Redirection of Th1 and Th2 Responses: 238 (Current Topics in Microbiology and Immunology) - Tapa blanda

Libro 167 de 253: Current Topics in Microbiology and Immunology
 
9783662097113: Redirection of Th1 and Th2 Responses: 238 (Current Topics in Microbiology and Immunology)
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ISBN 10: 3662097117 ISBN 13: 9783662097113
Editorial: Springer, 2013

Sinopsis

It has been 12 years since the first proposal was made to sub divide mouse CD4 I T cell clones into Th I and Th2 subsets, based on their differences in cytokine production, and 7 years since the first clear demonstration of a similar dichotomy among human T cell clones. In the ensuing period, it has been realized that inappropriate development of Th I or Th2 responses are important features of many immunological and infectious dis eases. Perhaps the first group of diseases to be understood in terms of preferential Th subset activation were allergic diseases (see PARRONC’HI et aI. , this volume). Several of the major, co ordinately regulated, features of allergy, including IgE, eosino philia and mastocytosis, were found to be stimulated by the T- specific cytokines I L-4 and IL-5 and inhibited by the Th I cyto kine, IFN-. This suggested that the presence and severity of al lergic responses reflected the relative numbers of Th I and Th2 cells specific for the offending allergen. Similarly, the very dif ferent consequences of protective Th I and nonprotective Th2 responses to a number of intracellular pathogens have been re cognized for some time (see TRINCHIERI and SCOTI, and COFF MAN et aI. , this volume).

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Reseña del editor

It has been 12 years since the first proposal was made to sub­ divide mouse CD4 I T cell clones into Th I and Th2 subsets, based on their differences in cytokine production, and 7 years since the first clear demonstration of a similar dichotomy among human T cell clones. In the ensuing period, it has been realized that inappropriate development of Th I or Th2 responses are important features of many immunological and infectious dis­ eases. Perhaps the first group of diseases to be understood in terms of preferential Th subset activation were allergic diseases (see PARRONC'HI et aI. , this volume). Several of the major, co­ ordinately regulated, features of allergy, including IgE, eosino­ philia and mastocytosis, were found to be stimulated by the T- specific cytokines I L-4 and IL-5 and inhibited by the Th I cyto­ kine, IFN-. This suggested that the presence and severity of al­ lergic responses reflected the relative numbers of Th I and Th2 cells specific for the offending allergen. Similarly, the very dif­ ferent consequences of protective Th I and nonprotective Th2 responses to a number of intracellular pathogens have been re­ cognized for some time (see TRINCHIERI and SCOTI, and COFF­ MAN et aI. , this volume).

Reseña del editor

The two major subsets of CD4+ helper T cells, designated Th1 and Th2, have quite different patterns of cytokine production and, as a consequence, have very different roles in immune responses. The articles in this volume review both basic and clinical studies of T cell heterogeneity, including: - The mechanisms by which Th1 and Th2 cells develop and maintain their differences in cytokine production - The different roles of Th1 and Th2 cells in allergy, autoimmunity and infectious diseases - The prospects and strategies for therapeutic manipulation of Th1 and Th2 cells - The control of Th1 and Th2 responses by regulatory T cell subsets. The volume will give the reader a current view of the development and function of Th1 and Th2 cells and the attempts to treat immunological diseases with therapies directed towards altering the Th1/Th2 balance.

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Editorial
Springer
Año de publicación
2013
Idioma
Inglés
ISBN 10 
3662097117
ISBN 13 
9783662097113
Encuadernación
Tapa blanda
Número de páginas
164
Editor
Coffman Robert L., Romagnani Sergio
Contacto del fabricante
Springer Nature Customer Service Center GmbH
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Heidelberg
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Alemania

Otras ediciones populares con el mismo título

9783540650485: Redirection of Th1 and Th2 Responses: Vol 238 (Current Topics in Microbiology and Immunology)

Edición Destacada

ISBN 10:  3540650482 ISBN 13:  9783540650485
Editorial: Springer-Verlag Berlin and Heide..., 1998
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