ISBN: 9783869557298 - sticky triangles: new tools for experimental phasing of biological macromolecules (8 resultados)

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Taschenbuch. Condición: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -X-ray crystallography is the prime method for the elucidation ofthree-dimensional molecular structures. The determination of novel structures is hampered by the crystallographic phase problem. For biological macromolecules experimental phasing is one technique to solve this phase problem; it usually requires the incorporation of heavy atoms in the protein crystal. In this thesis a new class of compounds was developed that combines heavy atoms for experimental phasing with functional groups for interaction with biological macromolecules. Three functional groups interact with protein residues and make the compounds sticky. Three halogen atoms provide a strong anomalous signal and may be used for experimental phasing. The halogen atoms form an equilateral triangle, which is easily recognised in the heavy-atom substructure. So far several novel protein structures have been solved with the iodine triangle compound. The sticky compounds of the current work are readily available and easy to use. 194 pp. Englisch.…

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Taschenbuch. Condición: Neu. nach der Bestellung gedruckt Neuware - Printed after ordering - X-ray crystallography is the prime method for the elucidation ofthree-dimensional molecular structures. The determination of novelstructures is hampered by the crystallographic phase problem. Forbiological macromolecules experimental phasing is one technique tosolve this phase problem; it usually requires the incorporation ofheavy atoms in the protein crystal.In this thesis a new class of compounds was developed that combinesheavy atoms for experimental phasing with functional groups for interactionwith biological macromolecules. Three functional groupsinteract with protein residues and make the compounds sticky. Threehalogen atoms provide a strong anomalous signal and may be usedfor experimental phasing. The halogen atoms form an equilateraltriangle, which is easily recognised in the heavy-atom substructure. So farseveral novel protein structures have been solved with the iodinetriangle compound. The sticky compounds of the current work arereadily available and easy to use.…

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Condición: New. Dieser Artikel ist ein Print on Demand Artikel und wird nach Ihrer Bestellung fuer Sie gedruckt. KlappentextrnrnX-ray crystallography is the prime method for the elucidation ofnthree-dimensional molecular structures. The determination of novelnstructures is hampered by the crystallographic phase problem. Fornbiological macromolecules experi.…

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Taschenbuch. Condición: Neu. This item is printed on demand - Print on Demand Titel. Neuware -X-ray crystallography is the prime method for the elucidation ofthree-dimensional molecular structures. The determination of novelstructures is hampered by the crystallographic phase problem. Forbiological macromolecules experimental phasing is one technique tosolve this phase problem; it usually requires the incorporation ofheavy atoms in the protein crystal.In this thesis a new class of compounds was developed that combinesheavy atoms for experimental phasing with functional groups for interactionwith biological macromolecules. Three functional groupsinteract with protein residues and make the compounds sticky. Threehalogen atoms provide a strong anomalous signal and may be usedfor experimental phasing. The halogen atoms form an equilateraltriangle, which is easily recognised in the heavy-atom substructure. So farseveral novel protein structures have been solved with the iodinetriangle compound. The sticky compounds of the current work arereadily available and easy to use.Cuvillier Verlag, Nonnenstieg 8, 37075 Göttingen 194 pp. Englisch.…

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Taschenbuch. Condición: Neu. Sticky triangles: New tools for experimental phasing of biological macromolecules | Tobias Beck | Taschenbuch | Kartoniert / Broschiert | Englisch | 2011 | Cuvillier | EAN 9783869557298 | Verantwortliche Person für die EU: Cuvillier Verlag, Nonnenstieg 8, 37075 Göttingen, info[at]cuvillier[dot]de | Anbieter: preigu Print on Demand.…