Paperback. Process development bridges the gap between the laboratory synthesis of an organic compound and its industrial manufacture on a large scale. In this concise text the authors use real examples to show the problems which may be encountered in scaling up chemical syntheses and the ways in which these problems may be overcome. The major part of the book is devoted to genuine case histories from ICI/Zeneca Pharmaceuticals. Through a range of carefully chosenexamples, the book explains how it is possible to synthesise multi-kilogram quantities of a new organic compound which have been made in the laboratory only on the milligram scale. A wide range of aliphatic,aromatic, and heterocyclic compounds is covered. The book will be of particular value to research chemists who are involved in the development phase of novel compounds and to advanced undergraduate and postgraduate students interested in the fine chemicals industry. Process development bridges the gap between the laboratory synthesis of an organic compound and its industrial manufacture on a large scale. This book uses real examples to show the range of problems which may be encountered in scaling up chemical syntheses and the ways in which they may be overcome. Shipping may be from multiple locations in the US or from the UK, depending on stock availability.

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Detalles bibliogr�ficos

T�tulo: Process Development (Paperback)
Editor: Oxford University Press, Oxford
Fecha de publicaci�n: 1995
Idioma: Ingl�s
ISBN 10: 0198558244
ISBN 13: 9780198558248
Encuadernaci�n: Paperback
Edici�n: 1� Edici�n
Estado: new

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Sinopsis

Process development bridges the gap between the laboratory synthesis of an organic compound and its industrial manufacture on a large scale. In this concise text the authors use real examples to show the problems which may be encountered in scaling up chemical syntheses and the ways in which these problems may be overcome. The major part of the book is devoted to genuine case histories from ICI/Zeneca Pharmaceuticals. Through a range of carefully chosen examples, the book explains how it is possible to synthesise multi-kilogram quantities of a new organic compound which have been made in the laboratory only on the milligram scale. A wide range of aliphatic, aromatic, and heterocyclic compounds is covered. The book will be of particular value to research chemists who are involved in the development phase of novel compounds and to advanced undergraduate and postgraduate students interested in the fine chemicals industry.

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Stan Lee and Graham Robinson are both at Zeneca Pharmaceuticals, Macclesfield, Cheshire.

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