9783659790010 - In Search of Selective 11?-HSD 1 Inhibitors without Nephrotoxicity: An Approach to Resolve the Metabolic Syndrome by Virtual Based Screening de Jagtap, Rakesh; Pate... (6 resultados)

Taschenbuch. Condición: Neu. In Search of Selective 11¿-HSD 1 Inhibitors without Nephrotoxicity | An Approach to Resolve the Metabolic Syndrome by Virtual Based Screening | Rakesh Jagtap (u. a.) | Taschenbuch | 56 S. | Englisch | 2015 | LAP LAMBERT Academic Publishing | EAN 9783659790010 | Verantwortliche Person für die EU: preigu GmbH & Co. KG, Lengericher Landstr. 19, 49078 Osnabrück, mail[at]preigu[dot]de | Anbieter: preigu.

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Taschenbuch. Condición: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Over expression of 11beta-HSD 1 in key metabolic tissues is related to the development of type 2 diabetes, obesity, hypertension and metabolic syndrome. Nephrotoxicity of corosolic acid (selective inhibitor of 11beta-HSD 1) is recently reported, which is one of the major drawback. Therefore, it is of great interest to find out the selective 11beta-HSD 1 inhibitors without nephrotoxicity. Using crystal structures of 11beta-HSD 1 in complex with inhibitors as a source of structural information, a combined structure-based virtual screening approach followed by PASS toxicity prediction, Lipinski's rule and ADME prediction implemented to find out the potent and selective 11 beta-HSD 1 analog of corosolic acid without nephrotoxicity. 56 pp. Englisch.

Condición: New. Dieser Artikel ist ein Print on Demand Artikel und wird nach Ihrer Bestellung fuer Sie gedruckt. Autor/Autorin: Jagtap RakeshMr. Rakesh has completed the Bachelor Degree of Pharmacy in year 2014. He recently doing his Masters of Pharmacy with India s best institute R. C. P. Institute of Pharmaceutical Education and Research, Shirpur. His recen.

Taschenbuch. Condición: Neu. This item is printed on demand - Print on Demand Titel. Neuware -Over expression of 11ß-HSD 1 in key metabolic tissues is related to the development of type 2 diabetes, obesity, hypertension and metabolic syndrome. Nephrotoxicity of corosolic acid (selective inhibitor of 11ß-HSD 1) is recently reported, which is one of the major drawback. Therefore, it is of great interest to find out the selective 11ß-HSD 1 inhibitors without nephrotoxicity. Using crystal structures of 11ß-HSD 1 in complex with inhibitors as a source of structural information, a combined structure-based virtual screening approach followed by PASS toxicity prediction, Lipinski's rule and ADME prediction implemented to find out the potent and selective 11 ß-HSD 1 analog of corosolic acid without nephrotoxicity.VDM Verlag, Dudweiler Landstraße 99, 66123 Saarbrücken 56 pp. Englisch.

Taschenbuch. Condición: Neu. nach der Bestellung gedruckt Neuware - Printed after ordering - Over expression of 11beta-HSD 1 in key metabolic tissues is related to the development of type 2 diabetes, obesity, hypertension and metabolic syndrome. Nephrotoxicity of corosolic acid (selective inhibitor of 11beta-HSD 1) is recently reported, which is one of the major drawback. Therefore, it is of great interest to find out the selective 11beta-HSD 1 inhibitors without nephrotoxicity. Using crystal structures of 11beta-HSD 1 in complex with inhibitors as a source of structural information, a combined structure-based virtual screening approach followed by PASS toxicity prediction, Lipinski's rule and ADME prediction implemented to find out the potent and selective 11 beta-HSD 1 analog of corosolic acid without nephrotoxicity.