Sinopsis
This volume summarizes the present basic and clinical knowledge on the complex syndrome "sepsis". The current findings rest on an interdisciplinary approach in attempting to unravel the molecular pathways causing this disease. The immune system senses bacterial toxins and is target as well. Recent insights into the cellular and molecular mechanisms underlying these processes unravelled for LPS the signal pathways triggering activation and acute cytokine release of the respective target cells. Based on the findings in animal model systems there is an urgend need to evaluate whether in humans the respective state of sensitisation can be defined and influences the impact of bacterial transition in causing the septic syndrome.
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Críticas
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Reseña del editor
Severe sepsis and septic shock are the most serious compli cations of bacterial infections. Both gram-positive and gram negative bacteria can trigger these extreme inflammatory re sponses and, by so doing, cause substantial morbidity and mortality. In the United States alone, over 400 000 patients suffer from septicaemia each year, and approximately 100 000 of these patients die despite optimal intensive care and modern antimicrobial therapy. These dramatic figures have prompted intensive research to define the bacterial and host factors involved in the septic response. Scientists from many disciplines, including chem istry, physics, biology, medical microbiology, immunology, and pharmacology, have worked closely with clinicians to achieve rapid and profound progress. To translate this newly acquired knowledge into clinical practice, clinical trials have also been performed to evaluate numerous new therapeutic drugs. The disappointing results from these trials have underscored a major lesson, namely, that sepsis constitutes an extremely complex syndrome and that basic and clinical research must be greatly intensified in order to illuminate its molecular mechan isms. At this stage, the editors of the present volume of Current Topics in Microbiology and Immunology considered it would be rewarding to compile a volume summarizing our present basic and clinical knowledge on sepsis. Our particular gratitude extends to those international experts who have followed our invitation and elaborated on particular areas of the basic and clinical aspects of this field.
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Pathology of Septic Shock.
Publicado por
Springer Berlin Heidelberg., 1996
ISBN 10: 354061026X
ISBN 13: 9783540610267
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Librería: Universitätsbuchhandlung Herta Hold GmbH, Berlin, Alemania
Calificación del vendedor: 4 de 5 estrellas
Hardcover. Versand aus Deutschland / We dispatch from Germany via Air Mail. Einband bestoßen, daher Mängelexemplar gestempelt, sonst sehr guter Zustand. Imperfect copy due to slightly bumped cover, apart from this in very good condition. Stamped. Sprache: Englisch. Nº de ref. del artículo: 45398HB
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