Predictive Methods in Percutaneous Absorption - Tapa dura

Gullick, Darren R.; Moss, Gary P.; Wilkinson, Simon C.

 
9783662473702: Predictive Methods in Percutaneous Absorption
Tapa dura
ISBN 10: 3662473704 ISBN 13: 9783662473702
Editorial: Springer, 2015

Sinopsis

This book sheds new light on the development and use of quantitative models to describe the process of skin permeation. It critically reviews the development of quantitative predictive models of skin absorption and discusses key recommendations for model development. Topics presented include an introduction to skin physiology; the underlying theories of skin absorption; the physical laboratory-based processes used to generate skin absorption data, which is in turn used to construct mathematical models describing the skin permeation process; algorithms of skin permeability including quantitative structure-activity (or permeability) relationships (QSARs or QSPRs); relationships between permeability and molecular properties; the development of formulation-focused approaches to models of skin permeability prediction; the use of artificial membranes, e.g. polydimethylsiloxane as alternatives to mammalian skin; and lastly, the use of novel Machine Learning methods in developing the next generation of predictive skin permeability models.

The book will be of interest to all researchers in academia and industry working in pharmaceutical discovery and development, as well as readers from the field of occupational exposure and risk assessment, especially those whose work involves agrochemicals, bulk chemicals and cosmetics.

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De la contraportada

This book sheds new light on the development and use of quantitative models to describe the process of skin permeation. It critically reviews the development of quantitative predictive models of skin absorption and discusses key recommendations for model development. Topics presented include an introduction to skin physiology; the underlying theories of skin absorption; the physical laboratory-based processes used to generate skin absorption data, which is in turn used to construct mathematical models describing the skin permeation process; algorithms of skin permeability including quantitative structure-activity (or permeability) relationships (QSARs or QSPRs); relationships between permeability and molecular properties; the development of formulation-focused approaches to models of skin permeability prediction; the use of artificial membranes, e.g. polydimethylsiloxane as alternatives to mammalian skin; and lastly, the use of novel Machine Learning methods in developing the next generation of predictive skin permeability models.

The book will be of interest to all researchers in academia and industry working in pharmaceutical discovery and development, as well as readers from the field of occupational exposure and risk assessment, especially those whose work involves agrochemicals, bulk chemicals and cosmetics.

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Editorial
Springer
Año de publicación
2015
Idioma
Inglés
ISBN 10 
3662473704
ISBN 13 
9783662473702
Encuadernación
Tapa dura
Número de páginas
216
Contacto del fabricante
Springer-Verlag GmbH
customerservice@springernature.com

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Heidelberg
Baden-Württemberg
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Alemania

Otras ediciones populares con el mismo título

9783662508312: Predictive Methods in Percutaneous Absorption

Edición Destacada

ISBN 10:  3662508311 ISBN 13:  9783662508312
Editorial: Springer, 2016
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