Rethinking Cancer: A New Paradigm for the Postgenomics Era (Vienna Series in Theoretical Biology) - Tapa blanda

Libro 11 de 17: Vienna Series in Theoretical Biology
 
9780262054348: Rethinking Cancer: A New Paradigm for the Postgenomics Era (Vienna Series in Theoretical Biology)
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ISBN 10: 0262054345 ISBN 13: 9780262054348
Editorial: MIT Press, 2025

Sinopsis

Leading scientists argue for a new paradigm for cancer research, proposing a complex systems view of cancer supported by empirical evidence.

Current consensus in cancer research explains cancer as a disease caused by specific mutations in certain genes. Thanks to dramatic advances in genome sequencing, never before have we known so much about the individual cancer cell—and yet it is still unclear how to use this knowledge for treatment success. In this volume, leading researchers argue for a new theory framework for understanding and treating cancer. The contributors propose a complex systems view of cancer, presenting conceptual building blocks for a new research paradigm supported by empirical evidence.

The contributors first discuss the new research framework in terms of theoretical foundations and then take up the relevance of a systems approach, reviewing such topics as nonlinearity, recurrence after treatment, the cellular attractor concept, network theory, and noncoding DNA—the “dark matter” of our genome. They address the temporality of cancer progression, drawing on evolutionary theory and clinical experience. Finally, they cover the dominant role of the tissue microenvironment in cancer, analyzing topics including altered metabolic pathways, the disease-defining influence on metastasis, and the interconnectedness of different environmental niches across levels of organization.

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Acerca del autor

Bernhard Strauss is Senior Research Associate in the Department of Biochemistry at the University of Cambridge.

Marta Bertolaso is Associate Professor of Philosophy of Science in the Faculty of Engineering at Università Campus Bio-Medico in Rome.

Ingemar Ernberg is Professor of Tumor Biology at the Department of Microbiology, Tumor, and Cell Biology at the Karolinska Institutet in Stockholm.

Mina J. Bissell is Distinguished Scientist in the Biological Systems and Engineering Division at Lawrence Berkeley National Laboratory.

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Editorial
MIT Press
Año de publicación
2025
Idioma
Inglés
ISBN 10 
0262054345
ISBN 13 
9780262054348
Encuadernación
Tapa blanda
Número de páginas
433
Editor
Strauss Bernhard, Bertolaso Marta, Ernberg Ingemar
Contacto del fabricante
no disponible
Persona responsable
no disponible

Otras ediciones populares con el mismo título

9780262045216: Rethinking Cancer: A New Paradigm for the Postgenomics Era (Vienna Series in Theoretical Biology)

Edición Destacada

ISBN 10:  0262045214 ISBN 13:  9780262045216
Editorial: The MIT Press, 2021
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