Fluorine is best known for its role in the prevention of cavities and in improving oral and bone health however equally there are millions of people around the world suffering from dental fluorosis due to chronic exposure to high levels of fluoride in drinking water. This volume, written by leading researchers in this area, examines the positives and negatives of fluorine and its effects on humans for example fluoride-induced oxidative stress in the liver, effects of fluoride on insulin and preventing fluoride toxicity. Extremely useful for underpinning cross-disciplinary fluorine research, this book provides a fascinating insight for those with an interest in the health and nutritional sciences.
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Victor R. Preedy is a senior member of King's College London (Professor of Nutritional Biochemistry) and King's College Hospital (Professor of Clinical Biochemistry; Hon). He is attached to both the Diabetes and Nutritional Sciences Division and the Department of Nutrition and Dietetics. He is also Director of the Genomics Centre and a member of the School of Medicine. Professor Preedy graduated in 1974 with an Honours Degree in Biology and Physiology with Pharmacology. He gained his University of London PhD in 1981 and in 1992, he received his Membership of the Royal College of Pathologists. Professor Preedy was elected as a Fellow of the Institute of Biology in 1995 and to the Royal College of Pathologists in 2000. Since then he has been elected as a Fellow to the Royal Society for the Promotion of Health (2004) and The Royal Institute of Public Health and Hygiene (2004). In 2009, Professor Preedy became a Fellow of the Royal Society for Public Health and in 2012 a Fellow of the Royal Society of Chemistry. During his career, Professor Preedy has worked at the National Heart Hospital (part of Imperial College London) and the MRC Centre at Northwick Park Hospital. He has collaborated with research groups in Finland, Japan, Australia, USA and Germany. He is a leading expert on nutritional and food sciences and has a long standing interest in how food, food quality, nutrition and diet affect wellbeing and health. He has lectured nationally and internationally. To his credit, Professor Preedy has over 600 publications, which includes peer-reviewed manuscripts based on original research, abstracts and symposium presentations, reviews, books and volumes.
Fluorine is best known for its role in the prevention of cavities and in improving oral and bone health however equally there are millions of people around the world suffering from dental fluorosis due to chronic exposure to high levels of fluoride in drinking water. This volume, written by leading researchers in this area, examines the positives and negatives of fluorine and its effects on humans for example fluoride-induced oxidative stress in the liver, effects of fluoride on insulin and preventing fluoride toxicity. Extremely useful for underpinning cross-disciplinary fluorine research, this book provides a fascinating insight for those with an interest in the health and nutritional sciences.
Fluorine is best known for its role in the prevention of cavities and in improving oral and bone health however equally there are millions of people around the world suffering from dental fluorosis due to chronic exposure to high levels of fluoride in drinking water. This volume, written by leading researchers in this area, examines the positives and negatives of fluorine and its effects on humans for example fluoride-induced oxidative stress in the liver, effects of fluoride on insulin and preventing fluoride toxicity. Extremely useful for underpinning cross-disciplinary fluorine research, this book provides a fascinating insight for those with an interest in the health and nutritional sciences.
Fluorine in Context,
Chapter 1 Fluoride in the Context of the Environment María Gabriela García and Laura Borgnino,
Chapter 2 Fluoride Intake in the Context of Dental Fluorosis Aline de Lima Leite, Camila Peres Buzalaf, and Marília Afonso Rabelo Buzalaf,
Chemistry and Biochemistry,
Chapter 3 The Chemistry of Fluorine Brenda Lorena Fina and Alfredo Rigalli,
Chapter 4 Fluoride Metabolism Camila Peres Buzalaf, Aline de Lima Leite, and Marília Afonso Rabelo Buzalaf,
Analysis,
Chapter 5 Fluorine Determination in Milk, Tea and Water by High-Resolution, High-Temperature Molecular Absorption Spectrometry Suleyman Akman, Bernhard Welz, Nil Ozbek, and Éderson R. Pereira,
Chapter 6 Blood, Plasma and Bone Fluoride Measurement Maela Lupo and Alfredo Rigalli,
Function and Effects,
Chapter 7 Fluoride Accumulation in Crops and Vegetables: Indian Perspectives Srimanta Gupta and Dali Mondal,
Chapter 8 Fluoride Levels in Herbal and Tea Infusions Ebru Emekli-Alturfan, Aysen Yarat, and Serap Akyuz,
Chapter 9 Bioavailability of Fluoride: Factors and Mechanisms Involved René A. Rocha, Dinoraz Vélez, and Vicenta Devesa,
Chapter 10 Fluoride in Saliva and its Impact on Health Serap Akyuz, Aysen Yarat, Ebru Emekli Alturfan, and Sarp Kaya,
Chapter 11 Teeth–Saliva Migration of Fluoride Ions and Health Implications Biljana M. Kalicanin, Dragan S. Velimirovic, and Aleksandra N. Pavlovic,
Chapter 12 Effect of Fluoride on Bone Metabolism, Structure and Remodeling Brenda Lorena Fina and Alfredo Rigalli,
Chapter 13 Fluoride and Dietary Calcium on Bone Dianjun Sun, Cheng Wang, Wei Zhang, and Lijun Zhao,
Chapter 14 Sodium Fluoride and PET Bone Scans Gholam R. Berenji, Yuxin Li, Roberto Gonzalez-Odriozola, and Anurada Thenkondar,
Chapter 15 Fluoride-Induced Oxidative Damage in Hippocampal Cells Iwona Inkielewicz-Stepniak and Narcyz Knap,
Chapter 16 Fluoride-Induced Oxidative Stress in the Liver Seyed Fazel Nabavi, Maria Daglia, Antoni Sureda, and Seyed Mohammad Nabavi,
Chapter 17 Effect of Fluoride on the Sensitivity and Secretion of Insulin Mercedes Lombarte, Alfredo Rigalli, Fernando Yamamoto Chiba, and Doris Hissako Sumida,
Chapter 18 Preventing Fluoride Toxicity with Selenium Swaran J. S. Flora and Megha Mittal,
Chapter 19 Fluoride and Effects on Caspases Jundong Wang and Ruiyan Niu,
Subject Index,
Fluoride in the Context of the Environment
MARÍA GABRIELA GARCÍA AND LAURA BORGNINO
1.1 Fluoride in the Environment and Health Implications
Fluoride has interesting properties related to human health, particularly in preventing dental caries. However, when it is concentrated in drinking water at levels higher than 1 mg l-1, a clinical condition called dental fluorosis may appear. This consists of a dental enamel hypomineralization that manifests through greater surface and subsurface porosity than in normal enamel, a condition that develops as a result of excessive fluoride intake (Burt and Eklund, 1992). Typical symptoms of dental fluorosis are fine white stripes to dark stains in the teeth surface. Endemic fluorosis is known to affect many millions of people around the world due to chronic exposure to high levels of fluoride in drinking water. The incidence of this illness is a
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