Cuvillier aug 2011 (60 resultados)
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Librería: AHA-BUCH GmbH, Einbeck, AlemaniaAHA-BUCH GmbH
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Taschenbuch. Condición: Neu. Neuware - Die vorliegende Arbeit setzt sich auseinander mit dem Biofilmwachstum von Pseudomonas aeruginosa in einem replikativen Kultivierungssystem, das eine katheterassoziierte Harnwegs-infektion simuliert.Es werden drei, aufgrund ihrer Eigenschaften ausgewählte klinische Isolate eingesetzt, wobei…u. a. die Beweglichkeit und die Fähigkeit der Biofilmbildung berücksichtigt wurden. Das Biofilmwachstum der P. aeruginosa-Stämme wird mit Hilfe des Kultivierungssystems charakterisiert und mit dem Referenzstamm P. aeruginosa PA14 verglichen. Als spezifische Parameter werden u. a. die maximale Biofilmwachstumsrate, die Biofilmdicke und -dichte sowie die Zellzahl im Biofilm ermittelt. Die Entwicklung phänotypischer Kolonievarianten, die einen weiteren charakteristischen Parameter der Pseudomonas-Biofilme darstellt, wird in Abhängigkeit von den Prozessparametern herausgestellt. Darüber hinaus wird der Einfluss des Antibiotikums Ciprofloxacin und einer gepulsten mechanischen Beanspruchung auf die Biofilme bzw. deren Entwicklung untersucht.
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Librería: BuchWeltWeit Ludwig Meier e.K., Bergisch Gladbach, , AlemaniaBuchWeltWeit Ludwig Meier e.K.
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Taschenbuch. Condición: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -/ 124 pp. Englisch.
Analysis and Optimization of AlGaN/GaN High Electron Mobility Transistors for Microwave Applications
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Librería: BuchWeltWeit Ludwig Meier e.K., Bergisch Gladbach, , AlemaniaBuchWeltWeit Ludwig Meier e.K.
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Taschenbuch. Condición: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This thesis deals with the analysis and optimization of some of the most prominent non-ideal effects in AlGaN/GaN high electron mobility transistors used in microwave applications as well as the optimization of the RF gain. The effe…ct of current collapse, the root cause of leakage currents as well as field-dependent self-heating effects have been investigated by eletrical characterization using well established techniques and have been analyzed using 2-dimensional physical device simulations. It will be shown that the origin of all effects is strongly related to the device surface and some are even competing effects making device optimization a challenge. However, a detailed localization of the regions affecting device performance will be given leading to a better understanding for fabrication process optimization. Finally, I simulation study is conducted giving suggestions for RF gain improvement based on very simple device layout variations. 130 pp. Englisch.
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Librería: BuchWeltWeit Ludwig Meier e.K., Bergisch Gladbach, , AlemaniaBuchWeltWeit Ludwig Meier e.K.
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Taschenbuch. Condición: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -The present study provides experimental and mathematical methods for the understanding and quantification of the water fluxes and solute transport in heterogeneous layered porous groundwater systems characterised by differences in h…ydraulic conductivities.On the one hand, multi-layered porous groundwater systems with different hydraulic conductivities are characterised by a heterogeneous flow field, which causes a heterogeneous mass transport. On the other hand, extreme differences in hydraulic conductivities create regions of immobile water which influence the mass transport. These two different structural heterogeneities ¿ variable hydraulic conductivities and immobile/stagnant water zones ¿ were investigated experimentally in different laboratory aquifer models. 154 pp. Englisch.
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Librería: BuchWeltWeit Ludwig Meier e.K., Bergisch Gladbach, , AlemaniaBuchWeltWeit Ludwig Meier e.K.
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Taschenbuch. Condición: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -The Dutch sugar industry and sugar beet research institute initiated the project SUSY (Speeding Up Sugar Yield) as a reaction to decreasing beet prices in relation to the reform of the European Unions sugar regime. The project was a…imed at softening the reform¿s impact on growers income by improving their knowledge on raising sugar yield and identifying possible cost savings. From each sugar beet growing region in The Netherlands, 26 pairs of ¿type top¿ (high yielding) and ¿type average¿ (average yielding) farmers were selected, based on the average yield of the farm in 2000-2004. All measures of sugar beet cultivation, costs calculation and phytopathological, agronomical and soil characteristics were investigated from 2006 and 2007 on 75 fields of ¿type top¿ and 74 fields of ¿type average¿ growersin relation to yield and quality. The factors year and grower caused most of the significant effects on yield, quality and cost variables. The ¿type top¿ growers had significantly 20% higher sugar yield in each year compared to ¿type average¿ growers, but the total variable costs did not differ. This makes the ¿type top¿ growers more efficient in resource use. Costs for manure and fertiliser, ¿other¿ and irrigation significantly increased the total variable costs. With higher fungicide costs, sugar yield significantly increased. However, there was no significant relation between the intensity of sugar beet production and sugar yield so that the observed differences in sugar yield were not caused by economical constraints. Based on this study, it can be concluded that the most profitable strategy for the growers is maximising sugar yield and optimising costs. 150 pp. Englisch.
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Taschenbuch. Condición: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Weaning in piglets is characterized by nutritional, environmental and social stress, often associated with reduced body weight gain, nutrient malabsorption and increased incidence of diarrhea. In fact, dietary components such as car…bohydrates and protein, but also a variety of feed additives may affect the intestinal microbial ecosystem. In most of the in vitro fermentation studies over the past years, a buffered system was used to maintain a constant osmolarity, thereby minimizing osmotic stress for the microbes and supporting optimal fermentation conditions. In the present work, the Hohenheimer Futterwerttest (HFT) was modified by increasing osmolarity in the medium, to impose osmotic stress on the microbes. Increased osmolarity in the environment might be more related to in vivo conditions, as they may occur during stress situations, e.g. diarrhea (chapter 3). Therefore, effects of an osmotic stress situation on selected bacteria strains in vitro were qualitatively and quantitatively analyzed by use of molecular techniques (real-time PCR) (chapter 3). In addition, the feed additive betaine, which is one of the most ubiquitous compatible solutes used both by prokaryotic and eukaryotic cells, has been suggested to enhance microbial fermentation. Therefore, the effects of betaine in combination with different carbohydrates and proteins on fermentation characteristics were tested under normal (chapter 2) and osmotic stress conditions (chapter 4) in vitro. In conclusion, increased osmolarity in vitro may influence microbial fermentation and bacterial composition by creating a stress situation for the microbiota of the inoculum. 156 pp. Englisch.
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Taschenbuch. Condición: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -In this work scanning probe techniques, namely frequency-modulated atomic force microscopy (FM-AFM) in the non-contact regime and related methods like Kelvin probe force microscopy (KPFM), magnetic force microscopy (MFM), and magnet…ic exchange force microscopy (MExFM), are utilized in ultra high vacuum and at low temperatures to structurally, electronically and magnetically study the monolayer regime of iron on tungsten (001) in real space. Implementing the spectroscopic mode of MExFM, that is, magnetic exchange force spectroscopy (MExFS), the exchange interaction between single iron atoms with antiparallel coupling is experimentally accessed for the ¿rst time.Iron grows pseudomorphically on W(001) whereby the layers are highly strained. Di¿erences in strain between ¿rst and second layer iron and hybridization with the substrate lead to di¿erences in electronic properties and magnetism: both layers exhibit a di¿erent work function, mapped with KPFM. Interestingly, even on the same layer, di¿erent work functions are observed. Moreover, both layers are magnetically di¿erent. The second layer is ferromagnetic (FM) with in-plane anisotropy as veri¿ed by MFM, while the ¿rst layer is antiferromagnetic (AF) with out-of-plane anisotropy. Using MexFM the AF alignment of the monolayer magnetic moments is resolved by detecting the short-ranged magnetic exchange force between tip and sample. The origin of the magnetic contrast formation is discussed and compared to ab initio calculations. Later, MExFS, which allows to directly measure the distance dependence of the magnetic exchange interaction between an atomically sharp magnetic tip and the antiferromagnetically ordered Fe monolayer on W(001), is employed. The site speci¿c distance dependence of the total tip-sample interaction is recorded above Fe atoms which exhibit parallel as well as antiparallel atomic magnetic moments. The contribution of the magnetic exchange interaction between both sites can be extracted by subtracting the two curves from each other. All other interactions are identical on both sites. The experimental results are compared to ab initio calculations accounting for magnetically di¿erent tips composed of either Cr or Fe, or mixtures of both. Depending on symmetry and stability of the experimentally used probe tips, qualitatively di¿erent MExFM contrasts and MExFS data with a stronger distance dependence are observed. By analyzing the energy loss per single cantilever oscillation cycle, simultaneously recorded with topography and frequency shift in the experiments, a bottom-up characterization of the structurally and magnetically unknown probe tip apex is given. Considering the tip apex as magnetically and structurally independent cluster allows to explain the observed tip behavior. 144 pp. Englisch.
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Taschenbuch. Condición: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -/ 166 pp. Englisch.
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Taschenbuch. Condición: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Contract logistics has received considerable attention in both research and practice over the past decades. Concentration on core competencies and cost-saving objectives in commerce and industry are the drivers for intensified colla…boration with contract logistics service providers (LSP). LSPs in turn are seeking long-term contracts and higher margins on comprehensive services compared to the price-driven transportation business. In order to reduce managerial efforts, various services are shifted to a limited number of service providers, resulting in comprehensive service bundles being outsourced. As these service bundles are complex and involve specific investments, creating dependency, long-term relationships between the customer ¿ the shipper ¿ and the LSP are established. Hence contract logistics requires profound knowledge and skills of both the LSP and the shipper to successfully establish satisfactory relationships. The design of appropriate service bundles is particularly challenging. The decisions made in this phase form the basis for the relationship of the involved parties. Contract logistics service bundles need to be designed in a way that satisfies both partners in order to guarantee successful contract logistics in the sense of a longterm, stable relationship. However, research has not satisfactory focused on this topic. This dissertation discusses factors that influence successful service bundle design and identifies significant contributors in order to conceptualise the design of contract logistics service bundles and provide guidance for service bundle design based on literature review and empirical investigation.The research at hand focuses on three cornerstones of successful contract logistics service bundle design. First, the resources of LSPs are analysed with respect to their relevance for the design of contract logistics service bundles. Second, the understanding and transfer of shipper needs into the designed service bundles is examined. Finally, the choice of the appropriate remuneration model in the design of contract logistics service bundles is addressed. 190 pp. Englisch.
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Librería: BuchWeltWeit Ludwig Meier e.K., Bergisch Gladbach, , AlemaniaBuchWeltWeit Ludwig Meier e.K.
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Taschenbuch. Condición: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Cultivations of filamentous fungi are of large industrial and scientific interest. However, the utmost starting point of the majority of those cultivations, the inoculum consisting of fungal spores, has previously been neglected. Th…is work hence introduces a total of nine spore quality indicators and subsequently correlates the sporulation environome to the properties of the generated spores and their performance in submerged cultivation. The model organism is Aspergillus ochraceus while the model process is the hydroxylation of a steroid. A positive correlation between the spore yield and the substrate¿s carbon content on solid medium was found with oat bran agar giving best yields of 26 107 spores/mL at carbon concentrations of 15.4 g/L in the solid medium. The assessment of the conidial metabolome revealed the presence of 126 metabolites. Particularly polyols, such as glycerol, erythritol and ribitol, are found at high concentrations of up to 55 ng/105 spores. It was further shown, that several of these metabolites are degraded within the spores during storage for 7 d in saline solution. Their concentrations also strongly correlate with the storage resistance of the conidia as well as with their performance in subsequent submerged cultivations. Highest reactant turnover of approx. 80 % was determined after 72 h of cultivation with spores generated on wheat bran agar. The culture performance is further a function of the portion of protein bound NADH, which was determined and spatially visualized by means of two-photon fluorescence lifetime imaging. 182 pp. Englisch.
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Taschenbuch. Condición: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Among the most important problems in combinatorial optimization are scheduling problems. In this paper, machine scheduling is considered. Usually in such problems a set of jobs and a set of machines are given. The task is to assign…the jobs to the machines and to determine a schedule for each machine. The schedule determines at what times the machine will process the jobs assigned to it. Often, constraints must be taken into account. Typical constraints are times by which certain jobs must be completed (deadlines), that some jobs can only be processed when certain other jobs are completed (precedence constraints), or that some jobs are only available from a given time (release dates). 222 pp. Englisch.
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Taschenbuch. Condición: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Spin-sensitive low temperature Scanning Tunneling Microscopy (STM) measurements provide the unique capability to study structural, electronic and magnetic properties of individual and coupled magnetic atoms on surfaces with high ene…rgy resolution. In this thesis, spin-polarized STM (SP-STM) and Inelastic Scanning Tunneling Spectroscopy (ISTS) are utilized to investigate Fe atoms on the semiconducting InSb(110) surface and the metallic Cu(111) and Ag(111) surfaces. Model calculations of tunneling through an excitable quantum spin system and analytical investigations of the model, as well as quasi-classical and Ising model calculations of coupled spin systems prepare the ground for the theoretical description of the experiments. The ISTS measurements of Fe on InSb(110) are the first observation of spin excitations of individual magnetic atoms on a semiconductor surface. By comparing the experimental data to Density Functional Theory (DFT) calculations performed by S. Schuwalow and F. Lechermann and to model calculations, it is found that the Fe atoms behave like quantum spins with spin quantum number S = 1, which are subject to magnetic anisotropy in the meV range. The Fe atoms are coupled to a two dimensional electron system (2DES) which is induced at the surface by positively charged adsorbates. The spectroscopic peaks of the spin-split Landau levels of this 2DES show an asymmetry of their amplitudes when the tunnel current is passed through the Fe atoms. It is shown that the Landau level asymmetry, recorded as a function of external magnetic field, can be interpreted as a new type of Single Atom Magnetization Curve (SAMC). Measurements of the Landau level asymmetry with magnetic tips can be used to quantitatively determine the spin polarization of the tip. SP-STM measurements of the SAMCs of single Fe atoms on Cu(111) show that the Fe atoms behave paramagnetically with a broad statistical distribution of the effective magnetic moment, centered around 3.5 ¿B. ISTS measurements on the same system reveal a magnetic anisotropy energy in the meV range, a g-factor of about 2.1, and a very broad, energy dependent spin-excitation line width in the meV range. Analogous ISTS measurements of Fe on Ag(111) show similar behavior, but with a three times larger anisotropy energy, and a g-factor of roughly 3.1. The observations can be interpreted in the context of advanced calculations including spin-orbit coupling and the Cu/Ag(111) surface state performed by S. Lounis et al. 206 pp. Englisch.
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Taschenbuch. Condición: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Ziel dieser Arbeit war die Synthese magnetisch interessanter Koordinationscluster der frühen Übergangsmetalle Vanadium und Chrom in Verbindung mit 4f-Metallionen. Die relativen Beiträge der jeweilig beteiligten Ionen zu dem gesamt r…esultierenden magnetischen Moment sollte untersucht werden, um zu sehen, ob diese Art von 3d/4f Verbindungen eine vielversprechende Route zu einer neuen Klasse von Einzelmolekülmagneten (Single-Molecule Magnets, SMMs) darstellt.Eine Reihe von Chrom-Lanthanoid und Vanadium-Lanthanoid-Verbindungen mit N-methyldiethanolamin- und N-n-butyldiethanolaminliganden wurde synthetisiert und auf ihre magnetischen Eigenschaften hin untersucht. Desweiteren wurden Reaktionen von Chrom und Vanadium in Verbindung mit 2-pyridyltriazol-Liganden durchgeführt und auch diese auf ihre magnetischen Eigenschaften hin untersucht. Als interessanteste Ergebnisse sind ein achtkerniger [Cr4Dy4]-3d/4f-Komplex zu nennen, der das erste Beispiel für eine Cr-Ln-Verbindung darstellt, die Einzelmolekülmagnet-Verhalten aufweist. Desweiteren ist es gelungen, das erste Beispiel einer V-Ln-Verbindung darzustellen, die als Einzelmolekülmagnet identifiziert werden konnte. Es handelt sich dabei um eine kristallographisch sehr interessante Struktur eines [V8Dy6]-Kerns. Aus Solvothermalreaktionen von Chrom und Vanadium in Verbindung mit den 2-pyridyltriazol-Liganden ist eine dimere Chromverbindung hervorzuheben, bei der es sich um eine der ersten Verbindungen handelt, die eine ferromagnetische Kopplung zwischen den Cr-Cr-Metallzentren aufweist. 218 pp. Englisch.
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Taschenbuch. Condición: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Geopolitische, ökonomische, ökologische und gesellschaftliche Entwicklungen haben dazu geführt, dass nachhaltiges Handeln zunehmend zu einer Generalanforderung für Unternehmen wird. Aufgrund der herausragenden Bedeutung von Innovati…onen zur Bewältigung dieser Herausforderung und zur Erlangung von Wettbewerbsvorteilen kommt der Innovationssteuerung eine besondere Bedeutung für den unternehmerischen Erfolg zu. Die gegenwärtig angewandten Verfahren zur Bewertung und Auswahl von Innovationsprojekten konzentrieren sich jedoch auf die Erfassung ihres direkten finanziellen Ergebnisses und lassen die nachhaltigkeitsorientierten Wirkungen außer Acht. Nachhaltigkeit wird dabei verstanden als integrative Berücksichtigung von Ökonomie, Ökologie und Sozialem. In diesem, auf dem Forschungsprojekt NaBI ¿ Nachhaltigkeitsorientierte Bewertung von Innovationsprojekten aufbauenden Buch wird daher ein Konzept vorgestellt, das nachhaltigkeitsorientierte Wirkungen in eine ganzheitliche Innovationsbewertung einbezieht. Das NaBI-Konzept strukturiert die Innovationsbewertung und ermöglicht es, abgestimmt auf die verfügbare Datenbasis, die nachhaltigkeitsorientierten Wirkungen von Innovationen zu erfassen. Dank der engen Zusammenarbeit mit Unternehmenspartnern im Projekt kann die Anwendung des Konzeptes praxisgerecht durch einen Leitfaden erläutert und anhand zweier realer Beispielprojekte illustriert werden. 116 pp. Deutsch.
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Taschenbuch. Condición: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Fußball fasziniert hunderte Millionen von Menschen weltweit. In den vergangenen Jahren ist Fußball zu einem Event geworden. Es ist heutzutage ¿in¿ und ¿hipp¿, ins Stadion zu gehen. Jedes Wochenende fasziniert das Treiben in und um d…ie Stadien Millionen von Fans in Deutschland. Nach seiner Außenseiterrolle in den 1980er und 199023 Jahren ist Fußball seit einigen Jahren in der Mitte der Gesellschaft und der medialen Aufmerksamkeit angekommen! Betrachtet man allerdings die öffentliche Wahrnehmung etwas differenzierter, so finden sich seit geraumer Zeit im Zusammenhang mit Fußballereignissen immer öfter auch Berichterstattungen und Studien, die von einer zunehmenden Gewaltbereitschaft von Fußballfans ausgehen. Dabei werden fälschlicherweise immer wieder die in ihren Ursprüngen und Intentionen völlig unterschiedlichen Phänomene der ¿Hooligans¿ und ¿Ultras¿ ¿in einen Topf geworfen¿.Für die meisten Ultras stellen der Fußball und die Betätigung für ihren Verein den Mittelpunkt ihres Lebens dar. Die Ultraszene ist eine vielschichtige subkulturelle Szene, die sich nicht nur durch gemeinhin sichtbare gewaltaffine Erscheinungsformen rund um das Stadion zeigt, sondern die auch durchgängig mit komplexen sozio-kulturellen Verflechtungen, wie beispielsweise der Auflehnung gegen tradierte Normen und Konventionen, durchdrungen ist. Ultras stehen ständig im Spagat zwischen einer gewaltbereiten Jugendkultur und einem erlebnis- und fußballbegeisterten Cliquenphänomen. Dabei gerät zu oft ihre sozio-kulturelle Funktion zwischen einem jugendlichen Freizeitphänomen, Werte- und Freundschaftsverbund, Abenteuerlust und Rebellion, in Vergessenheit.Um dieser weitreichenden Bedeutung für die gesamte Fanwelt gerecht zu werden, musste der ¿Gang ins Feld¿ gewagt werden. Eine der einflussreichsten Gruppierungen in Deutschland, die ¿Ultras Nürnberg 1994¿, steht im Mittelpunkt des vorliegenden Buches. Ziel war es, dieses komplexe soziale Gebilde einer Ultragruppierung und die auf sie einwirkenden Akteure (Verein, Polizei etc.) mit ihren unterschiedlichsten Interessen unvoreingenommen und offen verstehen und analysieren zu lernen. 148 pp. Deutsch.
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Taschenbuch. Condición: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -/ 426 pp. Deutsch.
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Taschenbuch. Condición: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Haiku® is an open source, light, fast and user-friendly operating system thatis inspired by the 'Multimedia Operating System' BeOS(TM). At the momentHaiku is still under development and the latest release was Alpha 2 which ismeant t…o be used only for testing. Unlike many other open source operatingsystems, such as Linux or FreeBSD, Haiku sets the focus on personal computingand the graphic user interface (GUI) is not just an 'Add-On' or 'additionalwindows management system', but it is an essential part of the kernel.This thesis analyses Haiku, especially regarding the ease of use, the GUIand the multimedia capabilities, by giving an introduction to Haiku, an overviewof the history and features of BeOS and a lot of general and technicalinformation about the architecture, the easy of use, the GUI and some otheraspects of operating systems in general respectively in the special case ofHaiku. In order to recognize the main fields of application of Haiku and theexpectations of the users regarding the further development of Haiku, theHaiku community has been analysed by doing an online survey that wasanswered by more than one thousand persons. 114 pp. Deutsch.
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Librería: buchversandmimpf2000, Emtmannsberg, BAYE, Alemaniabuchversandmimpf2000
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Taschenbuch. Condición: Neu. This item is printed on demand - Print on Demand Titel. Neuware -/Cuvillier Verlag, Nonnenstieg 8, 37075 Göttingen 124 pp. Englisch.
Analysis and Optimization of AlGaN/GaN High Electron Mobility Transistors for Microwave Applications
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Taschenbuch. Condición: Neu. This item is printed on demand - Print on Demand Titel. Neuware -This thesis deals with the analysis and optimization of some of the most prominent non-ideal effects in AlGaN/GaN high electron mobility transistors used in microwave applications as well as the optimization of the RF gain. The effect o…f current collapse, the root cause of leakage currents as well as field-dependent self-heating effects have been investigated by eletrical characterization using well established techniques and have been analyzed using 2-dimensional physical device simulations. It will be shown that the origin of all effects is strongly related to the device surface and some are even competing effects making device optimization a challenge. However, a detailed localization of the regions affecting device performance will be given leading to a better understanding for fabrication process optimization. Finally, I simulation study is conducted giving suggestions for RF gain improvement based on very simple device layout variations.Cuvillier Verlag, Nonnenstieg 8, 37075 Göttingen 130 pp. Englisch.
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Taschenbuch. Condición: Neu. This item is printed on demand - Print on Demand Titel. Neuware -The present study provides experimental and mathematical methods for the understanding and quantification of the water fluxes and solute transport in heterogeneous layered porous groundwater systems characterised by differences in hydra…ulic conductivities.On the one hand, multi-layered porous groundwater systems with different hydraulic conductivities are characterised by a heterogeneous flow field, which causes a heterogeneous mass transport. On the other hand, extreme differences in hydraulic conductivities create regions of immobile water which influence the mass transport. These two different structural heterogeneities - variable hydraulic conductivities and immobile/stagnant water zones - were investigated experimentally in different laboratory aquifer models.Cuvillier Verlag, Nonnenstieg 8, 37075 Göttingen 154 pp. Englisch.
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Taschenbuch. Condición: Neu. This item is printed on demand - Print on Demand Titel. Neuware -Weaning in piglets is characterized by nutritional, environmental and social stress, often associated with reduced body weight gain, nutrient malabsorption and increased incidence of diarrhea. In fact, dietary components such as carbohy…drates and protein, but also a variety of feed additives may affect the intestinal microbial ecosystem. In most of the in vitro fermentation studies over the past years, a buffered system was used to maintain a constant osmolarity, thereby minimizing osmotic stress for the microbes and supporting optimal fermentation conditions. In the present work, the Hohenheimer Futterwerttest (HFT) was modified by increasing osmolarity in the medium, to impose osmotic stress on the microbes. Increased osmolarity in the environment might be more related to in vivo conditions, as they may occur during stress situations, e.g. diarrhea (chapter 3). Therefore, effects of an osmotic stress situation on selected bacteria strains in vitro were qualitatively and quantitatively analyzed by use of molecular techniques (real-time PCR) (chapter 3). In addition, the feed additive betaine, which is one of the most ubiquitous compatible solutes used both by prokaryotic and eukaryotic cells, has been suggested to enhance microbial fermentation. Therefore, the effects of betaine in combination with different carbohydrates and proteins on fermentation characteristics were tested under normal (chapter 2) and osmotic stress conditions (chapter 4) in vitro. In conclusion, increased osmolarity in vitro may influence microbial fermentation and bacterial composition by creating a stress situation for the microbiota of the inoculum.Cuvillier Verlag, Nonnenstieg 8, 37075 Göttingen 154 pp. Englisch.
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Taschenbuch. Condición: Neu. This item is printed on demand - Print on Demand Titel. Neuware -In this work scanning probe techniques, namely frequency-modulated atomic force microscopy (FM-AFM) in the non-contact regime and related methods like Kelvin probe force microscopy (KPFM), magnetic force microscopy (MFM), and magnetic e…xchange force microscopy (MExFM), are utilized in ultra high vacuum and at low temperatures to structurally, electronically and magnetically study the monolayer regime of iron on tungsten (001) in real space. Implementing the spectroscopic mode of MExFM, that is, magnetic exchange force spectroscopy (MExFS), the exchange interaction between single iron atoms with antiparallel coupling is experimentally accessed for the ¿rst time.Iron grows pseudomorphically on W(001) whereby the layers are highly strained. Di¿erences in strain between ¿rst and second layer iron and hybridization with the substrate lead to di¿erences in electronic properties and magnetism: both layers exhibit a di¿erent work function, mapped with KPFM. Interestingly, even on the same layer, di¿erent work functions are observed. Moreover, both layers are magnetically di¿erent. The second layer is ferromagnetic (FM) with in-plane anisotropy as veri¿ed by MFM, while the ¿rst layer is antiferromagnetic (AF) with out-of-plane anisotropy. Using MexFM the AF alignment of the monolayer magnetic moments is resolved by detecting the short-ranged magnetic exchange force between tip and sample. The origin of the magnetic contrast formation is discussed and compared to ab initio calculations. Later, MExFS, which allows to directly measure the distance dependence of the magnetic exchange interaction between an atomically sharp magnetic tip and the antiferromagnetically ordered Fe monolayer on W(001), is employed. The site speci¿c distance dependence of the total tip-sample interaction is recorded above Fe atoms which exhibit parallel as well as antiparallel atomic magnetic moments. The contribution of the magnetic exchange interaction between both sites can be extracted by subtracting the two curves from each other. All other interactions are identical on both sites. The experimental results are compared to ab initio calculations accounting for magnetically di¿erent tips composed of either Cr or Fe, or mixtures of both. Depending on symmetry and stability of the experimentally used probe tips, qualitatively di¿erent MExFM contrasts and MExFS data with a stronger distance dependence are observed. By analyzing the energy loss per single cantilever oscillation cycle, simultaneously recorded with topography and frequency shift in the experiments, a bottom-up characterization of the structurally and magnetically unknown probe tip apex is given. Considering the tip apex as magnetically and structurally independent cluster allows to explain the observed tip behavior.Cuvillier Verlag, Nonnenstieg 8, 37075 Göttingen 144 pp. Englisch.
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Taschenbuch. Condición: Neu. This item is printed on demand - Print on Demand Titel. Neuware -/Cuvillier Verlag, Nonnenstieg 8, 37075 Göttingen 166 pp. Englisch.
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Taschenbuch. Condición: Neu. This item is printed on demand - Print on Demand Titel. Neuware -Contract logistics has received considerable attention in both research and practice over the past decades. Concentration on core competencies and cost-saving objectives in commerce and industry are the drivers for intensified collabora…tion with contract logistics service providers (LSP). LSPs in turn are seeking long-term contracts and higher margins on comprehensive services compared to the price-driven transportation business. In order to reduce managerial efforts, various services are shifted to a limited number of service providers, resulting in comprehensive service bundles being outsourced. As these service bundles are complex and involve specific investments, creating dependency, long-term relationships between the customer - the shipper - and the LSP are established. Hence contract logistics requires profound knowledge and skills of both the LSP and the shipper to successfully establish satisfactory relationships. The design of appropriate service bundles is particularly challenging. The decisions made in this phase form the basis for the relationship of the involved parties. Contract logistics service bundles need to be designed in a way that satisfies both partners in order to guarantee successful contract logistics in the sense of a longterm, stable relationship. However, research has not satisfactory focused on this topic. This dissertation discusses factors that influence successful service bundle design and identifies significant contributors in order to conceptualise the design of contract logistics service bundles and provide guidance for service bundle design based on literature review and empirical investigation.The research at hand focuses on three cornerstones of successful contract logistics service bundle design. First, the resources of LSPs are analysed with respect to their relevance for the design of contract logistics service bundles. Second, the understanding and transfer of shipper needs into the designed service bundles is examined. Finally, the choice of the appropriate remuneration model in the design of contract logistics service bundles is addressed.Cuvillier Verlag, Nonnenstieg 8, 37075 Göttingen 190 pp. Englisch.
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Taschenbuch. Condición: Neu. This item is printed on demand - Print on Demand Titel. Neuware -Cultivations of filamentous fungi are of large industrial and scientific interest. However, the utmost starting point of the majority of those cultivations, the inoculum consisting of fungal spores, has previously been neglected. This w…ork hence introduces a total of nine spore quality indicators and subsequently correlates the sporulation environome to the properties of the generated spores and their performance in submerged cultivation. The model organism is Aspergillus ochraceus while the model process is the hydroxylation of a steroid. A positive correlation between the spore yield and the substrate's carbon content on solid medium was found with oat bran agar giving best yields of 26 107 spores/mL at carbon concentrations of 15.4 g/L in the solid medium. The assessment of the conidial metabolome revealed the presence of 126 metabolites. Particularly polyols, such as glycerol, erythritol and ribitol, are found at high concentrations of up to 55 ng/105 spores. It was further shown, that several of these metabolites are degraded within the spores during storage for 7 d in saline solution. Their concentrations also strongly correlate with the storage resistance of the conidia as well as with their performance in subsequent submerged cultivations. Highest reactant turnover of approx. 80 % was determined after 72 h of cultivation with spores generated on wheat bran agar. The culture performance is further a function of the portion of protein bound NADH, which was determined and spatially visualized by means of two-photon fluorescence lifetime imaging.Cuvillier Verlag, Nonnenstieg 8, 37075 Göttingen 182 pp. Englisch.
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Taschenbuch. Condición: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Wie das Leben in Dörfern heute und in Zukunft aussieht, hängt ganz entscheidend davon ab, ob und auf welche Weise sich Bürger engagieren. In Zeiten des demographischen Wandels, meist knapper Gemeindekassen und drohender Lücken im Sy…stem der Daseinsvorsorge ist deutlich geworden, dass gerade in ländlichen Räumen die Ressource Mensch stärker 'genutzt' werden muss. Viele - alte und neue - Dorfbewohner jeden Alters sind bereit aktiv zu werden und sich für andere und das Gemeinwohl einzusetzen, wenn sie ernst genommen werden und die entsprechenden Rahmenbedingungen für ihre Aktivitäten geschaffen werden. Das kann in Form politischer Partizipation jenseits von Parteipolitik und im Ehrenamt in den verschiedensten Bereichen (z.B. in Vereinen, Initiativen, Gruppen, Projekten) sein. Die Formen bürgerschaftlichen Engagements in Dorfgemeinschaften, positive Beispiele, aber auch problematische Erfahrungen sowie Forderungenan die politischen Akteure zur Stärkung der Zivilgesellschaft in ländlichen Räumen standen im Zentrum des 17. Bleiwäscher Dorfsymposiums, das vom 2. bis 4. Mai 2010 stattfand und bei dem der bereits seit 32 Jahren gepflegte Dialog von Wissenschaft, Verwaltung, Planung und Praxis fortgeführt wurde.weniger anzeigen. 142 pp. Deutsch.
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Taschenbuch. Condición: Neu. This item is printed on demand - Print on Demand Titel. Neuware -Among the most important problems in combinatorial optimization are scheduling problems. In this paper, machine scheduling is considered. Usually in such problems a set of jobs and a set of machines are given. The task is to assign the…jobs to the machines and to determine a schedule for each machine. The schedule determines at what times the machine will process the jobs assigned to it. Often, constraints must be taken into account. Typical constraints are times by which certain jobs must be completed (deadlines), that some jobs can only be processed when certain other jobs are completed (precedence constraints), or that some jobs are only available from a given time (release dates).Cuvillier Verlag, Nonnenstieg 8, 37075 Göttingen 222 pp. Englisch.
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Taschenbuch. Condición: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -In der Maiszüchtung stellt die Doppelhaploidentechnik eine zeitsparende Alternative gegenüber der herkömmlichen Erzeugung homozygoter Linien dar. Die DH-Technik lässt sich in zwei Schritte unterteilen: 1.) die Induktion von maternal…en Haploiden durch Bestäubung mit sogenannten Inducerlinien und 2.) die Aufregulierung der Chromosomen-sätze zur Erzeugung von Doppelhaploiden durch die Behandlung mit einem Mitosegift. Insgesamt können bei jedem Schritt zwischen 1 - 10 % Haploide bzw. Doppelhaploide erzeugt werden. Dies zeigt somit noch ein deutliches Optimierungspotential auf. Zum einen ist der Mechanismus der Haploideninduktion noch nicht vollständig geklärt und die Induktionsraten sind teilweise stark vom jeweiligen Genotyp abhängig. Zum anderen wird zur Aufregulierung der Chromosomensätze immer noch sehr häufig das im Speziellen für Säuger hochtoxische Alkaloid Colchicin eingesetzt. Aufgrund seiner geringen Spezifität für Pflanzenspindeln wird eine relativ hohe Menge an Colchicin benötigt, was die Anwendung teuer und vor allem für den Anwender gefährlich macht.Ziel der vorliegenden Arbeit war es die Doppelhaploiden-Technik bei Mais durch die Bestimmung von mindergiftigen und möglichst effizienten Colchicin-Alternativen zu verbessern. Hierfür wurden folgende Arbeitsschritte durchgeführt:- Beurteilung von möglichen Colchicin-Alternativen durch Behandlung von Wurzelspitzen (chemische Substanzen, physikalische Methoden).- Optimierung der Inkubationsparameter zur Behandlung von Haploiden mit Colchicin-Alternativen.- Ermittlung neuer Colchicin-Alternativen über Hochdurchsatz-Screening einer Chemikalien-Bibliothek.- Untersuchung des Mechanismus der Haploideninduktion.Bei der Behandlung von Wurzelmeristemen konnte gezeigt werden, dass die drei Herbizide APM, Oryzalin und Pronamid als Colchicin-Alternativen eingesetzt werden können. Verglichen mit Colchicin weisen sie alle eine deutlich geringere Toxizität für Säuger auf. Außerdem wäre ihr Einsatz durch die deutlich geringer benötigten Konzentrationen auch kosteneffizienter als eine Colchicinbehandlung. Nach Behandlung Haploider konnten jedoch bisher mit keiner Alternativbehandlung Doppelhaploide erzeugt werden.Die Behandlungsparameter für Colchicin konnten im Rahmen der vorliegenden Arbeit weiter optimiert werden. So zeigte sich durch die Belüftung der Behandlungslösung ein deutlicher Anstieg der Keimlingsvitalität. Außerdem konnten nach der Behandlung zwei Tage alter Keimlinge die meisten Keimlinge mit verdoppeltem Chromosomensatz erzeugt werden. Aufgrund der vielversprechenden Eigenschaften der Herbizide APM, Oryzalin und Pronamid sollten weitere Experimente durchgeführt werden, sobald größere Mengen an haploidem Saatgut zur Verfügung stehen.Das Screeningverfahren der LATCA-Bibliothek unter Verwendung einer transgenen Arabidopsis thaliana Linie zeigte sich als äußerst effektiv zur Ermittlung von Mitoseinhibitoren. Nach Durchführung des Screenings von ~3600 chemischen Substanzen in drei Stufen konnten 51 Kandidaten von Colchicin-Alternativen ermittelt werden. Diese Substanzen sollten durch Behandlung von haploiden Maiskeimlingen genauer evaluiert werden. Denkbar wäre auch das Screening weiterer Bibliotheken zur Entdeckung von Mitoseinhibitoren.Durch ein besseres Verständnis des Mechanismus der Haploideninduktion könnte diese Technik verbessert und somit der Einsatz von Colchicin eingeschränkt werden. Anhand der bisherigen Ergebnisse können jedoch keine Aussagen über den Mechanismus der Haploideninduktion getroffen werden. Das eingesetzte Testsystem sollte daher noch weiter optimiert werden.Die vorliegende Arbeit konnte zeigen, dass die Effizienz zur Erzeugung doppelhaploider Maispflanzen durch den Einsatz von Colchicin-Alternativen verbessert werden könnte. Außerdem konnten nach einem Screening von ~3600 chemischen Substanzen mittels A. thaliana 51 Chemikalien als potenzielle Mitoseinhibitoren detektiert werden. 128.
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Taschenbuch. Condición: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Ziel dieser Arbeit war es, geschmacksmaskierte, multipartikuläre orale Arzneiformen mitdrei bitteren Modellarzneistoffen zu entwickeln. Der Fokus lag dabei auf der Entwicklung der festen Arzneiformen und der Geschmacksanalytik mitte…ls einer elektronischen Zunge. 154 pp. Deutsch.
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Taschenbuch. Condición: Neu. This item is printed on demand - Print on Demand Titel. Neuware -Spin-sensitive low temperature Scanning Tunneling Microscopy (STM) measurements provide the unique capability to study structural, electronic and magnetic properties of individual and coupled magnetic atoms on surfaces with high energy…resolution. In this thesis, spin-polarized STM (SP-STM) and Inelastic Scanning Tunneling Spectroscopy (ISTS) are utilized to investigate Fe atoms on the semiconducting InSb(110) surface and the metallic Cu(111) and Ag(111) surfaces. Model calculations of tunneling through an excitable quantum spin system and analytical investigations of the model, as well as quasi-classical and Ising model calculations of coupled spin systems prepare the ground for the theoretical description of the experiments. The ISTS measurements of Fe on InSb(110) are the first observation of spin excitations of individual magnetic atoms on a semiconductor surface. By comparing the experimental data to Density Functional Theory (DFT) calculations performed by S. Schuwalow and F. Lechermann and to model calculations, it is found that the Fe atoms behave like quantum spins with spin quantum number S = 1, which are subject to magnetic anisotropy in the meV range. The Fe atoms are coupled to a two dimensional electron system (2DES) which is induced at the surface by positively charged adsorbates. The spectroscopic peaks of the spin-split Landau levels of this 2DES show an asymmetry of their amplitudes when the tunnel current is passed through the Fe atoms. It is shown that the Landau level asymmetry, recorded as a function of external magnetic field, can be interpreted as a new type of Single Atom Magnetization Curve (SAMC). Measurements of the Landau level asymmetry with magnetic tips can be used to quantitatively determine the spin polarization of the tip. SP-STM measurements of the SAMCs of single Fe atoms on Cu(111) show that the Fe atoms behave paramagnetically with a broad statistical distribution of the effective magnetic moment, centered around 3.5 ¿B. ISTS measurements on the same system reveal a magnetic anisotropy energy in the meV range, a g-factor of about 2.1, and a very broad, energy dependent spin-excitation line width in the meV range. Analogous ISTS measurements of Fe on Ag(111) show similar behavior, but with a three times larger anisotropy energy, and a g-factor of roughly 3.1. The observations can be interpreted in the context of advanced calculations including spin-orbit coupling and the Cu/Ag(111) surface state performed by S. Lounis et al.Cuvillier Verlag, Nonnenstieg 8, 37075 Göttingen 206 pp. Englisch.
