Humana jan 1998 (12 resultados)

Buch. Condición: Neu. Neuware - 1 Introduction to G-Protein-Coupled Signal Transduction and Human Disease.- 2 Albright Hereditary Osteodystrophy, Pseudohypopara-thyroidism, and Gs Deficiency.- 3 Gas-Activating Mutations: A Cause of Acromegaly, Thyroid Adenomas, Fibrous Dysplasia, and the McCune-Albright Syndrome.- 4 Ulcerative Colitis in Mice Lacking G i2.- 5 G Proteins Regulating Insulin Action and Obesity: Analysis by Conditional, Targeted Expression of Antisense RNA in vivo.- 6 G;12- and G 3- Subunits of Heterotrimeric G Proteins : A Novel Family of Oncogenes.- 7 Hypo- and Hyperthyroidism Caused by Mutations of the TSH Receptor.- 8 Disorders Caused by Mutations of the Lutropin/ Choriogonadotropin Receptor Gene.- 9 Inactivating and Activating Mutations of the FSH Receptor Gene.- 10 Nephrogenic Diabetes Insipidus and Vasopressin Receptor Mutations.- 11 Disorders with Increased or Decreased Responsiveness to Extracellular Ca2+ Owing to Mutations in the Ca2+0-Sensing Receptor.- 12 Constitutively Active PTH/PTHrP Receptors Cause Jansen's Metaphyseal Chondrodysplasia.- 13 Mutation of the Growth Hormone-Releasing Hormone Receptor in the little Mouse.- 14 Functional Variants of the MSH Receptor (MC1-R), Agouti, and Their Effects on Mammalian Pigmentation.- 15 ACTH Resistance Syndromes.- 16 Altering Adrenergic Signaling and Cardiac Function in Transgenic Mice.- 17 Dopamine Receptors in Human Disease: Lessons from Targeted Mouse Mutants.- 18 The 3-Adrenergic Receptor and Susceptibility to Obesity, the Insulin Resistance Syndrome, and Noninsulin-Dependent Diabetes Mellitus.…

Buch. Condición: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -The invention of the polymerase chain reaction (PCR) eventually earned Kary B. Mullis half of the 1993 Nobel Prize for Chemistry (1 4). However, for several years, issues of quality control and reproducibility interfered with attempts at commercial or clinical application of PCR. More recently, persistent work and numerous methodological inno- tions and refinements have resulted in the establishment of PCR as a routine, sensitive, and specific detection method in hospital and agricultural labora- ries. This transformation of PCR from an experimental research technique to an established bioassay tool formed the impetus behind PCR in Bioanalysis. PCR has proven particularly valuable in clinical microbiology and the diagnosis of infectious diseases in humans and animals. This large and diverse group of applications is reviewed in Chapter 1 by Gorm Lisby. S- cific organisms now detectable by PCR include hepatitis C virus (protocols presented in Chapter 14), Mycobacterium tuberculosis (Chapter 18), Chla- dia and Trichomonas species (Chapter 20), Toxoplasma gondii (Chapter 17), Legionella species (Chapter 15), enterotoxigenic Escherichia coli (Chapters 9 and 10), HIV-1 subspecies (Chapter 8), bovine immunodeficiency-like virus (Chapter 6), rodent parvoviruses (Chapter 2), Ross River virus (Chapter 12), and porcine reproductive and respiratory syndrome virus (Chapter 7). 300 pp. Englisch.…

Taschenbuch. Condición: Neu. This item is printed on demand - Print on Demand Titel. Neuware -This book is a self-teaching guide to the SPSS for Windows computer package. 'It is designed to be used hand-in-hand with The New Statistical Analysis of Data by T. W. Anderson and Jeremy D. Finn, although it may be used as a stand-alone manual as well. This guide is very easy to follow since all procedures are outlined in a straightforward, step-by-step format. Because of its self-instructional nature, the beginning student can learn to analyze statistical data with SPSS without outside assistance. The reader is 'walked through' numerous examples that illustrate how to use the SPSS package. The results produced by SPSS are shown and discussed in each application. The data sets used in the examples are primarily those in the Anderson-Finn textbook. To the extent that SPSS performs the procedures in the Anderson-Finn text, this manual follows the book chapter-by-chapter. Except for Chapter 1, the section titles in the manual correspond to sections in the textbook. Each chapter demonstrates the statistical procedures described in the textbook and gives exercises that can be performed for further practice. (An instructor may choose to use these as additional class assignments. ) This manual was created using SPSS for Windows, Version 6. 1, on an IBM-compatible personal computer. There are other versions available, including: Version 7. 0 for Windows 95, Version 6. 1 for Macintosh, and Version 6. 1 for Power Macintosh.Springer-Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 216 pp. Englisch.…

Buch. Condición: Neu. This item is printed on demand - Print on Demand Titel. Neuware -Application of Nucleic Acid Amplification in Clinical Microbiology.- Detection of Rodent Parvoviruses by PCR.- The SURF Technique.- Prenatal and Presymptomatic Diagnosis of Marfan Syndrome Using Fluorescence PCR and an Automated Sequencer.- Measurement of TNF and iNOS mRNA Using cDNA-Equalized Reverse Transcriptase PCR.- PCR Diagnosis of the Bovine Immunodeficiency-Like Virus.- PCR Analysis for the Identification of Porcine Reproductive and Respiratory Syndrome Virus in Boar Semen.- Quantitative and Discriminative Detection of Individual HIV-1 mRNA Subspecies by an RNase Mapping Assay.- Detection of the Heat-Labile Toxin Coding Gene (LT-Gene) of Enterotoxigenic Escherichia coli.- Motif-Dependent Polymerase Chain Reaction (PCR).- In Vitro Transcription/Translation Analysis for the Identification of Translation-Terminating Mutations.- A Single-Tube Nested RT-PCR for the Detection of Ross River Virus.- Application of PCR to Transgenic Plants.- Detection of Hepatitis C Virus RNA by Semiquantitative Reverse-Transcription PCR.- Detection of Legionella Species in Bronchial Fluid by PCR.- Quantitative Measurement of mRNA Expression by Competitive RT-PCR.- PCR Detection of Toxoplasma gondii in Human Fetal Tissues.- Rapid Diagnosis of Pulmonary Tuberculosis Using Roche AMPLICOR(TM)Mycobacterium tuberculosis PCR Test.- The Use of Flow Cytometry and RT-PCR in the Detection of Circulating PSA-Positive Cells in Prostate Cancer.- Detection of Chlamydia trachomatis and Trichomonas vaginalis in the Vaginal Introitus, Posterior Vagina, and Endocervix by Polymerase Chain Reaction.- Detection and Isolation of Differentially Expressed Genes by PCR.- Detection of Transgene Integrants and Homologous Recombinants in Mice by Polymerase Chain Reaction.- Direct Analysis for Familial AdenomatousPolyposis Mutations.- PCR Fingerprinting for Detection of Deleted or Amplified Sequences in Human Cancer.Springer-Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 300 pp. Englisch.…

Buch. Condición: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Interest in retinoic acid, the main biologically active derivative of vi- min A or retinol, increased dramatically between 1989 and 1993, following the cloning of nuclear receptors or RARs reported in 1987 (Fig. 1). Important discoveries since then have shown how RARs work as all-trans retinoic ac- dependent heterodimers with related nuclear receptors for 9-cis retinoic acid called RXRs. This has stimulated the development of synthetic analogs s- cific for each type of receptor, and opens the way to develop new methods for regulating pharmacologically the activity ofretinoic acid-dependent pathways of gene activation. The potential for the development of new drugs by the pharmaceutical industry is now a maj or factor driving forward our understa- ing of vitamin A-regulated pathways in animal development and homeostasis. However, apart from the real potential ofretinoid analogs as novel pharma- logical agents, there remains the considerable intellectual challenge of und- standing the way in which vitamin A and its derivatives function in cell development and differentiation. Retinoid Protocols is an attempt to bring together various methodologies that will be vital for rising to this challenge in the future. Retinoid molecular biology has few methods of its own, but is reliant on standard molecular biology methods applied to this particular research area. 456 pp. Englisch.…

Buch. Condición: Neu. This item is printed on demand - Print on Demand Titel. Neuware -This book provides a through introduction to elementary particles and quantum field theory. The discussion emphasises the geoemtrical aspects of the theory, making the generally difficult concepts easy to visualize and to understand.Springer-Verlag KG, Sachsenplatz 4-6, 1201 Wien 688 pp. Englisch.…

Buch. Condición: Neu. This item is printed on demand - Print on Demand Titel. Neuware -Interest in retinoic acid, the main biologically active derivative of vi- min A or retinol, increased dramatically between 1989 and 1993, following the cloning of nuclear receptors or RARs reported in 1987 (Fig. 1). Important discoveries since then have shown how RARs work as all-trans retinoic ac- dependent heterodimers with related nuclear receptors for 9-cis retinoic acid called RXRs. This has stimulated the development of synthetic analogs s- cific for each type of receptor, and opens the way to develop new methods for regulating pharmacologically the activity ofretinoic acid-dependent pathways of gene activation. The potential for the development of new drugs by the pharmaceutical industry is now a maj or factor driving forward our understa- ing of vitamin A-regulated pathways in animal development and homeostasis. However, apart from the real potential ofretinoid analogs as novel pharma- logical agents, there remains the considerable intellectual challenge of und- standing the way in which vitamin A and its derivatives function in cell development and differentiation. Retinoid Protocols is an attempt to bring together various methodologies that will be vital for rising to this challenge in the future. Retinoid molecular biology has few methods of its own, but is reliant on standard molecular biology methods applied to this particular research area.Humana Press in Springer Science + Business Media, Heidelberger Platz 3, 14197 Berlin 456 pp. Englisch. …

Buch. Condición: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Award-winning researchers review of key aspects of DNA repair in a wide variety of organisms, including all-important model systems. The book focuses on DNA damage and repair in prokaryotic and model eukaryotic systems, emphasizing the significant progress that has been made in the past five years. Each chapter has undergone a rigorous peer-review cycle to ensure definitive and comprehensive treatment. Major topics include UV and X-Ray repair, repair of chemical damage, recombinational repair, mismatch repair, transcription-repair coupling, and the role of DNA repair in cell cycle regulation. 644 pp. Englisch.…

Buch. Condición: Neu. This item is printed on demand - Print on Demand Titel. Neuware -Award-winning researchers review of key aspects of DNA repair in a wide variety of organisms, including all-important model systems. The book focuses on DNA damage and repair in prokaryotic and model eukaryotic systems, emphasizing the significant progress that has been made in the past five years. Each chapter has undergone a rigorous peer-review cycle to ensure definitive and comprehensive treatment. Major topics include UV and X-Ray repair, repair of chemical damage, recombinational repair, mismatch repair, transcription-repair coupling, and the role of DNA repair in cell cycle regulation.Humana Press in Springer Science + Business Media, Heidelberger Platz 3, 14197 Berlin 644 pp. Englisch.…

Buch. Condición: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Contains important writings on the development of human psychology from early childhood to adolescence, by a Russian researcher working in the early 20th century. Section I contains about half of the chapters from Vygotsky's book, Pedology of the Adolescent, which was published during his lifetime. 388 pp. Englisch.…

Buch. Condición: Neu. This item is printed on demand - Print on Demand Titel. Neuware -Contains important writings on the development of human psychology from early childhood to adolescence, by a Russian researcher working in the early 20th century. Section I contains about half of the chapters from Vygotsky's book, Pedology of the Adolescent, which was published during his lifetime.Springer-Verlag KG, Sachsenplatz 4-6, 1201 Wien 388 pp. Englisch.…

Buch. Condición: Neu. This item is printed on demand - Print on Demand Titel. Neuware -Teleologically, the hemostatic mechanism is among The of Coronary Thrombosis and the most fundamental yet complex physiologic pro- in essence, represents a heartfelt gift of cesses in humans. Early scientists and physicians were knowledge from a dedicated group of scientists and fascinated by the blood's ability to remain in a liquid clinicians, who collectively have set out on a mission state only to clot in response to vascular injury. The to minimize the societal impact of'hemostasis in the cellular and noncellular components of normal wrong place. ' The book is divided into four distinct hemostasis took centuries to discover, and the intrica- sections: Part 1, Scientific Principles, lays down the cies of their delicate interactions are still being unrav- supporting foundation; Part 2, Clinical Application eled today. As is so often the case, an in-depth of Scientific Principles, places the knowledge base in appreciation of physiologic hemostasis, representing a a working perspective, directly applying science to basic life-sustaining sequence of events, paved the patient care; Part 3, New Dimensions, provides a way for understanding abnormal hemostasis or glimpse of tomorrow. Steering the field clear of se- pathologic thrombosis. Aristotle, Malpighi, and proclaimed victory and the dangers of complacency as Osier, representing but a few of the founding fathers we move into the 21st century, Part 4, Evolution of in the field, would undoubtedly be honored to see Thrombocardiology, focuses on laboratory standards, their observations form the template for lifesaving clinical trials, and drugs in development.Libri GmbH, Europaallee 1, 36244 Bad Hersfeld 704 pp. Englisch.…