Noninvasive Methods for the Quantification of Skin Functions: An Update on Methodology and Clinical Applications - Tapa blanda

 
9783642781599: Noninvasive Methods for the Quantification of Skin Functions: An Update on Methodology and Clinical Applications

Sinopsis

Noninvasive methods are gaining increasingly in influence and acceptance. This is also true in the field of dermatology, where it is no longer necessary to take biopsies in order to make statements, e.g., on the size of a skin tumor, on the epidermal water content, on the elasticity of the skin. Peter Frosch and Albert M. Kligman have managed to bring together international authors for the first time in one book, each of them a master of "his" investigation method.

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Reseña del editor

More than 10 years ago, I had the chance to visit the university hospital in Munster, Germany. At the outpatient clinic there, I accidently met a young dermatologist who was devoted to the study of the quantification of irritated skin during his busy daily clinical work. I sensed immediately that this Dr. P. Frosch was conducting his research with the ideals and enthusiasm which were so familiar to me. Soon we found that we shared a similar past experience; we both had begun our careers in dermatological investigation with the same mentor. For me it was more than 25 years ago that I first met Dr. Kligman, Professor at the University of Pennsylvania in Philadelphia, USA. I reminisced that I had been greatly shocked by his initial question ''As a dermatologist, do you want to study living or dead skin?" because, at that time and even today, whenever we cannot collect enough information about the skin with the naked eye, it is invasively removed is common practice to histologically examine a skin sample that from living tissue. Many dermatologists still would never think of studying the living intact skin itself noninvasively with the aid of existing advanced technologies to assess its structural and functional properties. At that time Dr. Kligman intended to build up a system of evaluating the skin from various aspects, using methods that had been unduly neglected in the past and introducing various technological instruments.

Reseña del editor

This book covers for the first time all the modern noninvasive techniques used to assess various functions of the skin in both normal and diseased states. In the first part, the basic so-called bioengineering methods are described such as quantification of the skin surface microrelief using image analysis, measurements of transepidermal water loss and skin blood flow, determination of skin thickness and elasticity, quantification of erythema by colorimetry, and analysis of sebum secretion. In the second part, numerous clinical applications are described and richlyillustrated such as dry skin, effects of aging, reactions to ultraviolet light, acne, eczema, psoriasis, and arterial occlusive diseases. The great value of these techniques becomes apparent in dermatopharmacology. The clinical response to therapeutics or prophylactic measures such as barrier creams can be objectively quantified - a long awaited goal of clinical and investigative dermatology.

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