ISBN: 9783659595363 - formulation and evaluation of fast dissolving sublingual tablet: of ivabradine hydrochloride for reduction in ischemic condition in stable angina (5 resultados)

Taschenbuch. Condición: Neu. Formulation and Evaluation of Fast Dissolving Sublingual Tablet | Of Ivabradine Hydrochloride for reduction in ischemic condition in Stable Angina | Brahmdutta Raval (u. a.) | Taschenbuch | 116 S. | Englisch | 2014 | LAP LAMBERT Academic Publishing | EAN 9783659595363 | Verantwortliche Person für die EU: preigu GmbH & Co. KG, Lengericher Landstr. 19, 49078 Osnabrück, mail[at]preigu[dot]de | Anbieter: preigu.…

Taschenbuch. Condición: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -The present study was aimed to formulate and evaluate Fast Dissolving Sublingual Tablets of Ivabradine Hydrochloride, a selective If current inhibitor to reduce ischemic condition in Stable Angina. Efficacy of sublingual administration, higher permeability of drug and improvement in bioavailability achievement for drug were the factors that lead to the development of the present work. Compatibility studies of drug and polymer were performed by FTIR and demonstrated no interaction between drug and excipients. Tablets were prepared by direct compression using different concentration of Croscarmellose sodium and Crospovidone. Pre-compression parameters for blend were in the range. Prepared tablets were evaluated for disintegration time, wetting time, Water absorption ratio, %CDR and Ex-vivo permeability study. Formulation F6 (3% CCS, 4.5% CP) was found to be the optimized and showed disintegration time of 25 sec. In vitro drug release was found within 7 minutes and maximum relative permeability from F6 was up to 21 minutes. Dosage form also showed better stability criteria. From the results it was concluded that prepared FDTs executed faster release of IBH with improved characteristic 116 pp. Englisch. …

Taschenbuch. Condición: Neu. nach der Bestellung gedruckt Neuware - Printed after ordering - The present study was aimed to formulate and evaluate Fast Dissolving Sublingual Tablets of Ivabradine Hydrochloride, a selective If current inhibitor to reduce ischemic condition in Stable Angina. Efficacy of sublingual administration, higher permeability of drug and improvement in bioavailability achievement for drug were the factors that lead to the development of the present work. Compatibility studies of drug and polymer were performed by FTIR and demonstrated no interaction between drug and excipients. Tablets were prepared by direct compression using different concentration of Croscarmellose sodium and Crospovidone. Pre-compression parameters for blend were in the range. Prepared tablets were evaluated for disintegration time, wetting time, Water absorption ratio, %CDR and Ex-vivo permeability study. Formulation F6 (3% CCS, 4.5% CP) was found to be the optimized and showed disintegration time of 25 sec. In vitro drug release was found within 7 minutes and maximum relative permeability from F6 was up to 21 minutes. Dosage form also showed better stability criteria. From the results it was concluded that prepared FDTs executed faster release of IBH with improved characteristic.…

Condición: New. Dieser Artikel ist ein Print on Demand Artikel und wird nach Ihrer Bestellung fuer Sie gedruckt. Autor/Autorin: Raval BrahmduttaBrahmdutta Raval, Master of Pharmacy, Pharmaceutics. Studied M. Pharm., Pharmaceutics from N R Vekaria Institute of Pharmacy, Junagadh, Gujarat, India under Gujarat Technological University. Published One Review Artic.…

Taschenbuch. Condición: Neu. This item is printed on demand - Print on Demand Titel. Neuware -The present study was aimed to formulate and evaluate Fast Dissolving Sublingual Tablets of Ivabradine Hydrochloride, a selective If current inhibitor to reduce ischemic condition in Stable Angina. Efficacy of sublingual administration, higher permeability of drug and improvement in bioavailability achievement for drug were the factors that lead to the development of the present work. Compatibility studies of drug and polymer were performed by FTIR and demonstrated no interaction between drug and excipients. Tablets were prepared by direct compression using different concentration of Croscarmellose sodium and Crospovidone. Pre-compression parameters for blend were in the range. Prepared tablets were evaluated for disintegration time, wetting time, Water absorption ratio, %CDR and Ex-vivo permeability study. Formulation F6 (3% CCS, 4.5% CP) was found to be the optimized and showed disintegration time of 25 sec. In vitro drug release was found within 7 minutes and maximum relative permeability from F6 was up to 21 minutes. Dosage form also showed better stability criteria. From the results it was concluded that prepared FDTs executed faster release of IBH with improved characteristicVDM Verlag, Dudweiler Landstraße 99, 66123 Saarbrücken 116 pp. Englisch.…