steinkopff dez 2011 (125 resultados)

Taschenbuch. Condición: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Proceedings of a congress serve the purpose to provide the reader with the latest know ledge in the specific field. They present at least for a limited time period a reference book that allows rapid access to the latest information for the medical profession and for an ongoing of future research. This volume is addressed not only to the participants of the VIIth World Symposium on Cardiac Pacing but to everybody involved in diagnostic and therapeutic cardiac stimula tion. The experience has shown that proceedings of conferences of comparable size are usually published with a considerable time delay limiting its value as a source of prime informa tion. The editors of this volume decided therefore, that their most important task was to guarantee the actuality of the publication. Even if it seems desirable to include as many presentations of a conference as possible, the large number of excellent presentations at the VIIth World Symposium on Cardiac Pacing, 337 oral presentations and 236 posters, could not be published within an accepta ble time period. The experience from previous conferences has shown that a book which includes all the papers can only be edited with a large delay, which reduces the value and actuality of the information. 1016 pp. Englisch.

Taschenbuch. Condición: Neu. This item is printed on demand - Print on Demand Titel. Neuware -Proceedings of a congress serve the purpose to provide the reader with the latest know ledge in the specific field. They present at least for a limited time period a reference book that allows rapid access to the latest information for the medical profession and for an ongoing of future research. This volume is addressed not only to the participants of the VIIth World Symposium on Cardiac Pacing but to everybody involved in diagnostic and therapeutic cardiac stimula tion. The experience has shown that proceedings of conferences of comparable size are usually published with a considerable time delay limiting its value as a source of prime informa tion. The editors of this volume decided therefore, that their most important task was to guarantee the actuality of the publication. Even if it seems desirable to include as many presentations of a conference as possible, the large number of excellent presentations at the VIIth World Symposium on Cardiac Pacing, 337 oral presentations and 236 posters, could not be published within an accepta ble time period. The experience from previous conferences has shown that a book which includes all the papers can only be edited with a large delay, which reduces the value and actuality of the information.Steinkopff Dr. Dietrich V, Poststr. 9, 64293 Darmstadt 1016 pp. Englisch.

Taschenbuch. Condición: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This book aims to provide an easily read general account of clinical cardiology. It is primarily designed to meet the needs of medical students, but should be helpful to advanced students in nursing and paramedical fields, as well as providing a review text for medical interns and residents. The book may help to practice modern medicine in a humane way. This means utilizing all possibilities available, but, at the same time, recognizing their limitations. Since progress in the field of cardiology advances rapidly the physician can only keep up with it by understanding diagnostic and therapeutic measures rather than by memorizing mUltiple facts. The need for a book such as this one has already been proven by the wide acceptance in Europe of the first two German editions (authored by M. K.). Indeed, this success prompted the collaborative effort represented here. Along with the translation into English, the authors have tried to maintain an international perspective, in tune with the greater global awareness and cooperation of the 1990s. 200 pp. Englisch.

Taschenbuch. Condición: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Calcium antagonists are currently the most extensively investigated drugs for the treatment of heart disease. They are used worldwide with great success and a comparatively low incidence of adverse reactions. The most prevalent and threatening diseases in modem industrialized societies - the various forms and complications of coronary arteriosclerosis and arterial hypertension - are amenable to treatment with calcium antagonists. The pharmacological spectrum of calcium antagonists is highly specific and was supplemen ted a few years ago by gallopamil, a verapamil analogue. The experimental work reported at this symposium was concerned with effects of gallopamil on the electrophysiology of the heart, particularly in acute myocardial ischemia. New therapeutic features of myocardial hypertrophy and hypertrophic cardiomyopathy are discussed. In medical practice, gallopa mil has proved particularly useful for the treatment of angina pectoris. Studies comparing gallopamil with other calcium antagonists are described to profile the properties of the drugs in terms of their specific therapeutic value. There is still a need for more differential therapeutic trials. This first international symposium on gallopamil was attended by experts from institutions devoted to theoretical and clinical research and general practice. 204 pp. Englisch.

Taschenbuch. Condición: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Traditionally, cardiac hypertrophy is regarded as an adaptation of the heart to permanent mechanical overload. Regardless of the fact that many different and often unknown primary causes can result in heart failure, mechanical overload and myocardial hypertrophy is found in almost all forms of manifest chronic heart failure (apart from failure due to extramyocardial hindrances to inflow or to relaxation). However, the reactive enlargement of myocardial mass in response to an enhanced hemodynamic burden appears to be a double-edged sword. Obviously, the hypertrophy helps to reduce the enhanced ventricular wall stress in heart failure by adding contractile units to the overdistended chamber wall. However, in recent years it became clear that this adaptive hypertrophic process is rather complex and may include problematic facets. The adaptive hypertrophy includes proliferation of the nonmyocyte cardiac cells as well as substantial alterations in the phenotype of the growing myocytes due to differential changes in gene expression. 220 pp. Englisch.

Taschenbuch. Condición: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -The myocardium in heart failure: Cellular and subcellular alterations in the failing human myocardium. H. Just Medizinische Universitatsklinik Freiburg i. Br., Innere Medizin III - Kardiologie, FRG The syndrome of heart failure continues to be a major challenge to clinicians and scientists. Incidence and mortality of the disease are high, the patient is disabled, and is permanently threatened by the high morbidity and mortality. The clinician faces a syndrome of complex pathophysiology. Multiple causes or underlying disorders of the heart have to be differentiated from heart failure itself, which often results in exceedingly difficult diagnoses. Likewise, prognostication meets with difficulties due to problems in separating influences of the underlying disease and the heart failure syndrome itself. In chronic refractory failure annual mortality may exceed 50%. If aortic stenosis or ischemic cardiomyopathy with main stem lesions are present, this percentage may be even higher. The situation becomes particularly threatening to the patient when the reduction in cardiac performance goes along with complex ventricular arrhythmias. Therapy has remained difficult and of limited effectiveness. Major progress was achieved with the introduction of diuretic substances. Of similar importance was the introduction of va so dilating drugs into the treatment of heart failure. The principle of vasodilation has greatly improved our understanding of the disease, and has brought about a major improvement of symptoms, increase of exercise capacity, and reduc tion of mortality. This is especially true for the introduction of the angiotensin converting enzyme inhibitors. 372 pp. Englisch.

Taschenbuch. Condición: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Although nitroglycerin is one of the oldest drugs in cardiology the problem of tolerance is a scientific challenge of today. The proceedings of this symposium highlight the most re cent questions related to this topic. Apparently, partial tolerance, or rather partial decrease in sensitivity, can arise during nitrate therapy. Probably this is the consequence of a partial readjustment of the vascular system. This readjustment refers particularly to the arterial system, i.e., to the hypoten sive effect of nitrates in the standing position. A similar effect on the venous side is not present. On the other hand, the results assembled in this volume confirm the experience of many decades that long-term antianginal therapy with nitrates remains effective even when high doses are applied. Thus partial tolerance which also occurs after other vasodilators such as prazosin, does not imply tolerance against antianginal effectiveness. From the information available to day it is reasonable to treat patients with angina pectoris acutely as well as chronically with nitrates in individually adjusted doses. Frankfurt, November 1982 M. Kaltenbach v Contents Foreword. V Session 1-Pharmacology Tolerance from the Pharmacokinetic and Pharmacodynamic Viewpoints N. Rietbrock, A. Lassmann, B. G. Woodcock . 3 Does Tolerance Develop During Long-Acting Nitrate Therapy A Critical Review J. Abrams . 13 Pharmacokinetics of Isosorbide Dinitrate During Tolerance Development Ho-Leung Fung . 25 Discussion . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 29 . . . . . . . . . . . . . . . . . . . Session II - Hemodynamics Lack of Tolerance Development to the Hemodynamic Effects of Nitrates in Patients with Chronic Congestive Heart Failure Joseph A. Franciosa . 35 Discussion . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 41 . . . . . . . . . . . . . . . . . . . . 184 pp. Englisch.

Taschenbuch. Condición: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -It was the genius of Gordon Murray in Toronto that introduced the use of allografts into cardiac surgery in the 1950s. Soon after this on opposite sides ofthe world, Sir Brian Barratt-Boyes in Auckland, New Zealand, and Mr. Donald Ross in London, undertook to use allografts for the replacement of diseased aortic valves. Since that time the global interest in allografts has been patchy, episodic, and without a con sensus. Nonetheless, for the last 20 years at least three groups in the world have steadfastly pursued the development of new and relevant information concerning the use of allograft valves in humans. These are the centres of Sir Brian Barratt Boyes, Mr. Donald Ross, and Mark O'Brien in Brisbane. More recently, talented investigators, including Drs. Yankah, Yacoub, and others, have been developing information concerning the immunological aspects of the use of allografts, as well as their clinical use. No doubt, at present, cardiac valve allografts of one sort or another are the devices of choice for conduits and have an important place in the surgery of aortic valve replacement. Even so, in the mind of this writer at least, the future usefulness of allografts for the replacement of diseased cardiac valves and conduits between a ventricle and the pulmonary artery, remains problematic, and depends upon improvements in other devices for this purpose and upon improve ments that may be made in preparing and using allografts. 416 pp. Englisch.

Taschenbuch. Condición: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -There is clear evidence that in severe hypertension lowering blood pressure, by drug therapy decreases the incidence of major cardiovascular events. Recent studies suggest that such benefit may also extend to patients with mild to moderate hypertension. The putative benefits of drugs may be offset, however, by their adverse effects and a prime example is the increased incidence of impotence and metabolic disorders in patients on thiazide diuretics. There is, therefore, a real need to look further into the therapy of patients with mild to moderate hypertension. The ideal drug in such patients would oppose the basic mechanisms responsible for the elevation in blood pressure, would prevent counter-regulatory responses and would have minimal side-effects in both the short-term and the long-term, the latter being of particular importance to younger patients. These aspects were considered at the symposium 'Mild hypertension. Current con troversies and new approaches' held at Titisee in West Germany, October 13-15 in 1983. The foundation for discussion was set with an exposition of the neural and hormonal regulation of blood pressure in normal man followed by a consideration of the pos~ible pathophysiological mechanisms involved in patients with hypertension. Particular at tention was focused on the central nervous system and on effects governed by activity of the peripheral nervous system as these may well provide further opportunities for logical therapeutic intervention in clinical hypertension. The current management of mild to moderate hypertension was then reviewed. 184 pp. Englisch.

Taschenbuch. Condición: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -During recent years, it has become evident that ventricular arrhythmias may arise from myocardial ischemia and that they may be harbingers of sudden cardiac death. On the other hand, ventricular arrhythmias may occur without any prognostic significance and sudden cardiac arrhythmic death may strike without any warning arrhythmia. The role of ischemia in the genesis of ventricular arrhythmias and of sudden cardiac death has been observed beyond doubt. However, the mechanism by which ischemia leads to the appearance of ventricular arrhythmias and/or sudden cardiac death has remained rather poorly understood, inspite of rather remarkable research efforts on the one hand, and the magnitude of the problem on the other hand. We have therefore set out to assemble scientists from around the world in order to define the current state of our knowledge on myocardial ischemia and arrhythmia. Well in line with the tradition of the Gargellen Conferences, we assembled clinicians and basic scientists for the 7th Gargellen Conference. This book presents the proceed ings of the Symposium in the attempt to define the current status of our understand ing of this significant problem. The Symposium was organized by the Society for Cooperation in Medicine and Science (SCMS) and was generously sponsored by Astra Chemicals, Wedel; Bayer AG, Leverkusen; Boehringer-Mannheim; CPI-Lilly, Giessen; Janssen GmbH, Neuss; Minden Pharma, Minden; Rahm Pharma, Weiter stadt; Schering AG, Berlin, and Siemens AG, Erlangen. 320 pp. Englisch.

Taschenbuch. Condición: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This is a Festschrift to Professor Sir Stanley Peart, Professor of Medicine at St. Mary's Hospital and Medical School, University of London since 1956, who has influenced and directed many of us in the better understanding of the patho physiological basis and the clinical practice of hypertension. It commemorates, and we hope will preserve, memories of a special occasion when we met to honour him at the Castella de Pomeiro, Como, Italy. At this meeting his 'extended family' (pictured above) shared experiences, discussed current scientific and clinical ap proaches in hypertension research and indulged in reminiscences of their exciting times on his Unit at St. Mary's. We particularly hope that this volume will illustrate the multifaceted approach needed in investigating and managing hypertension and that it will additionally remind Sir Stanley of the admiration and warm affection with which he has been, and will always continue to be regarded. Christopher J. Mathias Peter S. Sever Introduction P. S. Sever Welcome to Castello de Pomerio, for what I feel sure is to be a very special occasion. As all of you know, Stan Peart is retiring after 31 years as professor and head of the department of Medicine at St. Mary's, and after nearly 40 years of distinguished research in basic and clinical science related to the cardiovascular system, the kidney and particularly to hypertension. 132 pp. Englisch.

Taschenbuch. Condición: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -These Proceedings are published to give a full account of the Fifth International Conference on Atmospheric Electricity held in September 1974 in Garmisch-Partenkirchen in the Bavarian Alps in Germany. Traditionally, the Proceedings of these Conferences have served as reference books updating the textbooks and monographs on Atmospheric Electricity. As treated by these Conferences, Atmos pheric Electricity covers all aspects of this science, including the processes and problems which reach out into the Earth's environment as well as analogous processes on other planets and on the Moon. A history of these Conferences, an account of their purpose, and an outline of the scope and the preparation is to be found at the end of these Proceedings. There, also the Business Meetings of the involved organizations are mentioned. The Proceedings closely follow the original program and are accordingly organized into 'Sessions'. The papers printed in each 'Session' in this book are the ones which were accepted for the sessions of the Conference with the same numbers and titles. Only the two 'Special Sessions' have been given different numbers in the Proceedings, i.e. 2a and 10. In principle, all papers which were accepted by the Executive Panel either for full oral presentation or for printing in the Proceedings only, have in fact been included in these Proceedings, whether they were presented or not. In the latter case, a special note is made to explain the absence of a discussion. 892 pp. Englisch.

Taschenbuch. Condición: Neu. This item is printed on demand - Print on Demand Titel. Neuware -Traditionally, cardiac hypertrophy is regarded as an adaptation of the heart to permanent mechanical overload. Regardless of the fact that many different and often unknown primary causes can result in heart failure, mechanical overload and myocardial hypertrophy is found in almost all forms of manifest chronic heart failure (apart from failure due to extramyocardial hindrances to inflow or to relaxation). However, the reactive enlargement of myocardial mass in response to an enhanced hemodynamic burden appears to be a double-edged sword. Obviously, the hypertrophy helps to reduce the enhanced ventricular wall stress in heart failure by adding contractile units to the overdistended chamber wall. However, in recent years it became clear that this adaptive hypertrophic process is rather complex and may include problematic facets. The adaptive hypertrophy includes proliferation of the nonmyocyte cardiac cells as well as substantial alterations in the phenotype of the growing myocytes due to differential changes in gene expression.Steinkopff Dr. Dietrich V, Poststr. 9, 64293 Darmstadt 220 pp. Englisch.

Taschenbuch. Condición: Neu. This item is printed on demand - Print on Demand Titel. Neuware -There is clear evidence that in severe hypertension lowering blood pressure, by drug therapy decreases the incidence of major cardiovascular events. Recent studies suggest that such benefit may also extend to patients with mild to moderate hypertension. The putative benefits of drugs may be offset, however, by their adverse effects and a prime example is the increased incidence of impotence and metabolic disorders in patients on thiazide diuretics. There is, therefore, a real need to look further into the therapy of patients with mild to moderate hypertension. The ideal drug in such patients would oppose the basic mechanisms responsible for the elevation in blood pressure, would prevent counter-regulatory responses and would have minimal side-effects in both the short-term and the long-term, the latter being of particular importance to younger patients. These aspects were considered at the symposium 'Mild hypertension. Current con troversies and new approaches' held at Titisee in West Germany, October 13-15 in 1983. The foundation for discussion was set with an exposition of the neural and hormonal regulation of blood pressure in normal man followed by a consideration of the pos~ible pathophysiological mechanisms involved in patients with hypertension. Particular at tention was focused on the central nervous system and on effects governed by activity of the peripheral nervous system as these may well provide further opportunities for logical therapeutic intervention in clinical hypertension. The current management of mild to moderate hypertension was then reviewed.Steinkopff, Dietrich Verlag in Springer Science + Business M, Tiergartenstr. 15-17, 69121 Heidelberg 184 pp. Englisch.

Taschenbuch. Condición: Neu. This item is printed on demand - Print on Demand Titel. Neuware -. 29 . . . . . . . . . . . . . . . . . . . Session II - Hemodynamics Lack of Tolerance Development to the Hemodynamic Effects of Nitrates in Patients with Chronic Congestive Heart Failure Joseph A. Franciosa . 35 Discussion . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 41 . . . . . . . . . . . . . . . . . . . .Steinkopff Dr. Dietrich V, Poststr. 9, 64293 Darmstadt 184 pp. Englisch.

Taschenbuch. Condición: Neu. This item is printed on demand - Print on Demand Titel. Neuware -It was the genius of Gordon Murray in Toronto that introduced the use of allografts into cardiac surgery in the 1950s. Soon after this on opposite sides ofthe world, Sir Brian Barratt-Boyes in Auckland, New Zealand, and Mr. Donald Ross in London, undertook to use allografts for the replacement of diseased aortic valves. Since that time the global interest in allografts has been patchy, episodic, and without a con sensus. Nonetheless, for the last 20 years at least three groups in the world have steadfastly pursued the development of new and relevant information concerning the use of allograft valves in humans. These are the centres of Sir Brian Barratt Boyes, Mr. Donald Ross, and Mark O'Brien in Brisbane. More recently, talented investigators, including Drs. Yankah, Yacoub, and others, have been developing information concerning the immunological aspects of the use of allografts, as well as their clinical use. No doubt, at present, cardiac valve allografts of one sort or another are the devices of choice for conduits and have an important place in the surgery of aortic valve replacement. Even so, in the mind of this writer at least, the future usefulness of allografts for the replacement of diseased cardiac valves and conduits between a ventricle and the pulmonary artery, remains problematic, and depends upon improvements in other devices for this purpose and upon improve ments that may be made in preparing and using allografts.Steinkopff, Dietrich Verlag in Springer Science + Business M, Tiergartenstr. 15-17, 69121 Heidelberg 416 pp. Englisch.

Taschenbuch. Condición: Neu. This item is printed on demand - Print on Demand Titel. Neuware -The myocardium in heart failure: Cellular and subcellular alterations in the failing human myocardium. H. Just Medizinische Universitatsklinik Freiburg i. Br., Innere Medizin III - Kardiologie, FRG The syndrome of heart failure continues to be a major challenge to clinicians and scientists. Incidence and mortality of the disease are high, the patient is disabled, and is permanently threatened by the high morbidity and mortality. The clinician faces a syndrome of complex pathophysiology. Multiple causes or underlying disorders of the heart have to be differentiated from heart failure itself, which often results in exceedingly difficult diagnoses. Likewise, prognostication meets with difficulties due to problems in separating influences of the underlying disease and the heart failure syndrome itself. In chronic refractory failure annual mortality may exceed 50%. If aortic stenosis or ischemic cardiomyopathy with main stem lesions are present, this percentage may be even higher. The situation becomes particularly threatening to the patient when the reduction in cardiac performance goes along with complex ventricular arrhythmias. Therapy has remained difficult and of limited effectiveness. Major progress was achieved with the introduction of diuretic substances. Of similar importance was the introduction of va so dilating drugs into the treatment of heart failure. The principle of vasodilation has greatly improved our understanding of the disease, and has brought about a major improvement of symptoms, increase of exercise capacity, and reduc tion of mortality. This is especially true for the introduction of the angiotensin converting enzyme inhibitors.Steinkopff, Dietrich Verlag in Springer Science + Business M, Tiergartenstr. 15-17, 69121 Heidelberg 372 pp. Englisch.

Taschenbuch. Condición: Neu. This item is printed on demand - Print on Demand Titel. Neuware -Metabolic aspects and channel kinetics in cellular hypoxia.- Calcium homeostasis, myocardial ischemia and arrhythmogenic impact.- Selected metabolic alterations in the ischemic heart and their contributions to arrhythmogenesis.- Arrhythmogenic effects of selective inhibition of cyclic nucleotide phosphodiesterase isoenzymes in pig myocardium.- Ischemia and early extracellular K+ accumulation in cardiac cells.- Characteristics of transport processes involved in ischemia and reperfusion.- Ionic and metabolic progenitors of reperfusion arrhythmias.- Electrophysiologic properties of cellular hypoxia and myocardial ischemia.- Anisotropy and anisotropic reentry in myocardial infarction.- Effects of the sympathetic nervous system on conduction and refractoriness in normal and ischemic myocardium.- Sympatho-adrenergic activation of the ischemic myocardium and its arrhythmogenic impact.- Factors determining the arrhythmogenic potency of myocardial ischemia and time-course of ischemia related arrhythmias.- Pathophysiology of acute ischemia: Potential targets for Antiarrhythmic drugs.- Acute and chronic myocardial ischemia in the arrhythmogenesis and aggravation of ventricular arrhythmias.- Risk stratification and prediction of sudden death following myocardial infarction.- Ventricular tachyarrhythmias, myocardial ischemia and sudden cardiac death in patients with hypertensive heart disease.- Vascular mechanisms leading to myocardial ischemia and their relation to hypertension, left ventricular hypertrophy and arrhythmias.- Clinical evidence for the fatal interaction of ventricular tachyarrhythmias, myocardial ischemia and sudden cardiac death.- Autonomic nervous system, myocardial ischemia, and malignant ventricular arrhythmias: Experimental findings.- Assessment of autonomic tonus and reflexes in patients after myocardial infarction.- Clinical aspects in the treatment of ischemia-related ventricular arrhythmias.- Coronary artery bypass graft surgery for the prevention of sudden cardiac death.- Myocardial ischemia, ventricular arrhythmias and implantable cardioverter-defibrillators: Importance of stored electrograms.- Therapeutic consequences of newer studies addressing the problem of myocardial ischemia and ventricular arrhythmias.Steinkopff Dr. Dietrich V, Poststr. 9, 64293 Darmstadt 320 pp. Englisch.

Taschenbuch. Condición: Neu. This item is printed on demand - Print on Demand Titel. Neuware -Calcium antagonists are currently the most extensively investigated drugs for the treatment of heart disease. They are used worldwide with great success and a comparatively low incidence of adverse reactions. The most prevalent and threatening diseases in modem industrialized societies - the various forms and complications of coronary arteriosclerosis and arterial hypertension - are amenable to treatment with calcium antagonists. The pharmacological spectrum of calcium antagonists is highly specific and was supplemen ted a few years ago by gallopamil, a verapamil analogue. The experimental work reported at this symposium was concerned with effects of gallopamil on the electrophysiology of the heart, particularly in acute myocardial ischemia. New therapeutic features of myocardial hypertrophy and hypertrophic cardiomyopathy are discussed. In medical practice, gallopa mil has proved particularly useful for the treatment of angina pectoris. Studies comparing gallopamil with other calcium antagonists are described to profile the properties of the drugs in terms of their specific therapeutic value. There is still a need for more differential therapeutic trials. This first international symposium on gallopamil was attended by experts from institutions devoted to theoretical and clinical research and general practice.Steinkopff Dr. Dietrich V, Poststr. 9, 64293 Darmstadt 204 pp. Englisch.

Taschenbuch. Condición: Neu. This item is printed on demand - Print on Demand Titel. Neuware -These Proceedings are published to give a full account of the Fifth International Conference on Atmospheric Electricity held in September 1974 in Garmisch-Partenkirchen in the Bavarian Alps in Germany. Traditionally, the Proceedings of these Conferences have served as reference books updating the textbooks and monographs on Atmospheric Electricity. As treated by these Conferences, Atmos pheric Electricity covers all aspects of this science, including the processes and problems which reach out into the Earth's environment as well as analogous processes on other planets and on the Moon. A history of these Conferences, an account of their purpose, and an outline of the scope and the preparation is to be found at the end of these Proceedings. There, also the Business Meetings of the involved organizations are mentioned. The Proceedings closely follow the original program and are accordingly organized into 'Sessions'. The papers printed in each 'Session' in this book are the ones which were accepted for the sessions of the Conference with the same numbers and titles. Only the two 'Special Sessions' have been given different numbers in the Proceedings, i.e. 2a and 10. In principle, all papers which were accepted by the Executive Panel either for full oral presentation or for printing in the Proceedings only, have in fact been included in these Proceedings, whether they were presented or not. In the latter case, a special note is made to explain the absence of a discussion.Steinkopff, Dietrich Verlag in Springer Science + Business M, Tiergartenstr. 15-17, 69121 Heidelberg 892 pp. Englisch.

Taschenbuch. Condición: Neu. This item is printed on demand - Print on Demand Titel. Neuware -This book aims to provide an easily read general account of clinical cardiology. It is primarily designed to meet the needs of medical students, but should be helpful to advanced students in nursing and paramedical fields, as well as providing a review text for medical interns and residents. The book may help to practice modern medicine in a humane way. This means utilizing all possibilities available, but, at the same time, recognizing their limitations. Since progress in the field of cardiology advances rapidly the physician can only keep up with it by understanding diagnostic and therapeutic measures rather than by memorizing mUltiple facts. The need for a book such as this one has already been proven by the wide acceptance in Europe of the first two German editions (authored by M. K.). Indeed, this success prompted the collaborative effort represented here. Along with the translation into English, the authors have tried to maintain an international perspective, in tune with the greater global awareness and cooperation of the 1990s.Steinkopff Dr. Dietrich V, Poststr. 9, 64293 Darmstadt 200 pp. Englisch.

Taschenbuch. Condición: Neu. This item is printed on demand - Print on Demand Titel. Neuware -This is a Festschrift to Professor Sir Stanley Peart, Professor of Medicine at St. Mary's Hospital and Medical School, University of London since 1956, who has influenced and directed many of us in the better understanding of the patho physiological basis and the clinical practice of hypertension. It commemorates, and we hope will preserve, memories of a special occasion when we met to honour him at the Castella de Pomeiro, Como, Italy. At this meeting his 'extended family' (pictured above) shared experiences, discussed current scientific and clinical ap proaches in hypertension research and indulged in reminiscences of their exciting times on his Unit at St. Mary's. We particularly hope that this volume will illustrate the multifaceted approach needed in investigating and managing hypertension and that it will additionally remind Sir Stanley of the admiration and warm affection with which he has been, and will always continue to be regarded. Christopher J. Mathias Peter S. Sever Introduction P. S. Sever Welcome to Castello de Pomerio, for what I feel sure is to be a very special occasion. As all of you know, Stan Peart is retiring after 31 years as professor and head of the department of Medicine at St. Mary's, and after nearly 40 years of distinguished research in basic and clinical science related to the cardiovascular system, the kidney and particularly to hypertension.Steinkopff Dr. Dietrich V, Poststr. 9, 64293 Darmstadt 132 pp. Englisch.

Taschenbuch. Condición: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Cardiac hypertrophy and accompanying phenomena have received increasing attention in recent years - particularly in the basic sciences. The present volume contains the proceedings of the Erwin RIESCH SYMPOSIUM on 'CARDIAC ADAPTATION TO HEMODYNAMIC OVERLOAD, TRAINING AND STRESS' held in Tiibingen on Sep tember 19-22, 1982. In addition to the topics of the previous symposia (1976 and 1979) concerned with problems of cardiac hypertrophy, the scope of this sequel meeting has been expanded to include related fields. The intention was to consider numerous related features and problems of chronic reactions of the heart (and vascular system) to abnormal hemodynamic loading, as well as alterations due to maturation, aging, training, neuroendocrine status and stress. Special attention has been paid to cardiac reactions at the level of contractile proteins. The results are considered primarily in light of long-term adaptation of the heart. Of course, research at the forefront of current knowledge need not always lead to congruent conclusions. Neither can the individual contributions always agree with the viewpoint of the editors. However, the broad array of individual approaches employed by biochemists, biolo gists, pathologists, physiologists, pharmacologists and clinical cardio logists will certainly help to provide a more balanced interpretation of the results in individual fields, stimulate reexamination of established con cepts and provide direction for future research. 384 pp. Englisch.

Taschenbuch. Condición: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Spinal Cord Stimulation II (SCS) contains the state of the art of this innovative method in the treatment of peripheral vascular disease.The volume presents such topics as: Spinal Cord Stimulation for Chronic Pain.- Management of Critical Limb Ischemia.- Spinal Cord Stimulation for Angina Pectoris.- Buerger's Disease.- Miscellaneous. 256 pp. Englisch.

Taschenbuch. Condición: Neu. This item is printed on demand - Print on Demand Titel. Neuware -Cardiac hypertrophy and accompanying phenomena have received increasing attention in recent years - particularly in the basic sciences. The present volume contains the proceedings of the Erwin RIESCH SYMPOSIUM on 'CARDIAC ADAPTATION TO HEMODYNAMIC OVERLOAD, TRAINING AND STRESS' held in Tiibingen on Sep tember 19-22, 1982. In addition to the topics of the previous symposia (1976 and 1979) concerned with problems of cardiac hypertrophy, the scope of this sequel meeting has been expanded to include related fields. The intention was to consider numerous related features and problems of chronic reactions of the heart (and vascular system) to abnormal hemodynamic loading, as well as alterations due to maturation, aging, training, neuroendocrine status and stress. Special attention has been paid to cardiac reactions at the level of contractile proteins. The results are considered primarily in light of long-term adaptation of the heart. Of course, research at the forefront of current knowledge need not always lead to congruent conclusions. Neither can the individual contributions always agree with the viewpoint of the editors. However, the broad array of individual approaches employed by biochemists, biolo gists, pathologists, physiologists, pharmacologists and clinical cardio logists will certainly help to provide a more balanced interpretation of the results in individual fields, stimulate reexamination of established con cepts and provide direction for future research.Steinkopff Dr. Dietrich V, Poststr. 9, 64293 Darmstadt 384 pp. Englisch.

Taschenbuch. Condición: Neu. This item is printed on demand - Print on Demand Titel. Neuware -Spinal Cord Stimulation II (SCS) contains the state of the art of this innovative method in the treatment of peripheral vascular disease.The volume presents such topics as: Spinal Cord Stimulation for Chronic Pain.- Management of Critical Limb Ischemia.- Spinal Cord Stimulation for Angina Pectoris.- Buerger's Disease.- Miscellaneous.Steinkopff, Dietrich Verlag in Springer Science + Business M, Tiergartenstr. 15-17, 69121 Heidelberg 256 pp. Englisch.

Taschenbuch. Condición: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Inhaltsangabe1. Die Ernährungssituation heute und ihre Folgen (G. Wolfram).- 1.1. Änderungen von Lebenssituation und Umwelt und deren Einfluß auf die Ernährung.- 1.2. Methoden zur Erfassung von Entwicklungstendenzen der Ernährung und der aktuellen Ernährungssituation.- 1.3. Entwicklungstendenzen nach der Agrarstatistik.- 1.4. Aktueller Nährstoffverbrauch.- 1.5. Ernährungsabhängige Krankheiten.- 1.6. Mortalität durch ernährungsabhängige Krankheiten.- 1.7. Unterversorgung mit essentiellen Nährstoffen.- 1.8. Zusammenfassung.- Literatur.- 2. Stoffwechsel und Ernährung.- 2.1. Nahrungsaufnahme (R.Noack).- 2.1.1. Sensorische Empfindungen bei der Nahrungsaufnahme.- 2.1.1.1. Geruchssinn.- 2.1.1.2. Geschmackssinn.- 2.1.1.3. Bedeutung der sensorischen Empfindungen.- 2.1.2. Kontrolle der Nahrungsaufnahme.- 2.2. Verdauung und Resorption (R. Noack).- 2.2.1. Physiologische Grundlagen.- 2.2.2. Verdauung und Resorption der Kohlenhydrate.- 2.2.3. Verdauung und Resorption der Fette.- 2.2.4. Verdauung und Resorption der Eiweiße.- 2.2.5. Art der Transportvorgänge.- 2.2.6. Koordinierung von Verdauung und Resorption.- 2.3. Zwischenstoffwechsel (R. Noack; 2.3.1.-2.3.3.5.).- 2.3.1. Biologische Strukturen und Funktionen.- 2.3.2. Hauptwege des Zwischenstoffwechsels.- 2.3.2.1. Biologische Energieverwertung.- 2.3.2.2. Energieübertragung und Energieumwandlung.- 2.3.3. Zwischenstoffwechsel der Grundnährstoffe.- 2.3.3.1. Zwischenstoffwechsel der Kohlenhydrate.- 2.3.3.2. Zwischenstoffwechsel der Fette.- 2.3.3.3. Zwischenstoffwechsel der Eiweiße und Aminosäuren.- 2.3.3.4. Ernährungsphysiologische Aspekte des Nucleinsäure- und Porphyrinstoff-wechsels.- 2.3.3.5. Quantitative Aussagen zum Stoffwechsel der Grundnährstoffe, speziell der Proteine.- 2.3.4. Stoffwechsel der Vitamine (B. Gaßmann, H. Schmandke).- 2.3.4.1. Retinol (Vitamin A).- 2.3.4.2. Ergocalciferol (Vitamin D2) und Cholecaltiferol (Vitamin D3).- 2.3.4.3. Tocopherole (Vitamin E).- 2.3.4.4. 2-Methyl-1,4-Naphthochinone (Vitamin K).- 2.3.4.5. L-Ascorbinsäure (Vitamin C).- 2.3.4.6. Thiamin (Vitamin B1).- 2.3.4.7. Riboflavin (Vitamin B2).- 2.3.4.8. Nicotinsäure/Nicotinamid.- 2.3.4.9. Pyridoxol, Pyridoxal, Pyridoxamin (Vitamin B6).- 2.3.4.10. Biotin.- 2.3.4.11. Folsäure.- 2.3.4.12. Pantothensäure.- 2.3.4.13. Cobalamine (Vitamin B12).- 2.4. Stoffwechselregulation (R. Noack).- 2.4.1. Ernährung und Stoffwechselregulation.- 2.4.2. Mechanismen der Stoffwechselregulation.- 2.4.3. Hormone und Stoffwechselregulation.- 2.4.3.1. Insulin.- 2.4.3.2. Glucagon.- 2.4.3.3. Catecholamine.- 2.4.3.4. Schilddnisenhormone.- 2.4.3.5. Glucocorticoide.- 2.4.3.6. Mineralocorticoide.- 2.4.3.7. Parathormon und Calcitonin.- 2.4.3.8. Androgene und Estrogene.- 2.4.3.9. Prostaglandine.- 2.4.3.10. Gastrointestinale Hormone.- 2.4.3.11. Hormone der Hypophyse.- 2.4.3.12. Hormone des Hypothalamus.- 2.5. Bedeutung der Ballaststoffe fiir die Ernahrung (M. Friedrich, J. Schulze).- 2.5.1. Begriffsbestimmung.- 2.5.2. Herkunft von Ballaststoffen in der Nahrung.- 2.5.2.1. Kohlenhydrat-Ballaststoffe.- 2.5.2.2. Nicht-Kohlenhydrat-Ballaststoffe und Nahrungsbegleitstoffe.- 2.5.3. Analytik von Ballaststoffen.- 2.5.4. Einfluß von Ballaststoffen auf den Makroorganismus.- 2.5.4.1. Effekte von Ballaststoffen in Magen und Dünndarm.- 2.5.4.2. Physiologische Bedeutung der Beeinflussung der Nährstoffaufnahme durch Ballaststoffe.- 2.5.4.3. Effekte von Ballaststoffen im Dickdarm.- 2.5.4.4. Ballaststoffverzehr und Krankheit.- 2.5.5. Wünschenswerter Verzehr.- 3. Nahrungsbedarf.- 3.1. Bestimmung des Nahrungsbedarfs (M. Friedrich, B. Gaßmann, H.-A. Ketz).- 3.1.1. Bestimmung des Energiebedarfs.- 3.1.2. Bestimmung des Grundnährstoffbedarfs.- 3.1.3. Bestimmung des Vitaminbedarfs und des Vitaminversorgungszustandes.- 3.1.3.1. Retinol (Vitamin A).- 3.1.3.2. Cholecalciferol (Vitamin D3).- 3.1.3.3. Tocopherol (Vitamin E).- 3.1.3.4. Naphthochinone (Vitamin K).- 3.1.3.5. Ascorbinsäure (Vitamin C).- 3.1.3.6. Th.

Taschenbuch. Condición: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -In einem ruhenden Fluid kann ein Karper nur durch Leitung oder Strahlung Warme an das Fluid abgeben oder von dem Fluid aufnehmen. Treibende Kraft ist ein Temperaturgefalle. Ebenso kann in einem ruhen den Fluid eine Stofikomponente von einem Karper an das Fluid oder von dem Fluid an den Karper nur durch Diffusion oder elektrochemischen Transport gelangen. Treibende Kraft ist hier ein Konzentrations- bzw. Ladungsgefalle. Der Warmetransport durch Leitung und der Stofftransport durch Diffusion werden wesentlich erhaht, sobald das Fluid stramt. Durch die Stramung gelangt frisches Fluid an die Korper, die treibenden Ge falle werden graBer und damit der gesamte Transport. Dieses enge Zusammenspiel zwischen den molekularen Transport erscheinungen der Warmeleitung und der Diffusion mit der Stramung wird als Konvektion bezeichnet. Beim Wiirmetransport gilt: Konvektion = Warmeleitung + Stramung Beim StofJtransport gilt: Konvektion = Diffusion + Stromung Prinzipiell fUhrt jede Erhahung der Stramungsgeschwindigkeit zu einer Verbesserung des konvektiven Transports. Die Eigenschaften der Stramung wirken unmittelbar auf die Transportprozesse zurlick. Urn die konvektiven Transportprozesse zu verstehen, muB daher zunachst immer die Stramung untersucht werden. Wir unterscheiden zwischen erzwungener und freier Stromung. Flir einen Ubertragungsvorgang ist eine Stromung erzwungen, wenn sie auj3erhalb des V organgs erzeugt wird. 320 pp. Deutsch.

Taschenbuch. Condición: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Tachykarde ventrikuläre Arrhythmien stellen die Hauptursache des plötzlichen Herztodes dar. Identifikation von Risikopatienten und adäquate effektive antiarrhythmische Therapie sind daher von gröBter Bedeutung. Systematische Studien zeigen, daS mit den derzeit verfügbaren Antiarrhythmika nur ca. 50-60% der Patienten mit lebensbedrohlichen ventrikulären Tachykardien bei strenger Thera piekontrolle effektiv eingestellt werden können. Dabei sind in der praktischen Therapie nur wenige Antiarrhythmika verfügbar, die mit einer ausreichend hohen Responderrate einsetzbar sind. Andererseits stehen nichtpharmakologische BehandlungsmaSnahmen nur in begrenztem Umfang zur Verfügung, der klinische Stellenwert dieser Verfahren ist teilweise (z. B. Katheter ablation) noch nicht definiert. Es besteht somit ein Bedarf mr neue Antiarrhythmika, die sich in der Therapie lebensbedro hender Rhythmusstörungen als effektiv erweisen. Diprafenon, chemisch ein Propafenon Analogon, ist ein neues Antiarrhythmikum der Klasse le, we1ches über ausgeprägte betasympa tholytische Eigenschaften verfügt. Der vorliegende Band enthält eine erste Zusammenstellung der bisherigen experimentellen, pharmakokinetischen, pharmakodynarnischen und klinischen Befunde, die anläBlich eines Symposiums 1987 in Berlin zusammengetragen wurden. Obwohl mit den vorliegenden Daten eine endgültige Beurteilung des klinischen Stellenwertes von Diprafenon noch nicht möglich ist, erscheint die weitere klinische Prüfung der Substanz sehr erfolgversprechend, insbesondere unter den Indikationen 'ventrikuläre Tachykardie' sowie 'supraventrikuläre Tachyarrhythmie' bei Präexzitationssyndrom. 308 pp. Deutsch.

Taschenbuch. Condición: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Die koronare Herzkrankheit ist immer noch die hiiufigste Todesursache in der west lichen Welt. In den vergangenen Jahren sind sowohl bei der Entwicklung und dem Einsatz diagnostischer Verfahren als auch bei der medikamentosen, invasiven und chirurgischen Therapie entscheidende Fortschritte erzielt worden. Eine Vielzahl von Substanzen steht zur Pharmakotherapie der koronaren Herzkrankheit zur Verfu gung, inbesondere Nitrate, B-Blocker und Kalziumantagonisten, die einzeln oder in Kombination eingesetzt werden. Auf der anderen Seite hat die experimentell-kar diologische Forschung zunehmend das dynamische und komplexe Szenario der ischamischen Herzkrankheit betont, das Endothelschadigung, Gerinnungsprozesse, Veranderungen des Herzstoffwechsels und der Struktur, koronarkonstriktive Mechanismen, Umverteilungen der Durchblutung, Arrhythmogenese, kontraktile Dysfunktion wahrend Ischamie und Reperfusion und schlieBlich Vorhandensein oder Fehlen einer Schmerzempfindung umfaBt. Es erscheint daher unbedingt wiin schenswert, die Lucke zwischen experimenteller und klinischer Kardiologie zu schlieBen und damit eine pathophysiologische Grundlage fur rational begrundete diagnostische und therapeutische Entscheidungen zu liefern. Die Idee zu diesem Buch entstand bei der Vorbereitung einer Seminarserie zur experimentellen Kardiologie, als sich die Zusammenstellung der wesentlichen Infor mationen aus verschiedenen Lehrbuchern der Kardiologie, Physiologie, Pathologie und Pharmakologie sowie aus speziellen Ubersichts- und Originalarbeiten als muh sam erwies. Ich bin daher klinisch und experimentell tatigen Kollegen aus der ganzen daB Welt, die jeweils Experten auf ihrem Fachgebiet sind, ausgesprochen dankbar, sie gemeinsam mit mir eine zusammenfassende Darstellung der Pathophysiologie der ischiimischen Herzkrankheit und ihrer Pharmakotherapie ermoglicht haben. Dem Steinkopff Verlag, insbesondere Frau Sabine Muller, gilt mein Dank fUr die erfreuliche und konstruktive Zusammenarbeit bei der Herausgabe dieser Mono graphie. 384 pp. Deutsch.