springer new york aug 2015 (120 resultados)

Buch. Condición: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This is the story of the astronomer Milton La Salle Humason, whose career was integral to developing our understanding of stellar and universal evolution and who helped to build the analytical basis for the work of such notable astronomers and astrophysicists as Paul Merrill, Walter Adams, Alfred Joy, Frederick Seares, Fritz Zwicky, Walter Baade and Edwin Hubble. Humason's unlikely story began on the shores of the Mississippi River in Winona, Minnesota, in 1891 and led to the foot of Mount Wilson outside Los Angeles, California, twelve years later. It is there where he first attended summer camp in 1903 and was captivated by its surroundings. The mountain would become the backdrop for his life and career over the next six decades as he helped first build George Ellery Hale's observatory on the summit and then rose to become one of that institution's leading figures through the first half of the twentieth century. The story chronicles Humason's life on Mount Wilson, from his first trip to the mountain to his days as a muleskinner, leading teams of mules hauling supplies to the summit during the construction of the observatory, and follows him through his extraordinary career in spectroscopy, working beside Edwin Hubble as the two helped to reconstruct our concept of the universe. A patient, knowledgeable and persistent observer, Humason was later awarded an honorary doctorate for his work, despite having no formal education beyond the eighth grade. His skill at the telescope is legendary. During his career he photographed the spectra of stars, galaxies and other objects many thousands of times fainter than can be seen with the naked eye and pushed the boundary of the known universe deeper into space than any before him. His work, which included assisting in the formulation of Hubble's Law of redshifts, helped to set the field of cosmology solidly on its foundation. Milton Humason was one of the most charismatic characters in science during the first half of the 20th century. Uneducated, streetwise, moonshining, roguish, humble and thoroughly down to earth, he rose by sheer chance, innate ability and incredible will to become the leading deep space observer of his day. 'The Renaissance man of Mount Wilson,' as Harlow Shapley once referred to him, Humason's extraordinary life reminds us that passion and purpose may find us at any moment. 244 pp. Englisch.

Taschenbuch. Condición: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -As the European Union has evolved, it has also begun to address policy questions which are closer to the very heart of the state. From cooperation in Justice and Home Affairs, originally conceived as the third pillar of European cooperation, has emerged the Area of Freedom, Security, and Justice (AFSJ). A unique aspect of policy in this area is the desire to integrate the internal and external dimensions of this policy area. One of the tensions in this policy area has been balancing the protection of fundamental rights and increasing security. The first part of this book focuses on the institutional relations of policymaking in AFSJ, both within member states and between member states, in particular the issues of national executive control, national parliamentary scrutiny and peer review across the member states with regard to AFSJ. The second part focuses on specific policy areas which are part of AFSJ. Two chapters highlight the tension found in this policy area between security and human or fundamental rights, the first related to data retention and the second on policing external borders. The final two chapters are concerned with data exchange among European countries and transatlantically with the US, and the interface between AFSJ and the Common Foreign and Security Policy (CFSP). The chapters contained in the book were presented at the Dutch Ministry of the Interior and Kingdom Relations and the Dutch national parliament (Tweede Kamer), making it of interest to scholars and practitioners alike. 152 pp. Englisch.

Taschenbuch. Condición: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This book discusses the rapidly developing subject of mathematical analysis that deals primarily with stability of functional equations in generalized spaces. The fundamental problem in this subject was proposed by Stan M. Ulam in 1940 for approximate homomorphisms. The seminal work of Donald H. Hyers in 1941 and that of Themistocles M. Rassias in 1978 have provided a great deal of inspiration and guidance for mathematicians worldwide to investigate this extensive domain of research.The book presents a self-contained survey of recent and new results on topics including basic theory of random normed spaces and related spaces; stability theory for new function equations in random normed spaces via fixed point method, under both special and arbitrary t-norms; stability theory of well-known new functional equations in non-Archimedean random normed spaces; and applications in the class of fuzzy normed spaces. It contains valuable results on stability in random normed spaces, and is geared toward both graduate students and research mathematicians and engineers in a broad area of interdisciplinary research. 268 pp. Englisch.

Taschenbuch. Condición: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This monograph gives a short introduction to the relevant modern parts of discrete geometry, in addition to leading the reader to the frontiers of geometric research on sphere arrangements. The readership is aimed at advanced undergraduate and early graduate students, as well as interested researchers. It contains more than 40 open research problems ideal for graduate students and researchers in mathematics and computer science. Additionally, this book may be considered ideal for a one-semester advanced undergraduate or graduate level course. The core part of this book is based on three lectures given by the author at the Fields Institute during the thematic program on 'Discrete Geometry and Applications' and contains four core topics. The first two topics surround active areas that have been outstanding from the birth of discrete geometry, namely dense sphere packings and tilings. Sphere packings and tilings have a very strong connection to number theory, coding, groups, and mathematical programming. Extending the tradition of studying packings of spheres, is the investigation of the monotonicity of volume under contractions of arbitrary arrangements of spheres. The third major topic of this book can be found under the sections on ball-polyhedra that study the possibility of extending the theory of convex polytopes to the family of intersections of congruent balls. This section of the text is connected in many ways to the above-mentioned major topics and it is also connected to some other important research areas as the one on coverings by planks (with close ties to geometric analysis). This fourth core topic is discussed under covering balls by cylinders. 188 pp. Englisch.

Taschenbuch. Condición: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Fundamentals of Matrix-Analytic Methods targets advanced-level students in mathematics, engineering and computer science. It focuses on the fundamental parts of Matrix-Analytic Methods, Phase-Type Distributions, Markovian arrival processes and Structured Markov chains and matrix geometric solutions. New materials and techniques are presented for the first time in research and engineering design. This book emphasizes stochastic modeling by offering probabilistic interpretation and constructive proofs for Matrix-Analytic Methods. Such an approach is especially useful for engineering analysis and design. Exercises and examples are provided throughout the book. 368 pp. Englisch.

Taschenbuch. Condición: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This book focuses on a development of optimal, flexible, and efficient models and algorithms for cell formation in group technology. Its main aim is to provide a reliable tool that can be used by managers and engineers to design manufacturing cells based on their own preferences and constraints imposed by a particular manufacturing system. This tool could potentially lower production costs by minimizing other costs in a number of areas, thereby increasing profit in a manufacturing system. In the volume, the cell formation problem is considered in a systematic and formalized way, and several models are proposed, both heuristic and exact. The models are based on general clustering problems, and are flexible enough to allow for various objectives and constraints. The authors also provide results of numerical experiments involving both artificial data from academic papers in the field and real manufacturing data to certify the appropriateness of the models proposed. The book was intended to suit the broadest possible audience, and thus all algorithmic details are given in a detailed description with multiple numerical examples and informal explanations are provided for the theoretical results. In addition to managers and industrial engineers, this book is intended for academic researchers and students. It will also be attractive to many theoreticians, since it addresses many open problems in computer science and bioinformatics. 220 pp. Englisch.

Taschenbuch. Condición: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Brownian dynamics serve as mathematical models for the diffusive motion of microscopic particles of various shapes in gaseous, liquid, or solid environments. The renewed interest in Brownian dynamics is due primarily to their key role in molecular and cellular biophysics: diffusion of ions and molecules is the driver of all life. Brownian dynamics simulations are the numerical realizations of stochastic differential equations that model the functions of biological micro devices such as protein ionic channels of biological membranes, cardiac myocytes, neuronal synapses, and many more. Stochastic differential equations are ubiquitous models in computational physics, chemistry, biophysics, computer science, communications theory, mathematical finance theory, and many other disciplines. Brownian dynamics simulations of the random motion of particles, be it molecules or stock prices, give rise to mathematical problems that neither the kinetic theory of Maxwell and Boltzmann, nor Einstein's and Langevin's theories of Brownian motion could predict.This book takes the readers on a journey that starts with the rigorous definition of mathematical Brownian motion, and ends with the explicit solution of a series of complex problems that have immediate applications. It is aimed at applied mathematicians, physicists, theoretical chemists, and physiologists who are interested in modeling, analysis, and simulation of micro devices of microbiology. The book contains exercises and worked out examples throughout. 344 pp. Englisch.

Taschenbuch. Condición: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This SpringerBrief offers careful assessments of the appropriateness and effectiveness of currently available methodologies for fire flow. It explains the water supply requirements for firefighting including rate of flow, the residual pressure required at that flow, and the duration that is necessary to control a major fire in a specific structure.First reviewing existing fire flow calculation methodologies in the U.S. and globally, the authors determine the new information necessary to validate the existing fire flow calculation methodologies. After identifying 19 methods from the U.S., UK, France, Germany, the Netherlands, New England, and Canada, two types of methods are evaluated: those for building planning based on fire and building code requirements, and those for on-scene fire service use.Building planning methods are also examined, including an explanation of the range of building variables that determine fire flow. A survey form for fire departments is provided to help fire departments identify key predictive features based on construction and building parameters. Researchers and professionals in fire engineering will find the recommendations in Evaluation of Fire Flow Methodologies valuable. 64 pp. Englisch.

Taschenbuch. Condición: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -In creating interpretive strategies for maritime sites, archaeologists and resource managers often are required to think creatively to overcome challenges and problems. These issues include interpreting sites in inaccessible locations and extremely deep water, enabling and controlling access to fragile sites and restricted areas, monitoring visitor behavior, making information interesting to a wide audience, and creating opportunities for public engagement, among other concerns. Meeting Challenges presents cutting-edge interpretation and public education strategies for maritime resources, both on land and underwater, with emphasis on solving the unique problems often associated with presenting these fragile, limited-access sites as heritage attractions and on developing effective visitation and civic engagement opportunities. The examples presented ideally can serve as models for resource managers, archaeologists engaged in interpretation, and site administrators. This volume brings together a diverse group of heritage professionals to discuss issues they've encountered and to present ideas and case studies for adapting, improvising, and overcoming them. 228 pp. Englisch.

Taschenbuch. Condición: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -The rate at which geospatial data is being generated exceeds our computational capabilities to extract patterns for the understanding of a dynamically changing world. Geoinformatics and data mining focuses on the development and implementation of computational algorithms to solve these problems. This unique volume contains a collection of chapters on state-of-the-art data mining techniques applied to geoinformatic problems of high complexity and important societal value. Data Mining for Geoinformatics addresses current concerns and developments relating to spatio-temporal data mining issues in remotely-sensed data, problems in meteorological data such as tornado formation, estimation of radiation from the Fukushima nuclear power plant, simulations of traffic data using OpenStreetMap, real time traffic applications of data stream mining, visual analytics of traffic and weather data and the exploratory visualization of collective, mobile objects such as the flocking behavior of wild chickens.This book is designed for researchers and advanced-level students focused on computer science, earth science and geography as a reference or secondary text book. Practitioners working in the areas of data mining and geoscience will also find this book to be a valuable reference. 180 pp. Englisch.

Taschenbuch. Condición: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -The 'extensions' of rings and modules have yet to be explored in detail in a research monograph. This book presents state of the art research and also stimulating new and further research. Broken into three parts, Part I begins with basic notions, terminology, definitions and a description of the classes of rings and modules. Part II considers the transference of conditions between a base ring or module and its extensions. And Part III utilizes the concept of a minimal essental extension with respect to a specific class (a hull).Mathematical interdisciplinary applications appear throughout. Major applications of the ring and module theory to Functional Analysis, especially C\*-algebras, appear in Part III, make this book of interest to Algebra and Functional Analysis researchers. Notes and exercises at the end of every chapter, and open problems at the end of all three parts, lend this as an ideal textbook for graduate or advanced undergradate students. 452 pp. Englisch.

Buch. Condición: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This volume is a concise yet comprehensive resource for physicians dealing with, and interested in, the field of molecular pathology in dermatopathology. The book includes descriptions of the techniques and their application to cutaneous diseases and describes possible future techniques and their use in dermatopathology. Special emphasis is also given to the practical application of these techniques to particular situations illustrated by demonstrative cases.Written by experts in their fields, Precision Molecular Pathology of Dermatologic Diseases is of great value to pathologists, dermatologists, resident and fellows, internists, and general practitioners who deal with dermatologic diseases. 144 pp. Englisch.

Taschenbuch. Condición: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -The goal of this Third Edition is to update long-term data presented in earlier editions and to generate new syntheses and conclusions about the biogeochemistry of the Hubbard Brook Valley based on these longer-term data. There have been many changes, revelations, and exciting new insights generated from the longer data records. For example, the impact of acid rain peaked during the period of the HBES and is now declining. The longer-term data also posed challenges in that very marked changes in fluxes occurred in some components, such as hydrogen ion and sulfate deposition, calcium and nitrate export in stream water and biomass accumulation, during the almost 50 years of record. Thus, presenting 'mean' or 'average' conditions for many components for such a long period, when change was so prominent, do not make sense. In some cases, pentads or decades of time are compared to show these changes in a more smoothed and rational way for this long period. In some cases, a single period, often during periods of rapid change, such as acidification, is used to illustrate the main point(s). And, for some elements a unique mass balance approach, allowing the calculation of the Net Ecosystem Flux (NEF), is shown on an annual basis throughout the study. 240 pp. Englisch.

Taschenbuch. Condición: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -The goal of this work is to present the principles of functional analysis in a clear and concise way. The first three chapters of Functional Analysis: Fundamentals and Applications describe the general notions of distance, integral and norm, as well as their relations. The three chapters that follow deal with fundamental examples: Lebesgue spaces, dual spaces and Sobolev spaces. Two subsequent chapters develop applications to capacity theory and elliptic problems. In particular, the isoperimetric inequality and the Pólya-Szegö and Faber-Krahn inequalities are proved by purely functional methods. The epilogue contains a sketch of the history of functional analysis, in relation with integration and differentiation. Starting from elementary analysis and introducing relevant recent research, this work is an excellent resource for students in mathematics and applied mathematics. 228 pp. Englisch.

Taschenbuch. Condición: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Visualizations are visual representations of non-visual data. They are produced for people to interact with and to make sense of the underlying data. Rapid advances in display technology and computer power have enabled researchers to produce visually appealing pictures. However, the effectiveness of those pictures in conveying the embedded information to end users has not been fully explored.Handbook of Human Centric Visualization addresses issues related to design, evaluation and application of visualizations. Topics include visualization theories, design principles, evaluation methods and metrics, human factors, interaction methods and case studies. This cutting-edge book includes contributions from well-established researchers worldwide, from diverse disciplines including psychology, visualization and human-computer interaction.This handbook is designed for a professional audience composed of practitioners, lecturers and researchers working in the field of computer graphics, visualization, human-computer interaction and psychology. Undergraduate and postgraduate students in science and engineering focused on this topic will also find this book useful as a comprehensive textbook or reference. 768 pp. Englisch.

Taschenbuch. Condición: Neu. This item is printed on demand - Print on Demand Titel. Neuware -Fundamentals of Matrix-Analytic Methods targets advanced-level students in mathematics, engineering and computer science. It focuses on the fundamental parts of Matrix-Analytic Methods, Phase-Type Distributions, Markovian arrival processes and Structured Markov chains and matrix geometric solutions.New materials and techniques are presented for the first time in research and engineering design. This book emphasizes stochastic modeling by offering probabilistic interpretation and constructive proofs for Matrix-Analytic Methods. Such an approach is especially useful for engineering analysis and design. Exercises and examples are provided throughout the book.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 368 pp. Englisch.

Taschenbuch. Condición: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Valuing Intellectual Capital provides readers with prescriptive strategies and practical insights for estimating the value of intellectual property (IP) and the people who create that IP within multinational companies. This book addresses the crucial topic of taxation from a rigorous and quantitative perspective, backed by experience and original research that illustrates how large corporations need to measure the worth of their intangible assets. Each method in the text is applied through the lens of a model corporation, in order for readers to understand and quantify the operation of a real-world multinational enterprise and pinpoint how companies easily misvalue their intellectual capital when transferring IP rights to offshore tax havens. The effect contributes to the issues that can lead to budgetary crises, such as the so-called 'fiscal cliff' that was partially averted by passage of the American Taxpayer Relief Act on New Year's day 2013. This book also features a chapter containing recommendations for a fair and balanced corporate tax structure free of misvaluation and questionable mechanisms. CFOs, corporate auditors, corporate financial analysts, corporate financial planners, economists, and journalists working with issues of taxation will benefit from the concepts and background presented in the book. The material clearly indicates how a trustworthy valuation of intellectual capital allows a realistic assessment of a company's income, earnings, and obligations. Because of the intense interest in the topic of corporate tax avoidance the material is organized to be accessible to a broad audience. 564 pp. Englisch.

Taschenbuch. Condición: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -The book will be focused on the three most important aspects of food packaging: Modeling, Materials and Packaging Strategies. The modeling section will provide a complete overview of mass transport phenomena in polymers intended for food packaging applications. The materials section will cover the most interesting problem-solving solutions in the field of food packaging, i.e., low environmental impact active films with antimicrobial activity. Lastly, the packaging section will provide an overview of the most recent approaches used to prolong the shelf life of several food products. 204 pp. Englisch.

Taschenbuch. Condición: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -George Andrews is one of the most influential figures in number theory and combinatorics. In the theory of partitions and q-hypergeometric series and in the study of Ramanujan's work, he is the unquestioned leader. To suitably honor him during his 70th birthday year, an International Conference on Combinatory Analysis was held at The Pennsylvania State University during December 5-7, 2008. Three issues of the Ramanujan Journal comprising Volume 23 were published in 2010 as the refereed proceedings of that conference. The Ramanujan Journal was proud to bring out that volume honoring one of its Founding Editors. In view of the great interest that the mathematical community has in the influential work of Andrews, it was decided to republish Volume 23 of The Ramanujan Journal in this book form, so that the refereed proceedings are more readily available for those who do not subscribe to the journal but wish to possess this volume.As a fitting tribute to George Andrews, many speakers from the conference contributed research papers to this volume which deals with a broad range of areas that signify the research interests of George Andrews. In reproducing Volume 23 of The Ramanujan Journal in this book form, we have included two papers-one by Hei-Chi Chan and Shaun Cooper, and another by Ole Warnaar-which were intended for Volume 23 of The Ramanujan Journal, but appeared in other issues.The enormous productivity of George Andrews remains unabated in spite of the passage of time. His immensely fertile mind continues to pour forth seminal ideas year after year. He has two research papers in this volume. May his eternal youthfulness and his magnificent research output continue to inspire and influence researchers in the years ahead. 480 pp. Englisch.

Taschenbuch. Condición: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This book provides a crash course on various methods from the bifurcationtheory of Functional Differential Equations (FDEs). FDEs arise very naturally in economics, life sciences and engineering and the study of FDEs has been a major source of inspiration for advancement in nonlinear analysis and infinite dimensional dynamical systems. The book summarizes some practical and general approaches and frameworks for the investigation of bifurcation phenomena of FDEs depending on parameters with chap. This well illustrated book aims to be self containedso the readers will find in this book all relevant materials inbifurcation, dynamical systems with symmetry, functional differentialequations, normal forms and center manifold reduction. This material was used in graduate courses on functional differential equations at Hunan University (China) and York University (Canada). 300 pp. Englisch.

Buch. Condición: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This volume brings together a unique collection of protocols that cover standard, novel, and specialized techniques. Cell Cycle Oscillators: Methods and Protocols guides readers through recent progress in the field from both holistic and reductionist perspectives, providing the latest developments in molecular biology techniques, biochemistry, and computational analysis used for studying oscillatory networks. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.Authoritative and cutting-edge, Cell Cycle Oscillators: Methods and Protocols will serve as an invaluable reference to gain further insight into the complex and incompletely understood processes that are involved in the cell cycle and its regulation by oscillatory networks. 368 pp. Englisch.

Taschenbuch. Condición: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Lie Groups: Structures, Actions, and Representations, In Honor of Joseph A. Wolf on the Occasion of his 75th Birthday consists of invited expository and research articles on new developments arising from Wolf's profound contributions to mathematics. Due to Professor Wolf's broad interests, outstanding mathematicians and scholars in a wide spectrum of mathematical fields contributed to the volume. Algebraic, geometric, and analytic methods are employed. More precisely, finite groups and classical finite dimensional, as well as infinite-dimensional Lie groups, and algebras play a role. Actions on classical symmetric spaces, and on abstract homogeneous and representation spaces are discussed. Contributions in the area of representation theory involve numerous viewpoints, including that of algebraic groups and various analytic aspects of harmonic analysis. Contributors D. Akhiezer T. OshimaA. Andrada I. PacharoniM. L. Barberis F. RicciL. Barchini S. RosenbergI. Dotti N. ShimenoM. Eastwood J. TiraoV. Fischer S. TreneerT. Kobayashi C.T.C. WallA. Korányi D. WallaceB. Kostant K. WiboontonP. Kostelec F. XuK.-H. Neeb O. YakimovaG. Olafsson R. ZierauB. Ørsted 428 pp. Englisch.

Taschenbuch. Condición: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Presents a comprehensive synopsis of the current state of cosmic rays, their modulation and their effects in the Earth's atmosphere.Leading scientists in the field assess the current state of our understanding of the spatial and temporal variations of galactic and anomalous cosmic rays in the Heliosphere, and their relation to effects of the Sun. The main objective is to understand the spatial and temporal variation of galactic and anomalous cosmic rays in the light of recent observations, theory and modeling by identifying the key mechanism(s) of cosmic ray modulation and how changes on the Sun relate to changes in the observed characteristics of cosmic rays in the Heliosphere; examining the current long-lasting solar minimum and understand its implications for solar-cycle variations and long-term variations; and interpreting the long-term variations of cosmogenic radionuclides in terms of solar variability and climate change on Earth.This volume is aimed at graduate students active in the fields of solar physics, space science, and cosmic ray physics.Originally published in Space Science Reviews journal, Vol. 176/1-4, 2013. 412 pp. Englisch.

Taschenbuch. Condición: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This book describes an approach for designing Systems-on-Chip such that the system meets precise mathematical requirements. The methodologies presented enable embedded systems designers to reuse intellectual property (IP) blocks from existing designs in an efficient, reliable manner, automatically generating correct SoCs from multiple, possibly mismatching, components. 168 pp. Englisch.

Taschenbuch. Condición: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Collective view prediction is to judge the opinions of an active web user based on unknown elements by referring to the collective mind of the whole community. Content-based recommendation and collaborative filtering are two mainstream collective view prediction techniques. They generate predictions by analyzing the text features of the target object or the similarity of users' past behaviors. Still, these techniques are vulnerable to the artificially-injected noise data, because they are not able to judge the reliability and credibility of the information sources. Trust-based Collective View Prediction describes new approaches for tackling this problem by utilizing users' trust relationships from the perspectives of fundamental theory, trust-based collective view prediction algorithms and real case studies. The book consists of two main parts - a theoretical foundation and an algorithmic study. The first part will review several basic concepts and methods related to collective view prediction, such as state-of-the-art recommender systems, sentimental analysis, collective view, trust management, the Relationship of Collective View and Trustworthy, and trust in collective view prediction. In the second part, the authors present their models and algorithms based on a quantitative analysis of more than 300 thousand users' data from popular product-reviewing websites. They also introduce two new trust-based prediction algorithms, one collaborative algorithm based on the second-order Markov random walk model, and one Bayesian fitting model for combining multiple predictors. The discussed concepts, developed algorithms, empirical results, evaluation methodologies and the robust analysis framework described in Trust-based Collective View Prediction will not only provide valuable insights and findings to related research communities and peers, but also showcase the great potential to encourage industries and business partners to integrate these techniques into new applications. 160 pp. Englisch.

Buch. Condición: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This volume provides methods for characterization of muscarinic receptor in crystallography studies that advanced our understanding of structural properties and activation mechanism of muscarinic receptors and are cornerstone in molecular modeling and computer based approaches to study muscarinic receptors. Muscarinic Receptor: From Structure to Animal Models guides readers through binding techniques, protocols to investigate molecular properties of muscarinic receptors, protocols to study muscarinic receptors in the central nervous system using autoradiography and PET studies and protocols on animals with knock-out and knock-in muscarinic genes to study role of muscarinic receptors in physiology and behavior. Written in the popular Neuromethods series style, chapters include the kind of detail and key advice from the specialists needed to get successful results in your own laboratory.Concise and easy-to-use, Muscarinic Receptor: From Structure to Animal Models aims to ensure successful results in the further study of this vital field. 300 pp. Englisch.

Buch. Condición: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -The potential of human embryonic stem cells to advance not only regenerative medicine applications but also our fundamental understanding of stem cell biology continues to drive interest in research with these cells. This detailed volume collects some of the most interesting and useful protocols that have emerged in the area over the last several years. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and expert tips on troubleshooting and avoiding known pitfalls.Thorough and practical, Human Embryonic Stem Cell Protocols, Third Edition serves as a valuable resource to all those interested in exploring stem cell biology questions in a research setting. 416 pp. Englisch.

Buch. Condición: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This volume contains a collection of relevant information for drug discovery in cell cycle research. Protocols to develop screening assays or to identify novel CDK inhibitors are discussed in the first part of the book. The second part of the book describes elaborate procedures to evaluate activity and mechanism of action of new and already identified CDK inhibitors. The third part of the book talks about protocols to evaluate metabolomics changes associated to inhibitor treatment. Drug delivery strategies focused on nanoparticle development to provide alternative internalization systems for increasing inhibitor efficacy are also described. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.Authoritative and thorough, Cyclin-Dependent Kinase (CDK) Inhibitors: Methods and Protocols is a useful tool for scientists interested in this research field. 240 pp. Englisch.

Buch. Condición: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This detailed volume provides an overview of recent techniques employed in the field of G protein-coupled receptors (GPCRs) to screen for new drugs and to derive information about their receptor structure, dynamics, and function for the purpose of developing improved therapeutics. Owing to remarkable recent advances in the structural, biophysical and biochemical analyses of these receptors, as well as a growing body of evidence hinting at the possible relevance of allosteric modulators, biased agonists and oligomer-selective ligands as improved therapeutic agents, drug discovery for GPCRs has recently taken a completely new direction. For this book, expert contributors have shared their protocols and views on the impact of these methodologies on modern drug discovery. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols and tips on troubleshooting and avoiding known pitfalls.Practical and fully updated, G Protein-Coupled Receptors in Drug Discovery: Methods and Protocols, Second Edition serves as an ideal guide for a diverse audience from structural and molecular biologists to pharmacologists and drug designers who wish to explore this extensive class of key drug targets. 340 pp. Englisch.

Buch. Condición: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This detailed volume covers molecular biology, cellular biology, biomarkers, imaging, and neuropathological methods and techniques to explore multiple sclerosis (MS), with a special emphasis on disease models. With so much effort needed to elucidate basic disease mechanisms, to clone disease relevant genes, to define novel biomarkers, and to discover novel and improved therapeutic and curative treatments, this book serves to aid researchers in accomplishing these enormous goals. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.Practical and easy to use, Multiple Sclerosis: Methods and Protocols will empower the reader to perform novel research regarding pathophysiology and treatment for MS. 244 pp. Englisch.