Springer us sep 2026 (23 resultados)

Taschenbuch. Condición: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This extensive volume explores the phenomena of chaotic genomic rearrangements, known as chromoanagenesis, their formation mechanisms, and the state-of-the-art techniques used to detect them. The book delves into the potential impact of chromoanagenesis on cancers and congenital diseases, as well as its broader implications for genomic evolution and human health through a variety of cutting-edge methodologies. Written for the highly successful Methods in Molecular Biology series, most chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step and readily reproducible laboratory protocols, and tips for troubleshooting and avoiding known pitfalls. Authoritative and comprehensive, Chromoanagenesis: Methods and Protocols serves as an ideal guide to the mechanisms and consequences of chromoanagenesis and a resource for researchers and clinicians seeking to explore the cutting-edge techniques and models used to study this phenomenon. 643 pp. Englisch.…

Buch. Condición: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This detailed collection explores methods that leverage and extend the capabilities of synthetic biology, guiding the reader from foundational molecular manipulations to complex cellular applications. Beginning with chapters on engineering proteins and enzymes, the book continues by covering methods for the repurposing of viral architectures, from bacteriophages to virus-like particles, as programmable nanoscaffolds, CRISPR-driven genome engineering, directed evolution and selection, as well as the synthesis of functional genetic libraries and the groundbreaking technology of biological 'memory,' where a cell's history is permanently recorded into its DNA. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step and readily reproducible laboratory protocols, and tips for troubleshooting and avoiding known pitfalls.Authoritative and practical, Biological Macromolecule Engineering Technologies serves as an ideal guide for researchers looking to drive the next wave of discovery in biological macromolecule engineering and address some of humanity's most pressing challenges in health, energy, and manufacturing. 324 pp. Englisch. …

Buch. Condición: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This volume explores the practical application of quantum mechanical (QM) methods in modern drug design. Its chapters cover methodological developments, integration with molecular dynamics and artificial intelligence, applications to diverse target classes and modalities, and perspectives on automation and high-throughput deployment. The book is intended for a broad readership, including computational and medicinal chemists, structural biologists, pharmacologists, and researchers working at the interface of physics, chemistry, and drug design. Written for the highly successful Methods in Molecular Biology series, the chapters provide the detailed guidance necessary for successful implementation of these techniques.Expansive and cutting-edge, Quantum Mechanics Applications in Drug Design serves as both an authoritative reference and a practical guide for scientists seeking to harness quantum mechanical methods to accelerate and improve the design of new therapeutics. 352 pp. Englisch.…

Buch. Condición: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This volume discusses the current models and latest methodologies used to explore key questions in transfusion medicine. The chapters in this book cover topics such as mouse models of platelet alloimmunization refractoriness and immune thrombocytopenia; analysis of biotinylated red cell blood cells following transfusion; impact of intravascular hemolysis on erythropoiesis in sickle cell disease; western blot detection of blood group A and B antigens; and the role of marginal zone B cells in FVIII inhibitor development. Written in the highly successfulMethods in Molecular Biologyseries format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.Thorough and comprehensive,Methods in Transfusion Medicineis a valuable resource for all researchers interested in learning more about this field and leading us closer to optimal transfusion practice. 841 pp. Englisch.…

Buch. Condición: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This detailed volume navigates the journey from a promising chemical entity to a potential therapeutic agent in cancer research through systematic and rigorous protocols across a spectrum of increasingly sophisticated models. Beginning with foundational in vitro assays for assessing cytotoxicity and antiproliferative effects, the book continues by covering mechanisms of action studies, advanced 2D and 3D culture models for the tumor microenvironment and cellular architecture involved in modulating drug response and resistance, in vivo antitumor and efficacy models, as well as immunology and inflammation-related assays and forward-looking clinical studies for cancer research. Written for the Springer Protocols Handbooks series, chapters include the kind of precise implementation advice and methodological clarity that leads to success in advancing the current state of the research.Comprehensive and practical, Advanced Protocols in Cancer Research: Translational Models for Antitumor and Anticancer Drug Discovery serves as a valuable resource for fostering methodological precision and accelerating the translation of scientific discovery into effective cancer therapies. 332 pp. Englisch.…

Buch. Condición: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This second edition volume expands on the previous edition with a discussion of the latest methods used to explore collagen biology from molecular synthesis and folding to biomechanical analysis and tissue engineering applications. The chapters in this book are organized into four parts: Part One introduces strategies for manipulating collagen at the molecular level, including gene targeting, mutagenesis, and functional assays. Part Two focuses on cellular and biochemical aspects of collagen biology, featuring protocols to study the effects of hypoxia, assess triple helix stability, and investigate ECM-rich environments using proteomics and mass spectrometry. Part Three covers structural and imaging techniques such as atomic force microscopy and advanced visualization of collagen suprastructures, and Part Four looks at translational and biomedical research, providing protocols for constructing 3D ECM scaffolds, engineering collagen-based biomaterials, and modeling tumor microenvironments. Written in the highly successful Methods in Molecular Biologyseries format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.Cutting-edge and comprehensive,Collagen: Methods and Protocols, Second Editionis a valuable resource for researchers in cell biology, biochemistry, tissue engineering, and translational medicine, and will support the development of novel strategies to explore and manipulate the power of collagen. 280 pp. Englisch.…

Buch. Condición: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This volume describes the latest developments in using Artificial Intelligence (AI) and machine learning in the field of genomics. The chapters in this book cover a variety of topics such as ways toderive the biomarker and measure biological and pathological processes from transcriptomic data sets; techniques to infer the function of epigenetics using network-based methodology; a look at how CellOracle can figure out which gene-gene interaction is important; how to find a machine learning approach to figure out how microRNA affects the cardiovascular events; protocols on ways to find how AI/ML approaches can attack somatic variant detection in normal human tissue; and a description on how gene embeddings are powerful tools for predicting unknown functions of genes and drugs. Written in the highly successfulMethods in Molecular Biologyseries format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.Thorough and comprehensive,AI/ML-Driven Gene Analysis: Methods and Protocolsis a valuable tool for researchers interested in learning more about how cutting-edge methodology for AI/ML is applied to genomics. 268 pp. Englisch.…

Buch. Condición: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This second edition details new and updated techniques used to study disulfide bonds. Chapters guide readers through how disulfide bonds are classified, techniques used to study functional disulfides, allosteric disulfide bonds, and examples of how labile disulfide bonds are employed for new diagnostics and therapeutics. Written for the highly successfulMethods in Molecular Biologyseries, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.Authoritative and practical,Functional Disulphide Bonds: Methods and Protocols, Second Edition serves as a vital guide to this evolving area of study. 292 pp. Englisch. …

Buch. Condición: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This detailed volume examines techniques for better understanding mammalian preimplantation embryo development, the development and contribution of gametes, and how to manipulate such reproductive cells in the laboratory. Written by experts in their field, the book covers gamete preparation, in vitro embryo culture and cryopreservation, physiological and molecular methods for embryo assessment, and emerging methods for modeling key developmental processes encompassing gamete and embryo manipulation through implantation. As part of the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step and readily reproducible laboratory protocols, and tips for troubleshooting and avoiding known pitfalls.Authoritative and practical, The Preimplantation Embryo: Methods and Protocols serves as a comprehensive and practical toolbox and will be of immense value to scientists working on the fascinating and dynamic preimplantation embryo and the gametes from which it originates. 500 pp. Englisch.…

Buch. Condición: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This volume details encapsulation protocols with a focus on the combination of raw materials to enable an initial laboratory production of classic particles. Chapters guide readers through modification to produce porous starches, hydrogels, dry and insoluble particles, Layer-by-Layer, fluidized bed, and encapsulation methods and the general properties of the particles obtained. Written in the format of theMethods and Protocols in Food Scienceseries, chapters list necessary materials and methods for readily reproducible protocols and contain notes on how to avoid and solve typical problems.Authoritative and cutting-edge, Biopolymers: Encapsulation Methods provides well-established protocols used by both academics and industrials. 164 pp. Englisch.…

Buch. Condición: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This detailed volume explores practical and reproducible computational techniques and pipelines that span the translational neurosciences continuum. The first section of the book focuses on experimental platforms that generate high-dimensional biological data and the computational methodologies required to transform raw signals into mechanistic insights, while the second half transitions from bench to bedside, illustrating how computational methodologies reshape diagnosis, prognosis, and mechanistic inference across the whole pathophysiological spectrum of the nervous system, from normal brain function to neurological diseases. Written for the highly successful Methods in Molecular Biology series, each chapter provides step-by-step workflows, code snippets, tool recommendations, and the practical guidance needed for positive results.Authoritative and up-to-date, Computational Neuroscience serves as both a reference and a catalyst: a reference for reproducible pipelines across diverse subfields, and a catalyst for interdisciplinary collaboration. 296 pp. Englisch.…

Buch. Condición: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware 364 pp. Englisch.

Buch. Condición: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This second edition volume expands on the previous edition with updates on the latest advancements in the field that span from atomic-resolution structural analysis to whole-organism functional studies. The chapters in this book are organized into four parts. Part One: Structural Analysis Methodspresents cutting-edge approaches for determining high-resolution structures of multidrug exporters, and covers the full spectrum of structural biology techniques, from solution NMR spectroscopy for studying PfMATE to single-particle cryo-EM analysis of TolC. Part Two: Biochemical Analysis and Reconstitution focuses on functional characterization of multidrug exports and looks at methods such as site-specific fluorescent labeling of AcrB and analytical ultracentrifugation for studying oligomeric states. Part Three: Computational and Simulation Approaches showcases the power of in silico methods in multidrug exporter research such as molecular dynamics simulations of conformational changes in MdfA. Part Four: Genetic Tools and Functional Studiespresents a diverse array of methods for investigating multidrug exporters in their biological context. This section explores high-throughput gene mapping using TraDISort, evaluation of efflux pump inhibitors through growth curve analysis, and cloning and characterization protocols.Written in the highly successfulMethods in Molecular Biologyseries format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.Comprehensive and cutting-edge,Bacterial Multidrug Exporters: Methods and Protocols, Second Editionis a valuable resource for novel researchers entering this field and established investigators seeking to expand their methodological range. 274 pp. Englisch.…

Buch. Condición: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This volume details comprehensive and step-by-step microbiological methods on food quality. Chapters guide readers through aerobic plate counts, yeast, mold enumeration, endospore staining, rapid detection, Escherichia coli and other clinically significant contaminants in meat, dairy, vegetable, and processed food products. Written in the format of theMethods and Protocols in Food Scienceseries, chapters list necessary materials and methods for readily reproducible protocols.Authoritative and cutting-edge Food Quality Analysis: Microbiological Testing Protocols aims to be comprehensive guide forresearchers in the field. 212 pp. Englisch. …

Buch. Condición: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This volume provides comprehensive methods and protocols to detect and trace RNAs in biochemistry, molecular, cell biology, genetics, genomics of RNA biology. Chapters detail RNA labeling, RNA biology of mammalian cells, and methods on model organisms; including Zebrafish, Drosophila, C. elegans, budding yeast as well as prokaryotes including E. coli. Written for the highly successfulMethods in Molecular Biologyseries, chapters feature introductions to their respective topics, lists of the necessary materials and reagents, step-by-step and readily reproducible laboratory protocols, and tips for troubleshooting and avoiding known pitfalls.Authoritative and up-to-date,RNA Labeling: Methods and Protocols serves as a vital resource for researchers working in RNA labeling. 260 pp. Englisch.…

Buch. Condición: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This detailed new edition presents current techniques for researching arbuscular mycorrhizal (AM) fungi. With an updated and expanded collection of protocols, this book explores molecular quantification, high resolution imaging, metabolite profiling, transcriptomic and proteomic analyses, functional genomics, and advanced cultivation systems. Methods for asymbiotic growth and the study of functional traits of AM fungi and techniques to describe microbial communities, including viruses, associated with AM fungal hyphae are also included. Written for the highly successful Methods in Molecular Biology series, chapters feature introductions to their respective topics, lists of the necessary materials and reagents, step-by-step and readily reproducible laboratory protocols, and tips for troubleshooting and avoiding known pitfalls.Authoritative and up-to-date, Arbuscular Mycorrhizal Fungi: Methods and Protocols, Second Edition serves as a vital resource for researchers working in different areas of AM fungal biology. 281 pp. Englisch.…

Buch. Condición: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This sixth edition volume expands on the previous editions with a discussion of the latest methods used to detect RNA or DNA species in situ, including both short and long RNAs, and coding and non-coding RNAs. The chapters in this book are organized into five parts: RNA detection techniques; RNA and protein co-detection; 3D and wholemount ISH; spatial transcriptomics approaches; and image analysis and quantification. Some of the topics covered in this volume are detection of viral pathogens using RNAscope ; detection of therapeutic antisense oligonucleotides using miRNAscope assays; RNAscope HiPlex in tissue sections and wholemounts; spatial transcriptomics platforms with accompanying data processing; and various image analysis platforms for downstream quantitative assessment. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.Authoritative and thorough, In Situ Hybridization Protocols, Sixth Edition brings together a collection of protocols, along with practical notes and recommendations, and offers researchers a comprehensive introduction to the current leading edge of in situ hybridization. 436 pp. Englisch. …

Buch. Condición: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This volume bridges the gap between foundational principles and cutting-edge applications used in the evolving field of intrathecal drug delivery. The chapters in this book are organized into four parts: Part One explored the history of neuraxial therapy and the fundamental principles of neuroanatomy, cerebrospinal fluid physiology, and pharmacokinetics. Part Two looks at the transitions from theory to practice, detailing the established clinical applications and surgical techniques for chronic pain, spasticity, CNS infections, and oncology. Parts Three and Four delve into the application of novel therapeutics for neurodegenerative and leptomeningeal diseases, the design of advanced formulations such as nanoemulsions, and an examination of the challenges and emerging solutions that will define the next generation of intrathecal drug delivery systems. In theNeuromethods series style, chapters include the kind of detail and key advice from the specialists needed to get successful results in your laboratory.Cutting-edge and comprehensive, Intrathecal Drug Delivery is a valuable tool for researchers at all levels, from medical and graduate students to residents and postdoctoral fellows, who are interesting in learning more about this developing and important field. 260 pp. Englisch.…

Buch. Condición: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This volume serves as an indispensable guide for researchers, students, and professionals who wish to explore the intricate world of pollen biology and its modern methodologies. Chapters detail collecting, counting, storing pollen, artificial intelligence, pollen classification, flow cytometric analysis, pollen characteristics, multispectral imaging, pollen tube growth in stiff media and measuring self-incompatibility in plants, providing solutions and methodologies for these obstacles. Written in the highly successfulMethods in Molecular Biologyseries format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.Comprehensive and cutting-edge, Pollen and Pollen Tube Analysis: Methods and Protocols represents a collaborative effort to advance the understanding of pollen biology using modern techniques and applications. This volume will serve as a valuable resource for those entering the fascinating field of pollen research. 331 pp. Englisch. …

Buch. Condición: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware 460 pp. Englisch.

Buch. Condición: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This second volume provides updated and new methods on plant biotic interactions, including the use of bioinformatics as a tool, as well as various protocols from molecular biology, biochemistry, physiology, pathology, and agricultural sciences. Written in the format of theMethods and Protocols in Food Scienceseries, chapters list necessary materials and methods for readily reproducible protocols.Authoritative and cutting-edge, Plant Biotic Stress: Methods and Protocols, Volume 2aims to provide well-established protocols along with recent methodological advancements, enabling accurate, reproducible, and in-depth research, particularly in the context of crop protection. 292 pp. Englisch. …

Buch. Condición: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This volume presents a collection of bothclassic and modern experimental methods designed to highlight the biology, pathogenicity, and host interactions of Fusobacterium nucleatum. The chapters in this book provide practical guidance spanning microbiology, molecular biology, imaging, genetic engineering, metabolomics, and in vivo modeling. Some of the topics discussed in this volume are methods for visualizing and isolating F. nucleatumwithin its native oral environment; essential cellular processes such as surface protein assembly and peptidoglycan biosynthesis; protocols for asymmetric coculture systems; 3D tumor spheroid models; untargeted metabolite profiling of infected mammalian cells; and several in vivo platforms from murine models of periodontitis, oral cancer, and CRC to a Caenorhabditis elegansinfection model. Written in the highly successful Methods in Molecular Biologyseries format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.Comprehensive and cutting-edge, Fusobacterium nucleatum: Methods and Protocols is a fundamental resource for both new and experienced researchers looking to investigate F. nucleatum virulence mechanisms, colonization strategies, and its increasing contributions to diseases such as CRC, oral squamous cell carcinoma, and periodontitis. 216 pp. Englisch.…

Buch. Condición: Neu. This item is printed on demand - Print on Demand Titel. Neuware Springer Nature Customer Service Center GmbH, Europaplatz 3,69115 Heidelberg, Germany, 69115 Heidelberg 460 pp. Englisch.