9783846530498 - Molecular Modeling and Synthesis of HBV Polymerase Inhibitors:: Nucleoside and Non Nucleosides de El-Azab, Adel S.; Abdel-Aziz, Alaa A.-M. (4 resultados)

Taschenbuch. Condición: Neu. Molecular Modeling and Synthesis of HBV Polymerase Inhibitors: | Nucleoside and Non Nucleosides | Adel S. El-Azab (u. a.) | Taschenbuch | Englisch | LAP Lambert Academic Publishing | EAN 9783846530498 | Verantwortliche Person für die EU: preigu GmbH & Co. KG, Lengericher Landstr. 19, 49078 Osnabrück, mail[at]preigu[dot]de | Anbieter: preigu.

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Condición: New. Dieser Artikel ist ein Print on Demand Artikel und wird nach Ihrer Bestellung fuer Sie gedruckt. Autor/Autorin: El-Azab Adel S.Adel S. El-Azab and Alaa A.-M. Abdel-Aziz, awarded Ph.D. in organic Chemistry in 2001 from Tohoku and Kumamoto Universities, Japan. They are working as an Associate Professor at the College of Pharmacy, Al-Azhar and Ma.

Taschenbuch. Condición: Neu. nach der Bestellung gedruckt Neuware - Printed after ordering - Hepatitis B virus (HBV) is the major cause of acute and chronic hepatitis which could lead to hepatocellular carcinoma. Currently, interferon- and nucleosidic inhibitors of HBV reverse transcriptase, polymerase, lamivudine (3TC), adefovir and entecavir are the only drugs approved for the treatment of chronic HBV infection. However, interferon- -produces many side affects with partial efficacy less than 30% of the chronic carriers responding to treatment. In addition, about 50% of the patients who respond positively to interferon- treatments are known to suffer recurrence of the viremia after cessation of the treatment. In contrast, 3TC has more universal applicability and is able to reduce the viral load very rapidly. Complete and sustained suppression of viral replication remain the most important goal in the treatment of patient with chronic (HBV) infection. Nucleoside and Nucleotide analogues have greatly improved the disease outcome for these patients and have also prevented hepatic decompensation or the development of hepatocellular carcinoma. Therefore, there is need for drugs that directly inhibit HBV production. Most compounds explored so far are nucleoside analogs.