Sinopsis
Antisense technology has been used for several years to "knock down" the expression of specific genes in living tissues to study the functions of their protein products. Specifically designed antisense oligonucleotides (ODNs) are short lengths of man-made genetic material designed to interfere with the production of the protein encoded by the gene. This can shed light on the function of the protein; alternatively, if a disease process results from an excess of a certain protein, the method can in theory correct the problem. Although faster than transgenic techniques, antisense has been seen as something of a "black art". There are many technical problems to understand and overcome. This is the first book to provide a critical review of the uses of this technology in the central nervous system. It includes: Background to the technology Problems of design and synthesis of antisense molecules Administration in the brain Protection of ODNs from metabolic destruction
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Críticas
...This is the first book to provide a critical review of the uses of this technology in the central nervous system (Aslib Book Guide)
Reseña del editor
Antisense technology has been used for several years to "knock down" the expression of specific genes in living tissues to study the functions of their protein products. Specifically designed antisense oligonucleotides (ODNs) are short lengths of man-made genetic material designed to interfere with the production of the protein encoded by the gene. This can shed light on the function of the protein; alternatively, if a disease process results from an excess of a certain protein, the method can in theory correct the problem. Although faster than transgenic techniques, antisense has been seen as something of a "black art". There are many technical problems to understand and overcome. This is the first book to provide a critical review of the uses of this technology in the central nervous system. It includes: Background to the technology Problems of design and synthesis of antisense molecules Administration in the brain Protection of ODNs from metabolic destruction
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Antisense Technology in the Central Nervous System
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Paperback. Condición: Very Good. This book is in very good condition and will be shipped within 24 hours of ordering. The cover may have some limited signs of wear but the pages are clean, intact and the spine remains undamaged. This book has clearly been well maintained and looked after thus far. Money back guarantee if you are not satisfied. See all our books here, order more than 1 book and get discounted shipping. Nº de ref. del artículo: 6545-9780198505389
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Antisense Technology in the Central Nervous System
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Oxford University Press, 1999
ISBN 10: 0198505388
ISBN 13: 9780198505389
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Oxford University Press 1999 OUP 1999 xx 250pp paperback new unused book As New. Nº de ref. del artículo: 11668
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Antisense Technology in the Central Nervous System
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Oxford University Press, 1999
ISBN 10: 0198505388
ISBN 13: 9780198505389
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Soft cover. Condición: New. 1st Edition. SHRINK-WRAPPED NEW: Antisense Technology in the Central Nervous System 1999 PB ED 1 Antisense Technology in the Central Nervous System 1st Edition by Ronald A. Leslie (Editor), A. Jackie Hunter (Editor), Harold A. Robertson (Editor) 133A2-133D8-PB-0198505388-1P1-PplRed DESCRIPTION Antisense technology has been used for several years to "knock down" the expression of specific genes in living tissues to study the functions of their protein products. Specifically designed antisense oligonucleotides (ODNs) are short lengths of man-made genetic material designed to interfere with the production of the protein encoded by the gene. This can shed light on the function of the protein; alternatively, if a disease process results from an excess of certain protein, the method can in theory correct the problem. Faster thantransgenic techniques, but more problematic in practice, antisense has been seen as something of a "black art". There are many technical problems to understand and overcome. About the Author Ron A. Leslie, SmithKline Beecham Pharmaceuticals, Harlow. Jackie Hunter, SmithKline Beecham, Harlow. Harry Robertson, Professor and Head, Department of Pharmacology, Dalhousie University. Product details Publisher ‏ : ‎ Oxford University Press; 1st edition (December 15, 1999) Language ‏ : ‎ English Paperback ‏ : ‎ 250 pages ISBN-10 ‏ : ‎ 0198505388 ISBN-13 ‏ : ‎ 978-0198505389. Nº de ref. del artículo: 133A2-133D8-PB-0198505388-1P1-PplRed
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