Molecular Genetics of Recombination: 17 (Topics in Current Genetics, 17) - Tapa dura

Libro 11 de 17: Topics in Current Genetics
 
9783540710202: Molecular Genetics of Recombination: 17 (Topics in Current Genetics, 17)
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ISBN 10: 3540710205 ISBN 13: 9783540710202
Editorial: Springer, 2007

Sinopsis

The link between recombination defects and recombination proteins in a number of tumors as well as in human hereditary syndromes makes genetic recombination a cellular process of key importance not only in basic biology but also in biomedical studies.

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De la contraportada

Genetic recombination is an important process involved in shaping the genetic make up of progeny. Increasingly, it has become evident that recombination is a DNA repair pathway crucial during DNA replication in vegetatively growing cells. It plays a critical role in preserving the integrity of the genome by mediating the repair of DNA damage, which can occur during normal cellular metabolism as a result of oxidative stress, transcription, replication fork stalling or breakdown, or after the exposure to DNA damaging agents. Until recently, much of our knowledge on the mechanisms of genetic recombination has come from studies of prokaryotic and simple eukaryotic fungal systems. However, these studies have now been significantly extended to mammals, such that a comparative picture of the general factors and mechanisms of genetic recombination is beginning to emerge. Detailed genetic and biochemical studies have led to the isolation and characterization of many of the recombination-repair proteins in E. coli and S. cerevisiae, which in turn has led to the identification of homologues in human cells. The link between recombination defects and recombination proteins in a number of tumors as well as in human hereditary syndromes makes genetic recombination a cellular process of key importance not only in basic biology but also in biomedical studies.

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Editorial
Springer
Año de publicación
2007
Idioma
Inglés
ISBN 10 
3540710205
ISBN 13 
9783540710202
Encuadernación
Tapa dura
Número de páginas
552
Editor
Aguilera Andrés, Rothstein Rodney
Contacto del fabricante
ProductSafety@springernature.com
ProductSafety@springernature.com

Poststr. 9
Darmstadt
64293
Alemania

Otras ediciones populares con el mismo título

9783642090059: Molecular Genetics of Recombination: 17 (Topics in Current Genetics, 17)

Edición Destacada

ISBN 10:  3642090052 ISBN 13:  9783642090059
Editorial: Springer, 2010
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