Humana press 2009 (195 resultados)

Hardcover/Pappeinband. Condición: Sehr gut. 356 p. Very good. Shrink wrapped. / Sehr guter Zustand. In Folie verschweißt. Sprache: Englisch Gewicht in Gramm: 1390.

8vo, 375pp. A very good hardback copy.

hardcover. Condición: Very Good. Humana Press, c.2009, 8vo., glossy boards, 396pp., owner's name, ow NF $.

Buch. Condición: Neu. Neuware - In the dramatic and rapidly developing field of neural transplantation for CNS repair, the most powerful contributor has been the vital research focusing on stem cells. In Neural Cell Transplantation: Methods and Protocols, leading experts in the field examine tried-and-true laboratory techniques in order to supply scientists with a firm foundation upon which further advancements can be based. Written in the highly successful Methods in Molecular Biology(TM) series format, the chapters of this volume include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and Notes sections, which examine tips on troubleshooting and avoiding known pitfalls.Cutting-edge and easy to use, Neural Cell Transplantation: Methods and Protocols provides the most thorough and essential protocols that will allow new generations of neuroscientists to enter and contribute to this uniquely inspiring field.…

Buch. Condición: Neu. Neuware - With its complex anatomical, molecular, electrophysiological and behavioral components, epilepsy provides the neuroscientist with nearly boundless opportunities to examine basic neurobiological mechanisms. In Animal Models of Epilepsy: Methods and Innovations, prominent investigators in the field examine several novel models of epilepsy in mice as well as in genetically tractable 'simple' species such as Drosophila melanogaster (fruit flies), Caenorhabditis elegans (worms), Xenopus laevis (tadpoles) and Danio rerio (zebrafish). While covering some traditional models, the volume also explores the newest innovations like modeling seizure activity in silica and advanced strategies for seizure detection and gene therapy. As a volume in the successful Neuromethods(TM) series, the chapters provide clear, step-by-step protocols and thought-provoking reviews of the most recent advancements in the field.Comprehensive and cutting-edge, Animal Models of Epilepsy: Methods and Innovations is an ideal guide for scientists who wish to expand our understanding of the pathogenesis of this neurological disorder. …

Buch. Condición: Neu. Neuware - DNA microarray technology has revolutionized research in the past decade. Initially an application for mRNA expression studies, the technology now has spread to other applications such as comparative genomic hybridization, SNP and mutation analysis. In DNA Microarrays for Biomedical Research: Methods and Protocols, experts explore these now commonly used applications, addressing probe design strategies, fabrication issues and providing practical examples of detailed methods for generation of high quality DNA microarray data. Chapters incorporate information on some of the largest providers of microarray, including Affymetrix, Ilumina and Agilent, and their use on a variety of applications. Composed in the highly successful Methods in Molecular Biology series format, each chapter contains a brief introduction, step-by-step methods, a list of necessary materials, and a Notes section which shares tips on troubleshooting and avoiding known pitfalls.Authoritative and highly practical, DNA Microarrays for Biomedical Research: Methods and Protocols presents a variety of protocols which can be easily reproduced, allowing researchers to gain surprising insight into the complex world of DNA microarray technology.…

Taschenbuch. Condición: Neu. Neuware - Imaging of the airways is a fascinating undertaking and, if done expertly, a true art in medicine. Over the past years, imaging of the airways has become ever more exciting and demanding, as new therapies in pulmonary medicine have become available that require careful imaging assessment of patients to aid management and monitor therapeutic success. The increasing importance of imaging in pulmonary medicine is accompanied by a surge of revolutionary developments in imaging technology that enable ever finer assessment of lung structure and function. No modality has seen more rapid innovation over the last decade than computed tomography. Current multidetector-row CT technology makes high-resolution imaging of the chest with a spatial resolution of a couple of 100 m in a matter of mere seconds. Ever more sophisticated post-processing applications enable intuitive, quantitative assessment of lung structure and function in an efficient manner, so that these technologies are increasingly embraced in mainstream medicine to improve patient care. CT of the Airways, which was so expertly assembled by my dear friends Phil Boiselle and David Lynch, is one of the very first tomes that pays tribute to our new found prowess in airway imaging.…

Buch. Condición: Neu. Neuware - The transfer of hereditary information from genes to proteins is one of the essential pr- esses in all living organisms on our planet. Some genes are expressed without modu- tion throughout the life of a cell, while many others require various degrees of control to precisely balance cellular metabolism with environmental conditions. For many years, researchers attributed this regulatory function to protein molecules, which can direct gene expression at multiple levels, in response to various input signals, and with different degrees of selectivity. Even when the control of gene expression was achieved via direct interactions between proteins and mRNAs, the active role was routinely assigned to p- teins, while RNAs were considered merely as recipient molecules. The discovery of RNA interference and multiple bacterial regulatory RNAs caused a shift from the perception of proteins as the predominant regulators of gene expression to the acknowledgement of the importance of RNAs in many regulatory circuits. Such a viewpoint received strong support several years ago after the discovery of riboswitches and related RNA sensors - mRNA regions capable of alternating their conformations in response to the presence of cellular metabolites and other physical or chemical cues. These classes of RNA pass on cellular and environmental information directly to transcription or translation machinery without the assistance of proteins. The riboswitches are commonly defined as evolutionarily conserved mRNA regions capable of specific binding to metabolite molecules, and, as a result, adopting a particular RNA conformation that modulates gene expression.…

Buch. Condición: Neu. Neuware - Given the popularity and utility of Saccharomyces cerevisiae, yeast-based functional genomics and proteomics technologies, developed over the past decade, have contributed greatly to our understanding of bacterial, yeast, fly, worm and human gene functions. In Yeast Functional Genomics and Proteomics: Methods and Protocols, experts in the field contribute stand-alone protocols suitable for daily use in research laboratories. The volume examines methods from the most major and fundamental techniques to more cutting-edge, advanced concepts. As part of the highly successful Methods in Molecular Biology(TM) series, the chapters are clearly formatted with introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and notes on troubleshooting and avoiding known pitfalls.Authoritative and easy to use, Yeast Functional Genomics and Proteomics: Methods and Protocols is an ideal reference for both yeast researchers and those who wish to use yeast as a model system for the further study of functional genomics and proteomics.…

Buch. Condición: Neu. Neuware - Given the versatile utility of the determinination of epitopes, beneficial to a wide variety of scientists from immunologists to structural biologists to biotechnologists, the need for a thorough, state-of-the-art collection of experimental protocols is clear. In Epitope Mapping Protocols, Second Edition, expert contributors from a broad spectrum of scientific backgrounds update and expand the successful first edition with cutting-edge techniques and applications, including approaches to both antibody or B-cell epitope mapping and T-cell epitope mapping as well as a new section on the profiling of antibody signatures in biological fluids. Written in the popular Methods in Molecular Biology(TM) series format, chapters include brief introductions to the topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and Notes sections, which highlight tips on troubleshooting and avoiding known pitfalls.Comprehensive and up-to-date, Epitope Mapping Protocols, Second Edition is a reliable and valuable reference for all those who wish to understand and further investigate the diversifying field of epitope mapping.…

Kombiprodukt. Condición: Neu. Neuware - Each generation in a sexually reproducing organism such as a fly or a mouse passes through the bottleneck of meiosis, which is the specialized cell division that gives rise to haploid reproductive cells (sperm, eggs, spores, etc. ). The principal function of meiosis is to reduce the genome complement by half, which is accomplished through sequential execution of one round of DNA replication followed by two rounds of chromosome segregation. Within the extended prophase between DNA replication and the first meiotic division in most organisms, homologous maternal and paternal chromosomes pair with one another and undergo homologous recombination, which establishes physical connections that link the homologous chromosomes until the time they are separated at anaphase I. Recombination also serves to increase genetic diversity from one generation to the next by breaking up linkage groups. The unique chromosome dynamics of meiosis have fascinated scientists for well over a century, but in recent years there has been an explosion of new information about how meiotic chromosomes pair, recombine, and are segregated. Progress has been driven by advances in three main areas: (1) genetic identification of meiosis-defective mutants and cloning of the genes involved; (2) development of direct physical assays for DNA intermediates and products of recombination; and (3) increasingly sophisticated cy- logical methods that describe chromosome behaviors and the spatial and temporal patterns by which specific proteins associate with meiotic chromosomes.…

Buch. Condición: Neu. Neuware - As increasing global population and continuing economic development ensure the need for further production and cultivation of maize, the necessity of the application of transgenic technology to this model species and crop plant grows steadily. In Transgenic Maize: Methods and Protocols, experts in the various disciplines of the field contribute readily reproducible protocols covering such topics as transformation methods, transgenic maize in research, the analysis of transgenic plants, and breeding with transgenes. Written in the highly successful Methods in Molecular Biology(TM) series format, the chapters present brief introductions to their respective topics, lists of the necessary materials and reagents, step-by-step laboratory protocols, and notes on troubleshooting and avoiding known pitfalls.Cutting-edge and easy to use, Transgenic Maize: Methods and Protocols will greatly aid researchers wishing to use these procedures in their own laboratories, and will provide readers with a better understanding of the experiments being performed by cooperators or fee-for-service labs. …

Buch. Condición: Neu. Neuware - Within the last decade there have been a number of new and important areas of emphasis in HIV care and research, particularly in the context of brain involvement. Without question, clinical and research innovations in the modern era of the HIV pandemic warrant an update on HIV and the brain. Written by a panel of leading experts, HIV and the Brain: New Challenges in the Modern Era offers a clear picture of brain impairment associated with the virus with particular focus on three emerging areas including different genetic strains of the virus throughout the world, interactions between advanced age and HIV, and the impact of HIV on the brain in the context of chronic, long-term treatment with highly active antiretroviral therapy (HAART). HIV and the Brain: New Challenges in the Modern Era provides a comprehensive review of both basic science and clinical implications in these important areas of the disease. The text is of particular relevance to both research scientists and clinicians involved in HIV in the modern era.…

Buch. Condición: Neu. Neuware - Infertility is a widespread medical condition. As new technologies emerge, the rate at which our understanding of reproductive medicine grows can be overwhelming. The Biennial Review of Infertility provides the most up to date advances, ideas, and controversies together in one volume. Due to the distinctive nature of infertility, a panel of well-respected experts strives to present each chapter in a clear manner, specifically focused on evidence-based medicine. The Biennial Review of Infertility presents a balanced view of clinically relevant existing information for the evolving areas. Created to provide an ongoing appraisal of current knowledge, the Biennial Review of Infertility motivates communication amongst all those working to help couples resolve their infertility.…

Buch. Condición: Neu. Neuware - Functional selectivity refers to the ability of different ligands acting at one receptor subtype to activate multiple signaling pathways in unique combinations; that is, one drug can be an agonist at pathway A and an antagonist or partial agonist at pathway B, and another drug can have the reverse profile. Functional selectivity has profound implications for drug development, for chemical biology, and for the design of experiments to characterize receptor function. In Functional Selectivity of G Protein-Coupled Receptors expert neuroscientists and pharmacologists review the work that demonstrated the existence of functional selectivity, placed it within a theoretical framework, and provided a mechanistic basis for the phenomenon. This exciting, comprehensive, and future-oriented volume includes chapters that focus on theoretical and mechanistic aspects of functional selectivity and that cut across subfamilies of GPCRs. Additional chapters focus on subfamilies of therapeutically relevant receptors where there is considerable evidence of ligand functional selectivity. Accessible and authoritative, Functional Selectivity of G Protein-Coupled Receptors is a valuable educational tool and reference source for students and scientists interested in drug development, chemical biology, and GPCR function.…

Buch. Condición: Neu. Neuware - In the first volume, Fundamental Concepts in Biophysics, the authors lay down a foundation for biophysics study. Rajiv Singh opens the book by pointing to the central importance of 'Mathematical Methods in Biophysics'. William Fink follows with a discussion on 'Quantum Mechanics Basic to Biophysical Methods'. Together, these two chapters establish some of the principles of mathematical physics underlying many biophysics techniques. Because computer modeling forms an intricate part of biophysics research, Subhadip Raychaudhuri and colleagues introduce the use of computer modeling in 'Computational Modeling of Receptor-Ligand Binding and Cellular Signaling Processes'. Yin Yeh and coworkers bring to the reader's attention the physical basis underlying the common use of fluorescence spectroscopy in biomedical research in their chapter 'Fluorescence Spectroscopy'. Electrophysiologists have also applied biophysics techniques in the study of membrane proteins, and Tsung-Yu Chen et al. explore stochastic processes of ion transport in their 'Electrophysiological Measurements of Membrane Proteins'. Michael Saxton takes up a key biophysics question about particle distribution and behavior in systems with spatial or temporal inhomogeneity in his chapter 'Single-Particle Tracking'. Finally, in 'NMR Measurement of Biomolecule Diffusion', Thomas Jue explains how magnetic resonance techniques can map biomolecule diffusion in the cell to a theory of respiratory control. This book thus launches the Handbook of Modern Biophysics series and sets up for the reader some of the fundamental concepts underpinning the biophysics issues to be presented in future volumes.…

Buch. Condición: Neu. Neuware - In addition to their invaluable role in the fight against infection, Toll-Like Receptors (TLRs) in an under- or over-active state can lead to the pathogenesis of disease, making these receptors a key focal point for many research laboratories. In Toll-Like Receptors: Methods and Protocols, experts in the field contribute techniques currently used to study TLRs, their downstream signalling pathways, and their role in the pathogenesis of disease, with sections examining TLR expression and the application of genetic techniques and microarray analysis to TLR research. Written in the highly successful Methods in Molecular Biology(TM) series format, chapters include brief introductions to the topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and Notes sections highlighting tips on troubleshooting and avoiding known pitfalls.Versatile and cutting-edge, Toll-Like Receptors: Methods and Protocols provides an ideal manual for a wide range of biologists and medical researchers studying these vital components of the immune system. …

Buch. Condición: Neu. Neuware - Despite various difficulties, the field of gene therapy, particularly with regard to cancer, has accumulated a tremendous amount of vital pre-clinical and clinical data. 'Gene Therapy of Cancer: Methods and Protocols, Second Edition' fully updates the first edition with expert coverage of established and novel protocols involving both experimental and clinical approaches to cancer gene therapy. This state-of-the-art volume contains overviews of new concepts and strategies with chapters on regulatory and ethical issues, developments, problems and possible limitations of design and production of gene therapeutics as well as translational issues. Written in the highly successful Methods in Molecular Biology(TM) series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and notes on troubleshooting and avoiding known pitfalls.Cutting edge and authoritative, 'Gene Therapy of Cancer: Methods and Protocols, Second Edition' is an ideal guide for all those who wish to explore the fast-paced and critical study of nonviral, viral, experimental and clinical cancer gene therapy.…

Buch. Condición: Neu. Neuware - The striatum is the principal input structure of the basal ganglia. Numerically, the great majority of neurons in the striatum are spiny projection neurons, which produce the inhibitory output of the striatum to the globus pallidum and substantia nigra. The major glutamatergic afferents to the striatum from the cerebral cortex make monosynaptic contact with spiny projection neurons. The dopaminergic afferents from the substantia nigra also synapse directly on the spiny projection neurons. Thus, the spiny projection neurons play a crucial role in the input-output operations of the striatum by integrating glutamatergic cortical inputs with dopaminergic inputs and producing the output to other basal ganglia nuclei. Anatomical observations made nearly 30 years ago suggested that inhibitory interactions among the spiny projection neurons of the striatum are very pr- able. Individual spiny projection neurons produce a local axonal plexus in the spheroidal space occupied by their own dendritic trees [1, 2]. Based on the GABAergic nature of these neurons and their synaptic contacts with other spiny neurons, several authors have proposed that the spiny projection neurons form a lateral inhibition type of neural network [3-5]. In the idealised concept of lateral inhibition, each output neuron makes inhibitory synaptic contact with its neighbours [5]. However, there are physical limitations set by the extent of axonal and dendritic trees, and the number of synaptic sites, which mean that lateral inhibition is limited to a local domain of inhibition.…

Hardcover. Condición: New. Brand new book, sourced directly from publisher. Dispatch time is 24-48 hours from our warehouse. Book will be sent in robust, secure packaging to ensure it reaches you securely.

Buch. Condición: Neu. Neuware - This is the second edition of the comprehensive, concise summary of apoptosis research. It covers the major concepts, molecular architecture, the biochemical pathways, and pathophysiological significance of apoptosis. This book provides a guideline of standard biochemical and cell biologic approaches to apoptosis bench work with an emphasis on translational clinical applications for immune disorders, cancer research, ischemia, and neuronal degeneration. Since the original publication in 2003, the apoptosis field has expanded rapidly - chapters not only need to be revised and expanded, but there is a need for all new chapters covering exciting advances in bioinformatics, systems biology, oxidative stress, etc.…

Buch. Condición: Neu. Neuware - Cancers of the central nervous system are among the most lethal of human neoplasms. They are recalcitrant to even intensive multimodality therapies that include surgery, radiotherapy, and chemotherapy. Moreover, especially in children, the consequences of these therapies can itself be devastating and involve serious cognitive and developmental disorders. It is small wonder that such cancers have come under the intense scrutiny of each of the subspecialties of clinical care and investigation as well as attracting some of the best basic research scientists. Their joint efforts are gradually peeling away the mysteries surrounding the genesis and progression of these tumors and inroads are being steadily made into understanding why they resist therapies. This makes it an especially opportune time to assemble some of the best investigators in the field to review the ''state of the art'' in the various arenas that comprise the assault on CNS tumors. The breadth of this effort by the clinical and basic neuro-oncology community is quite simply amazing. To a large extent, it evolves from the knowledge of the human genome and its regulation that has been hard won over the past two decades.…

Buch. Condición: Neu. Neuware - Computational systems biology is the term that we use to describe computational methods to identify, infer, model, and store relationships between the molecules, pathways, and cells (''systems'') involved in a living organism. Based on this definition, the field of computational systems biology has been in existence for some time. However, the recent confluence of high-throughput methodology for biological data gathering,genome-scalesequencing,andcomputationalprocessingpowerhasdrivena reinvention and expansion of this field. The expansions include not only modeling of small metabolic (1-3) and signaling systems (2, 4) but also modeling of the relati- ships between biological components in very large systems, including whole cells and organisms (5-15). Generally, these models provide a general overview of one or more aspects of these systems and leave the determination of details to experimentalists focused on smaller subsystems. The promise of such approaches is that they will elucidate patterns, relationships, and general features, which are not evident from examining specific components or subsystems. These predictions are either interesting in and of themselves (e. g. , the identification of an evolutionary pattern) or interesting andvaluabletoresearchersworkingonaparticularproblem(e. g. ,highlightapreviously unknown functional pathway). Two events have occurred to bring the field of computational systems biology to theforefront. Oneistheadventofhigh-throughputmethodsthathavegeneratedlarge amounts of information about particular systems in the form of genetic studies, gene and protein expression analyses and metabolomics. With such tools, research to c- sidersystemsasawholearebeingconceived,planned,andimplementedexperimentally on an ever more frequent andwider scale.…

Buch. Condición: Neu. Neuware - According to the most recent clinical oncology data, one out of seven newly diagnosed malignancies worldwide result from infection and chronic inflammation in conjunction with cancer. In Inflammation and Cancer: Methods and Protocols, expert researchers deliver a systematic guide to techniques addressing various aspects of experimental cancer biology, selectively focused on inflammation-mediated tumorigenesis, while promoting improvisations on a per-case basis. Volume 2, Molecular Analysis and Pathways is devoted to an extensive description of experimental strategies aimed at investigating the molecular cross-talks between components of cell signaling chains and their ramifications in diagnostic development and drug target discovery. Written in the highly successful Methods in Molecular Biology(TM) series format, chapters include brief introductions to their subjects, lists of the necessary materials and reagents, step-by-step laboratory protocols, and a notes section, which examines tips on troubleshooting and avoiding known pitfalls.Comprehensive and cutting-edge, Inflammation and Cancer: Methods and Protocols promises to serve as a vital guide and resource for investigators and clinicians working toward the goal of combatting the estimated 2, 200 inflammation-related oncogenesis fatalities occurring every day.…

Kombiprodukt. Condición: Neu. Neuware - Bone densitometry (BD) is an extraordinary clinical tool. It provides a safe, non-invasive window to the skeleton. Through that window, a physician can obtain vital clinical information that enhances diagnosis and improves patient management. Further, much has changed in the last decade to make bone densitometry the especially fascinating field of medicine it is today, incorporating imaging, physics, quantitative analysis, statistics, and computer technology -- all applied in the diagnosis and management of osteoporosis.No text details the state-of-the-art and value of densitometry better than Bone Densitometry in Clinical Practice: Applications and Interpretation, Third Edition. Written by renowned expert Sydney Lou Bonnick, MD, this edition improves remarkably on her highly regarded previous volumes, with a significant update and expansion of material. New chapters reflect densitometry's growing applications as well as the evolving needs of the densitometrist. New material on radiation safety and assessment for secondary causes of bone fragility is included, and the text also incorporates material from the recent ISCD Position Development Conferences (PDC's), both the 4th adult and the 1st pediatric. Moreover, an entire appendix devoted to the PDCs has been added, providing solutions to many unanswered questions concerning bone densitometry applications.Comprehensive and invaluable, Bone Densitometry in Clinical Practice: Application and Interpretation, Third Edition offers all primary care physicians and specialists the ideal reference for practicing state-of-the-art bone densitometry and caring for patients with, or at risk for, osteoporosis.…

Buch. Condición: Neu. Neuware - Since the publication of the bestselling second edition of John Walker's widely acclaimed Protein Protocols Handbook, there have been continual methodological developments in the field of protein chemistry. This greatly enhanced third edition introduces 57 critically important new chapters, as well as significantly updating the previous edition's tried-and-true methods. Although the timely new chapters are spread throughout all of the book, the vital section on post-translational modifications has been expanded most to reflect the increasing importance of these modifications in the understanding of protein function. Each readily reproducible method follows the highly praised format of the Methods in Molecular Biology(TM) series, offering a concise summary of its basic theory, a complete materials list, a step-by-step protocol for its successful execution, and extensive notes on avoiding pitfalls, or on modifying the method to function within your own experimental circumstances. The expert authors of each chapter have demonstrated a hands-on mastery of the methods described, fine-tuned here for optimal productivity.Comprehensive, cutting-edge, and highly practical, The Protein Protocols Handbook, Third Edition is today's indispensable benchtop manual and guide, not only for all those new to the protein chemistry laboratory, but also for those established workers seeking to broaden their armamentarium of techniques in the urgent search for rapid and robust results.…

XXXIII, (1), 399 pp. Publisher's hard cover. A fine copy. (Curren Clinical Psychiatry.).

Buch. Condición: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Charisma is a widely used term in contemporary western culture, referring to a special innate quality of certain individuals. Yet 'charisma' has meant different things since the word was first used in the first century. This book traces the history of charisma - and the various meanings assigned to it from the first century to the twenty-first. The early chapters of the book chart the origin of charisma as a Christian concept meaning 'spiritual gift'. The second half of the book follows the re-invention of charisma as a form of authority by the sociologist Max Weber in the early twentieth century, and the ways in which Weber's concept of charisma has been popularised and adapted. The relationship between charisma and celebrity is closely examined. The book concludes with a study of the 2008 US Presidential campaign, in which Barack Obama was frequently described as a charismatic political candidate. This book explores the shifting cultural role of charisma over two millennia, paying close attention to the relationship between the religious and secular meanings of the term. It considers how much of the word's original religious meaning persists in the contemporary secular understanding of charisma. This book traces the history of charisma, and its various meanings, from its first-century origins in Christian theology to its manifestations in twenty-first century politics and culture 265 pp. Englisch.…

Buch. Condición: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This collection of peace education efforts in conflict and post-conflict societies brings together an international group of scholars to offer the very latest theoretical and pedagogical developments. Rather than focus on ad hoc peace education efforts this book investigates the need for long term, systemic approaches and innovative pedagogies. 274 pp. Englisch.…

Buch. Condición: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This is an illuminating discussion of guilt, fear, violence and aesthetics from a global perspective. Herlinghaus evaluates new Latin American novels, films and music through the lens of some of Walter Benjamin's controversial writings on violence and religion. 258 pp. Englisch.…