Springer nature apr 2005 (23 resultados)

Buch. Condición: Neu. Neuware - A collection of cutting-edge techniques for studying ubiquitin-dependent protein degradation via the proteasome. The topics covered range broadly from basic biochemistry to cellular assays to discovery techniques using mass spectrometric analysis. These biochemical and cellular methods are necessary to explore the ubiquitin-proteasome system and ubiquitin-proteasome-dependent functions. State-of-the-art and user-friendly, Ubiquitin-Proteasome Protocols offers novice and experienced bench scientists alike a thorough compendium of readily reproducible techniques that will accelerate discovery, enhance productivity, and permit manipulation of the system for varied research purposes. The targeted addition of ubiquitin to proteins is now known to regulate many cellular events, with the enzymes involved in protein ubiquitination linked to a variety of clinical problems, such as cancer, heart disease, and immune dysfunction. In Ubiquitin-Proteasome Protocols, hands-on leaders in the field, many of whom originally developed the methods they describe, detail cutting-edge techniques for studying ubiquitin-dependent protein degradation via the proteasome. The topics covered range broadly from basic biochemistry to cellular assays to discovery techniques using mass spectrometric analysis. These biochemical and cellular methods are necessary to explore the ubiquitin-proteasome system and ubiquitin-proteasome- dependent functions. The protocols follow the successful Methods in Molecular Biology series format, each offering step-by-step laboratory instructions, an introduction outlining the principle behind the technique, lists of the necessary equipment and reagents, and tips on troubleshooting and avoiding known pitfalls. State-of-the-art and user-friendly, Ubiquitin-Proteasome Protocols offers novice and experienced bench scientists alike a thorough compendium of readily reproducible techniques that will accelerate discovery, enhance productivity, and permit manipulation of the system for varied research purposes.…

Buch. Condición: Neu. Neuware - The Encyclopedia of Adult Education is the first comprehensive reference work in this important and fast-growing field, and is an invaluable resource for adult educators who research and teach in the fields of higher education, work in community-based settings, or practise in public or private organizations. Its 170+ articles, written by an international team of contributors from over 17 countries, detail the research and practice of the field from its emergence as a separate discipline to the present day, covering key concepts, issues and individuals and providing a cutting-edge summary of ongoing debates across a wide range of perspectives, from self-directed learning to human resource development. Entries are arranged A-Z and extensive cross-referenced, with detailed bibliographies for each topic to facilitate further research.…

Taschenbuch. Condición: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -The time has come to open a lucid debate on the ways and means to make Europe better deliver democracy and sustainable growth. The Report on the State of the European Union examines the progress of European integration and focus on economic aspects of the process. This volume explores the themes of: democracy and legitimacy, convergence and cohesion, macroeconomic policies and social integration. the report is written in an accessible way and will be a useful resource for academics, students, policymakers, journalists, and government advisors. 268 pp. Englisch.…

Taschenbuch. Condición: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Morality, Moral Luck and Responsibility is a critical examination of our understanding of morality and responsibility through the questions raised by the problem of moral luck. The book considers two different approaches to moral luck, the Aristotelian vulnerability to factors outside the agent's control and the Kantian ambition to make morality immune to luck, and concludes that both approaches have more in common than previously thought. At the same time, it also considers recent developments in the field of virtue ethics and neo-kantianism. This book will appeal to anyone with an interest in normative theories and the fundamental questions surrounding moral responsibility and the attribution of praise and blame. 200 pp. Englisch.…

Buch. Condición: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Diplomatic Interventions argues that war is a social construction. In so doing, it unsettles the definition of intervention, as a coercive interference by one state in the affairs of another, to examine the range of communicative or 'diplomatic' practices which through their presence modify the experience of war. The tension between claims that war is pervasive and that war is a social construct is analysed in relation to a range of moral, legal, military, economic, cultural, and therapeutic interventions. The concluding chapter highlights how the book itself is a critical intervention that requires us look at again from a new angle at international practice. 221 pp. Englisch.…

Buch. Condición: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This volume assesses the implementation of the EU's cohesion policy and the role that the policy has in stimulating ten new member states from eastern and southern European countries to join the EU in 2004 and another three to four countries that will join in the near future. 215 pp. Englisch.…

Buch. Condición: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This book offers guidelines for the upcoming discussions on reform, representing an attempt to work out conceptions for a better international competition order on the basis of the scientific approach 'law and economics'. It presents the dominant concepts of competition policy as a basis for an international competition order and formulates a synthesis. The result is a new neo-ordoliberal approach. Anti-dumping-measures are analysed of the effects on international competition and resource allocation, and alternatives and improvements are suggested. From national forms of competition policy a synthesis of international competition policies are derived. Currently reforms of the international competition order are heavily discussed and here a selection of the most important suggestions are presented, compared, and evaluated. Finally, this book offers strategies that might serve as second-best solutions, and though they may not be optimal for competition policy, they are politically feasible and an improvement on the current competition regulations. They would be a back-up in case the WTO competition regulations aren't realizable. 151 pp. Englisch.…

Taschenbuch. Condición: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Diplomatic Interventions argues that war is a social construction. In so doing, it unsettles the definition of intervention, as a coercive interference by one state in the affairs of another, to examine the range of communicative or 'diplomatic' practices which through their presence modify the experience of war. The tension between claims that war is pervasive and that war is a social construct is analysed in relation to a range of moral, legal, military, economic, cultural, and therapeutic interventions. The concluding chapter highlights how the book itself is a critical intervention that requires us look at again from a new angle at international practice. 221 pp. Englisch.…

Buch. Condición: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This provocative and critical work addresses the question of why scientific realists and positivists consider experimental physics to be a natural and empirical science. Taking insights from contemporary science studies, continental philosophy, and the history of physics, this book describes and analyses the metaphysical presuppositions that underwrite the technological use of experimental apparatus and instruments to explore, model, and understand nature. By revealing this metaphysical foundation, the author questions whether experimental physics is a natural and empirical science at all. 252 pp. Englisch.…

Buch. Condición: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This book examines the issue of philosophical skepticism in the light of its relevance for the critique of modernity associated with the Frankfurt School. It situates the problem of skepticism in the context of the history of philosophy and explores its significance for the modern crisis of reason manifested in post-Kantian philosophy, which presaged the critical turn toward social theory. 182 pp. Englisch.…

Buch. Condición: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Over the past fifty years, the history and culture of the Byzantine empire has ceased to be the preserve of a few scholars and is now taught and debated in universities all over the world. This book provides an introduction to the source material and to the very best recent writing on the empire's political history (306-1453), its art, army, religion, literature and economy. Recent developments in gender studies and archaeology are also explored. The book will be of interest to university students and anyone interested in understanding the ongoing debates about this mysterious and perplexing yet fascinating society. 252 pp. Englisch.…

Buch. Condición: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Morality, Moral Luck and Responsibility is a critical examination of our understanding of morality and responsibility through the questions raised by the problem of moral luck. The book considers two different approaches to moral luck, the Aristotelian vulnerability to factors outside the agent's control and the Kantian ambition to make morality immune to luck, and concludes that both approaches have more in common than previously thought. At the same time, it also considers recent developments in the field of virtue ethics and neo-kantianism. This book will appeal to anyone with an interest in normative theories and the fundamental questions surrounding moral responsibility and the attribution of praise and blame. 200 pp. Englisch.…

Buch. Condición: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Making Women Martyrs in Tudor England examines the portrayal of Protestant women martyrs in Tudor martyrology, focusing mainly on John Foxe's Book of Martyrs . Foxe's women martyrs often defy not just ecclesiastically and politically powerful men; they often defy their husbands by chastising them, disobeying them, and even leaving them altogether. While by marrying his female martyrs to Christ Foxe mitigates their subversion of patriarchy, under his pen his heroic women challenge the foundations of social and political order, offering an accessible model for resistance to antichristian rule. 239 pp. Englisch.…

Taschenbuch. Condición: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Palgrave Advances in Development Studies aims to provide readers with an understanding of the disparate theories concerning development, their assumptions and the intellectual forces underpinning them. In thirteen specially commissioned essays, leading contributors from the field of Development Studies present the relevant material to analyze and evaluate current debates about development, together with the intellectual tools to judge contemporary arguments concerning development across the world and the ability to relate theories of development to contemporary policy issues. 357 pp. Englisch. …

Buch. Condición: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -A 'non-election' in terms of popular perception, the 2004 European elections in the United Kingdom nevertheless provided a fascinating snapshot of the new, far more fluid electoral trends that have been emerging since the end of the Thatcher era, with Green, Eurosceptical, regional and single issue parties all jostling for electoral space with the bigger three. Like its predecessors, this book documents the background, framework and party preparations; recounts how the campaign unfolded; analyses the results and explores the consequences of the elections in both the British and the European context. 230 pp. Englisch.…

Buch. Condición: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Shelley and Vitality reassesses Percy Shelley's engagement with early nineteenth-century science and medicine, specifically his knowledge and use of theories on the nature of life presented in the debate between surgeons John Abernethy and William Lawrence. Sharon Ruston offers new biographical information to link Shelley to a medical circle and explores the ways in which Shelley exploits the language and ideas of vitality. Major canonical works are reconsidered to address Shelley's politicised understanding of contemporary scientific discourse. 231 pp. Englisch.…

Buch. Condición: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -In a time when racism is on the rise as a source of conflict and social justice has been increasingly demanded by the civic society, this collection stands as a timely reminder that to ignore the racial factor in the globalization forces is as mistaken as eliminating class analysis. The essays published here supplement the literature of comparative race relations from the standpoint of the theory of institutional racism and its effect on public policies such as immigration, citizenship, security and policing. 308 pp. Englisch.…

Buch. Condición: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -From various angles and perspectives this book shows how knowledge management is actually practised in many different European firms. New dimensions of well-known management principles and concepts emerge by focusing on knowledge. Leading researchers and experts from European business schools offer new insight into the range of practical problems that can be addressed and methods that can be applied when knowledge is put on the management agenda. 258 pp. Englisch.…

Buch. Condición: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Western societies are becoming increasingly complex and challenging to govern, yet the modern state continues to play a central role in governance. This book presents a detailed analysis of the challenges confronting the contemporary state and the processes through which the state addresses those challenges. The notion of 'governing without government' is critiqued; instead, Pierre and Peters argue that what is happening a more a matter of state transformation than state decline. 158 pp. Englisch.…

Buch. Condición: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Accident and emergency departments are the doorway to the hospital for acutely ill and injured patients. Whereas casualty departments have existed for over 150 years, they were often poorly staffed and managed. This book describes the fight to create a new medical specialty of accident and emergency medicine against much opposition from established specialties. The specialty was first recognised in 1972. The book also charts the major developments that occurred in the first 30 years of the specialty. 183 pp. Englisch.…

Buch. Condición: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -According to Vygotsky (1986), The decreasing vocalization of egocentric speech denotes a developing abstraction from sound, the child's new faculty to 'think words' instead of pronouncing them. This is the positive meaning of the sinking coefficient of egocentric speech. The downward curve indicates development toward inner speech, (p. 230) The purpose of this volume is to explore the faculty to 'think words,' not as the ability to mentally evoke words in the native (or first) language (LI) but as the faculty 1 to conjure up in the mind words in a second language (L2). To think words rather than to pronounce them is possible through inner speech, a function that humans develop in the course of childhood as they internalize the speech of the social group among which they grow. This means internalizing and being able to conduct inner speech in a particular linguistic code, the LI. But humans, at a very early or more mature age, may also come into contact and interact verbally with speakers of other languages, in classrooms or natural settings. The possibility thus emerges of internalizing an L2 in such a way that inner speech in the L2 might evolve. In this book, it is argued that, given certain conditions of L2 learning, it is possible for learners to attain inner speech in the L2. This book examines the distinctive nature of L2 inner speech and the processes that engender it and characterize its development. 252 pp. Englisch.…

Buch. Condición: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -The varied cultural functions of dress, textiles, and clothwork are used in this collection of essays to examine long-standing assumptions about the Middle Ages. At one end of the spectrum, questions of dress call up feminist theoretical investigations into the body and subjectivity, while broadening those inquiries to include theories of masculinity and queer identity as well. At the other extreme, the production and distribution of textiles carries us into the domain of economic history and the study of material commodities, trade and cultural patterns of exchange within western Europe and between east and west. Contributors to this volume represent a broad array of disciplines currently involved in rethinking medieval culture in terms of the material world. 279 pp. Englisch.…

Buch. Condición: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Practical quantum computing still seems more than a decade away, and researchers have not even identified what the best physical implementation of a quantum bit will be. There is a real need in the scientific literature for a dialogue on the topic of lessons learned and looming roadblocks. This reprint from Quantum Information Processing is dedicated to the experimental aspects of quantum computing and includes articles that 1) highlight the lessons learned over the last 10 years, and 2) outline the challenges over the next 10 years. The special issue includes a series of invited articles that discuss the most promising physical implementations of quantum computing. The invited articles were to draw grand conclusions about the past and speculate about the future, not just report results from the present. 308 pp. Englisch.…