ISBN: 9783540660026 - signal transduction and the coordination of b lymphocyte development and function i: transduction of bcr signals from the cell membrane to the ... topics in microbiology and immunology, 245/1) (10 resultados)

2000. 16 x 24 cm. XV, 267 S. XV, 267 p. hardcover 2nd Edition. Versand aus Deutschland / We dispatch from Germany via Air Mail. Einband bestoßen, daher Mängelexemplar gestempelt, sonst sehr guter Zustand. Imperfect copy due to slightly bumped cover, apart from this in very good condition. Stamped. (Current Topics in Microbiology and Immunology). Sprache: Englisch. …

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Condición: Gut. Zustand: Gut | Seiten: 264 | Sprache: Englisch | Produktart: Bücher | Keine Beschreibung verfügbar.

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Buch. Condición: Neu. Neuware - Proper development and differentiation of B lymphocytes is es sential to ensure that an organism has the ability to mount an effective humoral immune response against foreign antigens. The immune system must maintain a balance between the deletion of harmful self-reactive B cells and the generation of a diverse rep ertoire of B cells that has the ability to recognize an almost un limited array of foreign antigens. The need to delete self-reactive cells is tempered by the need to avoid the generation of large functional holes in the repertoire of foreign antigen-specific B cells that patrol the periphery. To accomplish this, the immune system must reach a compromise by eliminating only the most dangerous autoreactive clones, while allowing less harmful au toreactive B cells to exist in the periphery where they may com plement the organism's ability to mount a rapid response against invading micro-organisms. Those autoreactive cells that do enter the peripheral pool are subject to a number of conditional re straints that effectively attenuate their ability to respond to self antigens. Deleterious alterations in the homeostasis between tolerance induction and recruitment of B cells into the functional repertoire may lead to increased susceptibility to autoimmune disease or infection, respectively. Therefore, delineation of the molecular processes that maintain immunological homeostasis in the B cell compartment is critical.…

Hardcover. Condición: gut. 1999. Transduction of BCR Signals from the Cell Membrane to the Nucleus In deutscher Sprache. pages.

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