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Targeted Interference with Signal Transduction Events: 172 (Recent Results in Cancer Research, 172) - Tapa dura

 
9783540312086: Targeted Interference with Signal Transduction Events: 172 (Recent Results in Cancer Research, 172)
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ISBN 10: 3540312080 ISBN 13: 9783540312086
Editorial: Springer, 2007

Sinopsis

Introduction: The Rationale for the Development of Targeted Drugs in Cancer Therapy.- Identifying Critical Signaling Molecules for the Treatment of Cancer.- Tyrosine Kinase Inhibitors and Cancer Therapy.- Targeting ERBB Receptors in Cancer.- Inhibition of the IGF-I Receptor for Treatment of Cancer. Kinase Inhibitors and Monoclonal Antibodies as Alternative Approaches.- Inhibition of the TGF-? Signaling Pathway in Tumor Cells.- The Mammalian Target of Rapamycin Kinase and Tumor Growth Inhibition.- The Ras Signalling Pathway as a Target in Cancer Therapy.- The Mitogen-Activated Protein Kinase Pathway for Molecular-Targeted Cancer Treatment.- Clinical Relevance of Targeted Interference with Src-Mediated Signal Transduction Events.

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Reseña del editor

This book does nothing less than lay out the state of development of tomorrow’s cancer drugs, directed against growth factors, growth factor receptors and intracellular signaling molecules with kinase activities. The sequencing of the human genome and insights into signaling pathways have contributed to the understanding of cancer etiology and the development of new, improved cancer drugs such as Herceptin and Glivec. The deregulation of pathways due to mutated cancer genes provides the conceptual basis for future progress. Will it be possible to derive more efficient cancer drugs?

Reseña del editor

Two aspects of biological research are major contributors to the progress in the understanding of cancer etiology and the development of new and improved cancer drugs. The sequencing of the human genome provides us with a basic overview of all our genes and gene products, and the insights into signaling pathways allow us to align crucial components of cellular regulation into an ordered functional context. A comparison of the genes in normal and in tumor cells shows that mutations in the DNA of a limited set of genes are responsible for the multiple stages of tumorigenesis and metastasis. Many of the affected genes, including oncogenes, tumor suppressor genes and genome stability genes, can be fitted into pathways. They encode molecules that stimulate tumor cell division or inhibit their death. Matching of therapeutic intervention with insights into the underlying molecular disease mechanism has already led to the development of drugs such as Herceptin and Glivec. The deregulation of pathways as a consequence of the altered biochemical function of mutated cancer genes provides the conceptual basis for future progress. Will it be possible to extrapolate this principle and derive more efficient drugs targeting cancer pathway components? Promising cell surface molecules, potential targets of monoclonal antibodies, and intracellular molecules with enzymatic activity, potential targets for low-molecular-weight synthetic inhibitors, have been identified. Our ability to predict the consequences of inhibition of such components, however, is still limited. For this reason, the development of targeted drugs remains a complex process, comprising rational and empirical elements. The state of development of tomorrow's cancer drugs, directed against growth factors, growth factor receptors and intracellular signaling molecules with kinase activities, is described in this book.

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Editorial
Springer
Año de publicación
2007
Idioma
Inglés
ISBN 10 
3540312080
ISBN 13 
9783540312086
Encuadernación
Tapa dura
Número de edición
1
Número de páginas
200
Editor
Groner B.
Contacto del fabricante
no disponible
Persona responsable
CMN Printpool Inh. Mathis Neumann
https://www.also.com/ec/cms5/en_6000/6000/index.jsp

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