Malaria parasites comparative genomics (11 resultados)

Taschenbuch. Condición: Neu. Comparative Genomics and Drug Design Strategies | A Bioinformatics Approaches Based Study of Malaria Parasites | Manoj Kumar Yadav | Taschenbuch | 144 S. | Englisch | 2015 | LAP LAMBERT Academic Publishing | EAN 9783659683626 | Verantwortliche Person für die EU: preigu GmbH & Co. KG, Lengericher Landstr. 19, 49078 Osnabrück, mail[at]preigu[dot]de | Anbieter: preigu.…

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Buch. Condición: Neu. Neuware - Since the publication of the first two Plasmodium genome sequences in 2002, numerous other parasite genomes have been sequenced. These include the genomes of several more Plasmodium species, as well as those of other apicomplexans, including species of Toxoplasma, Cryptosporidium, Babesia, and Eimeria. This wealth of genome sequence data has provided researchers with a powerful new tool, comparative genomics, which has revolutionized research in this area. In this book, expert contributors from around the world comprehensively review the current advances in Plasmodium comparative genomics, highlighting the fascinating new insights into parasite evolution and molecular biology that have ensued. Topics include: Plasmodium taxonomy and phylogeny \* the apicomplexan genomic landscape \* the 'art' of sequencing Plasmodium genomes \* diversity of Plasmodium falciparum and Plasmodium vivax genomes \* Plasmodium functional genomics \* Plasmodium experimental genetic crosses \* P. falciparum epigenetic modification and transcriptional regulation \* Plasmodium invasion of host red blood cells \* protein export and trafficking by malaria parasites \* Plasmodium-mosquito vector interactions \* a practical guide to many of the revolutionary new techniques and molecular tools for Plasmodium research. The book will be essential reading for all researchers working with malaria parasites and related organisms - from the PhD student to the experienced scientist - and is a recommended text for all parasitologists. …

Taschenbuch. Condición: Neu. nach der Bestellung gedruckt Neuware - Printed after ordering - Malaria is a threat to mankind and responsible for millions of cases of morbidity and mortality worldwide. Plasmodium parasite is responsible for causing disease. This work investigates and reveals the hidden information inside the parasite genomes using comparative genome analysis and codon usage bias study. The possibility of using variable surface proteins as a common drug target has been checked in both the human infecting Plasmodium species and it was found that variable surface proteins cannot be used as a common drug target due to existence of sequential and structural differences at both the genome and proteome level. Metabolic network information is also utilized in this piece of work for identifying new drug targets. Further in silico approaches viz. molecular modeling, structure-based 3D pharmacophore model generation, virtual screening and docking etc. were also utilized to find the drug prototypes.…

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