for the first time to provide into one volume a series of chapters prepared by invited experts on the struc­ ture of these fascinating macromolecules. A particular emphasis is placed on the molecular features of these highly active biomolecules in rela­ tion to their biological properties and mechanisms of action. The researchers in bacterial protein toxinology of my generation have had the privilege of witnessing over 40 years the tremen­ dous development of this field of biological sciences, particularly in the past decade.

Reseña del editor

This book is about the determination of the molecular structures of protein toxins and the impact that this work has had on the understanding of toxin action. The key technique used in these studies has been X-ray crystallography. Protein crystallography is the study of the three-dimensional shapes of proteins at near atomic resolution. Toxins are excellent model systems for understanding the insertion and translocation of proteins across cellular membranes. Furthermore, studies on pore-forming toxins are providing insight into membrane protein biogenesis and the molecular architecture of membrane ion channels. Of particular interest to toxicologists is the possibility of rationally designing drugs using a knowledge of the three-dimensional structure of key protein toxins so as to inhibit bacterial virulence.

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Editorial
Springer
Año de publicación
2013
Idioma
Inglés
ISBN 10 
3662223546
ISBN 13 
9783662223543
Encuadernación
Tapa blanda
Número de páginas
332
Editor
Parker Michael W.
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Springer Nature Customer Service Center GmbH
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