9781496016584 - study of interaction of the cyclin-dependent kinase 5 with its activator, p25 and with the p25-derived inhibitor, cip de cardone, antonio; sriram, ram d.; albers, wayne; pant, harish c. (7 resultados)
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Study of Interaction of the Cyclin-Dependent Kinase 5 With Its Activator, P25 and With the P25-Derived Inhibitor, CIP
Cardone, Antonio; Sriram, Ram D.; Albers, Wayne; Pant, Harish C.
Idioma: Inglés
Editorial: CreateSpace Independent Publishing Platform, 2009
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Librería: GreatBookPrices, Columbia, MD, Estados Unidos de AmericaGreatBookPrices
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EUR 11,89
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Study of Interaction of the Cyclin-Dependent Kinase 5 With Its Activator, P25 and With the P25-Derived Inhibitor, CIP
Cardone, Antonio; Sriram, Ram D.; Albers, Wayne; Pant, Harish C.
Idioma: Inglés
Editorial: CreateSpace Independent Publishing Platform, 2009
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Librería: GreatBookPrices, Columbia, MD, Estados Unidos de AmericaGreatBookPrices
Contactar con el vendedorVendedor de 5 estrellasCondición: Nuevo
EUR 12,81
Envío por EUR 2,29Se envía dentro de Estados Unidos de AmericaCantidad disponible: Más de 20 disponibles
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Study of Interaction of the Cyclin-Dependent Kinase 5 With Its Activator, P25 and With the P25-Derived Inhibitor, CIP
Cardone, Antonio; Sriram, Ram D.; Albers, Wayne; Pant, Harish C.
Idioma: Inglés
Editorial: CreateSpace Independent Publishing Platform, 2009
- Tapa blanda
Librería: GreatBookPricesUK, Woodford Green, Reino UnidoGreatBookPricesUK
Contactar con el vendedorVendedor de 5 estrellasCondición: Usado - Como Nuevo
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Study of Interaction of the Cyclin-Dependent Kinase 5 With Its Activator, P25 and With the P25-Derived Inhibitor, CIP
Cardone, Antonio; Sriram, Ram D.; Albers, Wayne; Pant, Harish C.
Idioma: Inglés
Editorial: CreateSpace Independent Publishing Platform, 2009
- Tapa blanda
Librería: GreatBookPricesUK, Woodford Green, Reino UnidoGreatBookPricesUK
Contactar con el vendedorVendedor de 5 estrellasCondición: Nuevo
EUR 18,30
Envío por EUR 17,53Se envía de Reino Unido a Estados Unidos de AmericaCantidad disponible: Más de 20 disponibles
Condición: New.
Study of Interaction of the Cyclin-dependent Kinase 5 with its Activator, P25 and with the P25-derived Inhibitor, CIP
Cardone, Antonio; Sriram, Ram D.; Albers, Wayne; Pant, Harish C.
Idioma: Inglés
Editorial: CreateSpace Independent Publishing Platform, 2009
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- Impresión bajo demanda
Librería: California Books, Miami, FL, Estados Unidos de AmericaCalifornia Books
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Idioma: Inglés
Editorial: Createspace Independent Publishing Platform, 2009
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Paperback / softback. Condición: New. This item is printed on demand. New copy - Usually dispatched within 5-9 working days.
Idioma: Inglés
Editorial: Createspace Independent Publishing Platform, 2009
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Librería: CitiRetail, Stevenage, Reino UnidoCitiRetail
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Paperback. Condición: new. Paperback. A high-affinity inhibitor protein called CIP, which can be produced by small truncations of p35, was earlier identified by Amin, Albers, and Pant. P35 is one of the physiological activators of cdk5, a member of the cyclin-dependent kinase family. These proteins are known to be associated wit…h the hyperphosphorylation of specific neuronal proteins. This typically occurs in the case of neurodegenerative diseases such as Alzheimer s. In this paper the authors study in silico the binding mechanism of cdk5-p25 and cdk5-CIP complexes more in detail. This provides a better understanding of the inhibitory activity of the protein CIP. The authors use a geometry-based technique to verify the following hypothesis: p25 s truncation provides increased flexibility to CIP, and hence CIP is able to conform better to cdk5 interface than p25 is. Therefore CIP is expected to bind to cdk5 more easily than p25 and prevent it from reaching its active conformation. The authors' in silico study is based on a geometry-based alignment algorithm. The algorithm is capable of efficiently aligning two protein conformations with respect to their interfaces, which are represented as point sets. The algorithm is based on biochemical criteria as well as geometrical ones. This item is printed on demand. Shipping may be from our UK warehouse or from our Australian or US warehouses, depending on stock availability.
