Elsevier bv feb 1994 (7 resultados)

Buch. Condición: Neu. Neuware - This volume presents a variety of studies relating to the reach to grasp movement and provides a necessary and valuable contribution to the field of motor control. The professions covered in this book range from those interested in the basic sciences to those more interested in practical application. Neurophysiologists and biomechanists join with therapists and neural modelers to present an extensive overview of current developments. Evolutionary and developmental aspects are included together with descriptions of how this movement is affected by central nervous system damage. Purely theoretical aspects of the motor control of this movement are interspersed with treatment applications and robotics.…

Buch. Condición: Neu. Neuware - The simple task of grasping objects has been studied for centuries by scientists, therapists and engineers who have tried to understand and duplicate the versatility of the human hand. Using an interdisciplinary approach and new framework for looking at prehension, the authors uncover the subleties of the amazing interaction between the hand and the brain. They draw from such diverse fields as experimental psychology, kinesiology, robotics, neural networks, artificial intelligence, neuropsychology and rehabilitation. A triangle strategy is presented, starting from conceptual models that suggest both experimental and computational models. Chapters describe the multiple postures established by the hand, phases in the dynamic process of reaching for, grasping and manipulating various objects, and the constraints acting on such activity.Appendices provide the complete anatomy of the upper limb, the basics of computational modelling, and the fundamentals of prosthetic and dextrous robot hands. The ultimate goal of this book is to develop a common vocabularly for multidisciplinary researchers who strive to understand a system as complex as the hand under the control of the human brain. …

Buch. Condición: Neu. Neuware - This book is aimed at scientists and practicing engineers who are currently exploring or would like to explore the complexity of fabrication processes of polymer composites. It deals with the mechanics and modeling aspects of discontinuous and continuous fiber composites and familarizes the engineer with the critical and fundamental issues of material processing and transport phenomena in polymeric composites and their applications in modeling and simulating specific composite manufacturing processes.Divided into three parts, Part A deals with the deformation science or rheology of these filled materials. It clearly shows the need to characterize their flow behavior before one can draw any conclusions about its processibility during manufacturing. Part B focuses on development of constitutive equations to describe the flow and deformation behavior of such materials under external processing conditions. Part C discusses the mathematical models for selected composite processes and their implementation into a computer simulation to analyze the process behavior. The processes represented in Part C cover a cross-section of important manufacturing processes and maintain a balance between processes that use short fibers and continuous fibrous materials.…

Buch. Condición: Neu. Neuware - The technical advances in molecular biology have endowed us with a wealth of knowledge, which has allowed us to identify the cause of diseases not only at a single gene level but at a greater magnitude, where a substitution or deletion of a single base pair can be identified. Our present task is to establish a clear link between phenotype and nucleotide sequence. Obviously, a gene is no longer an imaginary entity. Recent discoveries in a number of bewildering traits, whose inheritance do not follow simple mendelian rules, have caused much amazement. For example, fragile X-syndrome, spine and bulbar muscular atrophy and myotic dystrophy arise from 'triples repeat mutation' and amplification in future generations. Genetic diseases which are inherited, can now be diagnosed prenatally; an idea that was once inconceivable.The aim of the second volume, entitled Morbid Anatomy of the Genome, is to reflect on the importance of molecular genetics in modern medicine. The field has expanded so as to warrant a volume dedicated exclusively toward understanding those who wish to know the cause, detection and in turn treatment of such diseases. In this volume, I have commissioned several scientists to contribute 12 chapters. A chapter describing a special role of molecular genetics in combating genetic diseases through gene therapy has also been included, while chapter 13 is a commentary.A complete account of all diseases whose genetic basis is well established would be a herculean task and is not within the scope of a single volume format. Therefore a few specific topics have been chosen which may be of the greatest interest to scientists and clinicians. The purpose of this issue is to keep abreast of the latest developments in a select group of genetic diseases.…

Buch. Condición: Neu. Neuware - Membranes are highly dynamic and operate not only as inert boundaries, but the packages they carry around in a cell are well addressed fro appropriate delivery. This holds for a variety of endomembrane systems engaged in exo- and endocytosis, for organelles along the biosynthetic pathway, phagosomes, and lysosomes. It also holds for the establishment of functional surface properties. Cell pairing (conjugation) phenomena are a good model for the problem of how a cell can discriminate between 'self' and 'non-self'. On the other hand parasitic sporozoa developed to experts in masking their molecular sur-'face'by frequent shedding of their variant antigens. The discovery of their glycosyl-phosphatidylinositol (GPI) anchor has led to the discovery, in polar epithelial cells, of a specific targeting mechanism for GPI-anchored surface glycoproteins. Over one hundred such proteins have been detected in metazoans since then.Many of these basic aspects are dealt with in this book using quite different methodical approaches. Of course, there are many more aspects previously known from metazoan systems and such aspects then had to be verified also for Protozoa systems and such aspects then had to be verified also for protozoa. In this context, it is fascinating to see how basic cellular functions are maintained - with variations of the basic theme - throughout evolution.However, sometimes cell biologists dedicated to work with protozoa have to live with a regrettable phenomenon. Colleagues working with 'higher' eukaryotic cells are frequently unaware of the fact that the primary input may have come from work with protozoa. Some phenomena may even be rediscovered inadvertently. In this sense, this book should address not only colleagues working with protozoa but also many of our fellow cell biologists working with metazoan cells.…

Buch. Condición: Neu. Neuware - This book provides a comprehensive treatise on the chemical and biochemical consequences of damaging free radical reactions, the implications for the pathogenesis of disease and how this might be controlled endogenously and by radical scavenging drugs. Oxidative stress may be influenced by exogenous agents of oxidative stress, radiation, trauma, drug activation, oxygen excess, or by exogenous oxidative stress which is associated with many pathological states including chronic inflammatory disorders, cardiovascular disease, injury to the central nervous system, and connective tissue damage. This and many other such aspects are presented clearly and in depth.The development of antioxidant drugs depends on the understanding of the mechanisms underlying the generation of excessive free radicals in vivo, the factors controlling their release and the site of their action. This excellent volume presents an up-to-date account of the current state of knowledge in these areas.…

Buch. Condición: Neu. Neuware - This book reflects the lectures, posters and workshops of the 7th Weurman Flavour Research Symposium held June 1993 in the Netherlands. The Weurman Symposia differ from most others in that attendance is only by invitation based on proposals for active participation. A uniform style and format have been maintained throughout the book as well as the usage of IUPAC chemical nomenclature. Under each topic the following items can be found: full papers and short contributions based on lectures read at the symposium, contributions based on the posters presented in the poster sessions and in some cases, a workshop report. The book is concluded with author and subject indexes aimed at improving the accessibility of this volume.…