Springer us apr 1985 (18 resultados)
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Buch. Condición: Neu. Neuware - Prostaglandins, Leukotrienes, and Cancer is a multi-volume series that will focus on an emerging area of cancer research. In 1968, R.H. Williams first reported that elevated prostaglandin levels are present in human medullary car cinoma. Since that time, the concept that arachidonic acid metabolit…es may be in volved in cancer has expanded to include every aspect of the disease from cell transformation through metastasis. Prostaglandins and leukotrienes are generic terms used to describe a family of bioactive lipids produced from unsaturated fatty acids (principally from and lipoxygenase pathways, respec arachidonic acid) via the cyclooxygenase tively. Cyclooxygenase products consist of diverse products such as prosta glandin E2 (POE), prostacyclin (POI) and thromboxane A2 (TXA), whereas 2 2 2 lipoxygenase products consist of hydroperoxy fatty acids and mono-, di- and tri-hydroxy acids including leukotrienes. The precursor fatty acids for the cyclooxygenase and lipoxygenase pathways are present in cellular phospholipids. This finding established an important control point in their biosynthesis-the release of substrate. This occurs in response to numerous stimuli that act at the cell surface. Dr. Bengt Samuelsson's extensive study of the metabolism of pros taglandins indicated that they are rapidly inactivated on a single pass through pulmonary circulation. Thus, they cannot act as circulating hormones and appear to be made on demand in or in the vicinity of target tissues leading to the concept that prostaglandins are local hormones or autocoids.
Idioma: Inglés
Editorial: Springer Us Apr 1985, 1985
Serie: Libro 33 de 253 - Developments in Cardiovascular Medicine
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Buch. Condición: Neu. Neuware - In summary, there are many animal models that are useful in selecting new antiarrhythmic drugs. The selection of which model is most idea depends upon precisely what question is being asked. The large number of experimental models used to evaluate antiarrhythmic compounds points out the inability…of anyone model to define the probability of antiarrhythmic efficacy in man. It has therefore become standard practice to utilize a batter of animal models for the evaluation of new antiarrhythmic agents. Each model has its own advantages and disadvantages and it is necessary to understand each model fully in oder to evaluate experimental findings and apply them to clinical settings. We believe that the availability of the chronic myocardial infarction ventricular tachyarrhythmia model provides 1) an excellent opportunity to more precisely understand arrhythmia mechanisms, 2) to develop new techniques such as signal averaging for evaluating late low level potentials identifying hearts at high risk of sudden death 3) to identify new antifibrillatory drugs versus drugs that are effective primarily against PVC's and ventricular tachycardia 4) to identify new surgical techniques to eliminate VT/VF, and 5) to evaluate new pacing modalities including implantable cardioverters. Although all animal models are wrong, many are very useful in furthering our knowledge directed at decreasing the distressingly high mortality from heart disease. NORMAL HtART TACHYCMDIA HtART , . '' I I I I I I I I I .
Idioma: Inglés
Editorial: Springer US Apr 1985, 1985
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Buch. Condición: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -The observation in the 1950s that nitrogen mustard and other toxic chemicals could induce antitumor responses in patients with refractory lymphoma initiated a massive search for active chemotherapeutic agents. The initial observations stim…ulated a search for new chemotherapeutic agents which might have increased antitumor activity with less toxicity for normal tissues. To aid in the search for these new chemicals and to attempt to distinguish among the many toxic chemicals which might be candidates for clinical studies, the National Cancer Institute, the pharmaceutical industry, and the cancer research laboratories of most Western nations developed systems for 'screening' drugs for antitumor activity. Perhaps the most extensive screening program was established by the National Cancer Institute (1). This screening program has evolved over the last two decades, an evolution which has been repeatedly reviewed (2-5). Various screening programs in use have examined over 500,000 compounds as potential anticancer agents. From these, there are now approximately forty anticancer drugs in clinical use. The utiliy of these compounds and their toxicities have been reviewed on many occasions. It is now apparent that more active and less toxic anticancer drugs are needed. It is also clear that the current screening programs are identifying compounds with similar levels of activity and with continuing moderate to severe toxicity (6). 212 pp. Englisch.
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Buch. Condición: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -The second edition of this classic text, which offers a comprehensive how-to approach to the psychotherapy of alcoholism in all its manifestations and subpopulations, features updated versions of the previous material as well as new chapte…rs and case histories. 436 pp. Englisch.
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Buch. Condición: Neu. This item is printed on demand - Print on Demand Titel. Neuware -The second edition of this classic text, which offers a comprehensive how-to approach to the psychotherapy of alcoholism in all its manifestations and subpopulations, features updated versions of the previous material as well as new chapters a…nd case histories.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 436 pp. Englisch.
Idioma: Inglés
Editorial: Springer US, Springer US Apr 1985, 1985
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Buch. Condición: Neu. This item is printed on demand - Print on Demand Titel. Neuware -The observation in the 1950s that nitrogen mustard and other toxic chemicals could induce antitumor responses in patients with refractory lymphoma initiated a massive search for active chemotherapeutic agents. The initial observations stimulat…ed a search for new chemotherapeutic agents which might have increased antitumor activity with less toxicity for normal tissues. To aid in the search for these new chemicals and to attempt to distinguish among the many toxic chemicals which might be candidates for clinical studies, the National Cancer Institute, the pharmaceutical industry, and the cancer research laboratories of most Western nations developed systems for 'screening' drugs for antitumor activity. Perhaps the most extensive screening program was established by the National Cancer Institute (1). This screening program has evolved over the last two decades, an evolution which has been repeatedly reviewed (2-5). Various screening programs in use have examined over 500,000 compounds as potential anticancer agents. From these, there are now approximately forty anticancer drugs in clinical use. The utiliy of these compounds and their toxicities have been reviewed on many occasions. It is now apparent that more active and less toxic anticancer drugs are needed. It is also clear that the current screening programs are identifying compounds with similar levels of activity and with continuing moderate to severe toxicity (6).Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 212 pp. Englisch.
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Buch. Condición: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Examination of the early literature attests to the fact that the study of copolymerization was initiated when polymer science was in its infancy. It has continued to grow to a subject of major importance and has been a source of interest t…o both academic and industrialist alike. The wide spectrum of structures and properties available in the statistical copolymer has made this a fruitful field of exploration, but one particular and more restricted form which has held its own fascination for many is the limiting case of the strictly alternating copolymer. This is formed, in the ideal situation, when two monomers in a reaction mixture add consecutively to create a polymer chain with a regular {ABABAB} structure, irrespective of the monomer feed ratio. When this happens the resulting copolymer will always have the same composition, a feature which can be advantageous but also somewhat restrictive, as the ability to vary the properties is then limited. Within a series entitled Speciality Polymers it seems appropriate then to deal with this subject, particularly as no previous attempt has been made to draw together the various facets of alternating copolymerization into one volume. It also seems timely to present a more unified picture of the subject which will also illustrate the progress made. 298 pp. Englisch.
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Buch. Condición: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -With the recent increase in the scope of drug and alcohol problems has come an awareness of the need for solutions. In this context, federal support for research on drug problems increased tremendously during the last 10 to 15 years with t…he establishment of the National Institute on Drug Abuse (NIDA) and the National Institute on Alcohol Abuse and Alcoholism (NIAAA). Funding from these and other sources has led to a substantial increase in the quantity and quality ofpublished work related to substance abuse. As data accumulate, it is becoming more apparent that substance abuse problems are extremely complex and are influenced by a variety ofbiological psychological, and environmental variables. Un fortunately it has proved difficult to go beyond this conclusion to a de scription of how these multiple factors work tagether to influence the development of, and recovery from, drug and alcohol dependence. The purpose of this book is to try to meet that objective by including, in one volume, Iiterature reviews and theoretical analyses from a wide variety of drug researchers. We chose the authors in an attempt to assure that each of the various Ievels of analysis appropriate to the substance abuse problems would be included. In each case, the author was asked to consider how the variables in is or her particular domain might con tribute to the appearance of individual differences in both alcohol and drug problems. 456 pp. Englisch.
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Buch. Condición: Neu. This item is printed on demand - Print on Demand Titel. Neuware -Examination of the early literature attests to the fact that the study of copolymerization was initiated when polymer science was in its infancy. It has continued to grow to a subject of major importance and has been a source of interest to bo…th academic and industrialist alike. The wide spectrum of structures and properties available in the statistical copolymer has made this a fruitful field of exploration, but one particular and more restricted form which has held its own fascination for many is the limiting case of the strictly alternating copolymer. This is formed, in the ideal situation, when two monomers in a reaction mixture add consecutively to create a polymer chain with a regular {ABABAB} structure, irrespective of the monomer feed ratio. When this happens the resulting copolymer will always have the same composition, a feature which can be advantageous but also somewhat restrictive, as the ability to vary the properties is then limited. Within a series entitled Speciality Polymers it seems appropriate then to deal with this subject, particularly as no previous attempt has been made to draw together the various facets of alternating copolymerization into one volume. It also seems timely to present a more unified picture of the subject which will also illustrate the progress made.Springer-Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 298 pp. Englisch.
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Buch. Condición: Neu. This item is printed on demand - Print on Demand Titel. Neuware -With the recent increase in the scope of drug and alcohol problems has come an awareness of the need for solutions. In this context, federal support for research on drug problems increased tremendously during the last 10 to 15 years with the e…stablishment of the National Institute on Drug Abuse (NIDA) and the National Institute on Alcohol Abuse and Alcoholism (NIAAA). Funding from these and other sources has led to a substantial increase in the quantity and quality ofpublished work related to substance abuse. As data accumulate, it is becoming more apparent that substance abuse problems are extremely complex and are influenced by a variety ofbiological psychological, and environmental variables. Un fortunately it has proved difficult to go beyond this conclusion to a de scription of how these multiple factors work tagether to influence the development of, and recovery from, drug and alcohol dependence. The purpose of this book is to try to meet that objective by including, in one volume, Iiterature reviews and theoretical analyses from a wide variety of drug researchers. We chose the authors in an attempt to assure that each of the various Ievels of analysis appropriate to the substance abuse problems would be included. In each case, the author was asked to consider how the variables in is or her particular domain might con tribute to the appearance of individual differences in both alcohol and drug problems.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 456 pp. Englisch.
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Buch. Condición: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This symposium is the third in a series featuring the propaga tion of higher plants through tissue culture. The first of these symposia, entitled 'A Bridge Between Research and Application,' was held at the University in 1978 and was publi…shed by the Technical Information Center, Department of Energy. The second symposium, on 'Emerging Technologies and Strategies,' was held in 1980 and pub lished as a special issue of Environmental and Experimental Botany. One of the aims of these symposia was to examine the current state of-the-art in tissue culture technology and to relate this state of technology to practical, applied, and commercial interests. Thus, the third of this series on development and variation focused on embryogenesis in culture: how to recognize it, factors which affect embryogenesis, use of embryogenic systems, etc.; and variability from culture. A special session on woody species again emphasized somatic embryogenesis as a means of rapid propagation. This volume emphasizes tissue culture of forest trees. All of these areas, we feel, are breakthrough areas in which significant progress is expected in the next few years. 412 pp. Englisch.
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Buch. Condición: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Prostaglandins, Leukotrienes, and Cancer is a multi-volume series that will focus on an emerging area of cancer research. In 1968, R.H. Williams first reported that elevated prostaglandin levels are present in human medullary car cinoma. S…ince that time, the concept that arachidonic acid metabolites may be in volved in cancer has expanded to include every aspect of the disease from cell transformation through metastasis. Prostaglandins and leukotrienes are generic terms used to describe a family of bioactive lipids produced from unsaturated fatty acids (principally from arachidonic acid) via the cyclooxygenase and lipoxygenase pathways, respec tively. Cyclooxygenase products consist of diverse products such as prosta glandin E, (POE,), prostacyclin (POI2) and thromboxane A2 (TXA2), whereas lipoxygenase products consist of hydroperoxy fatty acids and mono-, di- and tri-hydroxy acids including leukotrienes. The precursor fatty acids for the cyclooxygenase and lip oxygenase pathways are present in cellular phospholipids. This finding established an important control point in their biosynthesis-the release of substrate. This occurs in response to numerous stimuli that act at the cell surface. Dr. Bengt Samuelsson's extensive study of the metabolism of pros taglandins indicated that they are rapidly inactivated on a single pass through pulmonary circulation. Thus, they cannot act as circulating hormones and appear to be made on demand in or in the vicinity of target tissues leading to the concept that prostaglandins are local hormones or autocoids. 466 pp. Englisch.
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Buch. Condición: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -The importance of protecting the environment against pollution is an objective which gained international acceptance in the recent years. According to the first principle of the Declaration of the United Nations Conference on the Human Env…ironment which took place in Stockholm in 1972, 'man . bears a solemn responsibility to protect and improve the environment for present and future genera tions'. The United Nations again in their desire to improve the sanitation conditions allover the world decided to proclaim the period between 1981-1990 as the 'International Drinking Water Supply and Sanitation Decade.' Although attempts have been made by inter national organizations to prevent pollution, it is difficult to say that these attempts gave satisfactory results in developing countries. The most common reasons of failure are: a) To find solutions to their environmental problems, develop ing countries usually seek the assistance of engineers and scientists from developed countries. Many times, how ever, either out of ignorance of the local condition or due to financial motivations, these experts come out with solutions which are far from being considered as the 'most appropriate.' As a result, the basic objective of protecting the environment is not achieved. b) Attempts made by developed countries to 'export' their wastes - especially the hazardous ones - to the developing world, is another danger - and sometimes reason of failure encountered in the field of Environmental Management. 692 pp. Englisch.
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Buch. Condición: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This volume comprises a selection of papers that were contributed to the 7th International Congress of Logic, Methodology and Philosophy of Science, which was held in Salzburg from the 11th - 16th July, 1983. There were 14 sections in this… congress: 1. proof theory and foundations of mathematics 2. model theory and its applica ti on 3. recursion theory and theory of computation 4. axiomatic set theory 5. philosophical logic 6. general methodology of science 7. foundations of probability and induction 8. foundations and philosophy of the physical sciences 9. foundati ons and phi 1 osophy of biology 10. foundations and philosophy of psychology foundations and philosophy 11. of the social sciences 12. foundati ons and philosophy of linguistics 13. history of logic, methodology and philosophy of science 14. fundamental principles of the ethics of science In each section, three or four invited addresses were given, which will be published in the Congress Proceedings (Ruth Barcan Marcus, Georg J. W. Dorn and Paul Weingartner, eds. : Logic, Metho dology and Philosophy of Science VII. Proceedings of the Seventh International Congress of Logic, Methodology and Philosophy of v PREFACE Science, Salzburg, 1983. - Amsterdam, New York, Oxford: North-Holland Publishing 'Company, 1985. ) Every section with the exception of section 14 also contained contributed papers. 732 pp. Englisch.
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Buch. Condición: Neu. This item is printed on demand - Print on Demand Titel. Neuware -This symposium is the third in a series featuring the propaga tion of higher plants through tissue culture. The first of these symposia, entitled 'A Bridge Between Research and Application,' was held at the University in 1978 and was published… by the Technical Information Center, Department of Energy. The second symposium, on 'Emerging Technologies and Strategies,' was held in 1980 and pub lished as a special issue of Environmental and Experimental Botany. One of the aims of these symposia was to examine the current state of-the-art in tissue culture technology and to relate this state of technology to practical, applied, and commercial interests. Thus, the third of this series on development and variation focused on embryogenesis in culture: how to recognize it, factors which affect embryogenesis, use of embryogenic systems, etc.; and variability from culture. A special session on woody species again emphasized somatic embryogenesis as a means of rapid propagation. This volume emphasizes tissue culture of forest trees. All of these areas, we feel, are breakthrough areas in which significant progress is expected in the next few years.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 412 pp. Englisch.
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EUR 213,99
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Buch. Condición: Neu. This item is printed on demand - Print on Demand Titel. Neuware -The importance of protecting the environment against pollution is an objective which gained international acceptance in the recent years. According to the first principle of the Declaration of the United Nations Conference on the Human Environ…ment which took place in Stockholm in 1972, 'man . bears a solemn responsibility to protect and improve the environment for present and future genera tions'. The United Nations again in their desire to improve the sanitation conditions allover the world decided to proclaim the period between 1981-1990 as the 'International Drinking Water Supply and Sanitation Decade.' Although attempts have been made by inter national organizations to prevent pollution, it is difficult to say that these attempts gave satisfactory results in developing countries. The most common reasons of failure are: a) To find solutions to their environmental problems, develop ing countries usually seek the assistance of engineers and scientists from developed countries. Many times, how ever, either out of ignorance of the local condition or due to financial motivations, these experts come out with solutions which are far from being considered as the 'most appropriate.' As a result, the basic objective of protecting the environment is not achieved. b) Attempts made by developed countries to 'export' their wastes - especially the hazardous ones - to the developing world, is another danger - and sometimes reason of failure encountered in the field of Environmental Management.Springer-Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 692 pp. Englisch.
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Buch. Condición: Neu. This item is printed on demand - Print on Demand Titel. Neuware -Prostaglandins, Leukotrienes, and Cancer is a multi-volume series that will focus on an emerging area of cancer research. In 1968, R.H. Williams first reported that elevated prostaglandin levels are present in human medullary car cinoma. Since… that time, the concept that arachidonic acid metabolites may be in volved in cancer has expanded to include every aspect of the disease from cell transformation through metastasis. Prostaglandins and leukotrienes are generic terms used to describe a family of bioactive lipids produced from unsaturated fatty acids (principally from arachidonic acid) via the cyclooxygenase and lipoxygenase pathways, respec tively. Cyclooxygenase products consist of diverse products such as prosta glandin E, (POE,), prostacyclin (POI2) and thromboxane A2 (TXA2), whereas lipoxygenase products consist of hydroperoxy fatty acids and mono-, di- and tri-hydroxy acids including leukotrienes. The precursor fatty acids for the cyclooxygenase and lip oxygenase pathways are present in cellular phospholipids. This finding established an important control point in their biosynthesis-the release of substrate. This occurs in response to numerous stimuli that act at the cell surface. Dr. Bengt Samuelsson's extensive study of the metabolism of pros taglandins indicated that they are rapidly inactivated on a single pass through pulmonary circulation. Thus, they cannot act as circulating hormones and appear to be made on demand in or in the vicinity of target tissues leading to the concept that prostaglandins are local hormones or autocoids.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 466 pp. Englisch.
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Buch. Condición: Neu. This item is printed on demand - Print on Demand Titel. Neuware -This volume comprises a selection of papers that were contributed to the 7th International Congress of Logic, Methodology and Philosophy of Science, which was held in Salzburg from the 11th - 16th July, 1983. There were 14 sections in this con…gress: 1. proof theory and foundations of mathematics 2. model theory and its applica ti on 3. recursion theory and theory of computation 4. axiomatic set theory 5. philosophical logic 6. general methodology of science 7. foundations of probability and induction 8. foundations and philosophy of the physical sciences 9. foundati ons and phi 1 osophy of biology 10. foundations and philosophy of psychology foundations and philosophy 11. of the social sciences 12. foundati ons and philosophy of linguistics 13. history of logic, methodology and philosophy of science 14. fundamental principles of the ethics of science In each section, three or four invited addresses were given, which will be published in the Congress Proceedings (Ruth Barcan Marcus, Georg J. W. Dorn and Paul Weingartner, eds. : Logic, Metho dology and Philosophy of Science VII. Proceedings of the Seventh International Congress of Logic, Methodology and Philosophy of v PREFACE Science, Salzburg, 1983. - Amsterdam, New York, Oxford: North-Holland Publishing 'Company, 1985. ) Every section with the exception of section 14 also contained contributed papers.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 732 pp. Englisch.
