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Contents Foreword Preface 1 Solubility and Solubilization of NonelectrolytesSamuel H Yalkowsky 2 Drug Solubilization in Surfactant SystemsAT Florence 3 Solubilization of Drugs by cosolventsSamuel H Yalkowsky and Theodore J Roseman 4 Alteration of Apparent Solubility through ComplexationAJ Repta 5 Solubilization by Solid-State ManipulationEli Shefter 6 Drug Derivation as a means of Solubilization Physicochemical and Biochemical strategiesGordon L Amidon indexThis book was developed in an attempt to provide a comprehensive guide to the techniques available for solubilizing drugs in aqueous vehicles Since surfactant solubilization is extremely important in pharmaceutical systems and is by far the most studied of the techniques covered it is discussed in the greatest detail in the bookSolubilization by cosolvents complexing agents crystal modification and prodrug formation can individually or in combination be an extremely valuable means of solubilizing drugs Each of these techniques is discussed from both the theoretical and practical points of viewSalient Features For each technique a wide variety of examples is provided along with rational guidelines for application to new and unstudied drugs To aid the pharmaceutical scientist in understanding selecting and utilizing all of the available means of overcoming solubility problems 224 pp.