Sinopsis
Knud Nierhaus, who has studied the ribosome for more than 30 years, has assembled here the combined efforts of several scientific disciplines into a uniform picture of the largest enzyme complex found in living cells, finally resolving many decades - old questions in molecular biology. In so doing he considers virtually all aspects of ribosome structure and function - from the molecular mechanism of different ribosomal ribozyme activities to their selective inhibition by antibiotics, from assembly of the core particle to the regulation of ribosome component synthesis. The result is a premier resource for anyone with an interest in ribosomal protein synthesis, whether in the context of molecular biology, biotechnology, pharmacology or molecular medicine.
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Acerca del autor
Knud H. Nierhaus studied medicine and completed his thesis with Prof. Klaus Betke in Tubingen (Germany). In 1968 he joined the Max-Planck-Institut fur Molekulare Genetik in Berlin, where he currently leads a research group studying different aspects of translation. He is "aubetaerplanmabetaiger Professor" at the TU, Berlin and "adjunct Professor" at the Moscow State University. His main achievements include the development of a method to reconstitute the large subunit from E. coli ribosomes from its isolated components and the detection of a third tRNA binding site, the E site, on the ribosome. Daniel N. Wilson studied Biochemistry and Molecular Biology at Victoria University, Wellington (New Zealand). He carried out his PhD in the laboratory of Prof. Warren Tate in the Biochemistry Department at the University of Otago, Dunedin. In his thesis he focused on the mechanisms of translational termination and recoding events. Following completion of his studies in 1999, he was awarded an Alexander von Humboldt fellowship and currently works on the crystallography of ribosomes at the Max-Planck-Institut fur Molekulare Genetik in Berlin.
De la contraportada
Based on more than 30 years of ribosome research and incorporating the most recent strucutural evidence, this book presents a uniform picture of the largest enzyme complex found in living cells, shedding light on many decades-old questions in molecular biology.
From the contents:
Structure of the Ribosome
Ribosome Assembly
tRNA and Synthetases
mRNA Degradation
Initiation and Elongation
Termination and Ribosome Recycling
Regulation of Ribosome Biosynthesis
Inhibition of the Translational Apparatus by Antibiotics
A premier resource for anyone with an interest in ribosomal protein synthesis, whether in the context of molecular biology, biotechnology, pharmacology or molecular medicine.
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Protein Synthesis and Ribosome Structure - Translating the Genome
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Wiley VCH, Germany, 2004
ISBN 10: 3527306382
ISBN 13: 9783527306381
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Hardcover. Condición: As New. Estado de la sobrecubierta: No Dust Jacket. (?); (?). An in-depth and authoritative guide to the molecular machinery of protein synthesis, this volume explores the structure and function of the ribosome in detail. Combining insights from structural biology, genetics, and pharmacology, it offers a comprehensive look at how genetic information is translated into proteins. Ideal for researchers, students, and professionals in molecular biology and biochemistry. ; 18x25x3.9cm; 597 pages. Nº de ref. del artículo: 63911
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Protein Synthesis and Ribosome Structure: Translating the Genome
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Wiley-VCH Verlag GmbH & Co. KGaA 08.2004., 2004
ISBN 10: 3527306382
ISBN 13: 9783527306381
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Librería: Borkert, Schwarz und Zerfaß GbR, Berlin, Alemania
Calificación del vendedor: 5 de 5 estrellas
, Hardcover/Pappeinband. Condición: Gut. Auflage: 1. Auflage. 597 Seiten Fresh and clean hardcover copy in good condition. Frisches und sauberes Hardcover-Exemplar in gutem Zustand. Contents: Preface XV 1 A History of Protein Biosynthesis and Ribosome Research 1.1 Introduction 1.2 The Archaeology of Protein Synthesis - The 1940s: Forgotten Paradigms 1.3 Basic Mechanisms - The 1950s 1.3.1 Steps toward an in vitro Protein Synthesis System 1.3.2 Amino Acid Activation and the Emergence of Soluble RNA 1.3.3 From Microsomes to Ribosomes 1.3.4 Models 1.4 The Golden Age ofTranslation - The 1960s 1.4.1 From Enzymatic Adaptation to Gene Regulation: Messenger RNA 1.4.2 A Bacterial in vitro System ofProtein Synthesis 1.4.3 The Functional Dissection ofTranslation 1.4.4 The Structural Dissection ofthe Ribosome 1.5 1970-1990s: A Brief Synopsis 2 Structure of the Ribosome - Gregor Bloho 2.1 General Features ofthe Ribosome and Ribosomal Subunits 2.2 A Special Feature ofthe 50S Subunit: The Tunnel 2.3 Features of the Ribosomal Subunits at Atomic Resolution 2.4 The Domain Structure of the Ribosomal Subunits 2.5 Interactions ofRNA with RNA or Struts and Bolts in the 3D Fold ofrRNA: Coaxial Stacking and A-minor Motifs 2.5.1 Coaxial Stacldng 2.5.2 A-minor Motifs 2.5.3 Ribose Zippers and Patches ofA-minor Motifs 2.5.3.1 Canonical Ribose Zipper 2.5.3.2 Single-base Ribose Zipper 7 2.6 Progress and New Developments in Understanding rRNA Structures 2.6.1 K-turn 2.6.2 Lonepair Triloop 2.6 .2 .1 Classification of Lonepair Triloops 2.6 .3 Systemizing Base Pairs 2.6 .4 Systemizing RNA Structural Elements 2.7 RNA-protein Interactions 2.7 .1 Problem of RNA Recognition 2.7.2 Chemistry of RNA-protein Interactions 2.7.3 rRNA-protein Interaction 3 Ribosome Assembly 3.1 Assembly Of The Prokaryotic Ribosome - Knud H. Nierhaus 3.1 .1 Introduction 3.1 .2 Processing of rRNAs 3.1 .3 Precursor Particles and Reconstitution Intermediates 3.1 .4 Assembly-initiator Proteins 3 .1 .5 Proteins Essential for the Early Assembly: The Assembly Gradient 3 .1 .6 Late-assembly Components 3 .1 .7 Proteins Solely Involved in Assembly 3.1 .8 Assembly Maps 3.2 Eukaryotic Ribosome Synthesis - Denis L.J . Lafontaine 3.2.1 Introduction 3.1 .1 Prelude 3 .2 .2 Why so many RRPs? 3.2 .3 (Pre-)ribosome Assembly, the Proteomic Era 3.2 .4 Ribosomal RNA Processing, Getting there 3.2 .5 Ribosomal RNA Modification : A Solved Issue? 3.2 .5 .1 Ribose Methylation, Pseudouridines formation and the snoRNAs 3.2 .5 .2 The Emergence of the snoRNAs 3.2 .5 .3 Non-ribosomal RNA Substrates for the snoRNAs 3 .2 .5 .4 Possible function(s) of RNA modifications 3.2 .5 .5 Base methylation 3.2 .5 .6 U3 snoRNP, the 'SSU Processome', and the Central Pseudoknot 3.2 .6 SnoRNA Synthesis and Intranuclear Trafficking 3.2 .6.1 SnoRNAs Synthesis 3 .2 .6.2 Non-core snoRNP Proteins required for snoRNA Accumulation 3.2 .6 .3 Interactions between Cleavage Factors and Core snoRNP Proteins 3.2 .6 .4 SnoRNAs Trafficking 3.2 .6 .5 CB/NB are Conserved Sites of Small RNP Synthesis 3.2 .7 Ribosome Intranuclear Movements and Ribosome Export 3.2 .8 The Cytoplasmic Phase of Ribosome Maturation 3.2 .9 Regulatory Mechanisms, all along 3.2 .10 And Now . What's Next? 3.2 .11 Epilogue 3.3 .12 Useful WWW links 4 tRNA and Synthetases 4.1 tRNA : Structure and Function - Viter Marqudz and Knud H. Nierhaus 4.1 .1 Introduction 4.1 .2 Secondary Structure 4.1 .3 Tertiary Structure 4.1 .4 tRNA Modifications 4.1 .5 Recognition of tRNA by tRNA synthetase : Identity Elements 4.1 .6 Is the tRNA Cloverleaf Structure a Pre-requisite for the L-shape? 4.1 .7 Other Functions of tRNA outside the Ribosomal Elongation Cycle 4.1 .8 Human Neurodegenerative Disorders Associated with Mitochondrial tRNAs 4.2 Aminoacylations of tRNAs: Record-keepers for the Genetic Code Llu's Ribas de Pouplana and Paul Schimmel 4.2 .1 Introduction 4.2 .2 The Operational RNA Code 4.2 .3 Extant Aminoacyl-tRNA Synthetases 4.2 .4 The Origin of Aminoacyl-tRNA Synthetase Classes: Two Proteins bound to one tRNA 4.2 .5 A Common Genetic Origin for all Aminoacyl-tRNA Synthetases ? 4.2 .5 .1 Evolution of Extant Enzymes prior to LUCA 4.2 .5 .2 Changes in Acceptor Stem Identity Elements Correlate with Changes in the Code 5 rnRNA Decay and RNA-degrading Machines in Prokaryotes and Eukaryotes - Agamemnonf. Carpousis and Marc Dreyfus 5.1 Summary 5.2 Introduction 5.3 mRNA Decay in E. coli 5 .4 mRNA Decay in S. cerevisiae 5.5 A Comparison of mRNA Decay in E. coli and S. cerevisiae 5.6 RNase E Specificity: A Role in Translation Arrest? 5.7 The E. coli RNA degradosome 5.8 The Autoregulation of RNase E and PNPase Synthesis: A Link between Bulk Translation and mRNA Stability 5.9 RNA-degrading Machines in other Organisms 5 .10 DEAD-box ATPases 5 .11 Perspective 6 tRNA Locations on the Ribosome - Knud H . Nierhaus 6.1 tRNAs Move through Functional Sites on the Ribosome 6.2 Visualization of tRNAs on the Ribosome 6.3 tRNA-ribosome Contacts 7 Initiation of Protein Synthesis 7.1 Initiation of Protein Synthesis in Eubacteria - Daniel N . Wilson 7.1 .1 Overview of Initiation in Eubacteria 7.1 .2 Specialized initiation events : translational coupling, 70S initiation and leaderless mRNAs 7.1 .3 Initiation Factor 1 Binds to the Ribosomal A-site 7.1.4 The Domain Structure of Bacterial IF2 7.1 .5 Interaction Partners of IF2 7.1 .6 The Role of the IF2-dependent GTPase Activity 7.1 .7 The Mystery of the I173-binding Site on the 30S Subunit 7.2 Mechanism and Regulation of Protein Synthesis Initiation in Eukaryotes Alan G. Hinnebusch, Thomas E. Dever, and Nahum Sonenberg 7.2 .1 Introduction 7.2 .1 .1 Overview of Translation-initiation Pathways in Eukaryotes and Prokaryotes 7.2 .1 .2 Conservation and diversity of translation-initiation factors among bacteria, archaea and eukaryotes 7.2 .1 .3 Genetic assays for in vivo functions of eIF2 248 7.2 .2 Generation of Free 40S Subunits and 40S Binding of Met-tRNA 7.2 .2 .1 Dissociation of Idle 80S Ribosomes 7.2 .2 .2 Components of the eIF2/GTP/Met-tRNA Ternary Complex 7.2 .2 .3 The GEF eIF2B regulates terna. Nº de ref. del artículo: 1239295
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Protein Synthesis and Ribosome Structure
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Condición: New. pp. xviii + 579 Illus. Nº de ref. del artículo: 7362907
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Protein Synthesis and Ribosome Structure
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Condición: New. pp. xviii + 579. Nº de ref. del artículo: 18517774
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Protein Synthesis and Ribosome Structure. Translating the Genome : Translating the Genome
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Gebundene Ausgabe. Condición: Neu. Gebraucht - Sehr gut Mängelexemplar mit leichten Lagerspuren, Sofortversand - Seit 30 Jahren beschäftigt sich Knud Nierhaus mit dem Ribosom. In diesem Band fügt er, unterstützt von erfahrenen Fachleuten aus verschiedenen Disziplinen, die gegenwärtig gesicherten Erkenntnisse über Struktur und Funktion dieses größten in lebenden Zellen existierenden Enzymkomplexes zu einem beeindruckenden Porträt zusammen. Erwogen werden nahezu sämtliche denkbaren Aspekte des Themas, wobei sich Antworten auf manche schon vor Jahrzehnten gestellte Frage ergeben. Ein Muss für Molekularbiologen, Biotechnologen, Pharmakologen und Molekularmediziner! Nº de ref. del artículo: INF1000021189
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